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02 May 2020, Volume 2 Issue 2 Previous Issue   
News
Clinical rational use of traditional Chinese medicine
Editor Group of Asian Toxicology Research
8Asian Toxicology Research. 2020, 2 (2): 48-49.   https://doi.org/10.12032/ATR20200501
Abstract ( 44 )     PDF (192KB) ( 19 )  
Since the outbreak of COVID-19, more than 4,900 medical members of the national Chinese medicine teams stationed in Wuhan Jinyintan Hospital, Mobile Cabin Hosipital and Leishen Shan Hospital. The utilization rate of Traditional Chinese Medicine (TCM) in Hubei is 88.93% and it is 97.71% in the Chinese medicine hospital. The patients' fever, fatigue, coughing and other symptom were significantly improved. Along with the significant effects, slight adverse reaction and health concept, people pay more and more attention to the diagnostic and therapeutic approaches of TCM [1].
Article
Mechanism prediction analysis of an epidemic prevention sachet in preventing new coronavirus pneumonia
Xin-Zhe Zhao, Zi-Qi Jin, Yao Yang, Guo-Wei Zhang
8Asian Toxicology Research. 2020, 2 (2): 50-60.   https://doi.org/10.12032/ATR20200407
Abstract ( 117 )     PDF (937KB) ( 61 )  
Objective: To explore the prevention mechanism of an anti-epidemic sachet on the new coronavirus pneumonia (COVID-19) based on the network pharmacology and molecular docking method. Methods: The chemical constituents and action targets of wormwood leaves, white peony, borneol, Rhizoma atracylodis, and Herba pogostemonis in the epidemic-preventive sachet were retrieved in TCMSP database. Query the genes of targets through the Uniprot database, and then use Cytoscape 3.7.2 software to build a medicinal drugs-active ingredients-targets (genes) network for visualization. Then we used DAVID to perform gene ontology (GO) function enrichment analysis and genome encyclopedia (KEGG) pathway analysis to predict the mechanisms of action. Draw histograms and bubble charts for visualization with Excel software and Omicshare database. The crystal structure of ACE2 was searched in the RCSB PDB database, and the compounds and proteins were molecularly docked with the help of PyMOL, AutoDockTool, and Vina software. Results: Sixty-seven effective chemical components in the anti-epidemic sachet were screened and a drugs-chemical components-targets network was constructed to obtain 948 targets, and 18 core targets and 28 core target pathways were predicted. 6 compounds in Folium artemisiae argyi, 13 compounds in Radix angelicae dahuricae, 3 compounds in Rhizoma atracylodis, 4 compounds in Fructus tsaoko, 8 compounds in Herba pogostemonis, and 3 compounds in Rhizoma acori talarinowii have less binding energy with 1R42 than the ligand. Conclusion: It is predicted that the anti-epidemic sachet has prevention effects on new coronavirus pneumonia.
Review
Metabolomics and its application in the evaluation of toxicity of traditional Chinese medicine
Peng Lu, Xiao-Xin Dou, Zhi-Chao Wang, Ming Huang, Yu-Ying Yang, Yi-Hua Fan, Ning Fan, Xian-Bin Kong
8Asian Toxicology Research. 2020, 2 (2): 61-70.   https://doi.org/10.12032/ATR20200427
Abstract ( 68 )     PDF (615KB) ( 41 )  
Metabolomics is a newly developed discipline following genomics, transcriptomics, and proteomics. It is based on the theory of systems biology, supported by modern spectroscopy analysis technology and is analyzed by the external stimulation of organisms. By analyzing the overall changes of metabolites with low molecular weight in organism after being stimulated by the outside world, we can understand the physiological and pathological state of organism, and finally clarify the essence of biological changes of organism. In recent years, metabolomics has developed rapidly. It has been widely used in early toxicity screening of lead compounds, preclinical toxicity of drugs and toxicity evaluation of clinical drugs. The in-depth interpretation of metabolomics results is also developing. This article reviewed the progress of metabolomics technology and its application in the study of toxicity evaluation of traditional Chinese medicine.
Energy pharmacology of aconite (Radix aconiti lateralis reparata)
Yan Liu, Rui-Ping Li, Zhu Wang, Xi Sun, Han-Fei Shi, Wan-Sen Sun
8Asian Toxicology Research. 2020, 2 (2): 71-80.   https://doi.org/10.12032/ATR20200502
Abstract ( 49 )     PDF (578KB) ( 43 )  
Objective: To study the energy pharmacology of aconite (Radix aconiti lateralis reparata). Methods: Literature induction method was applied to study the energy properties, energy pharmacological connotation, and energy pharmacological effects of aconite (Radix aconiti lateralis reparata). Results: The warm and hot properties of aconite (Radix aconiti lateralis reparata) are exactly its energy properties. The energy pharmacology of aconite (Radix aconiti lateralis reparata) is based on its energy properties, which is different from the modern aconite (Radix aconiti lateralis reparata) pharmacology that is based on the chemical composition of aconite (Radix aconiti lateralis reparata). In addition, the energy pharmacology of aconite (Radix aconiti lateralis reparata) includes not only the traditional energy pharmacology but also the modern energy pharmacology of aconite (Radix aconiti lateralis reparata). The traditional energy pharmacology of aconite (Radix aconiti lateralis reparata) is mainly manifested as the energy effect of aconite (Radix aconiti lateralis reparata) at the whole-body level, warm yang and dissipate cold, whereas the modern energy pharmacology of aconite (Radix aconiti lateralis reparata) is manifested as the physiological and pathological energy effect of warm and thermal energy properties of aconite (Radix aconiti lateralis reparata) at the tissue, cellular, and molecular levels of the body, mainly strengthening the heart, protecting cardiac muscles, dilating blood vessels, and having anti-arrhythmia, anti-shock, anti-inflammatory, analgesic, and antineoplastic effects. The traditional energy pharmacology and modern energy pharmacology of aconite (Radix aconiti lateralis reparata) constitute the basic connotation of aconite (Radix aconiti lateralis reparata) energy pharmacology. For the aconite (Radix aconiti lateralis reparata) energy pharmacology, there is a substantial foundation, its chemical components such as alkaloids. In addition, the toxicity of aconite (Radix aconiti lateralis reparata) is a manifestation of its energy pharmacology. Conclusion: aconite (Radix aconiti lateralis reparata) has energy properties that have substantial foundation. The energy pharmacology of aconite (Radix aconiti lateralis reparata) is based on its high energy and hot properties and includes the traditional energy pharmacology and modern energy pharmacology of aconite (Radix aconiti lateralis reparata).
Report
Pseudo-hyperaldosteronism caused by compound glycyrrhizin tablets: a case report
Jing Lai, Yun-Ying Zhang, Qi Zhang
8Asian Toxicology Research. 2020, 2 (2): 81-84.   https://doi.org/10.12032/ATR20200426
Abstract ( 36 )     PDF (331KB) ( 20 )  
Compound glycyrrhizin tablets (CGT) is a glycyrrhizin-containing preparation for the treatment of chronic hepatic diseases, it contained Glycyrrhizin, Monoammonium Glycyrrhizinate, Aminoacetic Acid and Methionine. CGT has been shown to have anti-inflammatory, anti-oxidative, and anti-viral effects. Although pseudo-hyperaldosteronism was reported as its important side effects, the frequency was unknown. A 59-year-old male patient with tuberculous pleurisy received CGT to prevent impairment in liver function which was caused by antituberculosis drugs. After more than one month, it appeared edema in the lower extremity, blood pressure increased, serum potassium lowed, serum sodium raised at the normal high limit. Finally, it was improved by suspending the CGT and diuretic treatment.