01 November 2019, Volume 1 Issue 4 Previous Issue    Next Issue
Study on the mechanism of Coix seed in the treatment of colon cancer Based on network pharmacology
Jin-Lin Wu, Zhu Yang, Feng-Xi Long, Li Luo, Xun Liu, Jia Wang, Ting Yu, Dong-Xin Tang
8Food Therapy and Health Care. 2019, 1 (4): 102-113.   https://doi.org/10.12032/FTHC201910001
Abstract ( 214 )     PDF (3838KB) ( 99 )  
Objective: Study on the mechanism of Coix seed in the treatment of colon cancer based on network pharmacology. Methods: The main chemical components of Coix seed were identified by TCMP, and the target sites of drug components were screened. The target of the protein was mapped to the corresponding gene target through the Uniprot database. Genecards database was used to find the target gene of human colon cancer disease, and then the disease gene target was combined with the drug gene target to screen the common target of disease-drug composition, and the STRING platform was used to construct the drug component-disease target protein interaction. (PPI) network model. The Bioconductor database was used to analyze the potential targets, related molecular functions and signaling pathways of cocoon in the treatment of colon cancer by GO and KEGG enrichment. The disease-drug component-target-signal pathway network was established by Cytoscape software. Results: It was found that there are 9 pharmacodynamics and 28 targets related to colon cancer treatment, and GO functional enrichment analysis is based on correction. P<0.05 screened 346 molecular functional related items, including 256 biological processes, 48 molecular functions, and 42 cell components. KEGG functional enrichment analysis screened 24 related pathways according to the adjusted P<0.05. Conclusion: PTGS2, AR, ESR1, PGR, ADH1C, AKR1B1, LTA4H, NCOA1, NCOA2 and other related targets may be potential targets for the treatment of colon cancer.
Potential relevance of diet to breast cancer
Hui-Yang Lin, Xian Wang
8Food Therapy and Health Care. 2019, 1 (4): 114-122.   https://doi.org/10.12032/FTHC201911002
Abstract ( 145 )     PDF (934KB) ( 84 )  
Diet is thought to affect the occurrence and progression of breast cancer while the exact relationship between diet and breast cancer remains largely unclear. This review aims to elucidate the association of specific foods with breast cancer and potential underlying mechanisms. For example, sulforaphane is inversely related to the disease while the impacts of soy and meat on breast cancer are disputable. To some extent, soy is a protective factor while red and processed meat is an adverse one. Due to heterogeneity of breast cancer, menopausal and estrogen receptor statuses can influence the diet-cancer relation. In brief, it may be reasonable to recommend breast cancer patients to eat high soy foods and cruciferous vegetables and low red and processed meat.
The problems of nutritional support for head and neck malignant tumor patients undergoing radiotherapy
Ying-Na Bao
8Food Therapy and Health Care. 2019, 1 (4): 123-129.   https://doi.org/10.12032/FTHC201911003
Abstract ( 125 )     PDF (1142KB) ( 68 )  
Nutritional support is a vital approach to improve symptoms of head and neck cancer, which are caused by radiotherapy. Although nutritional support has rapid progress, it could appear a variety of problems in nutritional treatment for head and neck cancer patients during radiotherapy. It is introduced that how to implement nutritional support for head and neck cancer patients during radiotherapy. It is more important to analyze the problems in nutrition assessment and nutrition support and intervention. It could be designed more convenient nutrition assessment system and try to find out more sufficient and effective nutrition markers. It also needs to enhance the nutrition education for patients and their family. In addition to, it could be more work to do in oral, nasal feeding and gastrostomy nutrition supplementation and parenteral nutrition support and intervention. Thus, it is a long way to make nutritional support be better in head and neck cancer patients during radiotherapy.
The therapeutic mechanism of black soybean in atherosclerosis based on network pharmacology
Yi-Xin Jiang, Ming-Han Zhao, Qing-Feng Wang
8Food Therapy and Health Care. 2019, 1 (4): 130-139.   https://doi.org/10.12032/FTHC201911004
Abstract ( 161 )     PDF (6372KB) ( 79 )  
Objective: To investigate the cardiovascular mechanism of black soybean, the biological characteristics of black soybean were studied by bioinformatics, and the mechanism of its treatment for atherosclerosis was further determined. 
Methods: Firstly, the basic data sets of effective components and corresponding targets of black beans were constructed, and then mapped to the AS background network obtained from DisGeNET database and CTD database. Finally, the potential targets of black beans acting on AS were obtained. After constructing the protein-protein interaction (PPI) network, the topological characteristics of these targets were analyzed. KEGG and GO were enriched to obtain the potential mechanism of black soybean acting on AS. 
Results: There were 12 bioactive components reported in black soybean. Among them, beta-sitosterol, stigmasterol and N-(4-hydroxyphenylethyl) ACTINIDINE were the three most active components. There are 19 targets of black soybeans acting on PPI network of AS disease. Among them, ADRB2 and PTGS2 are important targets for black soybeans to alleviate AS. The therapeutic pathways include arachidonic acid metabolism and serotonin synapse. 
Conclusion: Black soybean can play a therapeutic role in AS through multi-target and multi-pathway. The application of network pharmacology can quickly clarify the characteristics of functional foods and identify their potential targets and mechanisms for disease treatment.
Nutritional support strategies for cancer cachexia
Jin Zhang, Hai-Tao Chen, Qing-Hua Yao
8Food Therapy and Health Care. 2019, 1 (4): 140-146.   https://doi.org/10.12032/FTHC201911005
Abstract ( 149 )     PDF (328KB) ( 88 )  
Tumor cachexia is widely seen in patients with various stages of cancer, manifested by inadequate intake or abnormal hypermetabolism resulting in negative nitrogen and energy balance. Early intervention of nutritional therapy and penetrate it into other anti-cancer treatment processes can significantly benefit cancer patients who receiving palliative treatment. Nutritional therapy for cancer is a process of planning, implementing, evaluating and nutritional intervention to treat cancer and its complications or physical condition, to improve the prognosis of cancer patients, including nutritional diagnosis (screening/evaluation), nutritional intervention, efficacy evaluation (including follow-up) three stages. In practice, we should choose appropriate nutritional risk assessment tools and intervention methods according to the actual situation of patients, avoid over-treatment, reduce complications, and maximize patients'interests as far as possible. Nutritional support therapy for cancer involves ethics, morality and the wishes of patients and their families, and needs further exploration and improvement. The best nutritional support strategy often requires the joint participation of many disciplines, including clinicians, nurses, nutritionists and psychosocial workers. Nutritional support group and multidisciplinary collaboration group on cancer are gradually becoming a trend. With the accumulation of experience in cancer nutrition therapy, the development and application of drugs and nutritional preparations, and the deepening of multi-disciplinary collaboration, more cancer patients will benefit in clinical work.