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Traditional Medicine Research  2018, Vol. 3 Issue (5): 243-250    DOI: 10.12032/TMR201813083
Ethnic and Regional Medicine     
Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility
Wang Hua1, Chen Yan1, Yin Yong1, Cao Chun-Hua1, Wang Sai-Li1, Wang Qin1,*(), Peng De-Xi1, Zhu Chun-Jian1, Chen Lin-Wei1,*()
1Taizhou Hospital of Traditional Chinese Medicine, Affiliated to Nanjing University of Traditional Chinese Medicine, Taizhou, China.
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Highlights

Thunder-Fire moxibustion with ovulation monitoring significantly improved the pregnancy rate of patients diagnosed with adenomyosis- associated infertility.

Editor’s Summary

Thunder-Fire moxibustion stemmed from the Taoism magic arts before the Yuan Dynasty of China (1271 A.D.-1368 A.D.) and took shape in the middle of the Ming Dynasty of China (1368 A.D.-1644 A.D.).

Abstract

This study evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring for the treatment of adenomyosis-associated infertility. A series of 120 patients diagnosed with uterine adenomyosis and infertility and cold coagulation blood stasis syndrome in traditional Chinese medicine (with the clinical manifestations of premenstrual or menstrual lower abdomen cold pain, pain reduction with heat application, and cold extremities) were randomized equally to treatment group with Thunder-Fire moxibustion and ovulation monitoring as well as control group with ovulation monitoring only. Treatment continued for six menstrual cycles. The pregnancy rate of the treatment group was significantly increased with the control group (50.0% vs. 23.3%, P = 0.021). Dysmenorrhea and the traditional Chinese medicine syndrome in the treatment group improved significantly compared with the control group (3.87 ± 2.03 vs. 5.70 ± 1.01, P = 0.002 and 7.33 ± 4.11 vs. 10.52 ± 2.33, P = 0.006, respectively), and there was also significant between-group differences in serum cancer antigen 125 (55.45 ± 14.65 vs. 63.34 ± 11.41, P = 0.031). However, the average uterus diameters in the treatment and control groups were not significantly different (67.13 ± 7.59 vs. 69.89 ± 5.30, P = 0.137). Thunder-Fire moxibustion with ovulation monitoring improved the pregnancy rate of patients diagnosed with adenomyosis-associated infertility.



Key wordsAdenomyosis      Infertility      Thunder-Fire moxibustion      Ovulation monitoring      Pregnant rate      Dysmenorrhea     
Published: 04 September 2018
Fund:  This study was supported in part by grants from the “333 Project” of Jiangsu province (BRA2016183).
Corresponding Authors: Wang Qin,Chen Lin-Wei     E-mail: wangqin322@126.com;simply0518@126.com
Cite this article:

Wang Hua, Chen Yan, Yin Yong, Cao Chun-Hua, Wang Sai-Li, Wang Qin, Peng De-Xi, Zhu Chun-Jian, Chen Lin-Wei. Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility. Traditional Medicine Research, 2018, 3(5): 243-250.

URL:

https://www.tmrjournals.com/tmr/EN/10.12032/TMR201813083     OR     https://www.tmrjournals.com/tmr/EN/Y2018/V3/I5/243

Figure 1 Location of thunder-fire moxibustion array

pregnancy occurred, the following indicators don’t need to be measured after the first treatment course or the second treatment course; otherwise, the following indicators need to be measured.

Main symptoms 0 points 2 points 4 points 6 points
Premenstrual or menstrual lower abdomen cold pain, pain reduced when got heat No cold pain or tingling in the lower abdomen Mild cold pain or tingling in the lower abdomen, not affect work and life Severe cold pain or tingling in the lower abdomen, affect work and life The lower abdomen cold pain or tingling pain is unbearable, must rest in bed
Formed cold extremities No Cold shape, low limb temperature Cold shape, cold limbs Cold shape, cold limbs as ice
Secondary symptoms No or - (0 points) Yes or + (2 points)
The menstrual was dark purple color with block No Yes
Less amount of menstruation, or delay No Yes
Vomiting during menstruation No Yes
Stool diarrhea during menstruation No Yes
More leucorrhea with white color No Yes
Tongue condition - +
Pulse condition - +
Table 1 Grading table of cold coagulation and blood stasis syndrome
Group Number of cases Age
(years)
Duration of infertility
(years)
The scores
of dysmenorrhea
The scores of TCM symptoms Average
diameter of uterus (mm)
The level
of serum CA-125 (IU/ml)
Treatment group 60 30.37 ± 3.55 2.27 ± 1.19 5.70 ± 1.63 10.47 ± 3.20 68.63 ± 7.07 60.45 ± 16.97
Control group 60 29.83 ± 3.61 2.82 ± 1.41 5.33 ± 1.28 9.80 ± 2.51 67.83 ± 7.61 59.37 ± 13.72
The value of P 0.187 0.131 0.104 0.072 0.143 0.159
Table 2 Comparison of baseline data ($\bar{x}$± s)
Course of treatment Group Number of cases Number of cases Number of cases
Effectiveness Ineffectiveness
After the first course of treatment Treatment group 60 12 (20.0%) 48 (80.0%)
Control group 60 4 (6.7%) 56 (93.3%)
The value of P 0.039 0.031
After the second course of treatment Treatment group 60 30 (50.0%) 30 (50.0%)
Control group 60 14 (23.3%) 46 (76.7%)
The value of P 0.021 0.020
Table 3 Comparison of pregnant rate
Group Number of cases The scores
of dysmenorrhea
The scores of TCM symptoms Average
diameter of uterus (mm)
The level
of serum CA-125 (IU/ml)
Treatment group 48 4.58 ± 1.46 8.08 ± 3.06 67.33 ± 7.52 57.52 ± 15.29
Control group 56 5.46 ± 0.99 9.93 ± 2.12 69.43 ± 6.67 61.96 ± 12.24
The value of P 0.005 0.009 0.113 0.178
Table 4 Comparison after a course of treatment ($\bar{x}$± s)
Group Number of cases (person) The scores
of dysmenorrhea
The scores of TCM symptoms Average
diameter of uterus (mm)
The level
of serum CA-125
Treatment group 30 3.87 ± 2.03 7.33 ± 4.11 67.13 ± 7.59 55.45 ± 14.65
Control group 46 5.70 ± 1.01 10.52 ± 2.33 69.89 ± 5.30 63.34 ± 11.41
The value of P 0.002 0.006 0.137 0.031
Table 5 Comparison after two courses of treatment ($\bar{x}$± s)
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