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2TMR Integrative Medicine  2019, 3: e19006.       DOI: 10.12032/TMRIM201903006
Exploring the relationship between Ca2+ and the "Qi" of TCM from the perspective of modern medicine
Ai-Wen Zhuang1, Xue-Min Fan2, Li-Na Ji2, Xian Deng2, Hong Ling2, Rong-Qun Li2,*()
1Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, 310007, China
2Zhejiang Chinese Medical University, Hangzhou 310053, China.
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There are many similarities and close relationships between Qi and Ca2+ in terms of source and function.


Ancient Chinese philosophy believed that Qi is the origin of all things in the universe, and it is the extremely fine material that exists in the universe and is ubiquitous. The Qi of traditional Chinese medicine (TCM) is put forward on the basis of philosophical meaning. It points out that Qi is a very invasive and extremely subtle substance with strong vitality in the human body. It is the basic substance that constitutes the human body and maintains its life activity. Qi is the basic concept of TCM, but the understanding of the essence of Qi is not clear. At present, there are more and more studies on the essence of Qi of TCM, but it has not achieved a major breakthrough, which has become one of the problems that limit the development of traditional Chinese medicine. Through the research on the literature, it is found that Qi and Ca2+ are inextricably similar. This paper attempts to explore the relationship between Qi and Ca2+ from the aspects of source of production and physiological function to explain their similar points. We hope to provide new ideas for the study of the essence of Qi and achieve the purpose of promoting the development of TCM.

Key wordsQi      Ca2+      TCM     
Published: 22 March 2019
Corresponding Authors: Li Rong-Qun   
Cite this article:

Ai-Wen Zhuang, Xue-Min Fan, Li-Na Ji, Xian Deng, Hong Ling, Rong-Qun Li. Exploring the relationship between Ca2+ and the "Qi" of TCM from the perspective of modern medicine. 2TMR Integrative Medicine, 2019, 3: e19006.  

URL:     OR 3/88888

1.   Guangren S.Basic theory of Chinese medicine M.Beijing. Traditional Chinese Medicine Press, China, 2002.
2.   Jiang WZ, Ni XH.Thinking about the concept of "Qi" in traditional Chinese medicine. Jiangxi Tradit Chin Med 2013, 44: 3-4.
3.   Lin HG, Xu DP.Discussion and thinking on the relationship between kidney essence and calcium theory. Chin J Practical Chin Western Med 2006, 19: 116-117.
4.   Wang Li, Duan XL, Yang ZL.The function of calcium ions in mammalian cells and its relationship with diseases. Advances Anatomical Sci 2004: 89-93.
5.   Gai PP, Sun ZF.On the essence of "Qi" in TCM theory. China Continuing Med Education 2016, 8: 175-176.
6.   Tian H, Huang SY. Wang ZS. Research progress on the biochemical effects of calcium in human body. Guangdong Trace Element Sci2004, 11: l-7.
7.   Yang Y, Lin C, Shen WT, et al. Observation of intracellular and extracellular calcium changes in children with respiratory failure. Shanghai Med J 1989, 4: 227.
8.   Xu TL, Su HC.Regulation of calmodulin and cell proliferation. J Cell Biology 1993, 15: 54-58.
9.   Gao YF.Inhibition of mesenchymal cell proliferation by calcium antagonists. J Nephrology Dialysis Transplantation 1997, 6: 134-138.
10.   Chen YS, Zhang YH, Zhang YH, et al. Effects of parathyroid hormone on calcium ion in rat bone marrow mesenchymal stem cells. Chin J Tissue Engineering 2017, 21: 4600-4604.
11.   Hong K, Liu X.Cardiac calcium channel disease. Chin J Cardiac Pacing Electrophysiology 2011, 25: 189-191.
12.   Zhou L.The physiological role of calcium ions and the clinical application of calcium preparations. J Zhoukou Teachers College 1996, 12: 55-57.
13.   Cheng SF.In vivo metabolism of calcium ions and its pharmacological effects. Med Herald 2000, 19: 63.
14.   Yao WJ, Xie LD, Ka WB.The effect of calcium ion on the rheological properties of red blood cells and its microscopic mechanism analysis. Beijing Biomedical Engineering 1999, 18: 249-253.
15.   Guo HB, Wang S, Zou F.Temperature effect of calcium-activated potassium channels in hypothalamic neurons. Chin Public Health 2002, 18: 8l-82.
16.   Jiang Y, Xia WB.Vitamin D and rickets / osteomalacia. Chin J Osteoporosis Bone Mineral Diseases 2018, 11: 51-55.
17.   An G, Zhao CY, Zhong GZ, et al. Effect of American ginseng polysaccharide on calcium-dependent potassium channels in mouse T lymphocytes. J Bethune Med Univer 1997, 23: 481-482.
18.   Zhong YS, Chen WQ, Cai SR, et al. Clinical study on serum calcium concentration and its changing trend in early stage of spontaneous cerebral hemorrhage. J Mathematical Med 2017, 30: 1760-1762.
19.   Cao WF, Chen ZY, Wang QT.The role of calcium ion in the mechanism of contraction of the urinary muscle. Foreign Med.Urology System 2004, 24: 309-311.
20.   Wu YF, Yan FM, Zhan F, et al. Study on the distribution of calcium ions induced by different moxibustion rabbits in Zusanli. J Liaoning Univer Tradit Chin Med 2014, 16: 78-80.
21.   Wang CM, Han LT, Li XY, et al. Relationship between blood and brain neurotransmitters and epileptic seizures. Basic Med Clinical Med 2002, 22: 285-286.
22.   Wu TT, Li RL, Zeng D, et al. Study on the regulation of calcium ion by Atractylodes macrocephala L. to promote cell migration and E-cadherin expression. New Drugs Clinical Pharmacology 2017, 28: 145-150.
23.   Wang Y, Li JL, Liang SH, et al. Determination of trace elements in four common Chinese herbal medicines. Anhui Agricultural Sci 2017, 45: 132-134.
24.   Sun PT, Yao HZ. Zhu HY.Determination and discussion of trace elements in Sijunzi Decoction, Siwu Decoction, Bazhen Decoction and Shiquan Dabu Decoction. Trace Elements Health Res 1988, 12. 39.
25.   Qian BQ, Zhu GL, Xia WC, et al. Effect of Feixin II on the trace elements in hair of 31 patients with pulmonary heart disease and pulmonary Qi deficiency. J Zhejiang College Tradit Chin Med 1990, 14: 27-30.
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