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7Drug Combination Therapy  2019, Vol. 1 Issue (4): 210-223    DOI: 10.12032/DCT201903005
Meta-analysis     
A Meta-analysis of the efficacy and safety of Kanglaite injection combined with chemotherapy in the treatment of pancreatic cancer
Lu Zhang1, Jia-Jian Lv1, Zhe Yang1, Shu-Zhen Wu1, Jun-Chen Feng1, Xin-Juan Wang1, Ya-Nan Liu1, Xiao-Chun Han1*
1. Shandong University of Traditional Chinese Medicine, Jinan, China, 250355.
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Objective: To investigate the efficacy and safety of Kanglaite injection (KLT) combined with chemotherapy in the treatment of pancreatic cancer. Methods: PubMed, EMBASE, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Data, and  Chinese Biomedical Database (CBM) were searched to get the studies about KLT plus chemotherapy for pancreatic cancer  (from established to May 2019). Data extraction and bias risk assessment were carried out by two authors independently according to the retrieval method. RevMan (version 5.3) were employed for data analysis. Results: A total of 151 literatures were retrieved and 11 literatures were finally included. A total of 614 patients were included, including 308 in the treatment group and 306 in the control group. The results of meta-analysis showed that compared with chemotherapy alone, KLT combined with chemotherapy could improve the effective rate [PORR = 0.0009, OR=1.96, 95% CI (1.32, 2.92)] and disease control rate [PDCR <0.00001, OR=2.53, 95% CI (1.76, 3.62)], improve KPS score [P<0.00001, OR=3.59, 95% CI (2.00, 6.44)] and body mass indexes [P=0.0003, OR=3.45, 95% CI (1.78, 6.69)], prolong progression free survival (PFS) and overall survival (OS), reduce the rate of myelosuppression [P=0.03, OR=0.54, 95% CI (0.30, 0.95)], but could not reduce the occurrence of neurotoxicity [P=0.49, OR=0.80, 95% CI (0.42, 1.51)] and digestive tract reaction [P=0.51, OR=0.83, 95% CI (0.48, 1.44)]. Conclusion: KLT combined with chemotherapy can improve the curative effect of pancreatic cancer, improve the quality of life of patients, prolong the survival of patients, and reduce the incidence of bone marrow suppression. However, due to the limitation of the quality and quantity of included literatures, this conclusion needs to be verified by high-quality study.



Key words Coix seed oil      Kanglaite injection      Chemotherapy      Pancreatic cancer      Meta-analysis      
Received: 22 May 2019      Published: 08 November 2019
Fund:  

This study was supported by the National Natural Science Foundation of China (No.81703838), the Key R&D Program of Shandong Province (No.2019GSF108210), Development Project of Traditional Chinese Medicine Science and Technology in Shandong Province (No.2017-027), Key Technology Projects of Key Industries in Shandong Province (No.2016CYJS08A01-4 and 2016CYJS08A01-3), Key Research and Development Plans in Shandong Province (No.2016ZDJS07A12), and 2018 National SRT Project of Shandong University of Traditional Chinese Medicine (No.201810441008).

Corresponding Authors: Xiao-Chun Han, Shandong University of Traditional Chinese Medicine, Jinan, China, 250355.   
E-mail: hanxch002@163.com.
Cite this article:

Lu Zhang, Jia-Jian Lv, Zhe Yang, Shu-Zhen Wu, Jun-Chen Feng, Xin-Juan Wang, Ya-Nan Liu, Xiao-Chun Han. A Meta-analysis of the efficacy and safety of Kanglaite injection combined with chemotherapy in the treatment of pancreatic cancer. 7Drug Combination Therapy, 2019, 1(4): 210-223. doi: 10.12032/DCT201903005

URL:

https://www.tmrjournals.com/dct/EN/10.12032/DCT201903005     OR     https://www.tmrjournals.com/dct/EN/Y2019/V1/I4/210

[1] Meng-Xi Gao, Ai-Ying Zhang, Tian-Tian Gai, Wei Fan, Yan Wang. Systematic evaluation of Kang-ai injection combined with chemotherapy versus chemotherapy alone in the treatment of ovarian cancer [J]. 7Drug Combination Therapy, 2019, 1(1): 19-30.