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The differences and similarities between regional ethnic medicine and traditional Chinese medicine in the prevention and treatment of cancer pain
Hui-Li Shui, Zhu Yang , Feng-Xi Long , Wen-Qi Huang , Bing Yang , Zhen Zhang , Dong-Xin Tang
93TMR Cancer    2019, 2 (3): 206-211.   https://doi.org/10.12032/TMRC201800044
Abstract ( 953 HTML PDF (576KB) ( 563 )  

Highlights

Regional ethnic medicine (REM) and traditional Chinese medicine (TCM) have unique experience in the treatment of cancer pain.

There are many different aspects of the treatment of cancer pain in REM and TCM.

Comments

TCM and REM are important cancer-assisted treatments in China. Especially for the treatment of cancer pain, TCM and REM are important alternatives.

Abstract

REM and TCMare both important parts of traditional medicine in China, and they have their own characteristics in the understanding and prevention of diseases. This article compares the understanding, the theoretical prevention and treatment guidance and the clinical application of the REM and TCMon the cancer pain.

Compound Kushen injection combined with chemotherapy in the treatment of gastric cancer: a meta-analysis of randomized controlled trials
Su-Tong Liu, Kai-Qi Su, Wen-Xia Zhao
93TMR Cancer    2019, 2 (1): 118-126.   https://doi.org/10.12032/TMRC201800043
Abstract ( 360 HTML PDF (1194KB) ( 197 )  

Highlights

Compound kushen injection is frequently used in patients with malignant tumor for adjuvant therapy in China. We are the first using meta-analysis evaluated the clinical efficacy and safety of compound kushen injection combined chemotherapy in the treatment of gastric cancer.

Editor’s Summary

Kushen injection is widely used in clinical practice, but there is still a lack of data to support its clinical effectiveness. This article summarizes the previous research experience through meta-analysis, and provides the basis for the clinical application of Kushen injection.

Abstract

Objective: This study aims to systematically evaluate the efficacy and safety of compound kushen injection (CKI) in combination with chemotherapy in patients with gastric cancer (GC). Methods: A comprehensive electronic search was conducted by searching PubMed, EMBASE, Cochrane Library, Chinese Biological Medical disc, China National Knowledge Infrastructure and Wanfang databases (the last update January 20, 2018). All randomized controlled trials (RCTs) of CKI plus chemotherapy versus chemotherapy alone in GC patients were identified. The quality of each study was evaluated using the Jadad’s scale, and the meta-analysis was performed using Review Manager 5.3 and STATA 14 software. Results: A total of nine studies on 688 cases were included in this study. The results showed that CKI combined with chemotherapy had a better effect on improving patients’ overall response rate (ORR) and life quality. The consequences of Egger’s and Begg’s tests showed there was no significant publication bias. Conclusion: The current evidence showed that CKI may enhance the clinical efficacy of chemotherapy, improve the quality of life and increase the safety in patients with gastric cancer.

Advances in research on tumor microenvironment of hepatocellular carcinoma
Gao Li, Dong-Xin Tang, Feng-Xi Long, Zhu Yang
93TMR Cancer    2019, 2 (1): 143-150.   https://doi.org/10.12032/TMRC201800046
Abstract ( 350 HTML PDF (649KB) ( 339 )  

Highlights

Chinese and Western medicine have different understandings of the tumor microenvironment and different treatment methods.

Editor’s Summary

The concept of the tumor microenvironment has been widely accepted. In the theory of Chinese and Western medicine, the concept of tumor microenvironment is similar, but there are still differences. Tumor treatment strategies for tumor microenvironment are receiving increasing attention.

Abstract

Modern medical research on cancer shows that hepatocellular carcinoma (HCC) is related to tumor microenvironment. Studying the relationship between tumor microenvironment and HCC can be used as a new research direction to provide more strategies and ideas for the prevention and treatment of HCC. This article describes the characteristics of tumor microenvironment, cytokines, related signaling pathways, the occurrence and development of traditional Chinese medicine and HCC, and treatment-related knowledge.

Study on the technical specification of Miao doctor's medicinal acupuncture therapy for interventional cancer pain
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang
93TMR Cancer    2019, 2 (2): 157-161.   https://doi.org/10.12032/TMRC201800042
Abstract ( 312 HTML PDF (497KB) ( 243 )  

Highlights

Miao doctor sputum acupuncture is an effective method for treating cancer pain.
Operational standard operation of Miao doctor sputum acupuncture treatment for cancer pain.

Editor’s Summary

The treatment of cancer pain is limited and the treatment effect is not satisfactory. Miao doctor's acupuncture treatment may be an effective treatment. This provides a new strategy for clinical treatment of cancer pain.

Abstract

Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation procedure of the intervention of the acupuncture and moxibustion acupuncture therapy for cancer pain was formulated according to the selection of acupoints in the Miao medicine Tianying acupoint, sputum manipulation method, and the routine operations such as medicine, acupuncture and canning. Results: A set of technical specifications for the treatment of cancer pain in a mobilized Miao doctor was sorted out. Conclusion: The sputum acupuncture treatment technique specification for cancer pain is easy to operate and easy to be applied in clinical application.

Anti-tumor mechanism of Angelica and its compound preparations
Xin-Xiao Lu, Xiong-Zhi Wu
93TMR Cancer    2019, 2 (2): 193-199.   https://doi.org/10.12032/TMRC201800041
Abstract ( 300 HTML PDF (595KB) ( 277 )  

Highlights

Angelica is a traditional Chinese medicine with anti-tumor effect and various anti-cancer ingredients.
Angelica's ingredients play different mechanisms of anti-cancer and may have different effects on different tumors.

Editor’s Summary

In China, many Chinese medicines are widely used in clinical treatment. These traditional Chinese medicines can not only reduce the side effects of chemotherapy but also improve the efficacy. Even some Chinese medicines have a excellent anti-tumor effect. However, due to the limitations of current Chinese medicine research, the mechanism by which Chinese medicine exerts anti-tumor effect remains to be further studied.

Abstract

Angelica is a holy medicine for gynecology, clinically used for blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, dysmenorrhea, abdominal pain, rheumatism, hemorrhoids, constipation. In recent years, with the discovery of polysaccharides enhancing the immune function and anti-tumor effects of the body, Angelica has attracted more and more attention from researchers at home and abroad.

Clinical observation of laparoscopic radical gastrectomy for advanced gastric cancer
Xiao-Xiao Yan, Yong-Hong Dong, Jing Wang, Ji-Guang Xie, Jun-Jun Su
93TMR Cancer    2019, 2 (1): 151-156.   https://doi.org/10.12032/TMRC201800047
Abstract ( 280 HTML PDF (711KB) ( 177 )  

Highlights

Endoscopic surgery for advanced gastric cancer significantly reduces operative time and reduces postoperative complications.

Editor’s Summary

At present, there is no unified recommendation for the choice of open surgery or endoscopic surgery for advanced gastric cancer. Comparing the recovery after laparoscopic and laparoscopic surgery may provide recommendations for clinical treatment.

Abstract

Objective: To explore the clinical efficacy of laparoscopic radical gastrectomy and traditional open radical gastrectomy for advanced gastric cancer. Methods: 116 patients with advanced gastric cancer in our hospital were randomly selected, including 55 cases in the experimental group and 61 cases in the control group. The clinical effects, CEA, CA-199, AFP and postoperative complications of the two groups were compared. Results: The indexes of operation and post-operation (average operation time, incision length, exhaust time, intraoperative bleeding volume, hospital stay, enteral nutrition time), and the total number of lymph nodes dissected in the experimental group was less than that in the control group (P < 0.05). There was no difference in CEA, CA-199 and AFP before operation and 1 month after operation. The incidence of complications in laparoscopic group was 9.1% lower than that in control group (27.9%). Conclusion: Laparoscopic radical gastrectomy has many advantages in the treatment of gastric cancer, which can effectively reduce complications and is worth promoting.

Effective ingredients, potential targets and mechanism in cancers treatment of Bushen Jiedu Sanjie recipe
Ru Jia, Xue-Qing Hu, Yan Wang, Li-Hong Zhou, Hua Sui, Qi Li, Qing Ji
93TMR Cancer    2019, 2 (1): 133-142.   https://doi.org/10.12032/TMRC201800051
Abstract ( 260 HTML PDF (1302KB) ( 170 )  

Highlights

Bushen Jiedu Sanjie Recipe is potential to treat various malignant tumors by regulating COX-2/β-catenin signaling pathway, STAT3 signaling pathway and MAPK/ERK signaling pathway.

Editor’s Summary

This study demonstrated that BSJDSJR targets EGFR, STAT3, Bcl2, MMP-9 proteins in accordance with STAT3 signaling pathway and exerts potential therapeutic effect on various malignant tumors.

Abstract

Objective: To analyze the active compounds, potential drug targets and corresponding therapy cancer of Bushen Jiedu Sanjie Recipe (BSJDSJR) based on network pharmacology and bioinformatics technology. Methods: The network databases including Cancer HSP, TCMSP, TCMID, TCM-PTD, TCM Database@Taiwan and DrugBank were applied to screen the active compounds, potential drug targets and corresponding cancers of BSJDSJR. Cytoscape3.3 software was used to construct the network between active compounds of Chinese medicine and the corresponding targets. Then, the enrichment of biological processes and KEGG pathways of BSJDSJR were analyzed using DAVID database. Results: According to Oral bioavailability (OB) ≥30% and drug like index (DL) ≥0.18, 129 active compounds in BSJDSJR were screened out and they targeted to 301 proteins. These targets were closely associated with the occurrence of various cancers, such as bladder cancer, pancreatic cancer, non-small cell lung cancer and colorectal cancer. Further investigation showed that, there were lots of active compounds in BSJDSJR are closely connected with the COX-2/β-catenin signaling pathway, STAT3 signaling pathway and MAPK/ERK signaling pathway. Conclusion: Based on the network pharmacology, the study disclosed the active chemical compounds, potential targets and possible action cancers of BSJDSJR.

Analyzing the effective compounds, potential targets and diseases of Jianpi Jiedu recipe based on network pharmacology and function validation of cytobiology
Xue-Qing Hu, Ru Jia, Xuan Liu, Qin Song, Hui-Rong Zhu, Qi Li, Qing Ji, Yu Feng
93TMR Cancer    2019, 2 (1): 127-132.   https://doi.org/10.12032/TMRC201800050
Abstract ( 244 HTML PDF (860KB) ( 245 )  

Highlights

Jianpi Jiedu Recipe regulates multiple targets and cancer-related pathways based on network pharmacology.

Ampelopsis is predicted to be effective in colorectal cancer treatment and cell experiment has validated it.

Editor’s Summary

Jianpi Jiedu Recipe can effectively treat colorectal cancer. Among them, Ampelopsis can inhibit the occurrence and development of cancer cells in various ways.

Abstract

Objective: To analyze the active compounds, potential drug targets and therapy diseases of Jianpi Jiedu Recipe (JPJDR) based on network pharmacology and bioinformatics technology, and verify the biological function of some active compounds by cytology experiments. Methods: The online databases including TCMSP, TCMID, Cancer HSP, TCM-PTD, TCM Database@Taiwan and DrugBank were applied to screen the active compounds and the potential drug targets of JPJDR. Cytoscape 3.3 software was executed to construct the network between active compounds and drug targets. DAVID database was used to probe the effective diseases and analyze the involved KEGG pathways according to the predicted targets corresponding to JPJDR. Results: According to the rules of oral bioavailability (OB) >30% and drug-likeness (DL) >0.18, 58 of 513 effective compounds in JPJDR were screened out, as well as the corresponding 437 potential drug targets. By the analysis of DAVID database, all these key targets were associated closely with the occurrence and development of metabolic disorders and cancers, and all the targets were closely correlated with the pathways in cancer. Further analysis demonstrated that, there were a lot of effective compounds in JPJDR, such as Quercetin, Formononetin, Stigmasterol, Diosgenin, β-sitsterol, Oxymatrine, Kaempferol, Isorhamnetin and Ampelopsis. The results of cell proliferation experiments further showed that, among the selected nine key traditional Chinese medicine compounds, only Ampelopsis can dose-dependently inhibit the proliferation of colorectal cancer cells. Conclusion: Through network pharmacology analysis, we found that JPJDR contains many effective compounds which may directly target to the cancer-related proteins. 9 compounds were the major active compounds with high degrees of targets. Among the 9 screened compounds, Ampelopsis was validated for its inhibitory effect on the proliferation of colorectal cancer cells using CCK-8 assay. Network pharmacology is an effective approach to explore the functional mechanism of formula.

Research progress in the treatment of colorectal cancer in classical prescriptions
Shi-Yun Shao, Qi Li
93TMR Cancer    2019, 2 (3): 200-205.   https://doi.org/10.12032/TMRC201800056
Abstract ( 206 HTML PDF (590KB) ( 161 )  

Highlights

Traditional Chinese medicine is an important tumor-assisted treatment.

Classical formula has a good effect in colorectal treatment, but the mechanism is not clear.

Comments

Classical Chinese medicine prescriptions are widely used in cancer treatment. Although obvious therapeutic effects have been observed in clinical practice, laboratory evidence is still lacking. Clinically effective prescriptions may become the research direction for the development of cancer therapeutic drugs.

Abstract

ShanghanZabingLun, an acient book of Chinese medicine that published in Han dynasty (219 C.E.), is the first monograph in China that has the principles of prescription and treatment. Modern physicians flexibly applied many classical prescriptions recorded on this acientd book, such as BanxiaXiexin decoction, DaChengqi decoction, YiyiFuziBijiang decoction and Wumeipill for the treatment of colorectal cancer and its complications, and made some progress in clinical and experimental research. Studies have shown that classical prescriptions alone or in combination with other therapies can improve immunity, prevent cancer from recurrence and metastasis, reduce the side effects of anticancer drugs, improve quality of life, and prolong the survival of cancer patients. However, the current clinical and mechanistic studies on the treatment of classical prescriptions still need to explore in depth. This study aims to summarize the clinical and research progress in the treatment of colorectal cancer with classical prescriptions in recent years.

Traditional Chinese Medicine for Treatment of Apatinib-induced Hand and Foot Skin Reaction:A case report
Shan-Qi Guo, Xiao-Jiao Gao, Xiao-Jiang Li, Ying-Jie Jia
93TMR Cancer    2019, 2 (2): 189-192.   https://doi.org/10.12032/TMRC201800049
Abstract ( 182 HTML PDF (776KB) ( 116 )  

Highlights

Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis.
Chinese medicine has a good effect in the treatment of skin lesions caused by chemotherapy.

Editor’s Summary

In many cases, the side effects of chemotherapy are difficult to treat, which has a very bad effect on the quality of life of patients. As an important adjuvant therapy, traditional Chinese medicine has a good therapeutic effect in the treatment of skin lesions caused by chemotherapy.

Abstract

Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis. A 78-year-old woman presented with left maxillary sinus carcinoma. The patient received four courses of chemotherapy after surgery in our center. Eight months after treatment, the patient experienced local progress, severe gastrointestinal reactions and asthenia. Then apatinib was used as third-line treatment. Good curative effect was achieved with 250 mg apatinib per day, while adverse reaction such as hand and foot skin reaction affected the quality of her life. Traditional Chinese medicine exhibits good results and no obvious side effects in relieving hand and foot skin reaction. Traditional Chinese medicine is Chinese treasure, it remains challenging, and further investigations are needed.

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