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Clinical efficacy of oral enteral nutrition in lung cancer patients receiving chemotherapy and/or radiotherapy: a systematic review of randomized controlled trials
Lang Huang, Jian-Guo Zhou, Wen-Xiu Yao, Yu Zhang, Fei Wang, Yi Wang, Shui-Ping Lv, Hu Ma
2TMR Integrative Medicine    2017, 1 (1): 20-29.   https://doi.org/10.12032/TMRIM201701113
Abstract ( 473 PDF (688KB) ( 319 )  

Background and Objectives: the effects of oral enteral nutrition (EN) in lung cancer patients receiving chemotherapy and/or radiotherapy were controversial, so we made a systematic review to analyze the clinical efficacy of EN in lung cancer patients after chemotherapy and/or radiotherapy. Methods and Study Design: Pertinent studies were identified by searching in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), WanFang Database, China Biomedical Literature database (CBM) and Chinese Science and Technology Periodical Database (VIP). Energy intake, protein intake, weight and other data were extracted. Results: Finally, 5 randomized controlled trials (RCTs) were included in this systematic review. Patients in 3 studies received chemotherapy, in 1 with radiotherapy and in 1 with chemo-radiotherapy. The combined results showed that EN significantly increased energy and protein intake in lung cancer during chemotherapy, while there was no significant effect on other results after patients had received chemotherapy and/or radiotherapy. Conclusions: Limited evidence is available to judge whether EN can improve clinical effect of lung cancer with or without chemotherapy and/or radiotherapy, as clinical heterogeneity and other potential variation existed in this review. Further studies are needed.

TCM syndrome types and the related factors in 145 cases of renal cell carcinoma
Dong Wang, Yu Gao, Xiao-Yu Zhu, Jia Zhang, Xi-Xing Wang
2TMR Integrative Medicine    2019, 3: e19022.   https://doi.org/10.12032/TMRIM201903022
Abstract ( 337 PDF (461KB) ( 269 )  

Background: To analyze the distribution of traditional Chinese medicine (TCM) syndromes and the related factors in patients with renal cell carcinoma, and to provide further guidance for the relapse prevention and combination of traditional Chinese and Western medicine in postoperative renal cancer patients. Methods: A retrospective survey was conducted to establish a postoperative clinical symptom assessment scale for patients with renal cell carcinoma. The distribution of TCM syndromes in 145 patients with renal cell carcinoma was analyzed statistically. Multivariate logistic regression was used to analyze the correlation between different TCM syndromes and risk factors. Results: The postoperative TCM syndromes of patients with cell carcinoma were mainly spleen-kidney deficiency (38.6%), liver-kidney Yin deficiency (15.9%), spleen-kidney Yang deficiency (13.1%), and damp-heat pouring downward (9.7%). The incidence of severe spleen-kidney Qi deficiency syndrome and spleen- kidney Yang deficiency syndrome was statistically different from that of liver-kidney Yin deficiency syndrome (P < 0.05). The history of drinking and BMI ≥ 24 kg/m2 were risk factors for spleen-kidney Qi deficiency syndrome; the history of hypertension was a protective factor for liver-kidney Yin deficiency syndrome after renal cancer surgery; male was a protective factor for patients with renal cancer who had damp-heat pouring downward syndrome; smoking history and drinking history were risk factors for damp-heat pouring downward; age was a protective factor for spleen-kidney Yang deficiency after renal cancer surgery. Conclusion: This study found that spleen-kidney Qi deficiency syndrome, liver-kidney Yin deficiency syndrome, spleen-kidney Yang deficiency syndrome, dampness and heat injection syndrome were the common TCM syndrome types after renal cell carcinoma patients. There was a correlation between the TCM syndromes of renal cell carcinoma and the risk factors such as drinking history, overweight and obesity, smoking history and drinking history. The distribution of TCM syndromes and its correlation with risk factors in renal cell carcinoma patients after surgery can provide ideas for clinical treatment and prognosis.

Research progress in immunotherapy of pancreatic cancer
Yong Tang, Hong-Yin Zhang, Xiao-Li Zhou
2TMR Integrative Medicine    2017, 1 (1): 2-8.   https://doi.org/10.12032/TMRIM201701111
Abstract ( 364 PDF (311KB) ( 268 )  

Pancreatic cancer is among the most lethal malignancies resistant to conventional therapies. The urgent need for new therapies has turned the spotlights on immunotherapy. In recent years, a growing body of evidence has already been gathered regarding the efficacy of genetic engineering modified T-cells, checkpoint inhibitors of T-cells, killer cells induced by dendritic cells and cytokine in patients with pancreatic cancer. Cryoimmunotherapy in situ and extra-tumor and immunotherapy combined with chemotherapy could also increase the effectiveness. Research of pancreatic cancer vaccine has made some progress. The immunity enhancing function of some traditional herbs have been reported, such as Ginsenoside Rg3, which could enhance T-cell subsets and NK cell activity in pancreatic cancer patients with chemotherapy.

Network pharmacology: an important breakthrough in traditional Chinese medicine research
Yuan Jin-Wei, Hao Jian, Chen Dan
2TMR Integrative Medicine    2018, 2 (3): 92-98.   https://doi.org/10.12032/TMRIM201802026
Abstract ( 454 HTML PDF (979KB) ( 264 )  

Highlights

Network pharmacology breaks through the traditional linear research model and coincides with the complexity of traditional Chinese medicine, provides technical support and new strategy in the research of traditional Chinese medicine.

Abstract

Objective: To study the relationship between traditional Chinese medicine (TCM) research and network pharmacology. Methods: Discuss the common features of TCM and network pharmacology through the analysis of the characteristics of TCM, the background of network pharmacology, so as better interpretation of TCM and in-depth understanding of TCM research and network pharmacology. Results: Multicomponent and multitarget characteristics of TCM as same as the study thought of network pharmacology. Network pharmacology breaks through the research model of linear and coincides with the complexity of TCM, provides technical support for rational design of TCM formulae, both and a new way in the research of TCM. It becomes a new strategy for modern TCM research. Conclusion: Network pharmacology is an important breakthrough in TCM research, its research promote modernization and internationalization process of TCM conduce to the research and development of TCM and have important significance for the integration of Chinese and Western medicine.

Non-pharmacological therapy of TCM for the treatment of essential hypertension
Meng-Lei Li, Shan-Fu Chen, Ying-Qiang Zhao
2TMR Integrative Medicine    2019, 3: e19010.   https://doi.org/10.12032/TMRIM201903010
Abstract ( 332 HTML PDF (530KB) ( 235 )  

Highlights:

It is necessary to strengthen the research on the mechanism of non-drug therapy of TCM, and combine clinical observation and experimental research to promote the promotion and application of non-pharmacological therapy of TCM in clinical practice.

Abstract

Non-pharmacological treatment is an important means to control hypertension, with many advantages such as low cost, less medication, stable blood pressure, less complications, and improved prognosis. This article reviews the research progress of non-drug treatment of hypertension in Chinese medicine in the past five years, and evaluates traditional Chinese medicine such as TCM Qigong, Wuhuo opera, Ba Duanjin and Taijiquan, and Chinese medicine acupuncture, moxibustion, massage, application, acupoint embedding and other traditional Chinese medicine. The effect of external treatment in hypertension control provides guidance for non-drug therapy to control hypertension.

An improved primary culture method for hippocampal neurons in fetal rats and MAP2 identification
Yi-Ran Shao, Yong Chang DI WU, Tao Yue
2TMR Integrative Medicine    2018, 2 (1): 1-6.   https://doi.org/10.12032/TMRIM201802011
Abstract ( 442 HTML PDF (359KB) ( 233 )  

Objective: To establish a simple, effective and high-purity primary culture method for fetal rat hippocampal neurons. Methods: Wistar rats of gestational age 18 days were taken and the brain tissue was separated under the microscope. Single neuronal cells were obtained by digestion with Brain Dissociation Kit, and then were seeded in cell plates to observe the basic morphologic structure after 24h, 3d, and 5d. Immunofluorescence of microtubule associated protein 2 was applied to assess cell purity of the culture. Results: The hippocampal neurons obtained in this culture method are in good condition and grow vigorously. On the 7th day after culture, the purity of neurons was up to 99.62%. Conclusion: The method is simple and effective for obtaining the high-purity and stable neurons.

TCM aerosol inhalation treatment in acute exacerbations of chronic bronchitis: a meta-analysis
Wei Luo, Ji-Ni Yang, Yi-Hua Fan, Ji-Fang Song, Fang-Jing Liu, Teng Zhang, Qiang Zhang
TMR Integrative Medicine    2017, 1 (1): 9-19.   https://doi.org/10.12032/TMRIM201701112
Abstract ( 415 PDF (584KB) ( 223 )  

Objectives: To determine whether traditional Chinese medicine (TCM) aerosol inhalation treatment is effective in the treatment of acute exacerbation of chronic bronchitis. Methods: Search double-blind randomised clinical trials (RCT) about the use of TCM aerosol inhalation in patient with acute exacerbation of chronic bronchitis via data base including Chinese biomedicine literature database, Wanfang Data, CNKI, Pubmed, EMBASE and Cochrane Library from the beginning to October 2016. Quality evaluation, data extraction and data analysis of these RCT was carried out with reference to the Cochrane systematic review. Results: 16 studies with 738 patients in TCM aerosol inhalation group and 675 in control group were included. The results of meta-analysis showed, (1) TCM aerosol inhalation group could improve the total cure rate. (2) TCM aerosol inhalation could increase the expression of IL-2 while decrease the expression of IL-8 and MDA in sputum and blood. (3) TCM aerosol inhalation could improve the symptoms of cough, cough with sputum, cough with dyspnea and lung wet rales. It also improve the symptoms of cough, expectorate and lung wet rales. (4) Shorten the time of cough and lung rale. (5) The adverse reactions were light only with 1 occurrence of nausea and vomiting. Conclusions: The use of TCM aerosol inhalation in the treatment of acute exacerbation of chronic bronchitis was effective. However, the inclusion researches quality were not very high, which only provided limited evidence for clinical application. Higher-quality randomized controlled trials were needed for further study.

Necessities and feasibilities of the establishment of traditional Chinese medicine clinical research protocol database
Si Jin-Hua, Li Nan, Du Liang, Cheng Yao-Long, Shang Hong-Cai
TMR Integrative Medicine    2018, 2 (3): 133-139.   https://doi.org/10.12032/TMRIM201802030
Abstract ( 340 HTML PDF (713KB) ( 216 )  

Highlights:

This research collected TCM clinical research protocols which were published in international journals and established Traditional Chinese Medicine Clinical Protocol Database (TCMCPD), in order to promote the localization of high quality researches and improve the ability of TCM clinical research in China. Further describes the necessities and feasibilities of building Traditional Chinese Medicine Clinical Protocol Database (TCMCPD) and puts forward some basic technological ideas, so as to provide a theoretical foundation for building the database.

Abstract

With the internationalization and modernization of traditional Chinese medicine (TCM), TCM clinical research has accumulated a lot of research information resources. However, these information resources are often scattered in various retrieval systems, which brings some difficulties to the reference and use of this information. Therefore, we collected TCM clinical research protocols which were published in international journals and established Traditional Chinese Medicine Clinical Research Protocol Database (TCMCRPD), in order to promote the localization of high-quality researches and improve the ability of TCM clinical research in China. After analyzing the major existing problems of TCM clinical research protocols, this essay describes the necessities and feasibilities of building Traditional Chinese Medicine Clinical Research Protocol Database (TCMCRPD) and puts forward some basic technological ideas, so as to provide a theoretical foundation for building the database.

Efficacy of acupuncture on treating obesity and adipose-incurred illnesses
Fung-Kei Cheng
2TMR Integrative Medicine    2018, 2 (4): 140-167.   https://doi.org/10.12032/TMRIM201802031
Abstract ( 464 HTML PDF (1399KB) ( 187 )  

Highlights:

This review reveals practical implications and future research directions, benefiting the development of acupuncture in the modern medical arena for both patients and practitioners.

Abstract

Being overweight and obese impacts health due to adiposity itself and illnesses it incurs, which produces individual and societal financial burdens. This urges effective interventions, including adjunct therapies. Acupuncture, a traditional Chinese medical practice, indicates positive signs for tackling these problems. Investigating 101 empirical human-based projects, this narrative review analyses their outcomes and then provides an overview of the effects of acupuncture in body weight reduction and obesity-induced diseases, either performed alone or with other approaches. It involves 15941 participants from 9-80 years old in mainland China, Taiwan, Turkey, Brazil, Egypt, Iran, Greece, Korea, Sudan, Thailand, and the USA. It also reveals practical implications and future research directions, benefiting the development of acupuncture in the modern medical arena for both patients and practitioners.

The concept of narrative evidence-based medicine and shared decision-making in traditional Chinese medical practice
Mu Wei, Shang Hong-Cai, Gu Xu-Fang, Zhang Li, Li Yan-Fen, Li Jie, Wang Rui-Hua, Huang Yu-Hong, Wang Bao-He
TMR Integrative Medicine    2018, 2 (3): 99-104.   https://doi.org/10.12032/TMRIM201802027
Abstract ( 256 HTML PDF (756KB) ( 183 )  

Highlights:

The author described the origins and development of evidence-based medicine, narrative medicine and shared decision-making, and analyzed the existing problems in TCM clinical decision-making.

Abstract

For the explosive development of emerging diagnostic and therapeutic technologies brought by the advancement of precision medicine strategy, shared decision-making could improve the quality of clinical decision-making and promote the transformation of clinical research evidence in TCM. Paying attention to patients' narrative needs and strengthening medical humanistic concerns could improve clinical outcome and patient satisfaction. We described the origins and development of evidence-based medicine, narrative medicine and shared decision-making, and analyzed the existing problems in TCM clinical decision-making. Further, we put forward the model of shared decision-making between clinicians and patients under the guidance of narrative evidence-based medicine concepts and methods.

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