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Efficacy of acupuncture on treating obesity and adipose-incurred illnesses
Fung-Kei Cheng
2TMR Integrative Medicine    2018, 2 (4): 140-167.   https://doi.org/10.12032/TMRIM201802031
Abstract ( 309 HTML PDF (1399KB) ( 127 )  

Highlights:

This review reveals practical implications and future research directions, benefiting the development of acupuncture in the modern medical arena for both patients and practitioners.

Abstract

Being overweight and obese impacts health due to adiposity itself and illnesses it incurs, which produces individual and societal financial burdens. This urges effective interventions, including adjunct therapies. Acupuncture, a traditional Chinese medical practice, indicates positive signs for tackling these problems. Investigating 101 empirical human-based projects, this narrative review analyses their outcomes and then provides an overview of the effects of acupuncture in body weight reduction and obesity-induced diseases, either performed alone or with other approaches. It involves 15941 participants from 9-80 years old in mainland China, Taiwan, Turkey, Brazil, Egypt, Iran, Greece, Korea, Sudan, Thailand, and the USA. It also reveals practical implications and future research directions, benefiting the development of acupuncture in the modern medical arena for both patients and practitioners.

Non-pharmacological therapy of TCM for the treatment of essential hypertension
Meng-Lei Li, Shan-Fu Chen, Ying-Qiang Zhao
2TMR Integrative Medicine    2019, 3: e19010.   https://doi.org/10.12032/TMRIM201903010
Abstract ( 213 HTML PDF (530KB) ( 170 )  

Highlights:

It is necessary to strengthen the research on the mechanism of non-drug therapy of TCM, and combine clinical observation and experimental research to promote the promotion and application of non-pharmacological therapy of TCM in clinical practice.

Abstract

Non-pharmacological treatment is an important means to control hypertension, with many advantages such as low cost, less medication, stable blood pressure, less complications, and improved prognosis. This article reviews the research progress of non-drug treatment of hypertension in Chinese medicine in the past five years, and evaluates traditional Chinese medicine such as TCM Qigong, Wuhuo opera, Ba Duanjin and Taijiquan, and Chinese medicine acupuncture, moxibustion, massage, application, acupoint embedding and other traditional Chinese medicine. The effect of external treatment in hypertension control provides guidance for non-drug therapy to control hypertension.

Efficacy of blood-letting puncture and cupping in the treatment of periarthritis of shoulder: a systematic review
Li-Hui Zhang, Li-Xin Wang, Qian Cui, Guo-Wei Zhang
2TMR Integrative Medicine    2018, 2 (4): 175-191.   https://doi.org/10.12032/TMRIM201802033
Abstract ( 204 HTML PDF (1123KB) ( 90 )  

Highlights:

The application of blood-letting puncture and cupping in the treatment of scapulohumeral periarthritis can provide strong evidence for future clinical treatment.

Abstract

Objective: To systematically evaluate the clinical efficacy and safety of blood-letting puncture and cupping in the treatment of periarthritis of shoulder. Methods: We electronically searched databases including CNKI, VIP, PubMed, WanFang Data, EMbase Cochrane Library and to collect randomized controlled trials (RCTs) and quasi-randomized controlled trials about blood-letting puncture and cupping for periarthritis of shoulder and evaluated the quality of the documents collected by the Cochrane collaboration, provided by Review Manager 5 software for statistical analysis. Then the quality of the included trials was assessed using the Jadad scale and GRADE system was used to score the quality and grade recommendation. Results: Thirty RCTs involving 2556 patients were included. The results of meta-analysis showed that: Total effective rate OR = 6.21 [OR = 6.21, 95%CI (4.69, 8.21), P < 0.001]. The results of GRADE system evaluation showed that the level of evidence was B, and the recommendation level was weak recommendation. Conclusion: Blood-letting puncture and cupping shows better effects than other treatments and preferably security in the treatment of periarthritis of shoulder. We do not find any serious adverse reaction reports. Due to limited quality of the included studies, more high quality studies are needed to verify the above conclusion.

Review of the mechanisms of TCM in relieving the chemotherapy-induced diarrhea
Xin-Yun Li, Zhen-Fei Xiong
2TMR Integrative Medicine    2018, 2 (4): 168-174.   https://doi.org/10.12032/TMRIM201802032
Abstract ( 180 HTML PDF (628KB) ( 66 )  

Highlights:

The article mainly discusses the mechanism of chemotherapy-related diarrhea and the prospect of traditional Chinese medicine in relieving the mechanism of chemotherapy-related diarrhea.

Abstract

With the clinical application of various chemotherapeutic drugs, the side effects are also followed. Diarrhea is one of the most serious side effects of chemotherapy. A large number of clinical and experimental studies have proven that traditional Chinese medicine has great prospects in relieving chemotherapy-related diarrhea. The article mainly discusses the mechanism of chemotherapy-related diarrhea and the prospect of traditional Chinese medicine in relieving the mechanism of chemotherapy-related diarrhea.

A method for isolating rat cardiomyocytes by acute enzymatic hydrolysis
Bo Liang, Hui-Ling Liao
2TMR Integrative Medicine    2019, 3: e19001.   https://doi.org/10.12032/TMRIM201903001
Abstract ( 161 HTML PDF (1152KB) ( 89 )  

Highlights:

This research was introduced a method of isolate rat cardiomyocytes though acute enzymatic hydrolysis, provides a new direction for clinical research.

Abstract

Objective: This research showed a method of isolate rat cardiomyocytes though acute enzymatic hydrolysis. Method: Our method was divided into five steps: preparation, heart extraction, perfusion, mechanical dissociation and purification and recalcification. Firstly, make a preparation, including solutions, equipment and so on. Secondly, after anesthesia satisfactorily, open the chest of rat and take the heart out. Thirdly, transect the aorta and hang the aorta onto the Langendroff perfusion system such that the tip is just distal to the aortic valve. Forth, perfuse the heart with digestion solution for 17-20 min after Ca2+ free tyrode solution for 5 min. Finally, remove the heart from the system quickly and dissociate mechanically in the KB solution and recalcification after filter. Result: Though the microscope, good-state cardiomyocytes (clear stripes, strong sense of three-dimensional, stick well) can be observed. Conclusion: Those cells can be used to undergo medical electrophysiological experiment, including the study of iron channel.

Exploring the relationship between Ca2+ and the "Qi" of TCM from the perspective of modern medicine
Ai-Wen Zhuang, Xue-Min Fan, Li-Na Ji, Xian Deng, Hong Ling, Rong-Qun Li
2TMR Integrative Medicine    2019, 3: e19006.   https://doi.org/10.12032/TMRIM201903006
Abstract ( 154 HTML PDF (525KB) ( 82 )  

Highlights:

There are many similarities and close relationships between Qi and Ca2+ in terms of source and function.

Abstract

Ancient Chinese philosophy believed that Qi is the origin of all things in the universe, and it is the extremely fine material that exists in the universe and is ubiquitous. The Qi of traditional Chinese medicine (TCM) is put forward on the basis of philosophical meaning. It points out that Qi is a very invasive and extremely subtle substance with strong vitality in the human body. It is the basic substance that constitutes the human body and maintains its life activity. Qi is the basic concept of TCM, but the understanding of the essence of Qi is not clear. At present, there are more and more studies on the essence of Qi of TCM, but it has not achieved a major breakthrough, which has become one of the problems that limit the development of traditional Chinese medicine. Through the research on the literature, it is found that Qi and Ca2+ are inextricably similar. This paper attempts to explore the relationship between Qi and Ca2+ from the aspects of source of production and physiological function to explain their similar points. We hope to provide new ideas for the study of the essence of Qi and achieve the purpose of promoting the development of TCM.

Based on the process management of traditional Chinese medicine comprehensive intervention method on outcomes in patients with mild / moderate chronic obstructive pulmonary disease: study protocol for a practical randomized controlled trial
Ming Ren, Li-Ping Guo, Xiao Sun, Yang Qiao, Lei Chen, Lei Zhang, Yan Shao, Xiang-Li Han, Huai-Ying Ding, Jian-Mei Zhao
2TMR Integrative Medicine    2018, 2 (4): 197-201.   https://doi.org/10.12032/TMRIM201802035
Abstract ( 148 HTML PDF (593KB) ( 68 )  

Highlights:

The practical randomized controlled trial reveal that the COPD patients will be benefit from therapy with Traditional Chinese medicine treatment.

Abstract

Background: The prevalence, morbidity and mortality of chronic obstructive pulmonary disease (COPD) is very high, so it has become a public health problem. The early stage of COPD has been paid much attention before it develops severely. As well, traditional Chinese medicine has some advantages in relieving symptoms and reducing the incidence of COPD exacerbations. Methods: A practical randomized controlled trial will be designed to test the clinical effects of traditional Chinese medicine treatment according to syndrome differentiation. A total of 80 patients with mild / moderate COPD will participate in this study, 40 in the treatment group and 40 in the control group. On the basis of the lifestyle intervention, traditional Chinese medicine formula granules for treatment group and the placebo simulation of traditional Chinese medicine granules for control group. The exacerbation and the improvement of pulmonary function will be used as the primary outcome measures. The improvement of clinical symptoms and signs, the quality of life and Dyspnea will be used as the secondary outcomes measures. Conclusion: We assume that the COPD patients will be benefit from therapy with Traditional Chinese medicine treatment.

Effects of hypoxia on sodium current in rat cardiomyocytes
Bo Liang, Hui-Ling Liao
2TMR Integrative Medicine    2018, 2 (4): 192-196.   https://doi.org/10.12032/TMRIM201802034
Abstract ( 140 HTML PDF (668KB) ( 91 )  

Highlights:

The results of this experiment shows that the continuous sodium current increases under anoxic environment.

Abstract

The aim of this study was to investigate the effect of hypoxia on the sodium current of rat cardiomyocytes in order to explore ion channel mechanism of cardiomyocyte hypoxia. The rat cardiomyocytes were isolated by acute enzymatic hydrolysis. A group of untreated cells were used to record sodium currents using whole-cell patch-clamp technique, another group was subjected to hypoxia and record sodium currents using same technique. The results showed that the morphological trajectory of sodium hypoxia was not changed compared with that of normal cells. The I-V curve of hypoxic cells was significantly higher than that of normal cells, and the peak current of INa was 15.68% higher than that of normal cells (P < 0.0001). Activation potential of normal and hypoxia cells was about -40mV, the maximum peak current corresponds to the stimulation voltage of -25mV. The above results suggest that rat cardiomyocytes sodium current increases in the case of hypoxia.

Effect of the Tiaobufeishen decoction on Caveolin-1-p38 MAPK signaling pathway and mechanism of improving the tracheobronchomalacia in chronic obstructive pulmonary disease
Peng-Cheng Zhou, Wei Yu, Ke-Ling Chen, Wen-Jun Tang, Wei Xiao, Qian-Ming Xia, Jun-Mei Ma, Yan Dong
2TMR Integrative Medicine    2019, 3: e19002.   https://doi.org/10.12032/TMRIM201903002
Abstract ( 118 HTML PDF (1147KB) ( 33 )  

Highlights:

Tiaobufeishen decoction could decrease the expression of the caveolin-1, p-p38, MMP3, inhibit the activation of the caveolin-1-p38MAPK signaling pathway.

Abstract

Objective: Reliving the relationship of the Caveolin-1-p38 MAPK signaling pathway and COPD tracheobronchomalacia, and research the mechanism of Tiaobufeishen decoction improve the regression of the weasand cartilage cells.Methods Flow cytometry was used to analyze the apoptosis rate to determine the optimal concentration of Tiaobufeishen decoction and CSE, CCK8 assay was used to determine the optimal concentration of P38-MAPK specific inhibitor. The COPD cell model was created by tracheal chondrocyte which dispose by optimal concentration CSE, then add the IL-1β set up the chondrocyte degeneration model, use the method of toluidine blue staining and immunohistochemical authenticate degeneration of cartilage. This research included control group, model group, model-Tiaobufeishen group, model-blocker group. When the model was set up succeed, add the Tiaobufeishen decoction and P38-MAPK blocker in the model-Tiaobufeishen and model-blocker groups, respectively. Western Blot was used to detect the expression of caveolin-1 and p-p38 in the chondrocyte. RT-PCR was used to detect the expression of MMP3 and caveolin-1 in the matrix.Results The cell activity was not influence by the concentration of Tiaobufeishen decoction and blocker, the concentration of the CSE model was moderation. Compared with control group, the level of caveolin-1, p38MAPK, MMP3 in the model group was significant increase, moreover, the result of toluidine blue staining and immunohistochemical methods show that the chondrocyte has obvious regression. The expression of caveolin-1, p38MAPK, and MMP3 have significant decrease than the control group, and the reduction of chondrocyte degeneration.Conclusion The caveolin-1-p38MAPK signaling pathway play an important role in the morbidity of the tracheobronchomalacia. Tiaobufeishen decoction could decrease the expression of the caveolin-1, p-p38, MMP3, inhibit the activation of the caveolin-1-p38MAPK signaling pathway, therefore, it can improve the tracheobronchomalacia.

The review of clinical application of X-shaped balance acupuncture therapy for joint pain and activity disorder
Cheng-Li Sun, Wen Lu, Li-Qun He, Jian-Dong Gao, Jing Xiao
2TMR Integrative Medicine    2019, 3: e19008.   https://doi.org/10.12032/TMRIM201903008
Abstract ( 95 HTML PDF (453KB) ( 23 )  

Highlights:

We have applied X-shaped balance acupuncture therapy in the clinic to treat local pain such as neck, shoulder, back and leg pain, and achieved good results. Most pain disorders are effective and lasting.

Abstract

Musculoskeletal diseases such as neck, shoulder, back and leg pain are extremely common in clinic. Diseases of the joints of the extremities, especially sputum, wrist sprains, and periarthritis of the shoulders, and even lumbar disc herniation, use X-shaped balance acupuncture therapy to relieve pain and improve motor function. The method of obtaining acupoints is simple and easy to operate. Many of clinical comparison shows that this therapy is simple to conventional acupuncture and moxibustion in the treatment of local pain and joint diseases. This review concluded the advantaged about the X-shaped balance acupuncture therapy and it worth to clinical promotion.

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