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The efficacy and safety of Chinese herbal medicine combined with ACEI/ARB for treatment of incipient diabetic nephropathy: A meta-analysis
Qi-Yan Zheng, Wei-Jing Liu, Wei-Wei Sun, Yao-Xian Wang, Hong-Fang Liu, Lu-Ying Sun
2TMR Integrative Medicine    2018, 2 (1): 7-29.   https://doi.org/10.12032/TMRIM201802012
Abstract HTML PDF (1365KB)  

Objective: This meta-analysis evaluated the efficacy and safety of Chinese herbal medicine (CHM) combined with angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin-receptor blockers (ARBs)for treatment of incipient diabetic nephropathy(IDN). Methods: Nine data bases were searched for randomized controlled trials of Chinese herbal medicine(CHM) and ACEI/ARB for treatment of IDN. Included articles were published between January2006 and December 2016. All studies were divided into prescriptions containing both Astragali Radix and Rehmanniae Radix (i subgroup), Astragali Radix(Huangqi) or Rehmanniae Radix(Dihuang) (ii subgroup), neither Astragali Radix nor Rehmanniae Radix (iii subgroup). Review Manager 5.3was used for subgroup analysis. Results: In total, 28 RCTs with 2017 patients were included. The results showed 1)the urinary albumin excretion rate (UAER) can be reduced significantly using CHM with ACEI or ARB for treatment of IDN compared to ACEI or ARB alone, and reduction of the UAER of the i subgroup was superior to that of the other two subgroups;2)serum creatinine (Scr) levels can be reduced significantly using CHM combined with ACEI or ARB, and reduction of Scr in the ii subgroup was superior to that in the iii subgroup;3)reduction of BUN in group A was not better than that in group B. Conclusion: In summary, CHMs combined with ACEI/ARB can decrease UAER and Scr significantly compared to the use of ACEI/ARB during IDN treatment. The effect was more significant in the CHM group containing Astragali Radix or Rehmanniae Radix. The application of Astragali Radix and Rehmanniae Radix should be emphasized in third stage diabetic nephropathy.

Effect of the Tiaobufeishen decoction on Caveolin-1-p38 MAPK signaling pathway and mechanism of improving the tracheobronchomalacia in chronic obstructive pulmonary disease
Peng-Cheng Zhou, Wei Yu, Ke-Ling Chen, Wen-Jun Tang, Wei Xiao, Qian-Ming Xia, Jun-Mei Ma, Yan Dong
2TMR Integrative Medicine    2019, 3: e19002.   https://doi.org/10.12032/TMRIM201903002
Abstract HTML PDF (1147KB)  

Highlights:

Tiaobufeishen decoction could decrease the expression of the caveolin-1, p-p38, MMP3, inhibit the activation of the caveolin-1-p38MAPK signaling pathway.

Abstract

Objective: Reliving the relationship of the Caveolin-1-p38 MAPK signaling pathway and COPD tracheobronchomalacia, and research the mechanism of Tiaobufeishen decoction improve the regression of the weasand cartilage cells.Methods Flow cytometry was used to analyze the apoptosis rate to determine the optimal concentration of Tiaobufeishen decoction and CSE, CCK8 assay was used to determine the optimal concentration of P38-MAPK specific inhibitor. The COPD cell model was created by tracheal chondrocyte which dispose by optimal concentration CSE, then add the IL-1β set up the chondrocyte degeneration model, use the method of toluidine blue staining and immunohistochemical authenticate degeneration of cartilage. This research included control group, model group, model-Tiaobufeishen group, model-blocker group. When the model was set up succeed, add the Tiaobufeishen decoction and P38-MAPK blocker in the model-Tiaobufeishen and model-blocker groups, respectively. Western Blot was used to detect the expression of caveolin-1 and p-p38 in the chondrocyte. RT-PCR was used to detect the expression of MMP3 and caveolin-1 in the matrix.Results The cell activity was not influence by the concentration of Tiaobufeishen decoction and blocker, the concentration of the CSE model was moderation. Compared with control group, the level of caveolin-1, p38MAPK, MMP3 in the model group was significant increase, moreover, the result of toluidine blue staining and immunohistochemical methods show that the chondrocyte has obvious regression. The expression of caveolin-1, p38MAPK, and MMP3 have significant decrease than the control group, and the reduction of chondrocyte degeneration.Conclusion The caveolin-1-p38MAPK signaling pathway play an important role in the morbidity of the tracheobronchomalacia. Tiaobufeishen decoction could decrease the expression of the caveolin-1, p-p38, MMP3, inhibit the activation of the caveolin-1-p38MAPK signaling pathway, therefore, it can improve the tracheobronchomalacia.

Banxiashengjiangdaizheshi decoction combined with warm acupuncture in the treatment of 10 cases of postoperative gastroparesis of gastric cancer
Gang Ye
2TMR Integrative Medicine    2019, 3: e19007.   https://doi.org/10.12032/TMRIM201903007
Abstract HTML PDF (393KB)  

Highlights:

Banxiashengjiangdaizheshi decoction combined warm acupuncture have the function of invigorating stomach and removing turbid, warming yang and lowering reverse.

Abstract

Objective: To study the treatment of postoperative gastroparesis in patients with gastric cancer.Methods 18 patients with gastroparesis after gastric cancer surgery were divided into two groups, including 10 patients in the observation group and 8 patients in the control group. The observation group was treated with traditional Chinese medicine combined with warm acupuncture and moxibustion, and the control group was treated with western medicine.Results After 7 days treatment, there was significant difference in cure rate and total effective rate between the two groups (P < 0.01), and the treatment group was obviously superior to the control group.Conclusion Traditional Chinese medicine combined with warm acupuncture is effective in the treatment of postoperative gastroparesis of gastric cancer.

Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced non-small cell lung cancer: a meta-analysis
Qiang Zhang, Yi-Huan Fan, Teng Zhang, Xiao-Lan Qin, Ji-Fang Song
TMR Integrative Medicine    2017, 1 (2): 68-78.   https://doi.org/10.12032/TMRIM201701119
Abstract PDF (547KB)  
Objective: To evaluate the clinical efficacy of Shenqi Fuzheng injection combined with gemcitabine plus cisplatin (GP) in the treatment of advanced non-small cell lung cancer (NSCLC). Methods: we performed a systematic search in the electronic databases such as Cochrane Library, Pubmed, Embase, Chinese Journal Full-text Database, Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Full-text Database and Wanfang Database up to 30 January 2017. Randomized controlled trials (RCT) of Shenqi Fuzheng Injection combined with GP chemotherapy in the treatment of advanced NSCLC were searched, and all the RCTs were conducted on methodological quality assessment. Data extraction and data analysis were according to standards of Cochrane systematic review. Results: Eight trials were included including a total of 701 patients. Meta-analysis results: Shenqi Fuzheng injection combined with GP chemotherapy could significantly improve the functional status of patients with NSCLC (OR = 3.44, 95% CI [2.26, 5.25], P < 0.0001) and clinical treatment efficacy (OR = (OR = 0.31, 95%CI [0.20, 0.47], P < 0.0001. The rate of leukopenia (OR = .31, 95%CI [0.20,0.47], P < 0.0001), thrombocytopenia (OR = 0.58, 95%CI [0.37, 0.91], P = 0.020), hemoglobin decline ((OR = 0.31, 95%CI [0.16, 0.59], P = 0.0004) and incidence of gastrointestinal reactions (OR = 0.58,P < 0.05) could be reduced. Conclusion: Shenqi Fuzheng injection combined with GP chemotherapy in the treatment of advanced NSCLC obtained significantly clinical efficacy. The quality of the literature incorporated is low, the conclusion requires high-quality research to further prove.
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