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04 May 2020, Volume 3 Issue 3 Previous Issue   
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Clinical efficacy of Qingxin Fupi Jieyu formula in the treatment of 28 cases with digestive tract cancer-related cognitive impairment
Qian-Qian Niu, Yuan-Hong Zhao, Zhi-Li Zhao, Li-Na Yan, Zheng Li
93TMR Cancer. 2020, 3 (3): 94-100.   https://doi.org/10.12032/TMRC201800072
Abstract ( 135 )     PDF (495KB) ( 107 )  
Objective: This study aimed to explore the efficacy and safety of Qingxin Fupi Jieyu formula (the herbal formula has the function of clear away the heart fire, tonify spleen, and relieve depression, QXFPJYF) in treating digestive tract cancer-related cognitive impairment (CRCI). Methods: 28 subjects with digestive tract CRCI were treated with QXFPJYF for 6 weeks. The scores of Montreal Cognitive Assessment and Mini-Mental State Examination were observed at four-time points (baseline, week 2, week 4, week 6). Besides, anxiety and depression scores and tumor markers were measured. Results: The scores of Montreal Cognitive Assessment and various fields were elevated steadily after treatment, such as visuospatial/executive, attention, language, delayed recall, and orientation. The differences were statistically significant (P < 0.05) besides the language score. The scores of Mini-Mental State Examination and various factors were elevated gradually at week 2, week 4 and week 6, including language and praxis, attention and calculation, recall and orientation, and the differences were statistically significant (P < 0.05) except for recall score. The results also showed the change of tumor markers were not obvious, but anxious and depressed emotions were improved. More importantly, no subjects developed with obvious adverse reactions during the study. Conclusion: The finding indicated that QXFPJYF treated digestive tract CRCI with great efficacy and safety, which improved cognitive function from several fields. Nevertheless, the current study was limited by sample and medical ethics, and which was a self-control trial, some limitations needed to be acknowledged, further high-quality research is required to explore and verify it.
Dehydrocostus lactone exerts the antitumor effect in non-small cell lung cancer H1299 cells
Chao-Yue Su, Hui Wang, Yan-Rui Pan, Ling-Ling Zhang, Qiao-Ru Guo, Yan-Yan Yan, Jia-Jun Li, Jia-Li Fu, Xin-Yue Fan, Yu-Qing Wang, Jian-Ye Zhang
93TMR Cancer. 2020, 3 (3): 101-111.   https://doi.org/10.12032/TMRC201800074
Abstract ( 112 )     PDF (2770KB) ( 86 )  
Background: Dehydrocostus lactone (DHC), a sesquiterpene lactone derived from Aucklandiae Radix, has been proved to possess various pharmacological activities. Recently, studies have reported that DHC has potential antitumor activity. However, few studies have reported the effect of DHC on non-small cell lung cancer (NSCLC). Here, we investigated the antitumor effect of DHC in NSCLC H1299 cells. Methods: MTT assay and colony formation assay was used to assess the anti-proliferation effects of DHC in H1299 cells. Wound healing and Transwell assays were utilized to determine the inhibitory effects of migration and invasion, respectively. Apoptosis was detected using the Annexin V/propidium iodide test. Real-time-quantitative PCR (RT-qPCR) was used to detect the mRNA expression level. Results: We demonstrated here that DHC inhibited the proliferation, migration and invasion of H1299 cells in a dose- or time-dependent manner. Additionally, after treating with DHC at the concentration of 32.0 μM, the apoptosis of H1299 cells was significantly induced. Moreover, DHC affected the mRNA expression of E-cadherin, N-cadherin, Snail, c-Myc, integrin α2, Survivin and matrix metalloproteinase 2. Conclusion: To summarize, our data support that DHC can inhibit proliferation, invasion, migration and induced apoptosis of NSCLC H1299 cells. DHC should be considered for its potential for adjuvant therapeutic development.
The practical value of serum TK1 concentration expression in clinical research of malignant tumors
Qiang Lv, Yuan-Hong Zhao, Yu Lu, Rui-Xue Yang, Yuan-Tao Zhong, Jie Wang, Zhi-Li Zhao, Long Zhang
93TMR Cancer. 2020, 3 (3): 112-118.   https://doi.org/10.12032/TMRC201800075
Abstract ( 110 )     PDF (295KB) ( 92 )  
Objective: To investigate the expression of serum thymidine kinase 1 (TK1) in malignant tumors and its relationship with common tumor markers. Methods:195 cancer patients in the First Teaching Hospital of Tianjin University of traditional Chinese medicine were selected as the subjects. The serum TK1 concentration was measured by enzyme-linked immune-electrotransfer blot and the correlation between TK1 concentration and some biological parameters of tumor patients were analyzed retrospectively. Results: The positive rate of serum TK1 in patients with tumor stage IV was higher than that in other stages (29.9% >16.4%, P =0.029<0.05). The positive rate of serum TK1 in patients with carbohydrate antigen 199 (CA199) positive was higher than the negative (43.5%>19.6%, P =0.036<0.05).There was a positive correlation between serum TK1 and CA199 (r = 0.244, P = 0.043<0.05). Conclusion: The expression of TK1 in serum is related to the proliferation of tumor cells. It is consistent with the concentration of CA199, which can be used as a combined choice for the study of digestive tract tumors, especially pancreatic cancer markers.
Tumor-associated macrophages, exosomes and tumor metastasis: a mini-review
Xiao-Dong Wang
93TMR Cancer. 2020, 3 (3): 119-126.   https://doi.org/10.12032/TMRC201800073
Abstract ( 149 )     PDF (250KB) ( 121 )  
Tumor invasion and metastasis is the primary cause of death in patients with malignant tumors. Tumor-associated macrophages are macrophages that infiltrate the tumor tissue, and are the most frequent immune cells in the tumor microenvironment. The macrophages could secrete a variety of cytokines and can recognize, identify and clear the tumor cells. As the tumor develops, it plays a vital role in the growth, invasion and metastasis of the cancer. However, the underline mechanisms of how the tumor-associated macrophages promoting tumor metastasis is still not fully understood. Present studies demonstrated that macrophage-related exosomes might play an essential role in tumor metastasis. Exosomes may provide potential targets for the prevention and treatment of macrophage-related tumor metastasis.
On the regulation of PP2A and its role in controlling sister chromatid cohesion and microtubule-kinetochore attachment
Jin-Wei Yuan
93TMR Cancer. 2020, 3 (3): 127-136.   https://doi.org/10.12032/TMRC201800076
Abstract ( 164 )     PDF (463KB) ( 133 )  
Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. PP2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes, which are regulated spatially and temporally by specific regulators. Mitosis requires the correct arrangement of sister chromatids so that replicated chromosomes can bind correctly to microtubules and segregate towards opposite poles. A large number of studies have shown that PP2A is mainly involved in a series of phosphorylation processes during the G2/M phase transition and the termination of M phase. Moreover, PP2A shows a more substantial contribution to sister chromatid cohesion and microtubule-kinetochore attachment. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases.

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