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2TMR Integrative Medicine  2018, Vol. 2 Issue (4): 168-174     DOI: 10.12032/TMRIM201802032
Review of the mechanisms of TCM in relieving the chemotherapy-induced diarrhea
Xin-Yun Li1(),Zhen-Fei Xiong2
1Hangzhou Xiaoshan First People Hospital, Zhejiang, China.
2Hangzhou Xiaoshan TCM Hospital, Zhejiang, China.
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The article mainly discusses the mechanism of chemotherapy-related diarrhea and the prospect of traditional Chinese medicine in relieving the mechanism of chemotherapy-related diarrhea.


With the clinical application of various chemotherapeutic drugs, the side effects are also followed. Diarrhea is one of the most serious side effects of chemotherapy. A large number of clinical and experimental studies have proven that traditional Chinese medicine has great prospects in relieving chemotherapy-related diarrhea. The article mainly discusses the mechanism of chemotherapy-related diarrhea and the prospect of traditional Chinese medicine in relieving the mechanism of chemotherapy-related diarrhea.

Key wordsChemotherapy-induced diarrhea      Traditional Chinese medicine      Chemotherapeutic drugs     
Published: 14 December 2018
Cite this article:

Xin-Yun Li, Zhen-Fei Xiong. Review of the mechanisms of TCM in relieving the chemotherapy-induced diarrhea. 2TMR Integrative Medicine, 2018, 2 (4): 168-174.  

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Figure 1 Mechanism of CID generation
Figure 2 Mechanism of TCM treatment of chemotherapy-related diarrhea
1.   Tarricone Rosanna1, Abu Koush, et al. A systematic literature review of the economic implications of chemotherapy induced diarrhea and its impact on quality of life. Critical Reviews Oncol 2016, 6: 37-48.
doi: 10.1016/j.critrevonc.2015.12.012 pmid: 26775731
2.   Zhang SL, Sun FL, Gao W, et al. Treatment of chemotherapy-related diarrhea. Chin J Integrated Tradit Western Med 2008, 10: 945-946.
3.   Saltz LB.Managing chemotherapy-induced diarrhea. Clin Adv Hematol Oncol 2006, 4: 203-204.
4.   Wisinski K, Benson A.Chemotherapy-induced mucositis: focusing on diarrhea. J Support Oncol 2007, 5: 270-271.
pmid: 17624051
5.   Fang QF.Mechanism and treatment strategy of chemotherapy-related diarrhea. Chin J Clinical Pharmacology Therapeutics 2009, 14: 351-355.
6.   Takasuna K, Hagiwara T, Hirohashi M, et al. Inhibition of intestinal microflora eta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats. Cancer Chemother Pharmacol 1998, 42: 280-286.
7.   Rivory LP, Bowles MR, Robert J, et al. Conversion of irinotecan (CPT-11) to its active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38), by human liver carboxylesterase. Biochem Pharmacol 1996, 52: 1103-1111.
doi: 10.1016/0006-2952(96)00457-1 pmid: 8831730
8.   Biason P, Masier S, Toffoli G.UGT1A1 and other UGT1A polymorphisms as determinants of irinotecan toxicity. J Chemother 2008, 20: 158-165.
doi: 10.1179/joc.2008.20.2.158 pmid: 18467239
9.   Lou T, Guo Y, Lu N, et al. Discussion on the treatment mode of chemotherapy-related diarrhea with integrated traditional Chinese and Western medicine. Chin J Emergency Medicine 2009, 18: 1457-1458.
10.   Tang QL, Yang F, Wang XL.A Survey of TCM Pathogenesis, Pathogenesis and Treatment of Colorectal Cancer. Changchun University Tradit Chin Med 2016, 1: 216-219.
11.   Deng JC.Research progress in treatment of diarrhea-predominant irritable bowel syndrome with traditional Chinese medicine. North Med 2016, 2: 130-131.
12.   Zhou CL, Wu YY, Wu YL, et al. Effects of moxibustion and its products on visceral pain and colonic water metabolism in rats with diarrhea-type irritable bowel syndrome. World Sci Tech Modern Tradit Chin Med 2014, 6: 1261-1267.
13.   Yu F, Chen XH, Chen ZS, et al. Correlation between UGT1A1 gene polymorphism and intestinal flora disorder and irinotecan chemotherapy-associated diarrhea. Chin J Micro 2016, 28: 741-744.
14.   Wang J, Liang SY, Yang Y, et al. Intervention of Yunpizhixie decoction on intestinal micro-ecology in children with persistent diarrhea of spleen deficiency type. Chinese J Maternal and Child Health 2016, 31: 1322-1324.
15.   Wu Q, Ye H, Zhu YZ, et al.Study on prevention of delayed diarrhea caused by irinotecan by Huangqin decoction. China J Exper Tradit Med Formulae 2013, 12: 163-168.
16.   Zhang XF, Qiao CX, Cheng XF, et al. Effect of Xianglian pill on nude mice model of chemotherapy-related diarrhea. Chin Patent Med 2016, 38: 1598-1601.
17.   Xu HZ, Xie JQ, Shi B, et al. Expression of inflammatory cytokines in colonic mucosa of rats with diarrhea-predominant irritable bowel syndrome and the effect of Wenzhongjianpi recipe on it. Shanghai J Tradit Chin Med 2007, 41: 69-72.
18.   Tao Y.Shuganjianpi method for the treatment of diarrhea-type irritable bowel syndrome. Chengdu university of Traditional Chinese Medicine, 2006.
19.   Du HY, Wang YH, Zhang XF, et al. Effects of Jianpihuashi granule on visceral sensitivity and CRF and its receptor in brain of D-IBS model rats. Lab Animal Sci 2013, 30: 15-19.
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