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Reanalysis of Lymph node metastasis as predictor of the survival of patients with follicular variant papillary thyroid carcinoma:From SEER database 2004-2014
Jin Yang, Qing-Qing Liu, Hai-Rong He, Hai-Sheng You, Zhen-Yu Pan, Jun Lyu,
92Medical Data Mining    2019, 2 (1): 1-9.
Abstract PDF (524KB)  
Background: Follicular variant papillary thyroid carcinoma (FVPTC) is the most common subset of papillary carcinoma. Lymph-node metastasis (LNM) is one of the main predictors of survival in PTC patients, but we found few data related to the correlation between LNM and FVPTC. We therefore aimed to elucidate the relationship between LNM and survival in patients with FVPTC. Method: Logistic regression models were used to determine the factors associated with LNM. The Cox proportional-hazards model was applied to assess the association between LNM and disease-specific mortality. Kaplan-Meier survival analysis and the log-rank test were used to estimate the disease-specific survival rates in patients with and without LNM. Results: In total, 1418 FVPTC patients were identified. The multivariate logistic regression model showed that age, female sex, being married, tumor size > 4cm and extrathyroidal extension and radiation were predictors of LNM. The multivariate Cox regression model showed that age, multifocality and radiation were risk factors of disease-specific mortality. Especially, LNM (p=0.271) did not independently predict disease-specific mortality. Kaplan-Meier survival analysis and the log-rank method also showed that LNM did not impact survival in FVPTC (p=0.235). Conclusion: Using data in the SEER database from 2004 to 2014, and after multivariate model correction, we found that age, multifocality and radiation were strongly related to disease-specific mortality. It is worth noting that LNM does not impact the survival of FVPTC patients.
Clinical Medicine Characteristics Study of Traditional Chinese Medicine in the treatment of cancer pain based on Data Mining
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang,
92Medical Data Mining    2019, 2 (1): 39-49.
Abstract PDF (762KB)  
Objective: To explore the clinical characteristics of traditional Chinese medicine in the treatment of cancer pain based on traditional Chinese medicine inheritance support system (TCMISS). Methods: China Chinese CNKI database, VIP database, Wanfang database (1979 - 2017) were searched to get the prescriptions for cancer pain treatment. At last, 290 prescriptions were got and used to, set up the cancer pain prescriptions database, The route of administration, medicinal properties and drug use frequency were analyzed, and the rules of drug use were analyzed by mining rules such as association rules and complex system entropy clustering. Results: A total of 286 drugs were involved, and the association rules of drug properties, taste, meridian tropism, drug frequency and drugs were defined, and 20 core combinations and 10 new prescriptions were developed. Conclusion: The clinical medication rule of Chinese medicine for treating cancer pain has been excavated, and its reflected drug philosophy of "Tong" is the main, the emphasis is on pain relief, "tonic" is the main, the emphasis is on harmony, qi and blood are treated together, the emphasis is on dredging, antitumor analgesic, treatment of symptoms and root causes is equally important.
Literature Research on Drug Use Regulation of Miao Medicine in Suppression of Gastric Cancer
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang,
92Medical Data Mining    2019, 2 (1): 31-38.
Abstract PDF (472KB)  
Objective: To investigate the rule of medication used by Miao medicine to inhibit gastric cancer. Methods: Taking the coil named Miao Medicine of Chinese Materia Medica as data source, formulating "drug name" + "gastric cancer" or "drug name" + "stomach tumor" as the key words to search papers in China Knowledge Network, Weipu Chinese database, Wanfang database to gather drugs that have the effect of inhibiting gastric cancer, this paper made statistical analysis from the views of Wu Xing, Zou Guan, Ru Jia, Efficacy and Toxicity. Results: There are 81 kinds of drugs that suppress stomach cancer eligible for inclusion. And the Soil Xing medicines are the mainstay in the Wu Xing classification, accounted for 70.4%; the distribution of Zou Guan drugs are dominated by Middle and Interior Guan drugs which accounted for 87.7%; Every kinds of Jia group was involved in the distribution of Jiu Jia groups, but the Body Jia, abdomen Jia, Lung Jia and Cave Jia have the most frequent occurrences accounted for 66.9%; the efficacy distribution mainly includes antidote and tonification accounted for 71.6%; the toxicity distribution mostly is non-toxic drugs which is up to 70 kinds. Conclusion: Treating poison and tonifying body are mainly used in the treatment of gastric cancer in Miao medicine, with Middle and Interior Guan medicine, most of which are non-toxic drugs effective in disease location.
Association rules analysis of Fufang Kushen injection in combination with traditional Chinese medicine or modern medications in treating Cervical cancer: real-world retrospective study
Fu-Mei Liu, Yan-Ming Xie, Yin Zhang, Cen Chen, Chang Zhang, Yan Zhuang
92Medical Data Mining    2018, 1 (1): 2-9.
Abstract PDF (789KB)  

Objective: The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine ( TCM) or modern medications in treating cervical cancer (CC) based on the electrical medical records extracted from real-world hospital information system. Methods: The clinicians’ prescriptions regarding to the combination of  with TCM or modern medications were from hospital information system electronic medical data integration warehouse established by the Institute of Basic Medical Research of Chinese Medicine, China Academy of Chinese Medical Sciences, which integrated the hospital information system data of 22 hospitals. The association rules of the drug characteristics were analyzed through Apriori algorithm. Results: A total of 839 patients with CC were included.  We found that  is often combined with prescriptions which could clear heat, remove toxicity, supplement Qi.  also combined with chemotherapeutic drugs, immunomodulatory drugs, 5-HT receptor blockers, and glucocorticoids. The combination presents a specific law. Conclusion: Fufang Kushen injection combined with hepatoprotective drugs, immunomodulators and glucocorticoids is often used to treat cervical cancer. 

Traditional Chinese Medicine for Bladder Cancer: a Systematic Review and Meta-Analysis
Li-Hui Zhang, Yao Yang, Ying Chen, Guo-Wei Zhang
92Medical Data Mining    2018, 1 (2): 68-82.
Abstract PDF (689KB)  
Objective: To evaluate the efficacy and safety of traditional Chinese medicine in the treatment of bladder cancer. Methods: The databases of CNKI (1989-2018.10), Wan fang Data (1989-2018.10), VIP (1989-2018.10), PubMed (1966-2018.10), EMbase (1986- 2018.10) and Cochrane Library (3rd issue, 2018) were searched.. Evidence quality and rating recommendations were scored using the GRADE system. Results: Thirty-six eligible studies were included with 3,109 patients. The meta-analysis showed that the total effective rate OR combination =2.85[OR=2.85,95% CI(1.98,4.09),P<0.00001].Recurrence OR merge = 0.33 [OR=0.33, 95% CI (0.26,0.42), P<0.00001];Adverse reaction rate OR combination =0.37[OR=0.37, 95%CI(0.32,0.43), P<0.00001];Incidence of adverse reactions OR combination =0.41[OR=0.41, 95%CI(0.30,0.55), P<0.00001];Survival rate OR combination =1.78[OR=1.78, 95%CI(0.55, 5.77), P=0.34];Quality of life improvement rate OR consolidation =12.42[OR=12.42 95%CI(3.21,48.11), P=0.0003].The GRADE system evaluation results show that the evidence level is B and the recommendation level is weak. The traditional Chinese medicine group was superior to the control group in the efficiency rate, postoperative recurrence rate, incidence rate of adverse reactions, survival rate, quality of life improvement rate and incidence rate of toxic and side effects in the treatment of bladder cancer. Conclusion: Traditional Chinese Medicine has a good effect on treating bladder cancer and controlling recurrence of bladder cancer. Due to the impact of the original study on the results of meta-analysis, larger sample and high-quality clinical trials are still needed to verify.
经典中医研究    2018, 1 (1): 5-8.
Abstract PDF (668KB)  
吴门验方 “ 阳和散结汤 ” 治疗乳腺癌理论浅析
成艳丽 彭涛 张国华
经典中医研究    2018, 1 (1): 9-12.
Abstract PDF (861KB)  
乳腺癌是女性最高发的恶性肿瘤,其发病率逐年上升,严重危害女性身心健康。吴雄志教授从事中医临床工作近 20 年,对肿瘤疾病有深刻的认识,所拟吴门验方 阳和散结汤 注重乳腺癌的病因与病位,采用中西汇通的思想,提高了对乳腺癌的治疗效果。
中医治疗肺神经内分泌癌 1 例体会
经典中医研究    2018, 1 (1): 18-22.
Abstract PDF (738KB)  
孙迎春, 孙要强
经典中医研究    2019, 2 (1): 18-21.
Abstract PDF (3648KB)  
Xiaoaiping injection combined with cisplatin and gemcitabine for non-small cell lung cancer: a meta-analysis
Yue Ji
5TMR Clinical Research    2019, 2 (1): 27-36.
Abstract PDF (487KB)  
Objective: To evaluate the clinical efficacy of Xiaoaiping injection (XAPI) combined with cisplatin plus gemcitabine(regimen of GP)for patients with non-small cell lung cancer (NSCLC). Methods: A literature search was conducted for collecting the randomized controlled trials (RCTs) on NSCLC treated by Xiaoaiping injection and GP in the Cochrane Library, PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), China Science and Technology Journal Database (VIP) and the Wanfang Database from inception to December, 2018. The quality of the RCTs was evaluated by the Cochrane risk of bias assessment tool, and data analysis were performed with Review Manager 5.3. Results: A total of 7 randomized controlled trials with 534 patients were incorporated. The results showed that there is no statistical significance in total effective rate [OR = 1.39, 95%CI (0.97, 1.98), P = 0.07] and gastrointestinal reactions rate [OR = 0.44, 95%CI (0.16, 1.23), P = 0.12] between GP alone and XAPI combined with GP. In comparison with GP alone, the XAPI combined with GP was associated with the lower effects on the decrease rate of hemoglobin [OR = 0.49, 95%CI (0.26, 0.92), P = 0.03], leukocyte [OR = 0.40, 95% CI (0.21, 0.74), P = 0.004] and platelet [OR = 0.43, 95%CI (0.22, 0.87), P = 0.02]. However, performance status [OR = 3.78, 95% CI (2.24, 6.38), P < 0.0001]of patients in XAPI plus GP group is better than GP alone group. Conclusion: The combination of XAPI and GP has certain curative effect for patients with NSCLC compared with only receiving GP. However, more well-designedand multicenter RCTs should be performed to verify this result because of the quality of enrolled RCTs.
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