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柴苓汤治疗 2 例儿童支原体肺炎的观察
李玉林
经典中医研究    2019, 2 (1): 14-17.   https://doi.org/10.12032/CCMR20190104
Abstract PDF (1206KB)  
目的 : 使用小柴胡汤合上五苓散(柴苓汤)治疗支原体肺炎。方法 : 小柴胡汤和解少阳枢机,五苓散通调三焦水道,从水液输布代谢链治疗支原体肺炎。结果 :2 例支原体肺炎患儿使用柴苓汤后,体温恢复正常,肌体不适感消除。结论 : 柴苓汤治疗支原体引发的儿童高热、咳嗽、肺炎疗效确切,合方有效
从伏邪与六经理论论治过敏性鼻炎
贾鲁栋, 李扬滔
经典中医研究    2019, 2 (2): 31-34.   https://doi.org/10.12032/CCMR20190203
Abstract PDF (627KB)  
过敏性鼻炎发病率呈逐年上升趋势,已成为严重影响人类健康及生活质量的隐患之一。 过敏性鼻炎多病情迁延不愈,反复发作。本文从伏邪和六经理探讨过敏性鼻炎的治疗。
Based on the process management of traditional Chinese medicine comprehensive intervention method on outcomes in patients with mild / moderate chronic obstructive pulmonary disease: study protocol for a practical randomized controlled trial
Ming Ren, Li-Ping Guo, Xiao Sun, Yang Qiao, Lei Chen, Lei Zhang, Yan Shao, Xiang-Li Han, Huai-Ying Ding, Jian-Mei Zhao
2TMR Integrative Medicine    2018, 2 (4): 197-201.   https://doi.org/10.12032/TMRIM201802035
Abstract HTML PDF (593KB)  

Highlights:

The practical randomized controlled trial reveal that the COPD patients will be benefit from therapy with Traditional Chinese medicine treatment.

Abstract

Background: The prevalence, morbidity and mortality of chronic obstructive pulmonary disease (COPD) is very high, so it has become a public health problem. The early stage of COPD has been paid much attention before it develops severely. As well, traditional Chinese medicine has some advantages in relieving symptoms and reducing the incidence of COPD exacerbations. Methods: A practical randomized controlled trial will be designed to test the clinical effects of traditional Chinese medicine treatment according to syndrome differentiation. A total of 80 patients with mild / moderate COPD will participate in this study, 40 in the treatment group and 40 in the control group. On the basis of the lifestyle intervention, traditional Chinese medicine formula granules for treatment group and the placebo simulation of traditional Chinese medicine granules for control group. The exacerbation and the improvement of pulmonary function will be used as the primary outcome measures. The improvement of clinical symptoms and signs, the quality of life and Dyspnea will be used as the secondary outcomes measures. Conclusion: We assume that the COPD patients will be benefit from therapy with Traditional Chinese medicine treatment.

Effect of the Tiaobufeishen decoction on Caveolin-1-p38 MAPK signaling pathway and mechanism of improving the tracheobronchomalacia in chronic obstructive pulmonary disease
Peng-Cheng Zhou, Wei Yu, Ke-Ling Chen, Wen-Jun Tang, Wei Xiao, Qian-Ming Xia, Jun-Mei Ma, Yan Dong
2TMR Integrative Medicine    2019, 3: e19002.   https://doi.org/10.12032/TMRIM201903002
Abstract HTML PDF (1147KB)  

Highlights:

Tiaobufeishen decoction could decrease the expression of the caveolin-1, p-p38, MMP3, inhibit the activation of the caveolin-1-p38MAPK signaling pathway.

Abstract

Objective: Reliving the relationship of the Caveolin-1-p38 MAPK signaling pathway and COPD tracheobronchomalacia, and research the mechanism of Tiaobufeishen decoction improve the regression of the weasand cartilage cells.Methods Flow cytometry was used to analyze the apoptosis rate to determine the optimal concentration of Tiaobufeishen decoction and CSE, CCK8 assay was used to determine the optimal concentration of P38-MAPK specific inhibitor. The COPD cell model was created by tracheal chondrocyte which dispose by optimal concentration CSE, then add the IL-1β set up the chondrocyte degeneration model, use the method of toluidine blue staining and immunohistochemical authenticate degeneration of cartilage. This research included control group, model group, model-Tiaobufeishen group, model-blocker group. When the model was set up succeed, add the Tiaobufeishen decoction and P38-MAPK blocker in the model-Tiaobufeishen and model-blocker groups, respectively. Western Blot was used to detect the expression of caveolin-1 and p-p38 in the chondrocyte. RT-PCR was used to detect the expression of MMP3 and caveolin-1 in the matrix.Results The cell activity was not influence by the concentration of Tiaobufeishen decoction and blocker, the concentration of the CSE model was moderation. Compared with control group, the level of caveolin-1, p38MAPK, MMP3 in the model group was significant increase, moreover, the result of toluidine blue staining and immunohistochemical methods show that the chondrocyte has obvious regression. The expression of caveolin-1, p38MAPK, and MMP3 have significant decrease than the control group, and the reduction of chondrocyte degeneration.Conclusion The caveolin-1-p38MAPK signaling pathway play an important role in the morbidity of the tracheobronchomalacia. Tiaobufeishen decoction could decrease the expression of the caveolin-1, p-p38, MMP3, inhibit the activation of the caveolin-1-p38MAPK signaling pathway, therefore, it can improve the tracheobronchomalacia.

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