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Advances in the relationship between Hashimoto’s thyroiditis and thyroid cancer
Yu Qiao
93TMR Cancer    2018, 1 (3): 66-73.   https://doi.org/10.12032/TMRC201800031
Abstract ( 1778 HTML PDF (883KB) ( 930 )  

Highlights: In this paper, various factors related to Hashimoto’s thyroiditis and thyroid cancer, especially papillary thyroid cancer, morbidity and lymph node metastasis, are reviewed concerning recent literature.

Editor’s Summary: In recent decades, it is very high for the incidence of HT and the thyroid cancer rate. This article is more likely that autoimmune thyroid inflammation such as HT is carcinogenic, and thyroid dysfunction related to HT may also promote tumor growth induced by stimulating TSH receptor.

Abstract: In recent years, the incidence of Hashimoto’s thyroiditis and thyroid cancer has shown a rapid growth trend. These two diseases have severely affected the public health. Many epidemiological studies have shown that thyroid cancer is often associated with Hashimoto’s thyroiditis. Hashimoto’s thyroiditis may promote the occurrence of thyroid cancer, as well as affecting the progression of the tumor, lymph node metastasis, and even the prognosis of patients. In this paper, the relationship between Hashimoto’s thyroiditis and thyroid cancer and the pathogenesis of thyroid cancer are reviewed regarding molecular mechanism, clinical pathology, and serology.

The differences and similarities between regional ethnic medicine and traditional Chinese medicine in the prevention and treatment of cancer pain
Hui-Li Shui, Zhu Yang , Feng-Xi Long , Wen-Qi Huang , Bing Yang , Zhen Zhang , Dong-Xin Tang
93TMR Cancer    2019, 2 (3): 206-211.   https://doi.org/10.12032/TMRC201800044
Abstract ( 1106 HTML PDF (576KB) ( 711 )  

Highlights

Regional ethnic medicine (REM) and traditional Chinese medicine (TCM) have unique experience in the treatment of cancer pain.

There are many different aspects of the treatment of cancer pain in REM and TCM.

Comments

TCM and REM are important cancer-assisted treatments in China. Especially for the treatment of cancer pain, TCM and REM are important alternatives.

Abstract

REM and TCMare both important parts of traditional medicine in China, and they have their own characteristics in the understanding and prevention of diseases. This article compares the understanding, the theoretical prevention and treatment guidance and the clinical application of the REM and TCMon the cancer pain.

The effect of Cordyceps Sinensis in the prognosis on patients receiving chemotherapy with malignant tumors: A systematic review and meta-analysis
Yi-Dan Sun, Ying Zhang, Pei-Ying Yang, Ying-Jie Jia
93TMR Cancer    2020, 3 (1): 19-27.   https://doi.org/10.12032/TMRC201800064
Abstract ( 302 HTML PDF (1582KB) ( 625 )  

Highlights

The combination therapy of Cordyceps Sinensis (CS) and chemotherapeutic drugs can reduce the inhibitory effect of bone marrow induced by chemotherapeutic drugs. CS can prevent leukocytes and white blood cells from decreasing in cancer patients during chemotherapy and radiotherapy. However, the prognostic role of CS in patients with malignant tumors after chemotherapy is still not clear. The mechanism of Chinese medicine treatment of tumor is a promising direction.

Abstract

Objective: The efficacy of Cordyceps Sinensis (CS) on malignant tumors remains controversial. We undertook a systematic meta-analysis of randomized controlled clinical studies on this issue. Method: A comprehensive literature search (by the end of Sep. 31, 2017) was conducted in following electronic databases: China National Knowledge Infrastructure (CNKI), VIP database, Wan fang database (VIP), PubMed, Medline, and EMBASE. Relevant studies were included according to inclusion criteria. Pooled relative risk was estimated by using the fixed effects model or random effects model according to heterogeneity. Data were extracted independently and the standardized mean deviation (SMD) of the calculated results was obtained. Result: After selection, 8 of 729 studies were included. The result showed that CS combined with chemotherapeutic drugs was favorable for the treatment of malignant tumor. The amount of CD3+ T cells in the experimental group was significantly higher than that in the control group (SMD = 0.86; 95% CI = 0.02, 1.70; P < 0.01; I2 = 91%). The amount of CD4+ T cells in the experimental group was significantly higher than that in the control group (SMD = 0.95; 95% CI = 0.22, 1.68; P < 0.01; I2 = 88%). The amount of CD8+ T cells in the experimental group was significantly higher than that in the control group (SMD = -0.07; 95% CI= -0.30, 0.17; P = 0.32; I2 = 14%). The rate of CD4+/CD8+ T cells in the experimental group was higher than that in the control group (SMD = 27.76; 95% CI = 25.25, 30.28; P = 0.39; I2 = 0%). And CS may retard the declining trend of KPS functional status evaluation (RR = 0.46, 95% CI = 0.2780, 0.7350; P < 0.01), thus improving the patients’ life quality. Conclusion: The current evidence suggested that CS is favorable to improve the efficacy of chemotherapeutic drugs in patients with malignant tumors, probably by improving immune system function.

Experimental study of Quercetin self-nanoemulsifying drug delivery system in inhibiting SMMC-7721 cells
Yang Sun, Yan-Xin Che, Bo-Yan Wu
93TMR Cancer    2018, 1 (4): 99-104.   https://doi.org/10.12032/TMRC201800036
Abstract ( 909 HTML PDF (918KB) ( 530 )  

Highlights

Quercetin self-nanoemulsifying drug delivery system promotes apoptosis of SMMC-7721 cells in vitro.

Quercetin self-nanoemulsifying drug delivery system inhibits the expression of STAT3 and Survivin in SMMC-7721 cells.

Editor’s Summary

This study describes the role of Quercetin in promoting apoptosis of SMMC-7721. Quercetin self-nanoemulsifying drug delivery system can also be used as a drug carrier, which providing ideas for precise treatment.

Abstract

Objective: To study the mechanism of inhibition of SMMC-7721 liver cancer cells by quercetin self-nanoemulsifying drug delivery system (Q-SNEDDS) in vitro. Methods: The inhibitory effect of Q-SNEDDS on hepatoma cells was detected by MTT assay. The effect of Q-SNEDDS on apoptosis of hepatoma cells was detected by flow cytometry. The changes of Q-SNEDDS after hepatoma cells were observed by fluorescence microscopy. The effect of Q-SNEDDS on the expression of signal transduction and activator of transcription 3 (STAT3) and anti-apoptotic factor (survivin) protein in hepatoma cells was examined by Immunohistochemistry. Results: Q-SNEDDS significantly inhibited the proliferation of hepatoma cells in a concentration-dependent manner. After 24 h of Q-SNEDDS treatment, the total apoptosis rate was 25.8%; STAT3 and survivin protein expression was down-regulated in the Q-SNEDDS group. Conclusion: Q-SNEDDS may play a role in inducing apoptosis by inhibiting the expression of STAT3 and survivin proteins.

Advances in research on tumor microenvironment of hepatocellular carcinoma
Gao Li, Dong-Xin Tang, Feng-Xi Long, Zhu Yang
93TMR Cancer    2019, 2 (1): 143-150.   https://doi.org/10.12032/TMRC201800046
Abstract ( 467 HTML PDF (649KB) ( 444 )  

Highlights

Chinese and Western medicine have different understandings of the tumor microenvironment and different treatment methods.

Editor’s Summary

The concept of the tumor microenvironment has been widely accepted. In the theory of Chinese and Western medicine, the concept of tumor microenvironment is similar, but there are still differences. Tumor treatment strategies for tumor microenvironment are receiving increasing attention.

Abstract

Modern medical research on cancer shows that hepatocellular carcinoma (HCC) is related to tumor microenvironment. Studying the relationship between tumor microenvironment and HCC can be used as a new research direction to provide more strategies and ideas for the prevention and treatment of HCC. This article describes the characteristics of tumor microenvironment, cytokines, related signaling pathways, the occurrence and development of traditional Chinese medicine and HCC, and treatment-related knowledge.

Significance, feasibility, and perspectives of network pharmacology in treating cancer
Yu-Yu Feng
93TMR Cancer    2018, 1 (4): 105-110.   https://doi.org/10.12032/TMRC201800037
Abstract ( 572 HTML PDF (691KB) ( 389 )  

Highlights

Network pharmacology is a new science and is becoming a new way for TCM study.

Network pharmacology combines with TCM is a new medical research model.

Editor’s Summary

The network pharmacology approach is capable of describing complex interactions among biological system, drugs, and diseases, such as cancer from a network perspective. It helps us to understand how herbal medicine works on people with cancer and how a new indication of a given herbal formula can be predicted.

Abstract

Traditional Chinese Medicine (TCM) emphasizes integrity and systematicity. Chinese Herbal Medicine (CHM) is characterized by multi-component, multi-target, multi-channel complex action. Cancer belongs to polygenic disease, and it is characteristic of complex traits of the disease which is determined by multiple genes. Network pharmacology integrates disease network, drug network, and biological system network, analyzes the interaction among diseases, drugs and specific nodes in the network, and studies the pathogenesis of cancer, the action mechanism of drugs and compatibility principle of prescription. In the field of cancer, by applying concepts and methods of network pharmacology, we are expected to find new type drugs-“biological networks regulatory drug”. It is helpful for individualized treatment, improved prognosis, and therapeutic effect.

Anti-tumor mechanism of Angelica and its compound preparations
Xin-Xiao Lu, Xiong-Zhi Wu
93TMR Cancer    2019, 2 (2): 193-199.   https://doi.org/10.12032/TMRC201800041
Abstract ( 402 HTML PDF (595KB) ( 377 )  

Highlights

Angelica is a traditional Chinese medicine with anti-tumor effect and various anti-cancer ingredients.
Angelica's ingredients play different mechanisms of anti-cancer and may have different effects on different tumors.

Editor’s Summary

In China, many Chinese medicines are widely used in clinical treatment. These traditional Chinese medicines can not only reduce the side effects of chemotherapy but also improve the efficacy. Even some Chinese medicines have a excellent anti-tumor effect. However, due to the limitations of current Chinese medicine research, the mechanism by which Chinese medicine exerts anti-tumor effect remains to be further studied.

Abstract

Angelica is a holy medicine for gynecology, clinically used for blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, dysmenorrhea, abdominal pain, rheumatism, hemorrhoids, constipation. In recent years, with the discovery of polysaccharides enhancing the immune function and anti-tumor effects of the body, Angelica has attracted more and more attention from researchers at home and abroad.

Study on the technical specification of Miao doctor's medicinal acupuncture therapy for interventional cancer pain
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang
93TMR Cancer    2019, 2 (2): 157-161.   https://doi.org/10.12032/TMRC201800042
Abstract ( 405 HTML PDF (497KB) ( 363 )  

Highlights

Miao doctor sputum acupuncture is an effective method for treating cancer pain.
Operational standard operation of Miao doctor sputum acupuncture treatment for cancer pain.

Editor’s Summary

The treatment of cancer pain is limited and the treatment effect is not satisfactory. Miao doctor's acupuncture treatment may be an effective treatment. This provides a new strategy for clinical treatment of cancer pain.

Abstract

Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation procedure of the intervention of the acupuncture and moxibustion acupuncture therapy for cancer pain was formulated according to the selection of acupoints in the Miao medicine Tianying acupoint, sputum manipulation method, and the routine operations such as medicine, acupuncture and canning. Results: A set of technical specifications for the treatment of cancer pain in a mobilized Miao doctor was sorted out. Conclusion: The sputum acupuncture treatment technique specification for cancer pain is easy to operate and easy to be applied in clinical application.

Compound Kushen injection combined with chemotherapy in the treatment of gastric cancer: a meta-analysis of randomized controlled trials
Su-Tong Liu, Kai-Qi Su, Wen-Xia Zhao
93TMR Cancer    2019, 2 (1): 118-126.   https://doi.org/10.12032/TMRC201800043
Abstract ( 452 HTML PDF (1194KB) ( 361 )  

Highlights

Compound kushen injection is frequently used in patients with malignant tumor for adjuvant therapy in China. We are the first using meta-analysis evaluated the clinical efficacy and safety of compound kushen injection combined chemotherapy in the treatment of gastric cancer.

Editor’s Summary

Kushen injection is widely used in clinical practice, but there is still a lack of data to support its clinical effectiveness. This article summarizes the previous research experience through meta-analysis, and provides the basis for the clinical application of Kushen injection.

Abstract

Objective: This study aims to systematically evaluate the efficacy and safety of compound kushen injection (CKI) in combination with chemotherapy in patients with gastric cancer (GC). Methods: A comprehensive electronic search was conducted by searching PubMed, EMBASE, Cochrane Library, Chinese Biological Medical disc, China National Knowledge Infrastructure and Wanfang databases (the last update January 20, 2018). All randomized controlled trials (RCTs) of CKI plus chemotherapy versus chemotherapy alone in GC patients were identified. The quality of each study was evaluated using the Jadad’s scale, and the meta-analysis was performed using Review Manager 5.3 and STATA 14 software. Results: A total of nine studies on 688 cases were included in this study. The results showed that CKI combined with chemotherapy had a better effect on improving patients’ overall response rate (ORR) and life quality. The consequences of Egger’s and Begg’s tests showed there was no significant publication bias. Conclusion: The current evidence showed that CKI may enhance the clinical efficacy of chemotherapy, improve the quality of life and increase the safety in patients with gastric cancer.

Analyzing the effective compounds, potential targets and diseases of Jianpi Jiedu recipe based on network pharmacology and function validation of cytobiology
Xue-Qing Hu, Ru Jia, Xuan Liu, Qin Song, Hui-Rong Zhu, Qi Li, Qing Ji, Yu Feng
93TMR Cancer    2019, 2 (1): 127-132.   https://doi.org/10.12032/TMRC201800050
Abstract ( 344 HTML PDF (860KB) ( 353 )  

Highlights

Jianpi Jiedu Recipe regulates multiple targets and cancer-related pathways based on network pharmacology.

Ampelopsis is predicted to be effective in colorectal cancer treatment and cell experiment has validated it.

Editor’s Summary

Jianpi Jiedu Recipe can effectively treat colorectal cancer. Among them, Ampelopsis can inhibit the occurrence and development of cancer cells in various ways.

Abstract

Objective: To analyze the active compounds, potential drug targets and therapy diseases of Jianpi Jiedu Recipe (JPJDR) based on network pharmacology and bioinformatics technology, and verify the biological function of some active compounds by cytology experiments. Methods: The online databases including TCMSP, TCMID, Cancer HSP, TCM-PTD, TCM Database@Taiwan and DrugBank were applied to screen the active compounds and the potential drug targets of JPJDR. Cytoscape 3.3 software was executed to construct the network between active compounds and drug targets. DAVID database was used to probe the effective diseases and analyze the involved KEGG pathways according to the predicted targets corresponding to JPJDR. Results: According to the rules of oral bioavailability (OB) >30% and drug-likeness (DL) >0.18, 58 of 513 effective compounds in JPJDR were screened out, as well as the corresponding 437 potential drug targets. By the analysis of DAVID database, all these key targets were associated closely with the occurrence and development of metabolic disorders and cancers, and all the targets were closely correlated with the pathways in cancer. Further analysis demonstrated that, there were a lot of effective compounds in JPJDR, such as Quercetin, Formononetin, Stigmasterol, Diosgenin, β-sitsterol, Oxymatrine, Kaempferol, Isorhamnetin and Ampelopsis. The results of cell proliferation experiments further showed that, among the selected nine key traditional Chinese medicine compounds, only Ampelopsis can dose-dependently inhibit the proliferation of colorectal cancer cells. Conclusion: Through network pharmacology analysis, we found that JPJDR contains many effective compounds which may directly target to the cancer-related proteins. 9 compounds were the major active compounds with high degrees of targets. Among the 9 screened compounds, Ampelopsis was validated for its inhibitory effect on the proliferation of colorectal cancer cells using CCK-8 assay. Network pharmacology is an effective approach to explore the functional mechanism of formula.

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