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7Drug Combination Therapy  2019, Vol. 1 Issue (3): 153-164    DOI: 10.12032/DCT201904001
Orginal Article     
Curcumin suppresses proliferation of MCF-7 breast cancer cells by modulating gap junction signaling
Xin-Qiang Song1,2*, Mu Zhang3, Kai-Ming Li1, Er-Qin Dai1, Yu Zhang1, Ning-Ning Yang1, Lei Chen1, Lei Wang1*
1. Department of Biological Sciences, Xinyang Normal University, Xinyang, 464000, China . 2. Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang, 464000, China. 3. Hospital Attached to Xinyang Normal University, Xinyang, 464000, China.
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Curcumin, an agent isolated from turmeric, shows therapeutic potential against breast cancer. However, the mechanism underlying anticancer activity has not been fully expounded. In this research, bioinformatics was utilized to analyze molecular mechanism of curcumin. and the results have been proved in breast cancer cells subsequently. In order to generate a breast cancer molecular network with which curcumin interacts, target proteins of curcumin from PubChem were combined with genes implicated in breast cancer in the NCBI within Ingenuity Pathway Analysis software.Predicted curcumin targets were verified by reverse transcription-quantitative polymerase chain reaction. Bioinformatics identified gap junction signaling and 14-3-3-mediated adherens junctions as the main canonical signaling pathways targeted by curcumin. Moreover, curcumin can substantially up-regulates the gap junction protein connexin in breast cancer cells. Our results suggest that curcumin through modulation of the gap junction signaling pathway to inhibit cell proliferation and differentiation in breast cancer cells.

Key wordsCurcumin      Gap junction signal pathway      Breast cancer      Bioinformatics analysis     
Received: 03 July 2019      Published: 08 August 2019
Fund:  The study was funded by National Natural Science Foundation of China (No.U1804179), Henan Science and Technology Innovation Team, Investigation on Plant Resources in Dabie Mountains and the study and utilization of active components of special plants (No.2017083), Nanhu Scholars Program for Young Scholars of Xinyang Normal University (No.2018001).
Corresponding Authors: Xin-Qiang Song and Lei Wang.   
E-mail: (Xin-Qiang Song); (Lei Wang).
Cite this article:

Xin-Qiang Song, Mu Zhang, Kai-Ming Li, Er-Qin Dai, Yu Zhang, Ning-Ning Yang, Lei Chen, Lei Wang. Curcumin suppresses proliferation of MCF-7 breast cancer cells by modulating gap junction signaling. 7Drug Combination Therapy, 2019, 1(3): 153-164. doi: 10.12032/DCT201904001

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