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7Drug Combination Therapy  2019, Vol. 1 Issue (3): 117-133    DOI: 10.12032/DCT201903003
Orginal Article     
Dissecting the underlying pharmaceutical mechanism of traditional Chinese medicine Wenxin Keli acting on atrial fibrillation through network pharmacology
Xian-Jun Wu1*, Xin-Bin Zhou1, Chen Chen1, Wei Mao1*
1. Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
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As a well-known Chinese medicine prescription, Wenxin Keli (WXKL) has been widely used in the treatment of many arrhythmias including atrial fibrillation and has achieved significant clinical effects, but the specific mechanism of its treatment of atrial fibrillation remains unclear. This study used a network pharmacology approach to reveal the potential molecular mechanisms of WXKL in the treatment of atrial fibrillation. It involves oral bioavailability screening of ingredients, drug-likeness evaluation, compound target fishing, H-C-T network and C-T-P network construction and analysis. Through the network pharmacology-based research strategy, the complex system of WXKL was analyzed. It was found that 14 representative compounds of WXKL, 30 protein targets and 12 related signaling pathways help us systematically understand the underlying mechanism of WXKL's anti-atrial fibrillation effects.



Key wordsNetwork Pharmacology      traditional chinese medicine      Wenxin Keli      Atrial fibrillation      Pharmacological mechanism     
Received: 23 May 2019      Published: 08 August 2019
Fund:  There is no funding to declare.
Corresponding Authors: Xian-Jun Wu and Wei-Mao, Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.    
E-mail: wuxianjunls@163.com (Xian-Jun Wu); maoweilw@163.com (Wei-Mao)
Cite this article:

Xian-Jun Wu, Xin-Bin Zhou, Chen Chen, Wei Mao. Dissecting the underlying pharmaceutical mechanism of traditional Chinese medicine Wenxin Keli acting on atrial fibrillation through network pharmacology. 7Drug Combination Therapy, 2019, 1(3): 117-133. doi: 10.12032/DCT201903003

URL:

https://www.tmrjournals.com/dct/EN/10.12032/DCT201903003     OR     https://www.tmrjournals.com/dct/EN/Y2019/V1/I3/117

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