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8Food Therapy and Health Care  2019, Vol. 1 Issue (4): 130-139    DOI: 10.12032/FTHC201911004
    
The therapeutic mechanism of black soybean in atherosclerosis based on network pharmacology
Yi-Xin Jiang1, Ming-Han Zhao2, Qing-Feng Wang3*
1Biological Engineering Department, Liaoning Vocational College of Economics, Shenyang 110122, China;
2College of Life Science and Engineering, Shenyang University Shenyang 110044, China;
3Basic Medical College, Liaoning University of Traditional Chinese Medicine,  Shenyang 110032, China.



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Abstract  Objective: To investigate the cardiovascular mechanism of black soybean, the biological characteristics of black soybean were studied by bioinformatics, and the mechanism of its treatment for atherosclerosis was further determined. 
Methods: Firstly, the basic data sets of effective components and corresponding targets of black beans were constructed, and then mapped to the AS background network obtained from DisGeNET database and CTD database. Finally, the potential targets of black beans acting on AS were obtained. After constructing the protein-protein interaction (PPI) network, the topological characteristics of these targets were analyzed. KEGG and GO were enriched to obtain the potential mechanism of black soybean acting on AS. 
Results: There were 12 bioactive components reported in black soybean. Among them, beta-sitosterol, stigmasterol and N-(4-hydroxyphenylethyl) ACTINIDINE were the three most active components. There are 19 targets of black soybeans acting on PPI network of AS disease. Among them, ADRB2 and PTGS2 are important targets for black soybeans to alleviate AS. The therapeutic pathways include arachidonic acid metabolism and serotonin synapse. 
Conclusion: Black soybean can play a therapeutic role in AS through multi-target and multi-pathway. The application of network pharmacology can quickly clarify the characteristics of functional foods and identify their potential targets and mechanisms for disease treatment.


Key wordsBlack bean      Cardiovascular disease      Network pharmacology      Mechanism of action     
Received: 20 July 2019      Published: 14 October 2019
Corresponding Authors: Qing-Feng Wang, Basic Medical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.    
E-mail: lntcmwqf@foxmail.com
Cite this article:

Yi-Xin Jiang, Ming-Han Zhao, Qing-Feng Wang. The therapeutic mechanism of black soybean in atherosclerosis based on network pharmacology. 8Food Therapy and Health Care, 2019, 1(4): 130-139.

URL:

https://www.tmrjournals.com/fthc/EN/10.12032/FTHC201911004     OR     https://www.tmrjournals.com/fthc/EN/Y2019/V1/I4/130

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