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Non-drug interventions for cancer-related fatigue: an updated review
Yan-Qiu Huang, Guo-Zhi Yang, Chang-De Jin, Sheng Gao
9TMR Non-Drug Therapy    2019, 2 (2): 42-47.   https://doi.org/10.12032/TMRND201902009
Abstract HTML PDF (579KB)  

Highlights

With the characters of easy operation, no damage and significant therapeutic effects, non-drug intervention for cancer-related fatigue can enhance drug therapeutic effects, improve life quality, reduce the financial burden of patients as well. Non-drug interventions are recommended for treating cancer related-fatigue.

Editor’s Summary

This paper reviews the effects of some non-drug interventions on cancer-induced fatigue. Non-drug interventions can improve the physical condition of patients, establish the confidence to overcome the disease, thereby reducing the severity of fatigue in cancer patients. The combination of drug treatment and non-drug intervention should be used to help patients to obtain the best therapeutic effects.

Abstract

Non-drug interventions are easy operation, no damage and with significant therapeutic effects for cancer-related fatigue (CRF), which also can reduce the economic burden of cancer patients and improve the quality of life. This paper reviews the effects of non-drug interventions on CRF including exercise intervention, long distance healthy education, cognitive behavior intervention, traditional Chinese medicine intervention and emotional intervention to provide reference for clinical medical staff and relevant scholars. These non-drug intervention can enhance the therapeutic effects of conventional medicine, improve life quality and reduce the financial burden of patients with CRF. However, non-drug intervention for patients with CRF is only an adjuvant treatment method, and it can not completely replace conventional medicine treatment. The combination of conventional medicine treatment and non-drug intervention should be used to help patients with CRF to obtain the best therapeutic effects.

Effects of moxibustion on cancer-related fatigue: a meta-analysis
Yuan Jia, Si-Yuan Yang, Li-Min Guo, Xue Bai, Ya-Nan Wang, Fan-Jie Meng
9TMR Non-Drug Therapy    2019, 2 (2): 62-70.   https://doi.org/10.12032/TMRND201902013
Abstract HTML PDF (910KB)  

Highlights

Moxibustion can improve cancer-related fatigue (CRF) and enhance immune function. With the advantages of simplicity, convenient, efficacy, inexpensiveness, and lack of side effects, moxibustion appeared to be efficacious auxiliary therapeutic method for CRF.

Editor’s Summary

The conclusion has some limitations as there exist few but rigorous randomized controlled trials and no trials in English, they were all from China. Much more high-quality studies with adequate design and power are in need urgently to confirm the therapeutic value of moxibustion for cancer-related fatigue profoundly.

Abstract

Objective: To systematically evaluate the efficacy of moxibustion in the treatment of cancer-related fatigue (CRF). Methods: Randomized controlled trials (RCTs) using moxibustion to treat cancer-related fatigue in Cochrane Library, PubMed, China Knowledge Network, Wanfang and VIP databases were searched. Two reviewers independently searched, reviewed the literature, extracted data, and evaluated the methodological quality. RevMan5.3 software was used for meta-analysis. Results: A total of 942 patients were included in 11 RCTs. The meta-analysis results showed that moxibustion can reduce fatigue score [MD = -2.04, 95% CI (-4.06, -0.33), P < 0.001], improve the score of quality of life QLQ-C30 [(MD = 8.44, 95% CI (1.85, 15.03), P < 0.001], also boost the number of differentiation antigen of T cells , such as CD3 [MD = 7.82, 95% CI (3.14, 12.49), P = 0.01], CD8 [MD = -3.15, 95% CI (-11.36, 5.06), P < 0.001], and the number of NK cells [MD = 5.88, 95% CI (3.56, 8.20), P = 0.01].Conclusion: Moxibustion can improve the degree of CRF, improve the quality of life and enhance immune function.

The effects of TCM nursing intervention on the life quality of cancer patients with pain: a review of recent research
Pei-Yao Li, Yun-Lan Jiao, Chun-Hua Zhang, Ling Wang, Wen-Wen Zhao, Hui-Xin Ding, Chun-Guang Yu
9TMR Non-Drug Therapy    2019, 2 (2): 55-61.   https://doi.org/10.12032/TMRND201902007
Abstract HTML PDF (544KB)  

Highlights

As a complementary and alternative therapy to Western analgesics, traditional Chinese medicine nursing has unique advantages in relieving pain in patient with cancer and can effectively improve quality of life.

Editor’s Summary

The conventional analgesics are selected to relieve pain in patient with cancer; however, their adverse reactions seriously affect the patient’s quality of life (QOL). Traditional Chinese medicine nursing can improve clinical symptoms and QOL through massage, external treatment of Chinese herbs, auricular therapy, etc. as well as reduce the toxic side effects of analgesics, making it worthy of clinical popularization and application.

Abstract

Tumor pain is common in patients with advanced cancer, 70-80 % have varying degrees of pain. Treatment of cancer pain has become a difficult issue in oncology, poor pain control often seriously affects the patients' quality of life (QOL). Traditional Chinese medicine (TCM) nursing intervention can improve symptoms and QOL through massage, external treatment of TCM, and auricular therapy, which have unique curative effects such as regulating Qi (a vital force that forms part of living entity in traditional Chinese culture) and blood, stabilizing the mind, and enhancing immunity. Not only does TCM nursing intervention prevent disease but also cultivates the mind, helps achieve systemic relaxation, and reduces the pain of cancer patients and the toxic side effects of painkillers, so as to improve QOL and satisfaction, making it worthy of clinical popularization and application. At present, there is an urgent need to carry out high-quality, multi-center, large-sample randomized controlled trials and develop a standardized TCM nursing intervention implementation scheme and efficacy standards to promote its application.

Kinesio tape in the treatment of postoperative lymphedema of breast cancer
Fu-Yu Leng, Zhu Yang, Feng-Xi Long, Li Luo, Wen-Yu Wu, Dong-Xin Tang
9TMR Non-Drug Therapy    2019, 2 (2): 36-41.   https://doi.org/10.12032/TMRND201902011
Abstract HTML PDF (607KB)  

Highlights

Kinesio tape has the advantages of convenient use, short operation time without affecting the mobility of limb, long curative effects and less side-effects and good patient's compliance. It is a new treatment for patients with lymphedema after breast cancer surgery.

Editor’s Summary

This paper analyzes the effects of Kinesio tape on breast cancer postoperative lymphedema, which will provide evidences for its clinical effects on lymphedema limbs. Kinesio tape has the advantages of short cure period, no pain, not easy to be repeated, economical, convenient and easy to operate, without any effects on limbs mobility. Kinesio taping has become a very popular treatment for several health conditions over the last decade. However, when choosing intramuscular patch to treat lymphedema after breast cancer surgery, strict screening should be carried out to prevent adverse effects caused by inferior products from aggravating diseases.

Abstract

The Kinesio tape, originally developed by Dr. Kenzo Kase, a Japanese chiropractor, was used for pain of joint and muscle. The elastic tape is capable of stretching up to 130-140% of its resting static length ensuring free mobility of the applied muscle or joint. It is claimed that Kinesio tape supports injured muscles and joints and helps relieve pain by lifting the skin and allowing improved blood and lymph flow. Therefore, Kinesio Taping has become a very popular treatment for several health conditions over the last decade. Nowadays, lymphatic drainage is a new function of Kinesio taping in the field of physical therapy. This article explores the application of Kinesio tape in breast cancer-related lymphedema in order to provide a new treatment for patients with lymphedema after breast cancer surgery.

Prevention and treatment of traditional Chinese medicine for elderly patients with colorectal cancer
Jia Wang, Zhu Yang, Feng-Xi Long, Jin-Lin Wu, Ting Yu, Xian-Man Wei, Xun Liu, Dong-Xin Tang
2TMR Integrative Medicine    2019, 3: e19016.   https://doi.org/10.12032/TMRIM201903016
Abstract PDF (436KB)  
As China's population ages, the incidence of colorectal cancer in the elderly has increased. At present, colorectal cancer depends on surgery, radiotherapy and chemotherapy. Due to the characteristics of the elderly, postoperative recovery is slow, prone to postoperative complications and difficult to tolerate radiotherapy and chemotherapy have become the main problem hindering the disease. Based on the theory of prevention, the use of drugs from the perspective of constitution and etiology can prevent the occurrence of colorectal cancer in the elderly. Traditional Chinese medicine (TCM) combined with radiotherapy and chemotherapy can alleviate adverse reactions and improve treatment efficacy. TCM with surgical treatment can reduce the occurrence of postoperative complications and promote postoperative recovery. For patients with advanced colorectal cancer, TCM can play a role in fighting cancer and improving the quality of life of patients. For patients in stable phase, TCM can prevent tumor recurrence and metastasis.
Traditional Chinese non-drug therapies for cancer pain treatment
Xun Liu, Zhu Yang, Feng-Xi Long, Jin-Lin Wu, Dong-Xin Tang
2TMR Integrative Medicine    2019, 3: e19017.   https://doi.org/10.12032/TMRIM201903017
Abstract PDF (293KB)  

Cancer pain is the most common and serious symptom of cancer, which seriously affects the quality of life of cancer patients. the most widely used three-step analgesia has received good effects, but the toxic side effects at the same time can be ignored. As a complementary therapy increasingly accepted around the world, traditional Chinese medicine (TCM) also plays an important role in cancer pain treatment. Traditional Chinese non-drug therapy has a good effect for cancer pain. In this mini-review, the commonly used traditional Chinese non-drug therapies such as acupuncture, moxibustion, acupoint catgut embedding and injection, massage, ear point pressing with coxherb seeds therapy, traditional music therapy were introduced.

Reanalysis of Lymph node metastasis as predictor of the survival of patients with follicular variant papillary thyroid carcinoma:From SEER database 2004-2014
Jin Yang, Qing-Qing Liu, Hai-Rong He, Hai-Sheng You, Zhen-Yu Pan, Jun Lyu,
92Medical Data Mining    2019, 2 (1): 1-9.   https://doi.org/10.12032/mdm2018011
Abstract PDF (524KB)  
Background: Follicular variant papillary thyroid carcinoma (FVPTC) is the most common subset of papillary carcinoma. Lymph-node metastasis (LNM) is one of the main predictors of survival in PTC patients, but we found few data related to the correlation between LNM and FVPTC. We therefore aimed to elucidate the relationship between LNM and survival in patients with FVPTC. Method: Logistic regression models were used to determine the factors associated with LNM. The Cox proportional-hazards model was applied to assess the association between LNM and disease-specific mortality. Kaplan-Meier survival analysis and the log-rank test were used to estimate the disease-specific survival rates in patients with and without LNM. Results: In total, 1418 FVPTC patients were identified. The multivariate logistic regression model showed that age, female sex, being married, tumor size > 4cm and extrathyroidal extension and radiation were predictors of LNM. The multivariate Cox regression model showed that age, multifocality and radiation were risk factors of disease-specific mortality. Especially, LNM (p=0.271) did not independently predict disease-specific mortality. Kaplan-Meier survival analysis and the log-rank method also showed that LNM did not impact survival in FVPTC (p=0.235). Conclusion: Using data in the SEER database from 2004 to 2014, and after multivariate model correction, we found that age, multifocality and radiation were strongly related to disease-specific mortality. It is worth noting that LNM does not impact the survival of FVPTC patients.
Clinical Medicine Characteristics Study of Traditional Chinese Medicine in the treatment of cancer pain based on Data Mining
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang,
92Medical Data Mining    2019, 2 (1): 39-49.   https://doi.org/10.12032/mdm2018014
Abstract PDF (762KB)  
Objective: To explore the clinical characteristics of traditional Chinese medicine in the treatment of cancer pain based on traditional Chinese medicine inheritance support system (TCMISS). Methods: China Chinese CNKI database, VIP database, Wanfang database (1979 - 2017) were searched to get the prescriptions for cancer pain treatment. At last, 290 prescriptions were got and used to, set up the cancer pain prescriptions database, The route of administration, medicinal properties and drug use frequency were analyzed, and the rules of drug use were analyzed by mining rules such as association rules and complex system entropy clustering. Results: A total of 286 drugs were involved, and the association rules of drug properties, taste, meridian tropism, drug frequency and drugs were defined, and 20 core combinations and 10 new prescriptions were developed. Conclusion: The clinical medication rule of Chinese medicine for treating cancer pain has been excavated, and its reflected drug philosophy of "Tong" is the main, the emphasis is on pain relief, "tonic" is the main, the emphasis is on harmony, qi and blood are treated together, the emphasis is on dredging, antitumor analgesic, treatment of symptoms and root causes is equally important.
Literature Research on Drug Use Regulation of Miao Medicine in Suppression of Gastric Cancer
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang,
92Medical Data Mining    2019, 2 (1): 31-38.   https://doi.org/10.12032/mdm2018013
Abstract PDF (472KB)  
Objective: To investigate the rule of medication used by Miao medicine to inhibit gastric cancer. Methods: Taking the coil named Miao Medicine of Chinese Materia Medica as data source, formulating "drug name" + "gastric cancer" or "drug name" + "stomach tumor" as the key words to search papers in China Knowledge Network, Weipu Chinese database, Wanfang database to gather drugs that have the effect of inhibiting gastric cancer, this paper made statistical analysis from the views of Wu Xing, Zou Guan, Ru Jia, Efficacy and Toxicity. Results: There are 81 kinds of drugs that suppress stomach cancer eligible for inclusion. And the Soil Xing medicines are the mainstay in the Wu Xing classification, accounted for 70.4%; the distribution of Zou Guan drugs are dominated by Middle and Interior Guan drugs which accounted for 87.7%; Every kinds of Jia group was involved in the distribution of Jiu Jia groups, but the Body Jia, abdomen Jia, Lung Jia and Cave Jia have the most frequent occurrences accounted for 66.9%; the efficacy distribution mainly includes antidote and tonification accounted for 71.6%; the toxicity distribution mostly is non-toxic drugs which is up to 70 kinds. Conclusion: Treating poison and tonifying body are mainly used in the treatment of gastric cancer in Miao medicine, with Middle and Interior Guan medicine, most of which are non-toxic drugs effective in disease location.
Association rules analysis of Fufang Kushen injection in combination with traditional Chinese medicine or modern medications in treating Cervical cancer: real-world retrospective study
Fu-Mei Liu, Yan-Ming Xie, Yin Zhang, Cen Chen, Chang Zhang, Yan Zhuang
92Medical Data Mining    2018, 1 (1): 2-9.   https://doi.org/10.12032/mdm2018001
Abstract PDF (789KB)  

Objective: The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine ( TCM) or modern medications in treating cervical cancer (CC) based on the electrical medical records extracted from real-world hospital information system. Methods: The clinicians’ prescriptions regarding to the combination of  with TCM or modern medications were from hospital information system electronic medical data integration warehouse established by the Institute of Basic Medical Research of Chinese Medicine, China Academy of Chinese Medical Sciences, which integrated the hospital information system data of 22 hospitals. The association rules of the drug characteristics were analyzed through Apriori algorithm. Results: A total of 839 patients with CC were included.  We found that  is often combined with prescriptions which could clear heat, remove toxicity, supplement Qi.  also combined with chemotherapeutic drugs, immunomodulatory drugs, 5-HT receptor blockers, and glucocorticoids. The combination presents a specific law. Conclusion: Fufang Kushen injection combined with hepatoprotective drugs, immunomodulators and glucocorticoids is often used to treat cervical cancer. 

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