Objective: A meta-analysis of randomized trials was performed to assess the injured degree of median nerve and sural nerve in patients with diabetic peripheral neuropathy (DPN).Methods: we searched Pubmed Database, China Biomedical Literature Database, VIP Database, ChinaNet for studies. Then evaluated these studies in order to find the researches in line with the requirements of the study; Each relevant research was carefully read to extract relevant data; The current perception threshold (CPT) value of median nerve and sural nerve were compared at 2000Hz, 250Hz and 5Hz between patients with DPN and the normal control group.Results: Finally 10 articles that meet the standards were included, with 1054 cases in the patient group and 719 cases in the normal group. The CPT values of median nerve and sural nerve at 2000 Hz, 250 Hz and 5 Hz of patients group were higher than those of normal control group (P<0.05 for all). Conclusion: Systematic reviews showed that the sensitivity of the median nerve and sural nerve in DPN patients was generally reduced. Sensory nerve quantitative detector could detect nerve damage early, accurately and monitor the effect treatment in patients with DPN.
Objective: This meta-analysis evaluated the efficacy and safety of Chinese herbal medicine (CHM) combined with angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin-receptor blockers (ARBs)for treatment of incipient diabetic nephropathy(IDN). Methods: Nine data bases were searched for randomized controlled trials of Chinese herbal medicine(CHM) and ACEI/ARB for treatment of IDN. Included articles were published between January2006 and December 2016. All studies were divided into prescriptions containing both Astragali Radix and Rehmanniae Radix (i subgroup), Astragali Radix(Huangqi) or Rehmanniae Radix(Dihuang) (ii subgroup), neither Astragali Radix nor Rehmanniae Radix (iii subgroup). Review Manager 5.3was used for subgroup analysis. Results: In total, 28 RCTs with 2017 patients were included. The results showed 1)the urinary albumin excretion rate (UAER) can be reduced significantly using CHM with ACEI or ARB for treatment of IDN compared to ACEI or ARB alone, and reduction of the UAER of the i subgroup was superior to that of the other two subgroups;2)serum creatinine (Scr) levels can be reduced significantly using CHM combined with ACEI or ARB, and reduction of Scr in the ii subgroup was superior to that in the iii subgroup;3)reduction of BUN in group A was not better than that in group B. Conclusion: In summary, CHMs combined with ACEI/ARB can decrease UAER and Scr significantly compared to the use of ACEI/ARB during IDN treatment. The effect was more significant in the CHM group containing Astragali Radix or Rehmanniae Radix. The application of Astragali Radix and Rehmanniae Radix should be emphasized in third stage diabetic nephropathy.
Copyright © TMR Publishing Group.
E-mail: | https://www.tmrjournals.com/im