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93TMR Cancer  2019, Vol. 2 Issue (3): 200-205    DOI: 10.12032/TMRC201800056
Integrative Oncology     
Research progress in the treatment of colorectal cancer in classical prescriptions
Shi-Yun Shao1,2, Qi Li1,2,*()
1. Department of Oncology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China
2. Cancer Institute, Shuguang Hospital Affiliated to Shanghai University of TCM,Shanghai 201203, China.
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Traditional Chinese medicine is an important tumor-assisted treatment.

Classical formula has a good effect in colorectal treatment, but the mechanism is not clear.


Classical Chinese medicine prescriptions are widely used in cancer treatment. Although obvious therapeutic effects have been observed in clinical practice, laboratory evidence is still lacking. Clinically effective prescriptions may become the research direction for the development of cancer therapeutic drugs.


ShanghanZabingLun, an acient book of Chinese medicine that published in Han dynasty (219 C.E.), is the first monograph in China that has the principles of prescription and treatment. Modern physicians flexibly applied many classical prescriptions recorded on this acientd book, such as BanxiaXiexin decoction, DaChengqi decoction, YiyiFuziBijiang decoction and Wumeipill for the treatment of colorectal cancer and its complications, and made some progress in clinical and experimental research. Studies have shown that classical prescriptions alone or in combination with other therapies can improve immunity, prevent cancer from recurrence and metastasis, reduce the side effects of anticancer drugs, improve quality of life, and prolong the survival of cancer patients. However, the current clinical and mechanistic studies on the treatment of classical prescriptions still need to explore in depth. This study aims to summarize the clinical and research progress in the treatment of colorectal cancer with classical prescriptions in recent years.

Key wordsClassical prescription      Colorectal cancer      Traditional Chinese medicine     
Received: 12 February 2019      Published: 02 September 2019
Corresponding Authors: Li Qi   
Cite this article:

Shi-Yun Shao, Qi Li . Research progress in the treatment of colorectal cancer in classical prescriptions. 93TMR Cancer, 2019, 2(3): 200-205. doi: 10.12032/TMRC201800056

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1.   Siegel RL, Miller KD, Jemal A.Cancer statistics 2017. CA Cancer J Clin 2017, 67: 7-30.
2.   Msph LAT, Bray F, Siegel RL,et al. Global cancer statistics. Global cancer statistics 2012. CA Cancer J Clin 2015,65: 87-108.
3.   Marley AR, Nan H.Epidemiology of colorectal cancer. International J MolEpidemiol & Gen 2016, 7: 105.
4.   Arnold M, Mónica SS, Laversanne M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut 2017, 66: 683-691.
5.   Wan Desen.Epidemiology and prevention of colorectal cancer. Chin J IntegrTraditi Western Med 2011, 17: 3-7.
6.   Chen D, Zhao J, Cong W.Chinese herbal medicines facilitates the control of chemotherapy-induced side effects in colorectal cancer: progress and perspective. Front Pharmacol 2018, 9:1442.
7.   Chen Y, Liu JT, Zhu Y, et al. TCM syndrome differentiation and treatment of colorectal cancer. Chin J Tumor 2015, 24.
8.   Kong J, Lin XN, Lin B.Clinical treatment of Banxia Xiexin decoction. J Tradit ChinMed 2013, 41: 160-161.
9.   Li YJ, Qiu SG, Liang J.Clinical study of Banxia Xiexin decoction in the treatment of liver and spleen syndrome after colorectal cancer operation. World Tradit Chin Med 2017, 12: 1523-1526.
10.   Wang J, An C, Yan CX.Analysis of the effect of Banxia Xiexin decoction on gastrointestinal reactions in patients with colorectal cancer chemotherapy. J Comm Med 2014, 12: 29-30.
11.   Matsuda C, Munemoto Y, Mishima H, et al. Double-blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucositis. ChemotherPharmacol 2015, 76:97-103.
12.   Nishikawa K, Aoyama T, Oba MS, et al. The clinical impact of Hangeshashinto (TJ-14) in the treatment of chemotherapy-induced oral mucositis in gastric cancer and colorectal cancer: analyses of pooled data from phase II randomized clinical trials. J Cancer 2018, 9: 1725-1730.
13.   Chen G, Yang Y, Liu M, et al. Banxia Xiexin decoction protects against dextran sulfate sodium-induced chronic ulcerative colitis in mice. J Ethnopharmacol 2015, 166:149-156.
14.   Zhu HH, Lu GQ.Clinical observation on prevention and treatment of postoperative intestinal obstruction in colorectal cancer with integrated traditional Chinese and western medicine. J Shandong Univer Tradit ChinMed 2012, 3: 207-208.
15.   Wei N.Therapeutic effect of FufangDa Chengqi decoction on bowel cancer complicated with acute intestinal obstruction. Chin J Chin 2013, 22: 652-653.
16.   Yu HL, Yu ZG, Bai XF.Clinical observation of Da Chengqi decoction in the treatment of 125 cases of postoperative bloating in colon cancer patients. Tradit Chin Med 2012, 29: 75-77.
17.   Li ZJ.Treatment of 33 cases of colorectal cancer with intestinal obstruction with Da Chengqi decoction and nursing enema.ChinPharmac 2015, 24:120-121.
18.   Du YL, Wang ZM, Lu DR, et al. Treatment of 33 cases of colorectal cancer with Qifuzi Sauce powder combined with chemotherapy. Tradit Chin Med 2015, 22: 213-214.
19.   Li J, Yang Z, Long FQ, et al. Professor Liu Shangyi uses FuziYiyiBaijiangdecoction to treat tumors. J Chengdu UniverTradit ChinMed 2017, 40: 66-68.
20.   Zhou Q, Yan B, Zhao XY, et al. Professor Tong Xiaolinuses FuziYiyiBaijiangdecoction to treat tumors. Chin J Clin 2013, 41: 70-71.
21.   Chen LL, Zhang SW, Li DP, et al. Effects of FuziYiyiBaijiangdecoctionon inflammatory factors and intestinal flora in diabetic mice. Shanxi JTraditChin Med 2018, 4: 415-418.
22.   Li ZM.Treatment of 40 cases of gastrointestinal dysfunction in colorectal cancer during rehabilitation with XiaoyaoSanheWumeipill. Massage Rehabilitation Med 2018, 4:112-117.
23.   Wang S, Xu X, Zhang MZ, et al. Professor Jiang Shiqing's experience in treating colorectal cancer fromJueyin of Liujing. J Tradit Chin Med 2016, 31: 467-469.
24.   Zhang R, Li SJ, Chen ZY,et al. Inhibition mechanism of colon cancer by Wnt pathway plus flavored Wumeipill. World Chin Med 2018,13: 1972-1975.
25.   Yu Y, Li XS, Wu B, et al. Therapeutic effect of Jiawei Huangqidecoction on prevention of delayed diarrhea caused by irinotecan chemotherapy in patients with advanced intestinal cancer. Beijing Chin Med 2015: 427-430.
26.   Liu DY, Yin PP, Bai ZC, et al. Therapeutic effect of Jiawei Huangqirecipe on prevention of delayed diarrhea caused by irinotecan chemotherapy in patients with advanced intestinal cancer. Guide to Health Care 2016: 321-321.
27.   Chen G, Yang Y, Hu C, et al. Protective effects of Huangqin decoctionis against ulcerative colitis and associated cancer in mice. Oncotargets 2016, 7: 61643-61655.
28.   Lam W, Bussom S, Guan F, et al. The Four-Herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. SciTransl Med 2010, 2:45ra 59.
29.   Kummar S, Copur MS, Rose M, et al. A phase I study of the Chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer. ClinColorec Cancer 2011, 10: 1-96.
30.   Liu SH, Cheng YC .Old formula, new Rx: The journey of PHY906 as cancer adjuvant therapy. J Ethnopharmacol 2012, 140: 1-623.
31.   Lam W, Jiang Z, Guan F, et al. The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018). BMC ComplAlternat Med 2014, 14: 490.
32.   Rockwell S, Grove TA, Liu Y, et al. Preclinical studies of the Chinese herbal medicine formulation PHY906 (KD018) as a potential adjunct to radiation therapy. Internal J RadiatBiol Related Studies in Physics, Chem Med 2013, 89: 16-25.
33.   Dai CS, Wang XH, Chen B, et al. Treatment of 48 cases of cancerous fever in the elderly with Jiawei Xiao Chaihu decoction. Fujian J Tradit Chinese Med 2013, 44: 35-41.
34.   Yang YQ, Zhang ZZ, Li Q.Professor Li Qi used Xiao Chaihu decoction to treat tumors. Jilin TraditChin Med 2018, 33: 132-137.
35.   Xu B, Liang XF, Lu J, et al. Effects of Xiao Chaihu decoction and its cold-heat reduction on colon cancer cell proliferation, fat and alkaline phosphatase. Chin J ExperTradit Med Formul 2018, 14: 132-139.
36.   Wu Z Q.Observation on the effect of Jiawei Sini decoction on thrombocytopenia after chemotherapy in patients with colorectal cancer.Heilongjiang Med 2018,31:1072-1073.
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