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Predict the anti-cancer mechanism of astragalus membranaceus based on network pharmacology
Jia Wang, Zhu Yang, Feng-Xi Long, Jin-Lin Wu, Ting Yu, Dong-Xin Tang
8Food Therapy and Health Care    2019, 1 (3): 63-72.
Abstract PDF (3834KB)  
Objective: To explore the anti-cancer mechanism of active ingredients of Astragalus membranaceus(AM) through network pharmacology. Methods: TCMSP, PubChem, STICTH and GeneCards databases were used to predict and screen the main active ingredients and anti-cancer targets of AM. Active ingredient-target-disease network was constructed by Cytoscape 3.7.0 software, and protein interaction network was constructed by STRING platform. KEGG signaling pathway and GO biological process of targets were analyzed by Bioconductor database. Results: Twenty-four active ingredients were screened from AM, which acted on 106 cancer targets such as PTGS, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1. Through these targets, the anti-cancer effect of AM mainly acts on small cell lung cancer, colorectal cancer, thyroid cancer, breast cancer, non-small cell lung cancer, hepatocellular carcinoma, pancreatic cancer, gastric cancer, endometrial cancer, enriched in chemical carcinogenesis, Platinum drug resistance, Epstein-Barr virus infection, TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, and PI3K - Akt signaling pathway. Conclusion: This study found that the main anti-cancer compounds of AM are kaempferol, quercetin, 7-O-methylisomucronulatol, formononetin, isorhamnetin, Calycosin, 3,9-di-O-methylnissolin. The main targets include PTGS, PTGS1, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1, F2. The mechanisms involved in anticancer could be summarized as following: blocking the chemical carcinogenesis, reversing the platinum drug resistance, anti - Epstein - Barrvirus infection, and inhibiting cell proliferation related signaling pathways, such as TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, PI3K - AKT signaling pathway.
Research on hypertension in hohhot of mongolian: analysis of 9675 cases survey data
Hong-Mei Yu, Jian-Qiang Wu
8Food Therapy and Health Care    2019, 1 (3): 73-77.
Abstract PDF (791KB)  
Objective: Through investigating the daily habits of hypertensive and non-hypertensive Mongolian in Hohhot to explore the effect of daily habits on hypertension and further provide basis for future policy making. Methods: Two community health service centers were identified in each of the four districts of Hohhot City using a stratified cluster random sampling method and a multi-stage stratified sampling method. Results: By January 2019, a total of 9,800 people was investigated, and 9675 people with complete data. The effective rate of the questionnaire was 98.7%. The standardized prevalence of hypertension was 21.8% in Mongolia. The prevalence rate of hypertension in Mongolia was statistically significant among the different genders, ages, presence or absence of obesity, different diet types, whether smoking or drinking, or having tea, and aerobic exercise. (P < 0.05 for all). Multivariate unconditional logistic regression analysis showed that males were risk factors for hypertension; female, non-obese, non-hobby meat, no smoking, hobby tea, no alcohol and aerobic exercise were protective factors. Obesity, hobbies, meat, smoking, drinking are important risk factors for hypertension in Mongolian population in Hohhot. Conclusion: It is preliminarily clarified that the risk factors related to hypertension are mainly related to their own health-related behaviors and genetic factors, suggesting the necessity of healthy physical examination, maintaining blood pressure stability, controlling body mass, and moderate exercise.
The progress of nutritional support for chronic obstructive pulmonary disease
Jiao-Jiao Wang, Mei Tang, Yun-Xian Ma, Peng-Cheng Zhou
8Food Therapy and Health Care    2019, 1 (3): 89-96.
Abstract PDF (1026KB)  
The patients with chronic obstructive pulmonary disease (COPD) often occur weight loss and reduced muscle mass, which leads to decreased exercise capacity and vital capacity. The nutritional status is closely related to the prognosis of patients with COPD and nutritional support has played an important role in the treatment of COPD. In order to provide proper nutritional support, this article reviews the progress of nutritional support in COPD from the causes of malnutrition, energy demand assessment, assessment of nutritional risk and nutritional support methods. Moreover, this review specially reviewed the application of traditional Chinese medicine diet.
Mining potential adverse drug reactions of Houttuynia cordata Thunb from "real world" cases.
Wei-Xiu Fan, Li-Ting Yu, Li-Ping Yang
8Food Therapy and Health Care    2019, 1 (3): 78-88.
Abstract PDF (912KB)  
Objective: Search the "real world" case reports of Houttuynia cordata Thunb (HCT)-associated adverse drug reactions (ADRs) to systematically mine potential ADRs of HCT and further investigate whether HCT contained preparations could cause aristolochic acid nephropathy or cancer. Methods: PubMed, EMBASE, Science Direct, Scopus, Web of Science, and CNKI, Wanfang, VIP, Sinomed databases were searched from databases setup to 1st January 2019. All case reports using HCT contained preparations were pooled according to inclusion and exclusion criteria. 15 items in case reportes including basic informations of studies/patients, characters/treaments of ADRs were extracted and analyzed. Results: A total of 346 case reports (441 patients) on the use of different preparations of HCT were finally pooled, among which 89 articles (117 patients) just presented efficacy reports without ADRs and 257 articles (324 patients) on the HCT-related ADRs were further analyzed. ① HCT in vivo injections were recorded in 265 articles (338 patients) including 249 ADR reports (315 patients) and 16 efficacy reports (23 patients). As for the ADRs reports, allergic reaction was the major ADRs with different symptoms and onset time. The worst consequences were anaphylactic shock (116/315) and death (11/315), followed by dyspnea (228/315), change of complexion (181/315), heart of abnormality (180/315), chest tightness (147/315), cyanosis (142/315) and so on. The fast onset time was 10 seconds and the most ADRs happened in 30 minutes. Dexamethasone was the mainly medication to treat ADRs. ② Oral HCT agents were descripted in 75 articles (94 patients) including 8 ADR reports (9 patients) and 67 efficacy reports (85 patients). Among the 8 ADR reports, 8 patients used Chinese patent medications contained HCT and only 1 patient used HCT decoction. The ADRs almost manifested as skin symptoms, including rubella, macula, rash and urticaria.③HCT external preparations reported in 6 articles (9 patients), none of those presented any ADRs symptoms. ④ No case was found to develop cancer, aristolochic acid nephropathy, interstitial nephritis, renal interstitial fibrosis or renal failure due to HCT preparations. Conclusion: The HCT-related ADRs were mostly caused by its processed preparations, including HCT injections and patent preparation. The oral HCT agents as docoction rearly caused ADRs. There were no reports of aristolochic acid nephropathy or cancer cases caused by HCT.
Research Progress in Arecoline-induced Oral Submucous Fibrosis
Jing-Wen Jiang, Xue-Wu Chen, Qing-Hua Yao, Hui Zhan
8Food Therapy and Health Care    2019, 1 (3): 97-101.
Abstract PDF (1756KB)  
Areca nut is a popular fruit, but is among the most common addictions following tobacco, alcohol and caffeine globally. Areca nut chewing is the major risk factor for OSF, which is a chronic, occult, and premalignant fibrotic disease. OSF is characterized by submucosal collagen accumulation and microvascular diseases, the primary microscopic manifestations of which include damaged vascular endothelial cells, increased vascular permeability, and decreased number of microvessels. As the basic structure of microvessels, endothelial cells paly an important role in the pathogenesis and progression of OSF. Arecoline is the main component of areca nut. This review summarized the machenism of arecoline-inducing OSF by acting on endothelial cells, mainly including that arecoline can promote endothelial cells inducing tissue fibrosis by acting on the vascular endothelial cells and is accomplished via multiple aspects such as inhibiting the proliferation and facilitating the apoptosis of endothelial cells, affecting their secretion of cytokines, or promoting the transformation process of EMT.
The implicit stress of eating meat
Christopher Anthony David, Peter Gerard Coan
90Life Research    2018, 1 (1): 9-17.
Abstract HTML PDF (6125KB)  

This paper gives a brief overview of the evolutionary history of human diet, discusses various reasons why some modern humans choose to abstain from eating animal products, and explores the psychological effects occasioned by the eating of meat. The authors argue that when modern, scientifically literate humans choose to eat meat and animal-milk-based products, while being simultaneously aware of the associated poor outcomes in terms of personal health, environmental sustainability, and animal suffering, then psychological stress is an inevitable outcome. They highlight some key recent additions to the growing body of evidence which demonstrates that the choice to eat meat is a factor in environmental destruction, animal misery, and personal health risks, and explore the causes and consequences of the predictable psychological stresses that result for those individuals who continue to habitually eat meat.

Green tea and its active compounds in cancer prevention and treatment
Yi Lu, Lu Xu, Hai-tao Chen, Qing-hua Yao
8Food Therapy and Health Care    2019, 1 (2): 50-55.
Abstract PDF (1747KB)  
Green tea is now widely considered as anticancer substance or food in global. Catechin, the main anticancer component in green tea, exhites the strong biological activity which not only eliminate free radicals showing antioxygenic function, but also suppress cell proliferation as well as induce cancer cell apoptosis via blocking corresponding signaling pathway. Furthermore, several studies have demonstrated it could regulate the gut microbiota. It also could regulate gut microbiota. Through these functions, it plays important roles in the occurrence and development of cancer. Here, the anticancer compounds in green tea, the theoretical basis of TCM, the clinic applications, as well as the anticancer mechanism are reviewed.
Correlation of Commonly Used Anthropometric Parameters with FPG, FPG-CV and HbA1C
Ya-Nan Zhao , Rui-Hua Wang , Li-Juan Zhang , Qiang Xu, Yan-Fen Li
8Food Therapy and Health Care    2019, 1 (1): 2-7.
Abstract PDF (330KB)  
Objective: To investigate the relationship between body mass index (BMI), waist circumference (WC), hip circumference (HC), 
waist-hip ratio (WHR), waist height ratio (WHtR), fasting blood glucose (FPG), fasting blood glucose variation (FPG-CV) and 
glycosylated hemoglobin (HbA1C) to provide a reference for predicting the risk and development trend of diabetesmellitus. Methods: From October 2016 to December 2017, 111 subjects from the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine were selected to measure their height and weight. BMI, WHR and WHtR were calculated and the concentrations of FPG and HbA1C were detected. Statistical analysis was carried out with SPSS21.0 software, and the data were processed by multiple linear regression analysis.Results: The concentration dependence of WHtR, FPG, FPG-CV and HbA1C were more closely related. There was a significant difference between WHtR and FPG, FPG-CV and HbA1C by multiple linear regression analysis (t = 8.531, 6.910 and 6.905, respectively, P < 0. 01), and the correlation coefficient was 0. 633, 0.552 and 0. 552 respectively (P < 0. 01). Conclusion: There is a significant correlation between WHtR and FPG, FPG-CV and HbA1C. Therefore, measuring the height and waist circumference for the predictive potential of diabetes needs 
to be emphasized and intensified.
Ginseng and Angiogenesis: Promotion or Inhibition?
Jun-Ju Zou , Xiao-Tao Zhou , Wen-Yi Li , Chao-Xi Zhu , Yue-Rong Ma
8Food Therapy and Health Care    2019, 1 (1): 22-29.
Abstract PDF (627KB)  
Ginseng has a unique pharmacological activity, which can treat ischemic diseases through angiogenesis, and inhibit 
tumor growth and metastasis by anti-angiogenesis. Angiogenesis is a common target for tumors and ischemic diseases. How 
could the ginseng regulateblood vessels in different diseases? Here, the mechanism of ginseng bidirectional regulation of 
angiogenesis in different pathological environments is reviewed, and the role of bidirectional regulation is elucidated.
A Summary about the Formation and Development of "Alcohol Injury" Theory
Gao Li, Dong-Xin Tang, Feng-Xi Long, Zhu Yang
8Food Therapy and Health Care    2019, 1 (1): 16-21.
Abstract PDF (294KB)  

The number of people who are sickened by alcohol is rising every year in China, and Traditional Chinese Medicine (TCM) has a long history and remarkable therapeutic effect on the treatment of "Alcohol Injury" diseases. Therefore, it is of great practical significance to study the theory of "Alcohol Injury". This paper expounds the historical origin, treatment prescription and related 

diseases of the theory of "Alcohol Injury".

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