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90Life Research  2018, Vol. 1 Issue (2): 51-56    DOI: 10.12032/life2018-0811-004
The relationship between the gender difference of depression and the polymorphism of AC-cAMP-PKA-CREB
Xiaobin Meng1,*(), Bo Zhao1
1Guiyang College of Traditional Chinese Medicine, Guiyang, 550002, China.
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According to the study, 5-HT mediated AC-cAMP-PKA-CREB is associated with the onset of depression. In recent years, many researchers have expounded the pathogenesis of depression from the perspective of genetic polymorphism. Depression incidence has obvious gender differences, but its mechanism is not clear. Is depression genetically determined? Or does it result from one or more pathological determinants pathological? Which one is more important? On the basis of previous studies, the 5-HT mediated AC-cAMP-PKA-CREB pathway on four protein (5-HT1AR, 5-HT2AR, BDNF, TrkB) whose gene polymorphism and expression may be the keys. Further, 5-HT mediated AC-cAMP-PKA-CREB signaling pathway may be related to Gender differences in depression, so their gene polymorphism variation may provide new ideas for the research on gender differences in depression.

Received: 25 July 2018      Published: 25 October 2018
Corresponding Authors: Meng Xiaobin   
Cite this article:

Xiaobin Meng, Bo Zhao. The relationship between the gender difference of depression and the polymorphism of AC-cAMP-PKA-CREB. 90Life Research, 2018, 1(2): 51-56.


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Figure 1. Signal molecule affects the depression through the activation of these main signaling pathways. Growth factor bind to their receptors in order to promote the main signaling pathways: the MAPK/ERK and the PI3-Ksignaling cascades. Once activated, they stimulate neuroplasticity, such as neuronal survival, growth, and differentiation. An status of cellular nutrient and energy levels is likely to induce antidepressant effects. BDNF, brain-derived neurotrophic factor; TrkB, tropomyosin-related kinase receptor B; FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; TNF Tumor necrosis factor; 5-HT 5-hydroxytryptamine; 5-HTR, 5-hydroxytryptamine receptor.
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