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2TMR Integrative Medicine  2019, 3: e19004.       DOI: 10.12032/TMRIM201903004
Pathogenesis and treatment status of adenomyosis complicated with infertility
Hua Wang1, Chun-Hua Cao1, Yan Chen1, Saili Wang1, Qin Wang1,*()
1Taizhou Hospital of Traditional Chinese Medicine, Affiliated to Nanjing University of Traditional Chinese Medicine, Taizhou, China.
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The treatment options for patients of AD with infertility should follow the principle of individual treatment and choose the most appropriate method based on the specific conditions of the hospital.


Adenomyosis (AD) refers to the endometrium (including glands and stroma) into myometrium growth of pathological changes, with the delay of women's childbearing age, the patients with AD-associated infertility increased significantly. Although scholars disagreed about the effect of AD on infertility, more and more evidence showed that AD was closely related to the structural and functional defects of the eutopic endometrium and myometrial junctional zone (MJZ), which may lead to embryo implantation failure and infertility. With the rapid development of imaging technology, the accuracy of diagnose AD has been enhanced, more and more infertility patients were diagnosed with AD. At the same time, a series of pathogenic hypothesis have been proposed to explain the relationship between AD. In addition, AD may influence the patient’s reproductive function by affecting sperm transport, embryo implantation, altering uterine peristalsis, influencing the structure and function of endometrium, and changing the intrauterine environment. At present, the treatment of AD-associated infertility is similar to the treatment of AD. The commonly used treatment methods include drug therapy, conservative operative treatment, drug combination surgery, and Chinese medicine treatment and so on. The clinical and experimental studies of AD complicated with infertility and its possible pathogenesis and treatment in recent years are reviewed in this article.

Key wordsAdenomyosis      Infertility      Pathogenesis      Treatment      Endometrium     
Published: 21 February 2019
Fund:  Funding:This study was supported in part by grants from the “333 project” project of Jiangsu province (BRA2016183)
Corresponding Authors: Wang Qin   
Cite this article:

Hua Wang, Chun-Hua Cao, Yan Chen, Saili Wang, Qin Wang. Pathogenesis and treatment status of adenomyosis complicated with infertility. 2TMR Integrative Medicine, 2019, 3: e19004.  

URL:     OR 3/88888

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