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7Drug Combination Therapy  2019, Vol. 1 Issue (3): 102-116    DOI: 10.12032/DCT201903002
Orginal Article     
Research trends and development status of TCM network pharmacology: a bibliometric study
Yu-Zhi Shang1 ?, Qing-Huai Zhang1 ?, Qiu-Xia Chen1, Xiu-Song Tang1, Yu-Zhou Pang 2*, Gang Fang 2*
1. Key Laboratory for Research on Foundation and Application of Zhuang Medicine and Prescriptions, Guangxi University of Chinese Medicine, Nanning, 530200, China.
2. Guangxi Engineering Research Center for Zhuang and Yao Medicine, Guangxi University of Chinese Medicine, Nanning, 530200, China.
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Objective: To analyze the research status, development context and trend of traditional Chinese medicine (TCM) network pharmacology from birth to the present. Methods: In this study, bibliographic data and references of articles on TCM network pharmacology were collected from Web of Science Core Collection (WoSCC), and software including CiteSpace, VOSviewer and Microsoft Excel were applied for the bibliometric analysis of periodicals and the quantity of literature, and for the construction and analysis of the co-occurrence network of countries, journals, research institutes and authors, clusters of co-cited references, and time distribution network of keywords. Results: 249 articles were included in this study. The time span was from 2011 to 2018, and the annual volume of publications showed an increasing trend year by year. The 77 journals contain relevant literature, and the average impact factor of the journal is 3.215. Chinese Journal of Natural Medicines, Scientific Reports, PLoS One have high influence in the field of TCM network pharmacology. Universities and research institutes including China Academy of Chinese Medical Science and Northwest Agriculture & Forestry University are the major forces in this field. Wang Yonghua and Li Shao are authors with high influence in this field, with a considerable number of relevant documents and citations. According to the clustering results of co-cited references, research topics can be classified into 13 development contexts such as “compound danshen formula”, “computational tool”, and “new multi-compound drug discovery”. Hotspots of TCM network pharmacology include “drug discovery”, “mechanism” and “cardiovascular disease”, and relevant research methods and research contents including drugs and diseases tend to be constantly enriched. Conclusion: This study comprehensively demonstrates the research status, development context and trends of TCM network pharmacology, and provides a scientific reference for TCM network pharmacology researchers.



Key words Chinese materia medica      Network pharmacology      Bibliometric analysis      CiteSpace      VOSviewer      
Received: 22 May 2019      Published: 08 August 2019
Fund:  

The study was funded by the Major Project for Research on Modernization of Traditional Chinese Medicine under National Key R&D Program of China (no. 2017YFC1704004), National Natural Science Foundation of China (no. 81674097), Guangxi Scholarship Fund of Guangxi Education Department (No. Gui Jiao Ren 201818), Guangxi First-class Discipline Construction Project  (No. Gui Jiao Ke Yan 201812), Funded by Development Program of High-level Talent Team under Qihuang Project of Guangxi University of Chinese Medicine (No.2018005) and Innovative Research Project for Postgraduates of Guangxi University of Chinese Medicine (no.YCSY20190010).

Corresponding Authors: Yu-Zhou Pang and Gang Fang, Guangxi Engineering Research Center for Zhuang and Yao Medicine, Guangxi University of Chinese Medicine, Nanning, 530200, China.    
E-mail: 2017yuzhoupang@sina.com (Yu-Zhou Pang); fglzyznn@yeah.net (Gang Fang).
Cite this article:

Yu-Zhi Shang, Qing-Huai Zhang, Qiu-Xia Chen, Xiu-Song Tang, Yu-Zhou Pang, Gang Fang. Research trends and development status of TCM network pharmacology: a bibliometric study. 7Drug Combination Therapy, 2019, 1(3): 102-116. doi: 10.12032/DCT201903002

URL:

https://www.tmrjournals.com/dct/EN/10.12032/DCT201903002     OR     https://www.tmrjournals.com/dct/EN/Y2019/V1/I3/102

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