Topics
Meta-analysis

Meta-analysis is the collection, arrangement and analysis of numerous empirical studies on a certain topic by scholars and experts in the hope of finding a clear relationship model between the problem or the variables concerned, which can make up for the deficiency of traditional review articles.
Please wait a minute...
The effects of Chinese herbal fumigation on the prevention of peripheral neurotoxicity caused by chemotherapy: a meta-analysis
Jing Yang, Zhu Yang, Feng-Xi Long, Xu Liu, Xian-Man Wei, Dong-Xin Tang
9TMR Non-Drug Therapy    2020, 3 (1): 36-43.   https://doi.org/10.12032/TMRND20200301004
Abstract HTML PDF (423KB)  

Highlights

The study evaluated the clinical efficacy of Chinese herbal fumigation in the past five years to prevent peripheral neurotoxicity caused by chemotherapy. Five Chinese literatures, with a total of 331 patients, were eventually included. Meta-analysis results demonstrate that herbal fumigation can effectively prevent the occurrence of peripheral neurotoxicity caused by chemotherapy without obvious adverse reactions.

Abstract

Backgroud: To evaluate the clinical efficacy of Chinese herbal fumigation to prevent peripheral neurotoxicity caused by chemotherapy. Methods: CNKI, VIP Database, Wanfang Database, PubMed and Cochrane Databases were searched from January 2014 to July 2019 for randomized controlled trials (RCTs) of herbal fumigation to prevent peripheral neurotoxicity caused by chemotherapy. The RCTs were selected according to the inclusion and exclusion criteria, and the data extraction and bias risk assessment were performed. RevMan 5.3 software was used for statistical analysis. Results: Five Chinese RCTs were eventually included, with a total of 331 patients. Meta-analysis showed that compared with the control group, herbal fumigation could significantly reduce the incidence of peripheral neurotoxicity induced by chemotherapy (OR = 0.34, 95% CI (0.21, 0.55), P < 0.01). Moreover, herbal fumigation could also reduce the incidence of peripheral neurotoxicity above grade 2 (OR = 0.17, 95% CI (0.04, 0.77) P = 0.02). Conclusion: Herbal fumigation can effectively prevent the occurrence of peripheral neurotoxicity caused by chemotherapy without obvious adverse reactions.

A meta-analysis of the treatment of cancer-related insomnia with acupuncture
Xue-Wei Qi, Man-Jing Pan, Tian-Yan Wen
90Life Research    2020, 3 (1): 15-25.   https://doi.org/10.12032/life2020-0125-102
Abstract PDF (611KB)  

Purpose: To systematically evaluate the clinical efficacy and safety of acupuncture in treating cancer-related insomnia. 

Methods: Randomized controlled trials (RCTs) and quasi-randomized controlled trials of acupuncture in the treatment of cancer-related insomnia were searched by computer in a Pubmed database, and the retrieved literature was screened according to inclusion and exclusion criteria. After the literature screening was completed, two reviewers read the literature titles independently and extracted effective information. The migration risk assessment was performed by Cochrane. All statistical calculation requirements for this study were fully completed by RevMan5.3 software. 

Results: Among the 68 selected works of literature, 3 RCTs were finally included, with a total of 133 patients. The risk of research bias is generally very low. In 3 RCTs, the sleep score of the experimental group was decreased by 0.48 more than that of the control group in 3 RCTs, with a 95% confidence interval of -0.82 and -0.13, and the degree of decrease was statistically significant (Z = 2.70, P < 0.05). 

Conclusions: Higher levels may indicate that acupuncture-related therapies are more effective in improving cancer-related insomnia. Although the included literatures feature low bias and no heterogeneity, the number may have reduced its clinical significance. Therefore, more studies on high-quality randomized controlled trials should be conducted in the future to better clarify the therapeutic effect of acupuncture and moxibustion on cancer-related insomnia.

Interventional effect of cognitive behavioral therapy on cancer-related fatigue in breast cancer patients: A systematic review
Ying Zhang, Jia-Lei Ren, Yu-Hong Chen, Wan-Min Qiang
3TMR Integrative Nursing    2019, 3 (6): 199-206.   https://doi.org/10.12032/TMRIN20191211
Abstract HTML PDF (710KB)  

Highlights

This article systematically evaluates the effect of cognitive behavioral therapy on cancer-related fatigue in breast cancer patients, and showed that cognitive behavioral therapy can alleviate the harm caused by cancer-related fatigue.

Editor’s summary

Cognitive behavioral therapy is a psychotherapy method which can change the cognitive orientation of patients. The results of this systematic review indicate that CBT can alleviate cancer-related fatigue in breast cancer patients to a certain extent.

ABSTRACT

Objective: To evaluate the effect of cognitive behavioral therapy on cancer-related fatigue in breast cancer patients. Methods: Computer search for CNKI, VIP, Wanfang database, CBM, PubMed, Embase, CINAHL, The Cochrane library as of 2019 randomized controlled trials on October 20 for cognitive behavioral therapy intervention for breast cancer due to fatigue. Results: A total of 6 RCTs were included, 472 patients. Cognitive Behavioral Therapy has a strong effect on cancer related fatigue compared with the usual care [SMD = -1.19, 95% CI (-1.86, -0.53), P = 0.0004]. Results: Available evidence suggests that CBT can alleviate cancer-related fatigue in breast cancer patients, and the above studies still need to continue to conduct relevant studies for validation.

Effect of social media utilization in 21st century nursing practices in Nigeria: Analytical review
Omolola Adams Olatayo
3TMR Integrative Nursing    2019, 3 (6): 189-198.   https://doi.org/10.12032/TMRIN20190912
Abstract HTML PDF (442KB)  

Highlights

This article recommended that nursing training curriculum should reflect current trend of social media and NMCN should review its code of professional practices highlighting the usage of social media.

Editor’s summary

The word social media is a compound term that involves social networking, content exposition, web publishing and wikis. Social media is an essential instrument that provides rooms sharing of thoughts and providing information to target audience. It encompasses information generation by user for end-users, divulging user opinion, reaction and counter-reactions by user and audience, and spreading information to a large audience at a point in time on the digital terrestrial.

ABSTRACT

Background and aim: Social Media is a global tool where information is disseminated and accessed within twinkle of an eye, it reaches the target audience within seconds locally, continentally or cross-continentally. Social Media usage in nursing practices across globe is a burning issue in contemporary 21st century, as its negativity is widely spreading unprofessional code of conducts. Therefore, the study is to examine the effect of social media usage among 21st century nurses in Nigeria. Methodology: This analytical study was carried out using previous studies on related subject matters, and review the outcomes of the subjects. Nurses in Federal Republic of Nigeria were used as the sample via WhatsApp group and Facebook closed group, hence, it was conducted on examining how impactful is the usage of social media among Nigerian nurses. Results: Findings revealed that social media has come to stay in nursing, and the potential should be harnessed and integrated into nursing practices and curriculum, which will translate into professional care. Nurses should be educated on its negative usage as it delineates from professional conduct. There is a need for Nursing and Midwifery Council of Nigeria (NMCN) as matter of urgency upgrade the code of professional conduct to accommodate the current trend of social media usage. Conclusion: It was concluded that Nurses in Nigeria should uphold professional code of practice while using social media as it’s a good source of litigation. It was recommended that nursing training curriculum should reflect current trend of social media and NMCN should review its code of professional practices highlighting the usage of social media.

Intervention effect of chewing sugar-free gum on xerostomia in hemodialysis patients: A meta-analysis
Yan-Qiu Huang, Si-Qi Xiong, Chang-De Jin
3TMR Integrative Nursing    2019, 3 (6): 207-213.   https://doi.org/10.12032/TMRIN20190405
Abstract HTML PDF (569KB)  

Highlights

In this article meta-analysis was used to evaluate the effect of chewing sugar-free gum on xerostomia in hemodialysis patients. Chewing sugar-free gum can improve the dry mouth in hemodialysis patients, but it has no effect on thirst and weight gain during dialysis.

Editor’s summary

Xerostomia is one of the common complications in end-stage renal disease patients are treated by using hemodialysis. sugar-free gum has been widely used in hemodialysis patients due to its low economic cost and good taste, but its clinical effect is still controversial.

ABSTRACT

Objective: Meta-analysis was used to evaluate the effect of chewing sugar-free gum on xerostomia in hemodialysis patients. Methods: Randomized controlled trials or semi-randomized clinical trials on the effects of chewing sugarless gum on xerostomia in hemodialysis patients were retrieved from the databases of Chinese national knowledge infrastructure (CNKI), Wanfang, Chinese sci-tech periodical full text databases Whipple (VIP), Chinese biomedical (CBM), Pubmed, Embase, Cochance, Web of science, Ovid and CINAHL. After data extraction and quality evaluation, we used Review Manager 5.3 software to carry out meta-analysis of the outcome indicators. Results: Five studies enrolled 237 patients were included eventually. The results showed that chewing sugar-free gum improved the symptoms of dry mouth [MD = -2.12, 95%CI (-2.53, -1.71), P < 0.001, but had no effect on patients' thirst symptoms [MD = -1.57, 95%CI (-3.41, 0.27), P = 0.09] and weight gain [MD = -0.38, 95%CI (-1.02, 0.27), P = 0.25] during dialysis. Conclusion: Chewing sugar-free gum can improve the dry mouth of hemodialysis patients, but it has no effect on thirst and weight gain during dialysis. However, due to the small number and the low quality of included literatures, it is still necessary to carry out large sample, multi-center and high-quality randomized controlled trials to further explore the effect of chewing sugar-free gum on xerostomia in hemodialysis patients.

Effect of auricular acupoint sticking and pressing on postoperative pain of patients with mixed hemorrhoids:A Meta-analysis
Qing-Long Wang, Hong-Mei Xu, Di Bao, Xiao-Li Pang
3TMR Integrative Nursing    2020, 4 (1): 22-32.   https://doi.org/10.12032/TMRIN20200209
Abstract HTML PDF (584KB)  

Highlights

We summarized the analgesic effect, commonly used acupoints and adverse reactions of auricular point pressing beans after mixed hemorrhoids operation. We found that auricular point pressing can improve the analgesic effect, reduce anal edema, and the price is low, and the operation is convenient, so it is recommended to be popularized clinically.

Abstract

Objective: To systematically evaluate the application effect of auricular acupuncture in postoperative analgesia in patients with mixed hemorrhoids. Methods: We searched Chinese Biomedical Literature Database, CNKI, WanFang, PubMed, Embase, and The Cochrane Library to collect randomized controlled trials about auricular acupuncture on Postoperative patients with mixed hemorrhoids. According to the inclusion criteria and exclusion criteria screening literature. RevMan 5.3 software was used for meta-analysis. Results: A total of 20 articles and 21 studies were included, including 1999 patients after mixed hemorrhoids. The control group was treated with routine nursing analgesia. The experimental group was treated with auricular acupressure beans based on the control group. The meta-analysis showed that the pain relief rate of the experimental group was better than that of the control group [OR = 2.84, 95% CI (2.12, 3.80), P < 0.05]. Subgroup analysis showed that the application of auricular acupressure after milligan morgan was superior to the control group in the analgesic effect [OR = 3.68, 95% CI (2.62, 5.18), P < 0.05], but it is not yet possible to apply auricular acupoint pressing to relieve pain after Stapler hemorrhoidectomy (P > 0.05). The pain scores of 24 hours and 48 hours after operation in the experimental group were lower than those of the control group, indicating that auricular acupoint sticking can relieve the pain after operation.The improvement of the postoperative anal margin edema was better in the experimental group than in the control group, 24 h [SMD = -1.99, 95% CI (-2.84, -1.14), P < 0.05], 48 h [SMD = -1.92, 95%CI (-2.72,-1.11), P < 0.05]. The adverse reactions were lower than the control group. Conclusion: The application of ear acupoint pressure pea after external exfoliation of mixed hemorrhoids can improve the analgesic effect and reduce the symptoms of postoperative anal edge edema, and the price is low, the operation is convenient, and the side effects are few. It is recommended to be popularized in clinical practice.

Efficacy of high-flow nasal cannula on acute exacerbation of chronic obstructive pulmonary disease: A meta-analysis
Ying-Ming Sun, Min Zhang, Na Sun, Zhi Guan, Ying Wang
Medical Data Mining    2019, 2 (4): 142-149.   https://doi.org/10.12032/mdm2019121302
Abstract PDF (464KB)  

Abstract 

Objective: To systematically evaluate the efficacy and feasibility of high-flow nasal cannula (HFNC) on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: Systematic searches on PubMed, Web of Science, the Cochrane Library, Embase, CBM (Chinese Biomedicine Database), CNKI (China National Knowledge Infrastructure), Wanfang Database and VIP were performed for randomized controlled trials (RCTs) which explored the effects of HFNC on patients with AECOPD. The retrieval time was from the establishment of each database to July 2019. RevMan5.3 software was used for statistical analysis. Results: A total of 12 articles were included, involving 812 patients. The results showed that: (1) Compared with conventional oxygen therapy, HFNC could improve patients' arterial partial oxygen pressure (PaO2) (MD = 12.70, 95% CI (7.00,18.40), Z = 4.37, P < 0.0001), reduce partial arterial blood carbon dioxide (PaCO2) (MD = -10.99, 95% CI (-14.42, -7.55), Z = 6.26, P < 0.00001) and reduce endotracheal intubation rate (OR = 0.19, 95% CI (0.04, 0.93), Z = 2.05, P = 0.04), shorten the hospitalization time (SMD = -0.74, 95% CI (-1.11,-0.37), Z = 3.95, P < 0.0001). (2) Compared with non-invasive positive pressure ventilation, it has fewer adverse reactions (OR = 0.18, 95% CI (0.09, 0.35), Z = 5.08, P < 0.00001) and shorter hospital stay (SMD = -0.57,95% CI (-0.90,-0.23), Z = 3.33, P = 0.0009). Conclusion: HFNC can improve the patients’ hypoxia symptoms and CO2 retention, reduce the rate of tracheal intubation, and alleviate adverse reactions. However, Limited by the quality and region of the included studies, more high-quality are needed to test it.

Network meta-analysis of acupuncture treatment for mammary gland hyperplasia
Yi-Hua Fan, Hui -Le Li, Yun-Rui Jin, Qiang Zhang
92Medical Data Mining    2018, 1 (1): 19-29.   https://doi.org/10.12032/mdm2018002
Abstract PDF (935KB)  

Objective: To evaluate the efficacy of acupuncture for the treatment of mammary gland hyperplasia. Methods: Randomized controlled trials before December 2017 in CNKI, China Biology Medicine disc, Chinese sci-tech periodical full-text database, Wanfang database, Cochrane Library, Pubmed, Embase and Web of Science were searched. The risks were evaluated by two investigators according to the Cochrane Handbook 5.1.0 criteria. Evaluation GeMTC was used for network-meta analysis. Results: A total of 43 articles were included, involving 5531 patients. Network meta-analysis results showed that there were differences in the comparison before and after treatment: acupuncture + Chinese herbal medicine vs acupuncture, acupuncture + Chinese herbal medicine vs Chinese herbal medicine, acupuncture + Chinese herbal medicine v s acupoint embedding, acupuncture + western medicine vs acupuncture, acupuncture + western medicine vs western medicine, acupuncture + western medicine vs Chinese herbal medicine, fire needle vs acupuncture, fire needle vs Chinese herbal medicine, moxibustion vs acupuncture, moxibustion vs Chinese herbal medicine, acupoint embedding line + Chinese herbal medicine vs Chinese herbal medicine, acupoint embedding line + Chinese herbal medicine vs western medicine, acupoint embedding line + Chinese herbal medicine vs acupuncture, acupoint embedding line + Chinese herbal medicine vs acupuncture + Chinese herbal medicine, acupoint embedding line + Chinese herbal medicine vs acupuncture + western medicine, acupoint embedding line + Chinese herbal medicine vs fire needle, acupoint embedding line + Chinese herbal medicine vs fire needle + Chinese herbal medicine, acupoint embedding line Chinese herbal medicine vs electroacupuncture, acupoint embedding line + Chinese herbal medicine vs acupoint embedding line, Acupoint embedding line + Chinese herbal medicine vs ear acupuncture, acupoint embedding line + Chinese herbal medicine vs moxibustion, acupoint embedding line + Chinese herbal medicine vs moxibustion + Chinese herbal medicine. Conclusion:Acupoint embedding + traditional Chinese medicine, acupuncture + western medicine is the best treatment for mammary gland hyperplasia, but the exact conclusion still needs high-quality clinical research to further verify.

Efficacy of empowerment education in self-management with Type 2 Diabetes Mellitus: A systematic review and meta-analysis
Yu-Di Cao, Ke-Jia Liu, Yue Hu , Li-Jiao Wei
92Medical Data Mining    2019, 2 (2): 56-65.   https://doi.org/10.12032/mdm2018016
Abstract PDF (1818KB)  
Objective: To evaluate the impact of empowerment education in self-management with Type 2 Diabetes Mellitus. Methods: A literature search was performed in PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), WanFang Data, CQVIP and China Biology Medicine disc (CBMdisc) and for randomized controlled trials published before November 2018. RevMan5.3 software was used for metaanalysis. Results: A total of 11 articles were included, involving 1139 patients. The group of empowerment education included 574 participants, and the regular education groups 565 participants. Meta-analysis showed that the group of empowerment education has an advantage over the control group in the levels of self-efficacy [MD= 17.55, 95%CI(14.14, 20.96), P<0.00001], self-management [SMD=0.85, 95%CI(0.60,1.11),P<0.00001] , as well as the effectiveness of short-term empowerment education(within 6 months ) on reducing HbA1c ( P<0.05); however failed to long-term empowerment education (beyond 12 months) (P= 0.05). Conclusion: This meta-analysis indicates that empowerment education can be an acceptable and appropriated nursing intervention for type 2 diabetes mellitus patients.
The application effect of swaddling bath in neonates: A meta-analysis
Hui-Ping Wang, Chang-De Jin
92Medical Data Mining    2019, 2 (2): 84-89.   https://doi.org/10.12032/mdm2018017
Abstract PDF (493KB)  
Objective: The meta-analysis is to objectively evaluate the efficacy of swaddling in neonates. Methods: Randomized controlled trials (RCTs) and Randomized cross-over design (RCD) about the effects of swaddling in neonates from multiple electronic databases (PubMed, Web of Science, the Cochrane Library, EMBASE, CINAHL,CNKI, Wanfang and VIP) until January 2019. Two investigators independently screened eligible studies, extracted data, and assessed the methodological quality by using the quality evaluation criteria for RCTs recommended by Cochrane Handbook. Then data were analyzed by Rev Man 5.3. Results: A total of 6 papers (4 randomized controlled trials and 2 Randomized cross-over design) with 318 participants were included. The meta-analysis indicated that there was a significant difference on Body Temperature, Heart Rate, crying time, incidence of open eyes and incidence of closed eyes (P<0.05); There was no significant difference in Spo2 level between the two groups (p>0.05). Conclusion: Swaddling bath has little influence on the Body Temperature, Heart Rate, and behavioral response of newborn. And it has no significant effect on maintaining Spo2 level. However it can reduce the stress behavior of the newborn. Due to the limitations of the quality of studies included, multi-centered randomized controlled trial large sample size are needed in the future to evaluate the effects of prone position ventilation on neonatal respiratory distress syndrome.
First page | Prev page | Next page | Last page Page 1 of 7, 61 articles found  

2019-nCoV

Annual Advances

TMR Data ExpandedMore

ScientistsMore

NoticesMore