Potential new metabolic approach for treatment of diabetes mellitus: converting glucose to ascorbic acid (vitamin C)
TMR Theory and Hypothesis. 2019, 2 (4): 241-248.
Through changing in lifestyle and increasing the global prevalence of diabetes mellitus, its crucial to find new approaches for treatment of this disease. This metabolic disease is characterized by hyperglycemia, insulin deficiency or insulin resistance. This disorder categorized into type 1 and type 2 diabetes. Type 1 usually initiate from childhood, have an autoimmune background and associated with destroying of beta cells of pancreas. Type 2 diabetes is defined as insulin resistance, hyperglycemia and usually appears in adulthood. In the process of diabetes, hyperglycemia and oxidative stress can induce diabetic retinopathy, nephropathy, neuropathy and cardiovascular disease. According to literature, oxidative stress and chronic inflammation play an essential role in initiation and development of the complications of diabetes. Hence, inhibition of chronic inflammation and oxidative stress besides with glycemic control is important to prevent from these clinical complications. Some researches explained the antioxidant and anti- inflammatory property of vitamin C in patients with diabetes mellitus. Moreover, ascorbic acid can help to better glycemic control in these patients. Thus, we propose a new idea to convert excess amount of glucose to vitamin C for treatment of patients with diabetes mellitus. By performing this idea, we can achieve to better clinical management of diabetes in terms of glycemic control and prevention of oxidative
stress which lead to significant decrease in clinical complications.
Analysis of uterine artery and sex hormones in treating diminished ovarian reserve with tiaojing decoction
TMR Theory and Hypothesis. 2019, 2 (4): 252-259.
Objective: To observe the effect of tiaojing decoction and climen on diminished ovarian reserve patients with deficiency of Kidney-Yin by sex hormone and uterine artery blood flow parameters. To verify the effectiveness of tiaojing decoction on diminished ovarian reserve and uterine artery blood flow parameters, explore the correlation between uterine artery blood flow parameters and sex hormones. Methods: Total 60 diminished ovarian reserve patients with deficiency of Kidney-Yin were randomly divided into the experimental group (n=30, taking tiaojing decoction and climen) and the control group (n=30, taking climen) and they were treated in 3 months. Observe bFSH, bE2, uterine artery PSV, EDV, S/D, RI before and after the treatment in the 2-4 day of menstruation. Results: After treatment, serum sex hormone levels and uterine artery blood flow parameters of the two groups were significantly different (P < 0.05), and the experimental group was significantly better than the control group. There was a linear correlation between PSV and FSH, PSV and
E2, FSH and E2. Conclusion: Tiaojing decoction combined with climen has significant effect on diminished ovarian reserve patients with deficiency of Kidney-Yin. Uterine artery blood flow parameters can reflect the sex hormone levels.
Interpretation of data and treatment of Jing-well point temperatures´ test
TMR Theory and Hypothesis. 2019, 2 (4): 260-266.
The Jing-well point temperatures´ test method is a method to diagnose and guide the treatment of diseases by measuring the subjects' symmetrical well point temperature. it is improved from the method of knowing heat sensitivity. The application of Jing-well point temperatures´ test method is wide, and it can be used in internal and external gynecology and pediatrics and facial features department. at the same time, it has the advantage of objective and accurate diagnosis. The old law has some shortcomings, such as poor intuition, unavoidable omission of information, incomplete interpretation of information and so on. In this paper, Excel software is used to transform the data into line chart form, which improves the intuition and comprehensiveness of this method, so that the data can be better interpreted and used. It is newly proposed in this article that in addition to observing the longitudinal difference of well point temperature, more attention should be paid to the horizontal contrast difference of well point temperature in different meridians. The article also summarizes a number of treatment methods, including acupuncture, moxa moxibustion, cupping and scraping, and the selection of acupoints, including mother acupoints, tenderness points and heat-sensitive moxibustion, so that doctors can combine traditional Chinese medicine professional knowledge in clinic.