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TMR Integrative Medicine  2017, Vol. 1 Issue (1): 9-19     DOI: 10.12032/TMRIM201701112
Article     
TCM aerosol inhalation treatment in acute exacerbations of chronic bronchitis: a meta-analysis
Wei Luo1, Ji-Ni Yang1, Yi-Hua Fan2, Ji-Fang Song3, Fang-Jing Liu3, Teng Zhang2, Qiang Zhang3* #br# 1Chongqing Jiangbei District Hospital of traditional Chinese Medicine, Chongqing 400020, China. 2Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. 3Third Military Medical University, People’ Liberation Army Of China Daping Hospital, Chongqing, 400042 China.
1Chongqing Jiangbei District Hospital of traditional Chinese Medicine, Chongqing 400020, China. 2Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. 3Third Military Medical University, People’ Liberation Army Of China Daping Hospital, Chongqing, 400042 China.
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Objectives: To determine whether traditional Chinese medicine (TCM) aerosol inhalation treatment is effective in the treatment of acute exacerbation of chronic bronchitis. Methods: Search double-blind randomised clinical trials (RCT) about the use of TCM aerosol inhalation in patient with acute exacerbation of chronic bronchitis via data base including Chinese biomedicine literature database, Wanfang Data, CNKI, Pubmed, EMBASE and Cochrane Library from the beginning to October 2016. Quality evaluation, data extraction and data analysis of these RCT was carried out with reference to the Cochrane systematic review. Results: 16 studies with 738 patients in TCM aerosol inhalation group and 675 in control group were included. The results of meta-analysis showed, (1) TCM aerosol inhalation group could improve the total cure rate. (2) TCM aerosol inhalation could increase the expression of IL-2 while decrease the expression of IL-8 and MDA in sputum and blood. (3) TCM aerosol inhalation could improve the symptoms of cough, cough with sputum, cough with dyspnea and lung wet rales. It also improve the symptoms of cough, expectorate and lung wet rales. (4) Shorten the time of cough and lung rale. (5) The adverse reactions were light only with 1 occurrence of nausea and vomiting. Conclusions: The use of TCM aerosol inhalation in the treatment of acute exacerbation of chronic bronchitis was effective. However, the inclusion researches quality were not very high, which only provided limited evidence for clinical application. Higher-quality randomized controlled trials were needed for further study.



Published: 30 January 2018
Corresponding Authors: Qiang Zhang, Third Military Medical University, People’Liberation Army Of China Daping Hospital, Oncology. Address: 10 Changjiang River branch, Daping, Yuzhong District, Chongqing. E-mail address: zq1010151602@163.com   
About author: Wei Luo1, Ji-Ni Yang1, Yi-Hua Fan2, Ji-Fang Song3, Fang-Jing Liu3, Teng Zhang2, Qiang Zhang3* 1Chongqing Jiangbei District Hospital of traditional Chinese Medicine, Chongqing 400020, China. 2Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. 3Third Military Medical University, People’ Liberation Army Of China Daping Hospital, Chongqing, 400042 China.
Cite this article:

Wei Luo, Ji-Ni Yang, Yi-Hua Fan, Ji-Fang Song, Fang-Jing Liu, Teng Zhang, Qiang Zhang. TCM aerosol inhalation treatment in acute exacerbations of chronic bronchitis: a meta-analysis. TMR Integrative Medicine, 2017, 1 (1): 9-19.  

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https://www.tmrjournals.com/im/EN/10.12032/TMRIM201701112     OR     https://www.tmrjournals.com/im/EN/Y2017/V1/I1/9

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