14 June 2020, Volume 2 Issue 2 Previous Issue   
Special Issue
Diagnosis and treatment of hyponatremia in patients with liver cirrhosis
Zhao-Chun Chi
Gastroenterology & Hepatology Research. 2020, 2 (2): 38-47.   https://doi.org/10.12032/ghr2020-06-012
Abstract ( 22 )     PDF (302KB) ( 2 )  
Hepatic cirrhosis complicated by hypocalcemia is a common electrolyte disorder and a sign of severe disease. This article summarized the pathophysiological research progress of cirrhosis: systemic vasodilation, water balance and effect of antidiuretic hormone, non-osmotic stimulation of the renin-angiotensin-aldosterone system, sympathetic nervous system. At the same time, we discussed the mechanism and clinical symptoms of hyponatremia complicated with hepatorenal syndrome and hepatic encephalopathy. Finally, we summarized the treatment progress of cirrhosis complicated with hypocalcemia from the aspects of water restriction, hypertonic Saline, correction of hypokalemia, albumin infusion, drug therapies. In this way, we hope to provide a reference for the diagnosis and treatment of liver cirrhosis complicated by hypocalcemia.
Experimental Research
Study on the potential mechanism of Pien Tze Huang Capsules against coronavirus disease 2019 based on network pharmacology
Hui Zhu, Ming-Zhong Xiao
Gastroenterology & Hepatology Research. 2020, 2 (2): 48-52.   https://doi.org/10.12032/ghr2020-06-013
Abstract ( 15 )     PDF (718KB) ( 1 )  

Objective: To discuss the possible underlying mechanism of the effect of Pien Tze Huang capsules (PTHCs) against coronavirus disease 2019 (COVID-19) using network pharmacology research methods. 

Methods: Through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), in this study, we searched for the active ingredients of PTHC, including Sanqi (Panax notoginseng), Shedan (snake’s bile), Niu-huang (Calculus Bovis or ox bezoars), and musk, as well as information on the corresponding targets. The GeneCards database was used to obtain relevant information on COVID-19 targets. The search tool for the retrieval of interacting genes/proteins (STRING) database was used to draw the protein–protein interaction network, and the R Programming Language was used to carry out gene ontology functional enrichment analysis and the Kyoto encyclopedia of genes and genomes pathway enrichment analysis. 

Results: In PTHC, there were 12 compounds that met the conditions and 232 gene targets. Along with the 394 gene targets associated with COVID-19, there were 41 potential targets related to the PTHC ingredients against COVID-19. The key targets included RELA, interleukin (IL)-6, IL-1β, mitogen-activated protein kinase (MAPK) 1, and C-X-C motif chemokine ligand 8, whereas the potential signaling pathways were nuclear factor-κB, cytokine-cytokine receptor interaction, the hypoxia-inducible factor 1 signaling pathway, the chemokine signaling pathway, and the MAPK signaling pathway.

Conclusion: PTHCs have the potential to combat COVID-19 by modulating key targets and potential signaling pathways that regulate immune function, providing theoretical support for more TCM treatments against COVID-19.

Real world studies and their impact on the prevention and treatment of liver disease with traditional Chinese medicine
Jing-Hao Zhang, Chao Zheng, Xiao-Jun Zhu, Xin Zhang, Zhen-Hua Zhou, Man Li, Yue-Qiu Gao, Xue-Hua Sun
Gastroenterology & Hepatology Research. 2020, 2 (2): 53-57.   https://doi.org/10.12032/ghr2020-06-014
Abstract ( 11 )     PDF (174KB) ( 1 )  
With the development of clinical practice and transformation of the medical model, traditional Chinese medicine (TCM) research has attracted considerable attention. Randomized controlled trials of traditional Chinese medicine are unable to meet the need of clinical research, while the real-world studies are more in accordance with the characteristics of traditional Chinese medicine research. In this paper, the concept and characteristics of real-world studies, characteristics of traditional Chinese medicine research, and the advantages of and the application of real-world studies in the clinical research of traditional Chinese medicine, were reviewed to provide new ideas for TCM research.
Liver regeneration microenvironment and heterogeneity of hepatocellular carcinoma
Xiang Gao, Han-Min Li
Gastroenterology & Hepatology Research. 2020, 2 (2): 58-62.   https://doi.org/10.12032/ghr2020-06-015
Abstract ( 11 )     PDF (181KB) ( 5 )  
The heterogeneity of hepatocellular carcinoma (HCC) has become a scientific problem, which must be solved urgently. Formerly, HCC prevention mainly focused on the HCC cells themselves but in recent years, HCC prevention based on the HCC microenvironment is the new strategy. Focusing on the liver regeneration microenvironment of HCC rather than just HCC cells may be a breakthrough in the study of HCC tumor heterogeneity and the prevention and treatment of HCC.
Idea and Method
Dietary regulation of people with wet constitution during COVID-19 epidemic
Zhu-Mou Zhang, Wen-Bo Liu, Yan-Bin Lin
Gastroenterology & Hepatology Research. 2020, 2 (2): 63-67.   https://doi.org/10.12032/ghr2020-06-016
Abstract ( 11 )     PDF (208KB) ( 1 )  
Based on the concept of traditional Chinese medicine diet health, in the context of the COVID-19 epidemic, help people with wet constitution to identify their own constitutions, and preliminarily put forward guidance and Suggestions for people with wet constitution to improve their biased constitution by adjusting diet. Under the guidance of Wang Qi, the master of Chinese medicine, and Sun Guangrong, the master of Chinese medicine, "Health is achieved by going with nature", dietary Suggestions for different people with wet constitutions are put forward from the perspective of TCM health maintenance. Specifically including different physical conditions, different seasons and different regions, more comprehensive and systematic guidance for people with wet physical conditions to adjust their diet structure, to help them maintain a healthy state in this epidemic.