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Clinical efficacy of oral enteral nutrition in lung cancer patients receiving chemotherapy and/or radiotherapy: a systematic review of randomized controlled trials
Lang Huang, Jian-Guo Zhou, Wen-Xiu Yao, Yu Zhang, Fei Wang, Yi Wang, Shui-Ping Lv, Hu Ma
2TMR Integrative Medicine    2017, 1 (1): 20-29.   https://doi.org/10.12032/TMRIM201701113
Abstract ( 377 PDF (688KB) ( 250 )  

Background and Objectives: the effects of oral enteral nutrition (EN) in lung cancer patients receiving chemotherapy and/or radiotherapy were controversial, so we made a systematic review to analyze the clinical efficacy of EN in lung cancer patients after chemotherapy and/or radiotherapy. Methods and Study Design: Pertinent studies were identified by searching in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), WanFang Database, China Biomedical Literature database (CBM) and Chinese Science and Technology Periodical Database (VIP). Energy intake, protein intake, weight and other data were extracted. Results: Finally, 5 randomized controlled trials (RCTs) were included in this systematic review. Patients in 3 studies received chemotherapy, in 1 with radiotherapy and in 1 with chemo-radiotherapy. The combined results showed that EN significantly increased energy and protein intake in lung cancer during chemotherapy, while there was no significant effect on other results after patients had received chemotherapy and/or radiotherapy. Conclusions: Limited evidence is available to judge whether EN can improve clinical effect of lung cancer with or without chemotherapy and/or radiotherapy, as clinical heterogeneity and other potential variation existed in this review. Further studies are needed.

Research progress in immunotherapy of pancreatic cancer
Yong Tang, Hong-Yin Zhang, Xiao-Li Zhou
2TMR Integrative Medicine    2017, 1 (1): 2-8.   https://doi.org/10.12032/TMRIM201701111
Abstract ( 298 PDF (311KB) ( 228 )  

Pancreatic cancer is among the most lethal malignancies resistant to conventional therapies. The urgent need for new therapies has turned the spotlights on immunotherapy. In recent years, a growing body of evidence has already been gathered regarding the efficacy of genetic engineering modified T-cells, checkpoint inhibitors of T-cells, killer cells induced by dendritic cells and cytokine in patients with pancreatic cancer. Cryoimmunotherapy in situ and extra-tumor and immunotherapy combined with chemotherapy could also increase the effectiveness. Research of pancreatic cancer vaccine has made some progress. The immunity enhancing function of some traditional herbs have been reported, such as Ginsenoside Rg3, which could enhance T-cell subsets and NK cell activity in pancreatic cancer patients with chemotherapy.

Network pharmacology: an important breakthrough in traditional Chinese medicine research
Yuan Jin-Wei, Hao Jian, Chen Dan
2TMR Integrative Medicine    2018, 2 (3): 92-98.   https://doi.org/10.12032/TMRIM201802026
Abstract ( 350 HTML PDF (979KB) ( 198 )  

Highlights

Network pharmacology breaks through the traditional linear research model and coincides with the complexity of traditional Chinese medicine, provides technical support and new strategy in the research of traditional Chinese medicine.

Abstract

Objective: To study the relationship between traditional Chinese medicine (TCM) research and network pharmacology. Methods: Discuss the common features of TCM and network pharmacology through the analysis of the characteristics of TCM, the background of network pharmacology, so as better interpretation of TCM and in-depth understanding of TCM research and network pharmacology. Results: Multicomponent and multitarget characteristics of TCM as same as the study thought of network pharmacology. Network pharmacology breaks through the research model of linear and coincides with the complexity of TCM, provides technical support for rational design of TCM formulae, both and a new way in the research of TCM. It becomes a new strategy for modern TCM research. Conclusion: Network pharmacology is an important breakthrough in TCM research, its research promote modernization and internationalization process of TCM conduce to the research and development of TCM and have important significance for the integration of Chinese and Western medicine.

TCM aerosol inhalation treatment in acute exacerbations of chronic bronchitis: a meta-analysis
Wei Luo, Ji-Ni Yang, Yi-Hua Fan, Ji-Fang Song, Fang-Jing Liu, Teng Zhang, Qiang Zhang
TMR Integrative Medicine    2017, 1 (1): 9-19.   https://doi.org/10.12032/TMRIM201701112
Abstract ( 328 PDF (584KB) ( 180 )  

Objectives: To determine whether traditional Chinese medicine (TCM) aerosol inhalation treatment is effective in the treatment of acute exacerbation of chronic bronchitis. Methods: Search double-blind randomised clinical trials (RCT) about the use of TCM aerosol inhalation in patient with acute exacerbation of chronic bronchitis via data base including Chinese biomedicine literature database, Wanfang Data, CNKI, Pubmed, EMBASE and Cochrane Library from the beginning to October 2016. Quality evaluation, data extraction and data analysis of these RCT was carried out with reference to the Cochrane systematic review. Results: 16 studies with 738 patients in TCM aerosol inhalation group and 675 in control group were included. The results of meta-analysis showed, (1) TCM aerosol inhalation group could improve the total cure rate. (2) TCM aerosol inhalation could increase the expression of IL-2 while decrease the expression of IL-8 and MDA in sputum and blood. (3) TCM aerosol inhalation could improve the symptoms of cough, cough with sputum, cough with dyspnea and lung wet rales. It also improve the symptoms of cough, expectorate and lung wet rales. (4) Shorten the time of cough and lung rale. (5) The adverse reactions were light only with 1 occurrence of nausea and vomiting. Conclusions: The use of TCM aerosol inhalation in the treatment of acute exacerbation of chronic bronchitis was effective. However, the inclusion researches quality were not very high, which only provided limited evidence for clinical application. Higher-quality randomized controlled trials were needed for further study.

Non-pharmacological therapy of TCM for the treatment of essential hypertension
Meng-Lei Li, Shan-Fu Chen, Ying-Qiang Zhao
2TMR Integrative Medicine    2019, 3: e19010.   https://doi.org/10.12032/TMRIM201903010
Abstract ( 207 HTML PDF (530KB) ( 170 )  

Highlights:

It is necessary to strengthen the research on the mechanism of non-drug therapy of TCM, and combine clinical observation and experimental research to promote the promotion and application of non-pharmacological therapy of TCM in clinical practice.

Abstract

Non-pharmacological treatment is an important means to control hypertension, with many advantages such as low cost, less medication, stable blood pressure, less complications, and improved prognosis. This article reviews the research progress of non-drug treatment of hypertension in Chinese medicine in the past five years, and evaluates traditional Chinese medicine such as TCM Qigong, Wuhuo opera, Ba Duanjin and Taijiquan, and Chinese medicine acupuncture, moxibustion, massage, application, acupoint embedding and other traditional Chinese medicine. The effect of external treatment in hypertension control provides guidance for non-drug therapy to control hypertension.

An improved primary culture method for hippocampal neurons in fetal rats and MAP2 identification
Yi-Ran Shao, Yong Chang DI WU, Tao Yue
2TMR Integrative Medicine    2018, 2 (1): 1-6.   https://doi.org/10.12032/TMRIM201802011
Abstract ( 350 HTML PDF (359KB) ( 166 )  

Objective: To establish a simple, effective and high-purity primary culture method for fetal rat hippocampal neurons. Methods: Wistar rats of gestational age 18 days were taken and the brain tissue was separated under the microscope. Single neuronal cells were obtained by digestion with Brain Dissociation Kit, and then were seeded in cell plates to observe the basic morphologic structure after 24h, 3d, and 5d. Immunofluorescence of microtubule associated protein 2 was applied to assess cell purity of the culture. Results: The hippocampal neurons obtained in this culture method are in good condition and grow vigorously. On the 7th day after culture, the purity of neurons was up to 99.62%. Conclusion: The method is simple and effective for obtaining the high-purity and stable neurons.

Necessities and feasibilities of the establishment of traditional Chinese medicine clinical research protocol database
Si Jin-Hua, Li Nan, Du Liang, Cheng Yao-Long, Shang Hong-Cai
TMR Integrative Medicine    2018, 2 (3): 133-139.   https://doi.org/10.12032/TMRIM201802030
Abstract ( 258 HTML PDF (713KB) ( 157 )  

Highlights:

This research collected TCM clinical research protocols which were published in international journals and established Traditional Chinese Medicine Clinical Protocol Database (TCMCPD), in order to promote the localization of high quality researches and improve the ability of TCM clinical research in China. Further describes the necessities and feasibilities of building Traditional Chinese Medicine Clinical Protocol Database (TCMCPD) and puts forward some basic technological ideas, so as to provide a theoretical foundation for building the database.

Abstract

With the internationalization and modernization of traditional Chinese medicine (TCM), TCM clinical research has accumulated a lot of research information resources. However, these information resources are often scattered in various retrieval systems, which brings some difficulties to the reference and use of this information. Therefore, we collected TCM clinical research protocols which were published in international journals and established Traditional Chinese Medicine Clinical Research Protocol Database (TCMCRPD), in order to promote the localization of high-quality researches and improve the ability of TCM clinical research in China. After analyzing the major existing problems of TCM clinical research protocols, this essay describes the necessities and feasibilities of building Traditional Chinese Medicine Clinical Research Protocol Database (TCMCRPD) and puts forward some basic technological ideas, so as to provide a theoretical foundation for building the database.

Advances in the research of high myopia treatment
Ming-shan Liu, Ya-Mo
2TMR Integrative Medicine    2017, 1 (3): 124-129.   https://doi.org/10.12032/TMRIM201701124
Abstract ( 249 PDF (236KB) ( 142 )  
High myopia, is a condition of the diopter over -6.00D, accompanied by axial extension and fundus changes, such as temporal arc plaque, pigment epithelium thinning, leopard-shaped fundus, fuchs spot, retina choroidal atrophy, progressive decline in vision, as well as amblyopia, glaucoma, cataract, vitreous opacity, retinal detachment and other ophthalmic diseases. High myopia is one of the common causes of blindness in China. It is necessary to review these cases in order to better guide the clinical and improve the level of vision of patients.
The optimal choice of chemotherapy regimens for patients with relapsed platinum-resistant epithelial ovarian cancer/primary peritoneal/fallopian tube cancer — protocol for a systematic review and network meta-analysis
Feng-Hua Liu, Xiao-Li Zhou, Hui-Ting Xiao, Jin-Hui Tian, Quan Hao, Yong Tang
TMR Integrative Medicine    2017, 1 (1): 30-36.   https://doi.org/10.12032/TMRIM201701114
Abstract ( 267 PDF (408KB) ( 130 )  

Background: Debulking surgery (residual disease of less than 1 cm) followed by platinum-taxane chemotherapy is the current standard therapy for patients with epithelial ovarian cancer, primary peritoneal carcinoma and primary fallopian cancer. But the prognosis remains poor. Several chemotherapy regimens could be selected for patients with recrudescent cancer. However, the standard second chemotherapy regimen remains a subject of debate. The purpose of our study is to carry out a systematic review and network meta-analysis to compare the efficacy and safety of different regimens for recurrent platinum-resistant ovarian cancer based on existing randomized controlled trials (RCTs). Methods and analysis: Medline, EMBASE, Cochrane Library and Cochrane Library databases, Science Citation Index Expanded, Conference Proceedings Citation Index-Science and ClinicalTrials.gov will be systematically searched for eligible studies. Randomized controlled trials (RCT) on chemotherapy, immune therapy, biological therapy, targeted therapy for recurrent platinum-resistant ovarian cancer with multiple outcome measures will be included. The Cochrane Risk of Bias Tool will be used to assess the quality of included studies. The primary outcomes are overall survival and median survival time. The secondary outcomes include the safety and side effects of these regimens. Direct meta-analysis and network meta-analysis (NMA) will be conducted to compare different regimens. Conclusion: The results of this network meta-analysis will provide direct and indirect evidence of treatments for recurrent platinum-resistant ovarian cancer, and it may provide a ranking of the chemotherapy regimens for patients and gynecological oncologists to help them select the best option.

The efficacy and safety of Chinese herbal medicine combined with ACEI/ARB for treatment of incipient diabetic nephropathy: A meta-analysis
Qi-Yan Zheng, Wei-Jing Liu, Wei-Wei Sun, Yao-Xian Wang, Hong-Fang Liu, Lu-Ying Sun
2TMR Integrative Medicine    2018, 2 (1): 7-29.   https://doi.org/10.12032/TMRIM201802012
Abstract ( 313 HTML PDF (1365KB) ( 128 )  

Objective: This meta-analysis evaluated the efficacy and safety of Chinese herbal medicine (CHM) combined with angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin-receptor blockers (ARBs)for treatment of incipient diabetic nephropathy(IDN). Methods: Nine data bases were searched for randomized controlled trials of Chinese herbal medicine(CHM) and ACEI/ARB for treatment of IDN. Included articles were published between January2006 and December 2016. All studies were divided into prescriptions containing both Astragali Radix and Rehmanniae Radix (i subgroup), Astragali Radix(Huangqi) or Rehmanniae Radix(Dihuang) (ii subgroup), neither Astragali Radix nor Rehmanniae Radix (iii subgroup). Review Manager 5.3was used for subgroup analysis. Results: In total, 28 RCTs with 2017 patients were included. The results showed 1)the urinary albumin excretion rate (UAER) can be reduced significantly using CHM with ACEI or ARB for treatment of IDN compared to ACEI or ARB alone, and reduction of the UAER of the i subgroup was superior to that of the other two subgroups;2)serum creatinine (Scr) levels can be reduced significantly using CHM combined with ACEI or ARB, and reduction of Scr in the ii subgroup was superior to that in the iii subgroup;3)reduction of BUN in group A was not better than that in group B. Conclusion: In summary, CHMs combined with ACEI/ARB can decrease UAER and Scr significantly compared to the use of ACEI/ARB during IDN treatment. The effect was more significant in the CHM group containing Astragali Radix or Rehmanniae Radix. The application of Astragali Radix and Rehmanniae Radix should be emphasized in third stage diabetic nephropathy.

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