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8Food Therapy and Health Care  2019, Vol. 1 Issue (3): 97-101    DOI: 10.12032/FTHC201908005
Review     
Research Progress in Arecoline-induced Oral Submucous Fibrosis
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Abstract  Areca nut is a popular fruit, but is among the most common addictions following tobacco, alcohol and caffeine globally. Areca nut chewing is the major risk factor for OSF, which is a chronic, occult, and premalignant fibrotic disease. OSF is characterized by submucosal collagen accumulation and microvascular diseases, the primary microscopic manifestations of which include damaged vascular endothelial cells, increased vascular permeability, and decreased number of microvessels. As the basic structure of microvessels, endothelial cells paly an important role in the pathogenesis and progression of OSF. Arecoline is the main component of areca nut. This review summarized the machenism of arecoline-inducing OSF by acting on endothelial cells, mainly including that arecoline can promote endothelial cells inducing tissue fibrosis by acting on the vascular endothelial cells and is accomplished via multiple aspects such as inhibiting the proliferation and facilitating the apoptosis of endothelial cells, affecting their secretion of cytokines, or promoting the transformation process of EMT.

Key wordsArecoline      OSF      Endothelial cells      Mechanism      TGF-β      EMT     
Received: 29 March 2019      Published: 01 August 2019
Cite this article:

Jing-Wen Jiang, Xue-Wu Chen, Qing-Hua Yao, Hui Zhan. Research Progress in Arecoline-induced Oral Submucous Fibrosis. 8Food Therapy and Health Care, 2019, 1(3): 97-101.

URL:

https://www.tmrjournals.com/fthc/EN/10.12032/FTHC201908005     OR     https://www.tmrjournals.com/fthc/EN/Y2019/V1/I3/97

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