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03 December 2019, Volume 2 Issue 4 Previous Issue   
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Integrative Oncology
Xiaoyan decoction inhibits tumor growth and improves the immunity of mouse with A549 lung carcinoma xenograft
Fan-Ming Kong, Yang Yao, Ren-Fen Deng, Tian-Qi Chen, Dong-Ying Liao, Xiao-Jiang Li, Ying-Jie Jia
93TMR Cancer. 2019, 2 (4): 227-232.   https://doi.org/10.12032/TMRC201800062
Abstract ( 24 )   HTML ( 3 )     PDF (694KB) ( 103 )  

Highlights

Xiaoyan decoction enhances the T cell immunity in lung cancer microenvironment, and thus inhibiting lung cancer in mice.

Comments

Clinical experience has demonstrated that traditional Chinese medicine may have anti-tumor function. However, the underline mechanisms remain largely unknown. This study revealed Chinese medicine Xiaoyan decoction may inhibit lung cancer by enhance T cell immunity.

Abstract

Background:Previously, Xiaoyan decoction (XYD) has been found to have a potential anti-tumor effect in vitro. The aim of this study was to explore the effect of XYD in A549 lung carcinoma xenograft mouse model. Method:The A549 lung carcinoma xenograft mouse model were established and divided into control and experiment group. The dynamic growth of the xenograft tumors was observed and the immune cells such as T cell, regulatory T cell (Treg) were explored by Fluorescence-activated cell sorter (FACS) analysis. In this study, network pharmacology was used to screen the anti-cancer monomers in XYD, and their effect targets were also predicted. Result:The result showed that the tumor growth was inhibited and the percent of Treg was down-regulated (P < 0.05). Ten drug monomers were screened to inhibit lung cancer cell proliferation and promote cell apoptosis through PI3K/Akt pathway. Conclusion:Our results suggested that XYD inhibited tumor growth and improved the immunity of A549 lung carcinoma xenograft mouse model.

Miao medicine may serve as an essential adjuvant therapy in cancer treatment
Dong-Xue Sun, Zhu Yang, Feng-Xi Long, Ming-Zhu Li, Guo Chen, Dong-Xin Tang
93TMR Cancer. 2019, 2 (4): 233-238.   https://doi.org/10.12032/TMRC201800059
Abstract ( 61 )   HTML ( 1 )     PDF (542KB) ( 119 )  

Highlights

Miao medicine may serve as an adjuvant therapy in cancer treatment.

Miao medicine may reduce the recurrence and metastasis rate after tumor surgery.

Comments

Traditional Chinese medicine includes many kinds of regional ethnic medicine, such as Miao medicine. Miao medicine has unique insights in cancer treatment. Studies on Miao medicine is still insufficient, its unique treatment methods may bring new ideas to cancer treatment. The use of Miao medicine in treating cancer may require more experimental and clinical evidence

Abstract

The Miao people have formed a unique treatment method for diseases in the long-term survival and development process, which lead to the formation of Miao medicine. Miao medicine is a kind of regional ethnic medicine in traditional Chinese medicine. Many studies and clinical trials have proved that Miao medicine played an active role in the prevention, treatment, and rehabilitation of tumors, which may reduce the recurrence and metastasis rate after tumor surgery, and decrease the toxic and side effects caused by radiotherapy and chemotherapy. Furthermore, Miao medicine may improve immunity and prolong the overall survival of patients with tumor. All these indicate that Miao medicine may serve as an essential adjuvant therapy. This article describes the specific application of Miao medicine in clinical and provides a scientific basis of Miao medicine in the treatment of cancer.

Clinical Cancer Research
Narrative nursing for cancer patients: a meta-analysis
Min Zhang, Ying-Ming Sun, Na Sun, Ya-Nan Leng
93TMR Cancer. 2019, 2 (4): 239-246.   https://doi.org/10.12032/TMRC201800063
Abstract ( 23 )   HTML ( 3 )     PDF (796KB) ( 91 )  

Highlights

Narrative nursing mode can effectively alleviate the degree anxiety and depression of patients and improve the capacity mental resilience and the quality of life.

Comments

This article systematically evaluated the effect of narrative nursing of patients with cancer. However, narrative therapy was not so widely used in hospitals. Narrative therapy would be more popular, covers all aspects form hospital to family.

Abstract

Objective:To systematically review the effect of narrative nursing for cancer patients. Methods:Systematic searches in PubMed, EMBASE, The Cochrane Library, Web of Science, Chinese biomedical literature database, China National Knowledge Infrastructure, Wanfang medical and VIP database were performed for randomized controlled trials (RCTs) or quasi-RCTs which explored the effects of narrative nursing mode for cancer patients. Then, meta-analysis was performed by RevMan 5.3 after two independent investigators screened the literature, extracted the data and evaluated the risk of bias of all included studies. Results:A total of 15 studies were included, including 1778 cancer patients. The meta-analysis showed that narrative nursing could effectively relieve patients' anxiety and depression compared with the conventional nursing model (WMD = -9.04, 95% CI = -11.82, -6.27; P < 0.001), reduce the the inner shame (WMD = -2.28, 95% CI = -3.76, -0.88; P = 0.001), improved the mental resilience (WMD = 18.20, 95% CI = 3.30, 33.11; P < 0.001) and the quality of life. Conclusion:This study has been systematically evaluated to show that narrative care can effectively improve the negative mood of patients with cancer and improve their quality of life. However, subject to the quality limitations of the included studies, the appeal conclusions are yet to be tested in more high-quality studies.

The role of Fuzheng Peiben in clinical oncology
Jia Wang, Zhu Yang, Feng-Xi Long, Jin-Lin Wu, Ting Yu, Dong-Xin Tang
93TMR Cancer. 2019, 2 (4): 247-251.   https://doi.org/10.12032/TMRC201800058
Abstract ( 48 )   HTML ( 1 )     PDF (435KB) ( 90 )  

Highlights

Fuzheng Peiben method aims to strength the immunity of patients with cancer.

Fuzheng Peiben herbs may have the function of enhance the efficiency and reduce the toxicity of radiotherapy and chemotherapy.

Comments

Traditional Chinese medicine has a variety of treatment theories for tumor. The method Fuzheng Peiben may have the function of strengthening the immunity of the patient's and may become an important auxiliary theory for treating tumors.

Abstract

As one of the treating methods of traditional Chinese medicine (TCM), Fuzheng Peiben method plays an essential role in the treatment of malignant tumors. Combining Fuzheng Peiben treatment with surgery, radiotherapy, chemotherapy, or other Western medicine methods in treating tumor complications and advanced tumors may become a new method. This study aims to reveal the clinical significance of Fuzheng Peiben method in tumor treatment. It is found that Fuzheng Peiben treatment may promote postoperative rehabilitation, prevent postoperative complications, reduce the toxicity of radiotherapy and chemotherapy, improve the efficacy of radiotherapy and chemotherapy, improve the life quality patients with tumors, and inhibit tumor growth. This article will provide a clinical basis for the application of Fuzheng Peiben method in cancer therapy.

Cancer Biology
Null links between vitamin B6 and B12 intake and occurrence risk of lung cancer: a meta-analysis
Li-Ping Shen, Rong Li, Ya-Juan Cao
93TMR Cancer. 2019, 2 (4): 252-260.   https://doi.org/10.12032/TMRC201800054
Abstract ( 71 )   HTML ( 1 )     PDF (879KB) ( 132 )  

Highlights

Vitamin B6 and vitamin B12 are coenzyme involved in the complex one-carbon metabolism pathway.

The relationship between vitamin B6 and B12 intake and occurrence risk of lung cancer remains controversial.

Comments

Vitamin B6 and vitamin B12 are considered play an important role in the DNA integrity maintenance, gene expression regulation, supply of methyl groups, and the growth and repair of cells, and disruption of this process may promote carcinogenesis, which may play an essential role in tumor progression.

Abstract

Vitamin B6 and B12 are involved in many biochemical reactions and might play a role in carcinogenesis. We summarized the evidences linking vitamin B6 and B12 to occurrence risk of lung cancer and conducted a meta-analysis of the relationship between vitamin B6 and B12 intake and the risk of lung cancer. Fixed-effect meta-analysis was used to calculate pooled relative risks (RRs) and their 95% confidence intervals (CIs). We identified four observational studies (participants, n = 206,290; cases, n = 1,134) and three randomized controlled trials (RCTs; participants, n = 97,569; cases, n = 952). Vitamin B6 and B12 supplementary was not statistically significantly associated with occurrence risk of lung cancer (124/11926 (1.04%) vs. 73/8497 (0.86%), RR = 1.06, 95% CI = 0.78-1.43, P = 0.71). A consistent association was also observed, findings from RCTs did not support a protective effect of vitamin B6 and B12intake orally decrease the risk of lung cancer occurrence (HR = 1.13, 95% CI = 0.86-1.50, P = 0.39). For the women, there was no confirmed evidence demonstrated vitamin B intake can decrease the occurrence risk of lung cancer across the subgroup analyses (HR = 0.96, 95% CI = 0.80-1.16, P = 0.99). Dietary vitamin B6 and B12 intake also had no influence on occurrence risk of lung cancer in difference doses and intake duration. In conclusion, no confirmed links were found between vitamin B6 and B12 intake and risk of lung cancer occurrence.

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