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3TMR Integrative Nursing  2017, Vol. 1 Issue (2): 36-44    DOI: 10.12032/TMRIN20171203
Original Research     
The effect of traditional Chinese medicine washing combined with massage for neonatal jaundice: a meta-analysis
Li Wanga, Ting Shuaib, Yun-Yun Wanga, Hong Caoc*()
aGraduate College, Tianjin University of Traditional Chinese Medicine, Nankai District, Tianjin, China. bSchool and Hospital of Stomatology, Peking University, Beijing, China. cDepartment of Osteoporosis Internal Medicine, Tianjin Hospital, Hexi District, Tianjin, China.
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Highlights

This meta-analysis systematically evaluated the efficacy of TCM washing combined with massage for neonatal jaundice, and showed TCM washing combined with massage can accelerate the excretion of meconium, shorten the time for transformation of meconium, and decrease transcutaneous bilirubin index and the level of serum bilirubin.

Editor’s Summary

TCM washing combined with massage is one of the common therapies avoiding the side effects of common treatments. However, the potential of TCM washing combined with massage remains debate. This article found that TCM washing combined with massage may be an effective therapy for the treatment of neonatal jaundice.

ABSTRACT

Objective: To systematically assess the effect of traditional Chinese medicine washing (TCM washing) combined with massage for the treatment of neonatal jaundice. Methods and analysis: Databases, including PubMed, the Cochrane Library, Embase, Web of Science, the Chinese Biomedical Literature Database (CBM), CNKI, and Wanfang Data were electronically searched for randomized controlled trials (from inception to July 2017). The methodological qualities of included trials were evaluated by the Cochrane risk of bias assessment tool. The meta-analysis was performed by using RevMan 5.3 software.Results: Overall, thirteen trials with a total of 1998 participants were included. The results of meta-analysis indicated that TCM washing combined with massage group was significantly superior to the control group in the first meconium time (MD, -16.67; 95% CI, -24.59 to -8.74; P<0.001), time for transformation of meconium (MD, -15.44; 95% CI, -23.59 to -7.28; P<0.001), transcutaneous bilirubin index changes [after treating three days (MD, -1.99; 95% CI, -2.57 to -1.40; P<0.001), after treating four days (MD, -1.86; 95% CI, -2.77 to -0.95; P<0.001), after treating five days (MD, -2.44; 95% CI, -3.47 to -1.42; P<0.001), after treating six days (MD, -2.23; 95% CI, -3.30 to -1.16; P<0.001), and the changes of serum bilirubin levels [after treating five days (MD, -3.17; 95% CI, -5.83 to -0.50; P=0.02), after treating six days (MD, -1.63; 95% CI, -3.10 to -0.16; P=0.03), after treating fifteen days (MD,-1.20; 95% CI, -1.99 to -0.41; P=0.003).Conclusions: TCM washing combined with massage may be an effective therapy for the treatment of neonatal jaundice. It can accelerate the excretion of meconium, shorten the time for transformation of meconium, and decrease transcutaneous bilirubin index and the level of serum bilirubin. But it should be careful to interpreting these findings. Well-designed RCTs are needed to further clarify the conclusion.



Key wordsTraditional Chinese medicine washing      Massage      Neonatal jaundice      Meta-analysis     
Received: 12 September 2017      Published: 15 January 2018
Corresponding Authors: Cao Hong     E-mail: caohong1968@yeah.net
About author: These authors have contributed equally to this work as first author.
Cite this article:

Li Wang, Ting Shuai, Yun-Yun Wang, Hong Cao. The effect of traditional Chinese medicine washing combined with massage for neonatal jaundice: a meta-analysis. 3TMR Integrative Nursing, 2017, 1(2): 36-44. doi: 10.12032/TMRIN20171203

URL:

https://www.tmrjournals.com/in/EN/10.12032/TMRIN20171203     OR     https://www.tmrjournals.com/in/EN/Y2017/V1/I2/36

Figure 1 Flow diagram of literature retrieval and study selection
Study Gestational age (weeks) Number Interventions Outcomes
T
(M/F)
C
(M/F)
Study group (T) Control group (C)
Yang 2017 T:38.1±1.5
C:38.7±1.7
40/22 41/26 Bathing in TCM decoction combined with abdominal massage plus routine therapy Routine therapy ①④
Shao et al 2013 T:37.5±4.3
C:37.7±4.6
35/25 32/28 Herbal hydrotherapy and massage plus routine therapy Routine therapy ③④
Chen et al 2009 T:39.52±1.13
C:39.16±1.36
140/140 138/142 Bathing in TCM water combined with massage Bathing in pure water ②③
Chen 2009 T:37~42
C:37~42
52 48 TCM bath combined with massage plus phototherapy Phototherapy
Du et al 2015 T:39.5±1.31
C:39.5±1.28
85/65 80/70 TCM bath combined with massage Bathing in pure water ①②
Chen et al 2014 T:38.92±1.73
C:38.75±1.75
14/16 16/14 TCM bath combined with massage plus routine therapy Routine therapy
Wen 2011 T:38~42
C:38~42
60 60 Swimming in TCM decoction combined with massage Swimming in pure water ②③
He 2013 T:37~41
C:37~41
27/23 26/24 TCM bath combined with abdominal massage plus basic nursing Basic nursing ①②③
Li et al 2009 n.a.
n.a.
100 100 Swimming in TCM decoction combined with massage plus routine therapy Routine therapy ①③
Feng et al 2015 T:39.1±1.3
C:38.9±1.36
23/20 25/21 TCM bath combined with massage plus routine therapy Routine therapy
Zhang et al 2011 T:37~42
C:37~42
60 60 Swimming in TCM decoction combined with massage Oral Yinzhihuang injection combined with BTT
Duan 2015 T:38.71±1.24
C:39.14±1.27
18/12 19/11 TCM bath combined with massage Oral Yinzhihuang Granules ①②
Wei et al 2016 T:37.21±3.71
C:36.82±4.68
12/8 14/16 TCM washing combined with massage plus routine therapy Routine therapy
T = treatment group; C = control group; M = male; F = female; BTT = Bifidobaeterium tetravaccine table; ① = first meconium time; ② = time for transformation of meconium; ③ = transcutaneous bilirubin index changes; ④ = the changes of serum bilirubin levels.
Table 1 Basic characteristics of the included studies
Figure 2 Risk of bias summary: review authors' judgements about each risk of bias item for each included study
Figure 3 Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies
Figure 4 Meta-analysis of first meconium time
Figure 5 Meta-analysis of time for transformation of meconium
Figure 6 Meta-analysis of transcutaneous bilirubin index changes
Figure 7 Meta-analysis of the changes of serum bilirubin levels
Figure 8 Funnel plot for assessing publication bias
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