Objective:Antrodia camphorata (AC), a precious medicinal mushroom in Taiwan, is popularly used for adjuvant cancer therapy. This paper aims to clarify the metabolites which are present in tumor tissues after oral administration of AC in Sarcoma-180 tumor-bearing mice, as well as their contents in tumors. Methods:Tumors of Sarcoma-180 tumor-bearing mice were obtained at 1 h and 4 h after oral administration of AC extract, and the metabolites in the tumor homogenate samples were characterized using UHPLC-orbitrap/MS analysis. Then, a fully validated LC-MS/MS method was developed for quantitative analysis of the most abundant compounds in tumor tissues, namely (25R/S)-antcin H. Results:A total of 33 compounds were characterized in tumor homogenate samples including 28 prototypes of triterpenoids and 5 metabolites. Among them, (25R)-antcin H and (25S)-antcin H had the highest contents of 2.03 and 0.66 μg/g tumor tissues for the 1 h group, and 2.04 and 0.59 μg/g tumor tissues for the 4 h group, respectively. It was obvious that (25R)-antcin H had higher tumor affinity than (25S)-antcin H, since the content of (25R)-antcin H was lower than that of (25S)-antcin H in AC extract (P < 0.01). Conclusion:Triterpenoids can enter tumor tissues after oral administration of AC. Particularly, (25R)-antcin H showed higher exposure to tumor than (25S)-antcin H. These compounds could contribute to the anticancer activities of AC.
Metabolites of Antrodia camphorata in mice tumor tissues were profiled by UHPLC-orbitrap/MS analysis for the first time after oral administration, and a total of 33 compounds were characterized. The most abundant compounds in tumor tissues, namely (25R)-antcin H and (25S)-antcin H, were quantified by a fully validated LC-MS/MS method. The results indicated that (25R)-antcin H had higher tumor affinity than (25S)-antcin H.
Objective: To observe the clinical efficacy and safety of WenYang HuoXue Washing Prescription (WYHX) in the treatment of upper limb edema after breast cancer surgery. Methods: Seventy-eight patients with upper extremity edema after operation of breast cancer with Yin Syndrome were given wet compress with prescription and nursing guidance. The symptom score of affected extremity was observed before and 14 days after treatment, and the total effective rate was evaluated. Results: Twenty-three cases were markedly effective, 41 cases were effective and 14 cases were Invalid. The total effective rate was 82.1%. There was no significant difference between the two groups according to stage I and stage II of edema (P > 0.05). Conclusion: WYHX can effectively improve the discomfort symptoms of upper limb edema and cold after breast cancer surgery, and is worthy of clinical application.
WenYang HuoXue Washing prescription can effectively improve the discomfort symptoms of upper limb edema and cold after breast cancer surgery. The DASH score can be evaluated purely from the perspective of traditional Chinese medicine. The therapy can improve the discomfort symptoms such as arm swelling, pain and numbness to a certain extent without adverse reactions
Objective: Excavate the medication rule of traditional Chinese medicine in the treatment of prostate cancer, and predicting the biomolecular level mechanism of high-frequency drug compatibility. Methods: Relevant documents in CNKI, Wanfang Medical Network and VIP Chinese Biomedical Periodical Database Pubmed, EMbase were collected and collated systematically. Frequency statistics, association rule analysis and new party mining were carried out using TCMISSV2.5. BATMAN-TCM was used to analyze the interaction relationship and related pathways between high-frequency drug targets. Results: Huangqi (Astragalus membranaceus) was the single drug most used of the 102prescriptions included in the standard. There are 6 pairs of combinations with high confidence in association rule analysis. System entropy cluster analysis resulted in 20 core drug combinations and 9 new prescriptions. Through KEGG pathway analysis of Huangqi, Fuling (Poria cocos), Gancao (Glycyrrhiza uralensis) and Dihuang (Rehmannia glutinosa), it was found that the number of potential targets of the neural active ligand receptor rented pathway and purine metabolism pathway was the largest. Conclusions: Prostate cancer is mainly treated with deficiency-tonifying drugs, which are combined with drugs for promoting blood circulation, removing blood stasis, clearing heat, promoting diuresis, detoxifying and resolving hard mass. The mechanism of action of high-frequency traditional Chinese medicine may be realized by interfering with the neuroactive ligand receptor interaction pathway and purine metabolism pathway.
This article found that deficiency-tonifying drugs, which are combined with drugs for promoting blood circulation, removing blood stasis, clearing heat, promoting diuresis, detoxifying and resolving hard mass are commonly used to treat prostate cancer. Core herbs may play their role by interfering with the neuroactive ligand-receptor interaction pathway and purine metabolic pathway.
order to find a genetic marker to predict the prognosis of patients with
ovarian cancer based on multi-omics data. Methods: We download RNA-Seq
SNP, CNV data and clinical follow-up information from TCGA database and
randomly divide them into training set and test set. GSE17260 dataset in GEO is
taken as an external validation set. Prognosis-related genes, copy number
difference genes and mutant genes are screened in the training set. After the
integration of genes, the random forest algorithm is further used for feature
selection, ultimately obtaining a robust biomarker. On this basis, a
gene-related prognostic model is established and verified in the test set and
verification set. Results: We have obtained 2097 prognostic related
genes, 447 copy amplification genes, 1069 copy deletion genes and 654
significant mutations genes. Through the feature selection of random forest
algorithm, five feature genes (PSMB1, COL6A6, SLC22A2, KLHL23 and CD3G) are
obtained by integrating these genes, some of which have been reported to be
related to tumor progress. Furthermore, the prognostic risk assessment model of
5-gene signature is established by Cox regression analysis. The model can
evaluate the risk of patient samples in training set, test set and external
verification set. 5-gene signature shows strong robustness and clinical
independence. The results of GSEA analysis also show that the pathway of 5-gene
signature enrichment is significantly related to the pathway and biological
process of the occurrence and development of ovarian cancer. Conclusion: In
this study, 5-gene signature is constructed as a new prognostic marker to
predict the survival of patients with ovarian cancer.
This article designed updated systematic review to comprehensively establish the efficacy of progressive muscle relaxation for the prevention and alleviation of chemotherapy-induced nausea and vomiting among cancer patients.
Progressive muscle relaxation reduces anxiety and fatigue, and progressive muscle relaxation exercise has been widely applied to prevent and alleviate the toxic resulted from chemotherapy.
Background and aim: Progressive muscle relaxation (PMR) is one of the most common complementary and alternative therapies. Published systematic review unfolded that PMR has a positive impact on chemotherapy-induced nausea and vomiting among adult cancer patients. However, the pooled findings were not reliable and valid because included trials have poor quality. It must be noted is that additional studies with good quality have been published recently. So, we design this updated systematic review to comprehensively establish the efficacy of PMR for the of chemotherapy-induced nausea and vomiting among cancer patients.Methods: We will search PubMed, Cochrane Controlled Register of Trial (CENTRAL), Cumulative Index to Nursing and Allied Health Literature (CINAHL), China Biomedical Literature database (CBM), China National Knowledge Infrastructure (CNKI), and Wanfang data to capture all potential items. Data extraction sheet will be used to extract all essential information, the Cochrane risk of bias assessment tool will be utilized to appraise the risk of bias of eligible studies. Finally, a quantitative analysis will be performed if sufficient data were obtained. In contrast, a qualitative analysis will be used to summarize the results of all included studies. Ethics and dissemination: Ethics approval and patient written informed consent will not be required because all of the analyses in the present study will be performed based on data from published studies. We will submit our systematic review and network meta-analysis to a peer reviewed scientific journal for publication.
This article systematically evaluates the effect of cognitive behavioral therapy on cancer-related fatigue in breast cancer patients, and showed that cognitive behavioral therapy can alleviate the harm caused by cancer-related fatigue.
Cognitive behavioral therapy is a psychotherapy method which can change the cognitive orientation of patients. The results of this systematic review indicate that CBT can alleviate cancer-related fatigue in breast cancer patients to a certain extent.
Objective: To evaluate the effect of cognitive behavioral therapy on cancer-related fatigue in breast cancer patients. Methods: Computer search for CNKI, VIP, Wanfang database, CBM, PubMed, Embase, CINAHL, The Cochrane library as of 2019 randomized controlled trials on October 20 for cognitive behavioral therapy intervention for breast cancer due to fatigue. Results: A total of 6 RCTs were included, 472 patients. Cognitive Behavioral Therapy has a strong effect on cancer related fatigue compared with the usual care [SMD = -1.19, 95% CI (-1.86, -0.53), P = 0.0004]. Results: Available evidence suggests that CBT can alleviate cancer-related fatigue in breast cancer patients, and the above studies still need to continue to conduct relevant studies for validation.
Backgroud: Summarize the formula rule of traditional Chinese
medicine for preventing and treating bladder cancer recurrence after operation
and explore the molecular mechanism of core medicines. Methods: Literatures collected from CNKI, Wanfang Med Online, CMJD,
PUBMED and Elsiver databases were as prescription sources, and association
rules and complex system entropy clustering analysis were carried out using the
Traditional Chinese Medicine Inheritance Support System (TCMISSV2.5).
BATMAN-TCM online analysis tool was used to construct target-pathway-disease
correlation map to reveal the potential mechanism of action. Results: A
total of 122 prescriptions were eligible for data analysis. The high-frequency
traditional Chinese medicines are Poria, Radix et Rhizoma Rhei, Radix Astragali, Herba Hedyotidis
Diffusae and Rhizoma Atractylodis Macrocephalae. The high-frequency
drug pairs are Rhizoma Atractylodis
Macrocephalae/Poria, Poria/Rhizoma Alismatis, Radix Astragali/Rhizoma Atractylodis Macrocephalaeand and Herba Hedyotidis Diffusae/Herba Scutellariae Darbatae..
There are 5 groups of drug pairs with high correlation strength. Cluster
analysis shows 6 core drug combinations and 3 new prescriptions. In clinical
practice, the core compatibility of traditional Chinese medicines for preventing
postoperative recurrence of bladder cancer is Poria, Radix Astragali and Herba Hedyotidis Diffusae. The possible
signaling pathways are the neuroactive ligand receptor interaction signaling
pathway and calcium signaling pathway. Conclusion: Prevention and
treatment of postoperative recurrence of bladder cancer mainly use medicines
with effects of eliminating dampness and diuresis for removing edema,
heat-clearing and detoxifying, and qi-invigorating. The potential mechanism of
the compatibility of core drugs may be realized by interfering with the signal
pathway of neuroactive ligand receptor interaction and calcium signal pathway.
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