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05 June 2019, Volume 2 Issue 2 Previous Issue    Next Issue
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Integrative Oncology
Study on the technical specification of Miao doctor's medicinal acupuncture therapy for interventional cancer pain
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang
93TMR Cancer. 2019, 2 (2): 157-161.   https://doi.org/10.12032/TMRC201800042
Abstract ( 319 )   HTML ( 11 )     PDF (497KB) ( 243 )  

Highlights

Miao doctor sputum acupuncture is an effective method for treating cancer pain.
Operational standard operation of Miao doctor sputum acupuncture treatment for cancer pain.

Editor’s Summary

The treatment of cancer pain is limited and the treatment effect is not satisfactory. Miao doctor's acupuncture treatment may be an effective treatment. This provides a new strategy for clinical treatment of cancer pain.

Abstract

Objective: Under the guidance of the theory of Miao medicine, the technical norm scheme for intervention of acupuncture and moxibustion for the treatment of cancer pain is proposed. Methods: The standard operation procedure of the intervention of the acupuncture and moxibustion acupuncture therapy for cancer pain was formulated according to the selection of acupoints in the Miao medicine Tianying acupoint, sputum manipulation method, and the routine operations such as medicine, acupuncture and canning. Results: A set of technical specifications for the treatment of cancer pain in a mobilized Miao doctor was sorted out. Conclusion: The sputum acupuncture treatment technique specification for cancer pain is easy to operate and easy to be applied in clinical application.

Therapeutic effect of Liyan Baidu decoction combined with oxygen spray on radioactive stomatitis in patients with nasopharyngeal carcinoma
Zi-Wei Qi, Xiang-Kun Yuan, Jian-Wei Hu, Jun-Jun Miao, Lei Gao, Yong-Xia Zhang, Guang-Ying Hou, Mang-Mang Cui
93TMR Cancer. 2019, 2 (2): 162-169.   https://doi.org/10.12032/TMRC201800045
Abstract ( 182 )   HTML ( 4 )     PDF (730KB) ( 179 )  

Highlights

Liyan Baidu Decoction is a traditional Chinese medicine for treating radioactive stomatitis. Combined oxygen spray therapy may have a better local treatment effect.

Editor’s Summary

Radioactive stomatitis is a serious syndrome after radiotherapy for nasopharyngeal carcinoma, and there is currently no effective treatment. Liyan Baidu Decoction combined with oxygen spray treatment can effectively alleviate radiation stomatitis.

Abstract

Objective: To observe the efficacy of Liyan Baidu Decoction combined with Oxygen Spray in the treatment of radiation oropharyngeal cancer in patients with nasopharyngeal carcinoma. Methods: Forty patients with radionomephicitis of nasopharyngeal carcinoma from 2015.03-2017.05 were randomly divided into treatment group (27 cases) and control group (23 cases). The treatment group was treated with Liyan Baidu Decoction combined with oxygen spray; the control group was treated with rehabilitation fluid. Results: Compared with the control group, the time of oral mucosal reaction was delayed (P < 0.05), the cumulative radiation of oral mucosal reaction increased (P < 0.05), and the oral mucosal reaction index decreased (P < 0.05). The degree of salivary gland damage was decreased (P < 0.05), and most of the KPS scores were improved compared with before treatment. However, the quality of life of Liyan Baidu Decoction group was higher than that of the control group (P < 0.05). Conclusion: Liyan Baidu decoction combined with oxygen spray may effectively delay the time of acute radioactive oral mucosal reaction in patients with nasopharyngeal carcinoma, and effectively reduce the radiation oral mucosal damage and salivary gland damage in patients with nasopharyngeal carcinoma. This study provides a clinical basis for the application of Liyan Baidu Decoction.

Immunoregulation of KangAi injection combined with chemotherapy in advanced non-small cell lung cancer: a systematic review and meta-analysis
Liu Pu, Wei-Hao Chen, Kun-Ji Wu, Ji-Huan Lin, Cheng-Lu Li, Shu-Lian Chen, Lu-Xi Cao, Shi-Qi Wang, Shu-Jun Lin, Yi-Min Zhang, Ming-Min Zhu
93TMR Cancer. 2019, 2 (2): 170-180.   https://doi.org/10.12032/TMRC201800052
Abstract ( 174 )   HTML ( 5 )     PDF (1474KB) ( 127 )  

Highlights

There is still a lack of systematic evaluation criteria for the effect of KangAi (KA) injection on immune function.
KA injection combined chemotherapy may enhance clinical efficiency in patients with advanced NSCLC by regulating immune system.

Editor’s Summary

The mechanism of adjuvant chemotherapy for traditional Chinese medicine to improve the efficacy of chemotherapy is not fully understood. By regulating the immune system, it may be one of the important ways to play an important role.

Abstract

Objective: To evaluate the immunoregulation of KangAi (KA) injection combined with chemo-treatment (chemo) for Non-small cell lung cancer (NSCLC). Methods: We systematically searched the literature of PubMed, EMBASE, CENTRAL, MEDLINE, CNKI, Wanfang, and VIP databases for all Randomized controlled trials (published from the earliest possible year to January 2019, no language restrictions) comparing KA injection combined with chemo and chemo alone in patients with NSCLC. Our main endpoints were immune function, clinical efficiency, KPS score and adverse events. The Cochrane Risk of Bias tool was applied for quality assessment. Results: 11 studies involving 1060 participants were included. The immune function (MD=3.18, 95% CI: 0.98-4.00, P<0.00001), clinical response rate (RR=1.28, 95%CI: 1.17-1.40, P<0.00001), KPS score (RR=1.86, 95%CI: 1.35-2.57, P=0.0002), and adverse events (RR=0.57, 95%CI: 0.50-0.65, P<0.00001) in the group of KA injection plus Chemo were vastly different from those in Chemo alone. Conclusion: KA injection combined with Chemo in the treatment of NSCLC improved the immune function, clinical efficiency and safety compared to Chemo alone. However, because many of the methodologies included in randomized controlled trials are of poor quality, more rigorous design and large randomized controlled trials are needed to test this benefit.

Clinical Cancer Research
Research progress on radiation-induced bystander effect
Chao-Ning Zhang, Jin-Tian Li
93TMR Cancer. 2019, 2 (2): 181-188.   https://doi.org/10.12032/TMRC201800048
Abstract ( 182 )   HTML ( 6 )     PDF (709KB) ( 125 )  

Highlights

Radiation-induced bystander effect is a common side reaction of radiotherapy and has a strong impact on the cancer patients.

Editor’s Summary

The mechanism of the bystander effect is not fully understood. Recently, studies on exosomes have attracted widespread attention. Whether exosomes play an important role in the bystander effect requires further research.

Abstract

Radiation-induced bystander effect is the phenomenon that the cells which are not directly exposed to radiation have identical or similar biological reactions with the cells of direct exposure to radiation. It is a common second reaction of radiotherapy and has a strong impact on cancer patients. Here we review and synthesize its studies in vitro and in vivo, its time effect and the mechanism. And the existing problems and its research significance are also discussed.

Traditional Chinese Medicine for Treatment of Apatinib-induced Hand and Foot Skin Reaction:A case report
Shan-Qi Guo, Xiao-Jiao Gao, Xiao-Jiang Li, Ying-Jie Jia
93TMR Cancer. 2019, 2 (2): 189-192.   https://doi.org/10.12032/TMRC201800049
Abstract ( 185 )   HTML ( 3 )     PDF (776KB) ( 116 )  

Highlights

Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis.
Chinese medicine has a good effect in the treatment of skin lesions caused by chemotherapy.

Editor’s Summary

In many cases, the side effects of chemotherapy are difficult to treat, which has a very bad effect on the quality of life of patients. As an important adjuvant therapy, traditional Chinese medicine has a good therapeutic effect in the treatment of skin lesions caused by chemotherapy.

Abstract

Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis. A 78-year-old woman presented with left maxillary sinus carcinoma. The patient received four courses of chemotherapy after surgery in our center. Eight months after treatment, the patient experienced local progress, severe gastrointestinal reactions and asthenia. Then apatinib was used as third-line treatment. Good curative effect was achieved with 250 mg apatinib per day, while adverse reaction such as hand and foot skin reaction affected the quality of her life. Traditional Chinese medicine exhibits good results and no obvious side effects in relieving hand and foot skin reaction. Traditional Chinese medicine is Chinese treasure, it remains challenging, and further investigations are needed.

Cancer Biology
Anti-tumor mechanism of Angelica and its compound preparations
Xin-Xiao Lu, Xiong-Zhi Wu
93TMR Cancer. 2019, 2 (2): 193-199.   https://doi.org/10.12032/TMRC201800041
Abstract ( 304 )   HTML ( 7 )     PDF (595KB) ( 279 )  

Highlights

Angelica is a traditional Chinese medicine with anti-tumor effect and various anti-cancer ingredients.
Angelica's ingredients play different mechanisms of anti-cancer and may have different effects on different tumors.

Editor’s Summary

In China, many Chinese medicines are widely used in clinical treatment. These traditional Chinese medicines can not only reduce the side effects of chemotherapy but also improve the efficacy. Even some Chinese medicines have a excellent anti-tumor effect. However, due to the limitations of current Chinese medicine research, the mechanism by which Chinese medicine exerts anti-tumor effect remains to be further studied.

Abstract

Angelica is a holy medicine for gynecology, clinically used for blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, dysmenorrhea, abdominal pain, rheumatism, hemorrhoids, constipation. In recent years, with the discovery of polysaccharides enhancing the immune function and anti-tumor effects of the body, Angelica has attracted more and more attention from researchers at home and abroad.

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