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25 July 2019, Volume 2 Issue 3       Anti-aging Research Previous Issue   
Report
A darkfield microscopic evaluation of the live blood effects caused by Moringa oleifera
Howard W. Fisher, Colombe Gauvin
90Life Research. 2019, 2 (3): 87-92.   https://doi.org/10.12032/life2019-0725-002
Abstract ( 372 )   HTML ( 7 )     PDF (5462KB) ( 61 )  

Erythrocyte aggregation is the tendency of erythrocytes to form aggregates whose shapes change according to normal variations or pathological conditions. Consequently, regardless of cause, these anomalies effect changes to flow dynamics and predispose the inability to carry out transportation activities and decrease functional capillary density or decrease erythrocyte surface area, also decreasing functional efficiency. Functional capillary density is the determination of the number of capillaries in an area that have erythrocyte flow and relates to the subsequent ability of the blood to deliver nutrients, fluid and solute exchange, and waste product excretion. Red blood cell aggregation has a significant impact on functional capillary density. Moringa oleifera, one of the most phytonutrient dense plants as identified by the NIH, has garnered interest by those involved with anti-aging medicine. The US National Institutes of Health, the nation’s medical research agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability, has affirmed Moringa oleifera can “arrest, reverse, and cure, over 300 different diseases and disorders.” Regular use of Moringa oleifera has been shown to have a multitude of health benefits. In addition to this, Moringa oleifera provides all of the essential amino acids, vital vitamins, contains several important minerals, is an incredibly powerful antioxidant, is high in fiber, stimulates the immune system to fight cancerous cells, tumours, ulcers, epileptic seizures and cleanses and detoxifies the entire body. Moringa oleifera has been shown to protect platelets against aggregation. In this investigation, live blood microscopic evaluation indicates positive changes in the shape and spatial orientation of the erythrocytes and decreased incidence of aggregation and rouleaux indicating improved functional capillary density. In conclusion, a proprietary formula of raw organic Moringa oleifera has empirically demonstrated subjective beneficial changes in patients who have supplemented with this formula.

Review
A summary of the pharmacologically tested aphrodisiac plants for sexual dysfunction
Marko Mornar Jelavic, Hrvoje Pintaric
90Life Research. 2019, 2 (3): 93-98.   https://doi.org/10.12032/life2019-0725-301
Abstract ( 84 )   HTML ( 3 )     PDF (1003KB) ( 35 )  

Sexual dysfunction is a disruption of normal sexual intercourse and may be a consequence of various organic and psychological disorders. It is the most frequent at patients with cardiovascular and neurological diseases sedentary lifestyle arterial hypertension diabetes obesity and metabolic syndrome and may disrupt their emotional life. But sexual dysfunction may occur simply because of the physical aging of the body. Physiologic changes that occur with aging will affect sexual function and could be exacerbated by the above-mentioned diseases. Except for the sexual counseling and standard medications (phosphodiesterase type 5 (PDE5) - inhibitors local estrogen therapy) some of the herbal medicines (aphrodisiacs) may be helpful in the treatment of these patients making them emotionally younger and happier. In this review we bring a list of the pharmacologically tested aphrodisiac plants. But we have a lack of information about their mechanisms of action drug interaction and safety profile. Until the relevant information is collected uses of these products may be risky to the human being and should be prescribed only in consultation with a specialist. Sexual dysfunction is a disruption of normal sexual intercourse and may be a consequence of various organic and psychological disorders. It is the most frequent at patients with cardiovascular and neurological diseases sedentary lifestyle arterial hypertension diabetes obesity and metabolic syndrome and may disrupt their emotional life. But sexual dysfunction may occur simply because of the physical aging of the body. Physiologic changes that occur with aging will affect sexual function and could be exacerbated by the above-mentioned diseases. Except for the sexual counseling and standard medications (phosphodiesterase type 5 (PDE5) - inhibitors local estrogen therapy) some of the herbal medicines (aphrodisiacs) may be helpful in the treatment of these patients making them emotionally younger and happier. In this review we bring a list of the pharmacologically tested aphrodisiac plants. But we have a lack of information about their mechanisms of action drug interaction and safety profile. Until the relevant information is collected uses of these products may be risky to the human being and should be prescribed only in consultation with a specialist.

Tau pathology in Alzheimer’s disease and associated hypotheses
Shiruli Dash
90Life Research. 2019, 2 (3): 99-105.   https://doi.org/10.12032/life2019-0725-302
Abstract ( 43 )   HTML ( 1 )     PDF (1146KB) ( 5 )  

This review aims to summarize how Tau pathology, in particular, brings about Alzheimer’s disease (AD). Various studies from the past decade have been analyzed with the purpose of providing a compact description on how Tau protein influences AD. The pathologies associated with the accumulation of Amyloid and Tau have always been at the forefront of all research on Alzheimer’s disease, which have usually centered around a deeper understanding of the pathophysiological mechanisms, or on developing therapeutics targeting these proteins. Recent data has also continuously been challenging the ubiquitous acceptance of amyloid being the driving force for Alzheimer’s disease as anti-amyloid therapies continue to fail. Tau protein shows an independent ability to accumulate within nerve cells, and its propagation shows a continuous seeding and spreading pattern. The purpose of this review is thus to enforce the importance of Tau pathology and tailor future developments in AD treatment accordingly. By the end of this review, we thus infer how regional accumulations of Tau affect AD, how and why the amyloid cascade hypothesis needs to change, and we end by looking at findings from the recent “Beyond Amyloid” symposium where factors like a loss in DNA integrity, cell cycle disorders and microtubular dysregulation have been proposed as potential mediators of AD.

Empirical six-dimensional framework for slowing and reversing ageing using modern science and ancient wisdom
Asoka Nimal Jinadasa
90Life Research. 2019, 2 (3): 106-112.   https://doi.org/10.12032/life2019-0725-303
Abstract ( 110 )   HTML ( 2 )     PDF (1398KB) ( 28 )  

There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that explains in simple terms the key aspects of ageing and provides a set of daily practices for staying young and healthy. An attempt is made here to select a 6-dimensional framework symbolized by heart, mind, passion, focus, body and health, and correlate it to the mental, emotional, physical and health aspects of ageing. Based on grounded theory, this paper empirically correlates 30 practical methods that can be used to develop all six dimensions, with 18 key factors that were found to influence ageing: Neurogenesis; Epigenetic reprogramming; Removing dying cells; Mitochondria resuscitation; Calorie restriction; Plant-based diet; Regular physical activity; Chi Kung (Qigong); Overcoming anxiety, depression and stress; Positive mind-set; Some worrying; Vitamins and minerals; L-Theanine; Omega-3 and healthy fats; Coenzyme Q-10; Pyrroloquinoline quinone; Nitric oxide; Choline. In this study, 26 references were used to establish that all 18 of these seemingly unrelated key anti-ageing factors can be developed using 30 daily practices derived from the 6-dimensional framework. These simple daily practices can help people of all ages to stay young and healthy, and help older people who are living alone to self-improve their quality of life without needing anyone to look after them. Since many anti-ageing drugs seem to be ineffective, this study provides a holistic new research direction for using modern science and ancient human energy practices combined with wholesome nutrition to slow ageing and age-related illnesses.

Hypothesis
Anti-aging theory of quantum nature and brain reprogramming
Yurii Pozniak
90Life Research. 2019, 2 (3): 113-118.   https://doi.org/10.12032/life2019-0725-401
Abstract ( 100 )   HTML ( 3 )     PDF (2093KB) ( 34 )  

As many scientists believe, human aging is a very important part of the program of life-human activity rather than a disease. The human brain may be the controller, performer and participant of the natural program of life-human activity, from birth to death. The program of life-activities of the brain and the human body is very similar to a conventional computer program and it may also be malfunctioning. The work of the natural program of life-activity resembles the work of AI. Each program of life-activity of an individual is repeatedly subjected to natural correction of program tasks in the life of a biophysical being. However, in recent years, scientists from different countries began to seek to reprogram the brain and find the real cause of death. Some biologists and evolutionists believe that this process is nonrandom and that it is controlled by a kind of “death program.” So they call a special set of genes, forcing the body to become decrepit and die, giving way to a new generation of their own kind. The aim of our work is to design new technologies and methods to adjust the life-activity programs from biophysical views, increasing the useful life of bodies by delaying destructive processes and the aging process. Our life-activity program is carried out through the device and IT programs in a mobile application, using contact/contactless frequency code effects on the brain, which is decoded and accepted by the human brain for execution (reprogramming), as a natural addition and an integral part of the brain work. Code programs are compiled according to the working algorithms of the Cosmo-terrestrial structure of life-activity of biophysical objects on the planet Earth. Our technology is one of the varieties of brain-computer technology.

Comment
Exercise and nutrition research on longevity and quality life
Pierluigi Vagali
90Life Research. 2019, 2 (3): 119-123.   https://doi.org/10.12032/life2019-0725-601
Abstract ( 87 )   HTML ( 6 )     PDF (676KB) ( 27 )  

Exercise and Nutrition are complementary parts of a preventive and curative process to improve the quality of life, longevity and compress the life phase subject to disability. Physical activity and nutrition play an essential role both for the prevention of chronic non-communicable diseases and for their treatment. Nutraceuticals and exercise constitute the new frontier for healthy aging. We therefore motivate people by teaching them a new "life style", a delicate balance of adequate physical exercise and correct food hygiene, ensuring an unusual and surprising well-being and well-being, to which it will not be easier to give up.