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Predict the anti-cancer mechanism of astragalus membranaceus based on network pharmacology
Jia Wang, Zhu Yang, Feng-Xi Long, Jin-Lin Wu, Ting Yu, Dong-Xin Tang
8Food Therapy and Health Care    2019, 1 (3): 63-72.   https://doi.org/10.12032/FTHC201908001
Abstract ( 186 PDF (3834KB) ( 60 )  
Objective: To explore the anti-cancer mechanism of active ingredients of Astragalus membranaceus(AM) through network pharmacology. Methods: TCMSP, PubChem, STICTH and GeneCards databases were used to predict and screen the main active ingredients and anti-cancer targets of AM. Active ingredient-target-disease network was constructed by Cytoscape 3.7.0 software, and protein interaction network was constructed by STRING platform. KEGG signaling pathway and GO biological process of targets were analyzed by Bioconductor database. Results: Twenty-four active ingredients were screened from AM, which acted on 106 cancer targets such as PTGS, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1. Through these targets, the anti-cancer effect of AM mainly acts on small cell lung cancer, colorectal cancer, thyroid cancer, breast cancer, non-small cell lung cancer, hepatocellular carcinoma, pancreatic cancer, gastric cancer, endometrial cancer, enriched in chemical carcinogenesis, Platinum drug resistance, Epstein-Barr virus infection, TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, and PI3K - Akt signaling pathway. Conclusion: This study found that the main anti-cancer compounds of AM are kaempferol, quercetin, 7-O-methylisomucronulatol, formononetin, isorhamnetin, Calycosin, 3,9-di-O-methylnissolin. The main targets include PTGS, PTGS1, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1, F2. The mechanisms involved in anticancer could be summarized as following: blocking the chemical carcinogenesis, reversing the platinum drug resistance, anti - Epstein - Barrvirus infection, and inhibiting cell proliferation related signaling pathways, such as TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, PI3K - AKT signaling pathway.
Progress of Bai He Di Huang decoction on intestinal flora of mouse with depression
Dong-Xue Chen, Cun-Xia Ren, Ya-Wen Bai, Bao-Shan Rong, Xin Ding, Chang-Qing Li, Hui-Min Zhao, Zhan-Hong Qian
8Food Therapy and Health Care    2019, 1 (2): 30-34.   https://doi.org/10.12032/FTHC201905001
Abstract ( 437 PDF (1480KB) ( 147 )  
Depression is a recurrent, common, and potentially life-threatening psychiatric disease. Intestinal flora is a large number of microbial communities that are parasitic in the human digestive tract. Current evidence suggests that the occurrence of depression may be related to intestinal flora. Long time ago, Bai He Di Huang decoction was used to treat the depression. Recently, researchers found that Bai He Di Huang decoction could affect the the intestinal flora of patients with depression. This review focuses on the clinical progress of Bai He Di Huang decoction in the treatment of depression, and explores the effect and mechanism of Bai He Di Huang decoction on the intestinal flora of depressive mouse.
Experimental Study on Relieving Physical Fatigue of Mice by Qixue Shuangbu Tinctura
Lin-Wei Chen, Bao-Chang Cai, Nan Chen, Qin Wang, De-Xi Peng, Hua Wang, Cheng-Ye Yuan, Chun-Hua Cao
8Food Therapy and Health Care    2019, 1 (1): 8-15.   https://doi.org/10.12032/FTHC201902003
Abstract ( 289 PDF (816KB) ( 86 )  
Objective: To explore the effect of Qixue Shuangbu Tinctura on alleviating the physical fatigue of mice. Method: Male ICR mice were randomly divided into 6 groups, high dose, middle dose and low dose group, liquor control group, positive control group and negative control (saline) group. According to "Health Food Test and Evaluation Technical Specifications" (2003 edition) on the effect of alleviating physical fatigue experimental study, the weight-bearing swimming test of mice was carried out after gavage for 30 days. Result: Qixue Shuangbu Tinctura can effectively prolong the time of weight-bearing swimming in mice, reduce the production of blood lactic acid in vivo, and timely eliminate serum urea nitrogen, and promote the reserve of hepatic glycogen in mice after weight-bearing swimming exercise. Conclusion: Qixue Shuangbu Tinctura has the function of relieving physical fatigue.
Ginseng and Angiogenesis: Promotion or Inhibition?
Jun-Ju Zou , Xiao-Tao Zhou , Wen-Yi Li , Chao-Xi Zhu , Yue-Rong Ma
8Food Therapy and Health Care    2019, 1 (1): 22-29.   https://doi.org/10.12032/FTHC201902005
Abstract ( 439 PDF (627KB) ( 285 )  
Ginseng has a unique pharmacological activity, which can treat ischemic diseases through angiogenesis, and inhibit 
tumor growth and metastasis by anti-angiogenesis. Angiogenesis is a common target for tumors and ischemic diseases. How 
could the ginseng regulateblood vessels in different diseases? Here, the mechanism of ginseng bidirectional regulation of 
angiogenesis in different pathological environments is reviewed, and the role of bidirectional regulation is elucidated.
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