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Editors-in-Chief: CG Sun PhD, Prof.
ISSN 2538-130X
4TMR Theory and Hypothesis is a peer-reviewed quarterly journal sponsored by TMR publishing group. It has been included in ScienceOpen and Google Scholar. The journal primarily aims to include innovative papers that combine these two theories with modern biomedicine, physics, chemistry and mathematic models. Hypotheses, basic and clinical researches, literature review and analysis which are carried out on a certain theory, phenomenon and development process of traditional Chinese medicine, and paper that reported the influence of traditional medicine on politics, economy, and culture can also be included. ... More


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Current Issue     20 March 2020, Volume 3 Issue 1 Previous Issue   
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Thinking about traditional Chinese medicine treatment for COVID-19
Editor Group of TMR Theory and Hypothesis
4TMR Theory and Hypothesis. 2020, 3 (1): 267-.   https://doi.org/10.12032/TMRTH202001001
Abstract ( 21 )     PDF (251KB) ( 14 )  
Meta-analysis of Laparoscopic cyst decortication versus traditional open cyst decortication for ADPKD in China: evidence based on 362 cases and 399 controls
Jing Gan, Xin Guan, Sheng-Qiang Yu, Yi-Yi Ma, Jian-Dong Gao
4TMR Theory and Hypothesis. 2020, 3 (1): 268-280.   https://doi.org/10.12032/TMRTH202001002
Abstract ( 15 )     PDF (2307KB) ( 2 )  
Objectives: To assess the safety, feasibility and clinical benefits of LCD and OCD for the treatment of ADPKD. Methods: Databases articles comparing LCD and OCD in treating PKD were collected through March 2019. After screening for inclusion and data extraction, meta-analysis was performed by the RevMan 5.3 software. Results: A total of 9 studies involving 761 patients were finally included, with 362 cases in LCD group and 399 cases in OCD group. LCD was associated with a shorter operative time (MD = -36.24, 95%CI: -44.20 ~ -28.28, P < 0.00001) and postoperative hospital stay (MD = -4.04, 95%CI: -5.13 ~ -2.95, P < 0.00001). Besides, LCD had an earlier time to postoperative ambulation (MD = -14.90, 95%CI: -16.33 ~ -13.48, P < 0.00001) and earlier time to first flatus (MD = -1.52 days, 95%CI: -1.65 ~ -1.40, P < 0.00001; MD = -10.76 hours, 95%CI: -12.71 ~ -8.81, P < 0.00001). In addition, LCD had a lower intraoperative blood loss (MD = -159.81, 95%CI: -243.32 ~ -76.31, P = 0.0002) and lower analgesic dosage (MD = -56.62, 95%CI: -84.16 ~ -29.08, P < 0.0001). There showed no statistically significant difference between the two groups in Scr, Bun, systolic and diastolic blood pressure (all P > 0.05). Conclusions: Current evidence demonstrated a shorter postoperative hospital stay, lower blood loss, less postoperative pain, and other advantages. LCD may therefore be a feasible and safe surgical approach of ADPKD.
Immunotherapy with activation of NK cells
Shaghayegh Pezeshki, Payam Hashemi
4TMR Theory and Hypothesis. 2020, 3 (1): 281-284.   https://doi.org/10.12032/TMRTH202001003
Abstract ( 14 )     PDF (469KB) ( 13 )  
Given the role of CAR-T cell in the fight against cancer cells, as well as the role of NK cell as an innate immune cell with anti-tumor function too, we hypothesize that Insert the CD16 antibody-producing gene or activator protein CD16, CD16 is one of the most important markers of NK cell activation for ADCC, into the CAR-T cell panel. So with this hypothesis in addition to the role of CAR-T cells to fight cancer, the role of NK cells in the fight against cancer too.
Application of Internet plus education in medical technical training
Jian Zhu, Da-Wei Jiang, Yun Wu
4TMR Theory and Hypothesis. 2020, 3 (1): 285-289.   https://doi.org/10.12032/TMRTH202001004
Abstract ( 7 )     PDF (290KB) ( 2 )  
With the rapid development of Internet technology, the mode of medical education is constantly changing, and the training mode of traditional medical technology gradually reveals its shortcomings. Based on that, the staff combined the Internet technology and medical education, formed the "Internet+education" model, as the main way of medical technology training, so as to optimize the medical education system, improve the level of medical education, improve the interactive, real-time, science and technology and modernity of medical education, and further promote the construction and development of medical education in China. This article analyzes the application theory of the previous "Internet+education" in medical technology training, and proposes a set of theories that can supplement the lack of traditional medical technology training and education in order to integrate "Internet+education" in medical technology training To maximize the role of the role of China, and put forward their own hypotheses and ideas for future development.
Arrangement and analysis of processing technology of Anguo traditional Chinese medicine: Taking Chinese patent medicine making process as an example
Yao Yang, Ying Chen , Meng-Yi Xie, Guo-Wei Zhang
4TMR Theory and Hypothesis. 2020, 3 (1): 290-296.   https://doi.org/10.12032/TMRTH202001005
Abstract ( 12 )     PDF (357KB) ( 1 )  
Processing of traditional Chinese medicine is a traditional pharmaceutical technology in China. The processing technology and methods in different places have their own characteristics. Anguo County, known as Qizhou in ancient times for its well-developed pharmaceutical industry, is known as "millennium medicine capital" and "the world's first pharmaceutical market". It is one of China's famous distribution centers of medicinal materials. Its traditional medicinal material processing and processing technology has high popularity. However, Influenced by inheritance mode and mechanical modernization, A large number of processing techniques of traditional Chinese medicine are in danger of being lost. This article focused on the traditional manufacturing process of Anguo's Chinese patent medicine. Relying on the literature, we collected and organized the Chinese patent medicine of Anguo, analyzed its varieties, sources of prescriptions and processing technology, which improves the understanding of Anguo's traditional Chinese medicine processing technology and its cultural connotation and provides a research basis for its inheritance and development.

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