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8Food Therapy and Health Care  2019, Vol. 1 Issue (4): 102-113    DOI: 10.12032/FTHC201910001
    
Study on the mechanism of Coix seed in the treatment of colon cancer Based on network pharmacology
 Jin-Lin Wu1, Zhu Yang1, 2, Feng-Xi Long1, 2, Li Luo2,3, Xun  Liu1, Jia Wang1,  Ting Yu1, Dong-Xin Tang1, 2*
1Graduate School,Guizhou University of Traditional Chinese Medicine, Guiyang 550002, China; 
2Department of Traditional Chinese Medicine,Guizhou Provincial TCM Inheritance and Technology Innovation Talent Base, Guiyang 550002, China; 
3Oncology Department,Guihang Group 300 Hospital, Guiyang 550000, China.
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Abstract  Objective: Study on the mechanism of Coix seed in the treatment of colon cancer based on network pharmacology. Methods: The main chemical components of Coix seed were identified by TCMP, and the target sites of drug components were screened. The target of the protein was mapped to the corresponding gene target through the Uniprot database. Genecards database was used to find the target gene of human colon cancer disease, and then the disease gene target was combined with the drug gene target to screen the common target of disease-drug composition, and the STRING platform was used to construct the drug component-disease target protein interaction. (PPI) network model. The Bioconductor database was used to analyze the potential targets, related molecular functions and signaling pathways of cocoon in the treatment of colon cancer by GO and KEGG enrichment. The disease-drug component-target-signal pathway network was established by Cytoscape software. Results: It was found that there are 9 pharmacodynamics and 28 targets related to colon cancer treatment, and GO functional enrichment analysis is based on correction. P<0.05 screened 346 molecular functional related items, including 256 biological processes, 48 molecular functions, and 42 cell components. KEGG functional enrichment analysis screened 24 related pathways according to the adjusted P<0.05. Conclusion: PTGS2, AR, ESR1, PGR, ADH1C, AKR1B1, LTA4H, NCOA1, NCOA2 and other related targets may be potential targets for the treatment of colon cancer.

Key wordsCoix seed      Colon cancer      Network pharmacology      Mechanism     
Received: 01 August 2019      Published: 13 October 2019
Fund:  This study was supported by National Natural Science Foundation of China (81673862, 81660833, 81760814); Ministry of Education of Guizhou Province (GZS word [2016] 08); Guizhou Provincial Science and Technology Department (Qiankehe Talents (2016) 4032); Tumor Inheritance and Scientific and Technological Innovation Talents Base of Guizhou Province (Qianren Leading Development [2018] 3); Graduate Student Workstation of Guizhou Province Set up a project (Guizhou Teaching and Research Co-operation JYSZ word [2014] 018).
Corresponding Authors: Dong-Xin Tang, Graduate School,Guizhou University of Traditional Chinese Medicine, No. 50 Shidong Road, Nanming District, Guiyang 550002, China;Department of Traditional Chinese Medicine,Guizhou Provincial TCM Inheritance and Technology Innovation Talent Base, No. 50 Shidong Road, Nanming District, Guiyang 550002, China.   
E-mail: tangdongxin@sina.com
Cite this article:

Jin-Lin Wu, Zhu Yang, Feng-Xi Long, Li Luo, Xun Liu, Jia Wang, Ting Yu, Dong-Xin Tang. Study on the mechanism of Coix seed in the treatment of colon cancer Based on network pharmacology. 8Food Therapy and Health Care, 2019, 1(4): 102-113.

URL:

https://www.tmrjournals.com/fthc/EN/10.12032/FTHC201910001     OR     https://www.tmrjournals.com/fthc/EN/Y2019/V1/I4/102

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