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93TMR Cancer
    
Breast cancer among Iraqi female in their fifth decade: a retrospective study
Dhuha Mohammed Kasib1, Manwar Abdulelah Al-Naqqash2*, Ahmed Salih Alshewered3
1Basra Specialist Children's Hospital, Basrah Health Directorate, Basra, Iraq. 2Department of Surgery, University of Baghdad, College of Medicine/Baghdad Radiotherapy and Nuclear Medicine Center/Oncology Teaching Hospital/National Cancer Center, Baghdad Medical City Complex, Baghdad, Iraq. 3Baghdad Radiotherapy and Nuclear Medicine Center, Baghdad Medical City Complex, Baghdad, Iraq.
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Background: Breast cancer is a major public health concern for women around the world. Breast cancer incidence increases with age, and this is an important factor for the management of this disease. The aim of this study was to assess the clinical profiles of female Iraqi breast cancer patients in their fifth decade, and to evaluate patients’ molecular profiles and 5-year disease-free survival (DFS). Methods: A retrospective study was conducted at Baghdad Oncology Teaching Hospital between 1 January 2012 and 12 December 2016. Of 979 individuals seen, 285 were aged between 40 and 49 years. Results: The median age at diagnosis was 45 years. The highest incidence of breast cancer occurred among women in their fifth (40-49 years old) and sixth (50-59 years old) decades of life (29% and 28%, respectively). The most common stages at diagnosis were stages II and III, with 40.8% and 39.5%, respectively. Luminal A-like cancers were seen in 124 women (58.5%) and 29 women (13.7%) presented with triple-negative cancers. De novo metastatic disease comprised just 6.7% of the group studied. The median DFS was 48 months (95% CI: 41.4-54.5 months). Conclusions: The highest incidence of breast cancer occurred among women in their fifth and sixth decades of life. The most common diagnosis was stage II breast cancer of the luminal A molecular subtype. HER-2 (human epidermal growth factor receptor 2) overexpression and triple-negative were the least common subtypes. The median DFS was 48 months.

Key wordsIraqi breast cancer      Molecular classification      Luminal A-like      DFS     
Published: 10 October 2019
Corresponding Authors: Manwar Al-Naqqash, Department of Surgery, University of Baghdad, College of Medicine/Baghdad Radiotherapy and Nuclear Medicine Center/Oncology Teaching Hospital/National Cancer Center, Baghdad Medical City Complex, Baghdad, Iraq. Email: abudallaham@gmail.com.   
Cite this article:

Dhuha Mohammed Kasib, Manwar Abdulelah Al-Naqqash, Ahmed Salih Alshewered. Breast cancer among Iraqi female in their fifth decade: a retrospective study. 93TMR Cancer, Online.

URL:

https://www.tmrjournals.com/cancer/EN/10.12032/TMRC201800060     OR     https://www.tmrjournals.com/cancer/EN/Y0/V/I/1

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