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01 August 2019, Volume 1 Issue 3 Previous Issue    Next Issue
Orginal Article
Predict the anti-cancer mechanism of astragalus membranaceus based on network pharmacology
Jia Wang, Zhu Yang, Feng-Xi Long, Jin-Lin Wu, Ting Yu, Dong-Xin Tang
8Food Therapy and Health Care. 2019, 1 (3): 63-72.   https://doi.org/10.12032/FTHC201908001
Abstract ( 288 )     PDF (3834KB) ( 114 )  
Objective: To explore the anti-cancer mechanism of active ingredients of Astragalus membranaceus(AM) through network pharmacology. Methods: TCMSP, PubChem, STICTH and GeneCards databases were used to predict and screen the main active ingredients and anti-cancer targets of AM. Active ingredient-target-disease network was constructed by Cytoscape 3.7.0 software, and protein interaction network was constructed by STRING platform. KEGG signaling pathway and GO biological process of targets were analyzed by Bioconductor database. Results: Twenty-four active ingredients were screened from AM, which acted on 106 cancer targets such as PTGS, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1. Through these targets, the anti-cancer effect of AM mainly acts on small cell lung cancer, colorectal cancer, thyroid cancer, breast cancer, non-small cell lung cancer, hepatocellular carcinoma, pancreatic cancer, gastric cancer, endometrial cancer, enriched in chemical carcinogenesis, Platinum drug resistance, Epstein-Barr virus infection, TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, and PI3K - Akt signaling pathway. Conclusion: This study found that the main anti-cancer compounds of AM are kaempferol, quercetin, 7-O-methylisomucronulatol, formononetin, isorhamnetin, Calycosin, 3,9-di-O-methylnissolin. The main targets include PTGS, PTGS1, NCOA2, ADRB2, PRSS1, NOS2, NOS3, GABRA1, F2. The mechanisms involved in anticancer could be summarized as following: blocking the chemical carcinogenesis, reversing the platinum drug resistance, anti - Epstein - Barrvirus infection, and inhibiting cell proliferation related signaling pathways, such as TNF signaling pathway, Toll-like receptor signaling pathway, p53 signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, PI3K - AKT signaling pathway.
Research on hypertension in hohhot of mongolian: analysis of 9675 cases survey data
Hong-Mei Yu, Jian-Qiang Wu
8Food Therapy and Health Care. 2019, 1 (3): 73-77.   https://doi.org/10.12032/FTHC201908002
Abstract ( 191 )     PDF (791KB) ( 64 )  
Objective: Through investigating the daily habits of hypertensive and non-hypertensive Mongolian in Hohhot to explore the effect of daily habits on hypertension and further provide basis for future policy making. Methods: Two community health service centers were identified in each of the four districts of Hohhot City using a stratified cluster random sampling method and a multi-stage stratified sampling method. Results: By January 2019, a total of 9,800 people was investigated, and 9675 people with complete data. The effective rate of the questionnaire was 98.7%. The standardized prevalence of hypertension was 21.8% in Mongolia. The prevalence rate of hypertension in Mongolia was statistically significant among the different genders, ages, presence or absence of obesity, different diet types, whether smoking or drinking, or having tea, and aerobic exercise. (P < 0.05 for all). Multivariate unconditional logistic regression analysis showed that males were risk factors for hypertension; female, non-obese, non-hobby meat, no smoking, hobby tea, no alcohol and aerobic exercise were protective factors. Obesity, hobbies, meat, smoking, drinking are important risk factors for hypertension in Mongolian population in Hohhot. Conclusion: It is preliminarily clarified that the risk factors related to hypertension are mainly related to their own health-related behaviors and genetic factors, suggesting the necessity of healthy physical examination, maintaining blood pressure stability, controlling body mass, and moderate exercise.
Mining potential adverse drug reactions of Houttuynia cordata Thunb from "real world" cases.
Wei-Xiu Fan, Li-Ting Yu, Li-Ping Yang
8Food Therapy and Health Care. 2019, 1 (3): 78-88.   https://doi.org/10.12032/FTHC201908003
Abstract ( 193 )     PDF (912KB) ( 65 )  
Objective: Search the "real world" case reports of Houttuynia cordata Thunb (HCT)-associated adverse drug reactions (ADRs) to systematically mine potential ADRs of HCT and further investigate whether HCT contained preparations could cause aristolochic acid nephropathy or cancer. Methods: PubMed, EMBASE, Science Direct, Scopus, Web of Science, and CNKI, Wanfang, VIP, Sinomed databases were searched from databases setup to 1st January 2019. All case reports using HCT contained preparations were pooled according to inclusion and exclusion criteria. 15 items in case reportes including basic informations of studies/patients, characters/treaments of ADRs were extracted and analyzed. Results: A total of 346 case reports (441 patients) on the use of different preparations of HCT were finally pooled, among which 89 articles (117 patients) just presented efficacy reports without ADRs and 257 articles (324 patients) on the HCT-related ADRs were further analyzed. ① HCT in vivo injections were recorded in 265 articles (338 patients) including 249 ADR reports (315 patients) and 16 efficacy reports (23 patients). As for the ADRs reports, allergic reaction was the major ADRs with different symptoms and onset time. The worst consequences were anaphylactic shock (116/315) and death (11/315), followed by dyspnea (228/315), change of complexion (181/315), heart of abnormality (180/315), chest tightness (147/315), cyanosis (142/315) and so on. The fast onset time was 10 seconds and the most ADRs happened in 30 minutes. Dexamethasone was the mainly medication to treat ADRs. ② Oral HCT agents were descripted in 75 articles (94 patients) including 8 ADR reports (9 patients) and 67 efficacy reports (85 patients). Among the 8 ADR reports, 8 patients used Chinese patent medications contained HCT and only 1 patient used HCT decoction. The ADRs almost manifested as skin symptoms, including rubella, macula, rash and urticaria.③HCT external preparations reported in 6 articles (9 patients), none of those presented any ADRs symptoms. ④ No case was found to develop cancer, aristolochic acid nephropathy, interstitial nephritis, renal interstitial fibrosis or renal failure due to HCT preparations. Conclusion: The HCT-related ADRs were mostly caused by its processed preparations, including HCT injections and patent preparation. The oral HCT agents as docoction rearly caused ADRs. There were no reports of aristolochic acid nephropathy or cancer cases caused by HCT.
The progress of nutritional support for chronic obstructive pulmonary disease
Jiao-Jiao Wang, Mei Tang, Yun-Xian Ma, Peng-Cheng Zhou
8Food Therapy and Health Care. 2019, 1 (3): 89-96.   https://doi.org/10.12032/FTHC201908004
Abstract ( 254 )     PDF (1026KB) ( 151 )  
The patients with chronic obstructive pulmonary disease (COPD) often occur weight loss and reduced muscle mass, which leads to decreased exercise capacity and vital capacity. The nutritional status is closely related to the prognosis of patients with COPD and nutritional support has played an important role in the treatment of COPD. In order to provide proper nutritional support, this article reviews the progress of nutritional support in COPD from the causes of malnutrition, energy demand assessment, assessment of nutritional risk and nutritional support methods. Moreover, this review specially reviewed the application of traditional Chinese medicine diet.
Research Progress in Arecoline-induced Oral Submucous Fibrosis
Jing-Wen Jiang, Xue-Wu Chen, Qing-Hua Yao, Hui Zhan
8Food Therapy and Health Care. 2019, 1 (3): 97-101.   https://doi.org/10.12032/FTHC201908005
Abstract ( 249 )     PDF (1756KB) ( 69 )  
Areca nut is a popular fruit, but is among the most common addictions following tobacco, alcohol and caffeine globally. Areca nut chewing is the major risk factor for OSF, which is a chronic, occult, and premalignant fibrotic disease. OSF is characterized by submucosal collagen accumulation and microvascular diseases, the primary microscopic manifestations of which include damaged vascular endothelial cells, increased vascular permeability, and decreased number of microvessels. As the basic structure of microvessels, endothelial cells paly an important role in the pathogenesis and progression of OSF. Arecoline is the main component of areca nut. This review summarized the machenism of arecoline-inducing OSF by acting on endothelial cells, mainly including that arecoline can promote endothelial cells inducing tissue fibrosis by acting on the vascular endothelial cells and is accomplished via multiple aspects such as inhibiting the proliferation and facilitating the apoptosis of endothelial cells, affecting their secretion of cytokines, or promoting the transformation process of EMT.