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Effects of music therapy in depression and anxiety disorder
Ednaldo Antonio dos Santos, Esperanza Marchant Sanchez, Maria Angeles Niguez Ortiz, Maria Amparo Oliver Germes
90Life Research    2019, 2 (2): 64-70.   https://doi.org/10.12032/life2019-0425-003
Abstract ( 1042 HTML PDF (1019KB) ( 365 )  

Mental disorders are considerate "the evil of the century" by renowned researchers, because a large part of the population in many countries is a diagnosticated, and currently affect youth and children. Among the numerous therapeutic interventions, the music therapy is a non-invasive approach. However, there are very few people who are professionally engaged in research and studies on the subject. Therefore, this article is a literature to talk about the benefits of music therapy sessions for people with stress, depression and anxiety disorders.

A darkfield microscopic evaluation of the live blood effects caused by Moringa oleifera
Howard W. Fisher, Colombe Gauvin
90Life Research    2019, 2 (3): 87-92.   https://doi.org/10.12032/life2019-0725-002
Abstract ( 561 HTML PDF (5462KB) ( 118 )  

Erythrocyte aggregation is the tendency of erythrocytes to form aggregates whose shapes change according to normal variations or pathological conditions. Consequently, regardless of cause, these anomalies effect changes to flow dynamics and predispose the inability to carry out transportation activities and decrease functional capillary density or decrease erythrocyte surface area, also decreasing functional efficiency. Functional capillary density is the determination of the number of capillaries in an area that have erythrocyte flow and relates to the subsequent ability of the blood to deliver nutrients, fluid and solute exchange, and waste product excretion. Red blood cell aggregation has a significant impact on functional capillary density. Moringa oleifera, one of the most phytonutrient dense plants as identified by the NIH, has garnered interest by those involved with anti-aging medicine. The US National Institutes of Health, the nation’s medical research agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability, has affirmed Moringa oleifera can “arrest, reverse, and cure, over 300 different diseases and disorders.” Regular use of Moringa oleifera has been shown to have a multitude of health benefits. In addition to this, Moringa oleifera provides all of the essential amino acids, vital vitamins, contains several important minerals, is an incredibly powerful antioxidant, is high in fiber, stimulates the immune system to fight cancerous cells, tumours, ulcers, epileptic seizures and cleanses and detoxifies the entire body. Moringa oleifera has been shown to protect platelets against aggregation. In this investigation, live blood microscopic evaluation indicates positive changes in the shape and spatial orientation of the erythrocytes and decreased incidence of aggregation and rouleaux indicating improved functional capillary density. In conclusion, a proprietary formula of raw organic Moringa oleifera has empirically demonstrated subjective beneficial changes in patients who have supplemented with this formula.

Traditional Chinese medicine five-tone therapy
Haoran Zhang
90Life Research    2019, 2 (2): 80-83.   https://doi.org/10.12032/life2019-0425-005
Abstract ( 482 HTML PDF (399KB) ( 115 )  

From the perspective of the application of medical value orientation music therapy, this paper summarized the ancient Chinese sound therapy, such as shaman music therapy and five-tone therapy. It also compared five-tone therapy with Tibetan Singing bowl music therapy. The ancient music therapy is a kind of medical means which is oriented to the treatment effect. At first, it was mainly based on the music medical behavior of Taoist, and then gradually evolved into the modern treatment application of folk pentatonic therapy. On the basis of inheritance and development of ancient traditional music treatment, contemporary medicine proposed a new individualized music treatment. Therefore, the theory of five-tone therapy has updated the research on traditional Chinese music treatment theory and system, and will provide reference for the establishment of accurate music treatment system in the future.

A case report about a new frequency-code therapy of type 2 diabetes for 12 days
Yurii Pozniak
90Life Research    2019, 2 (4): 137-144.   https://doi.org/10.12032/life2019-1025-201
Abstract ( 362 HTML PDF (2525KB) ( 782 )  

The mainstay of type 2 diabetes treatment used to be blood glucose control in order to prevent or delay the development of various diabetic complications. On September 1, 2018, one of our patients was diagnosed with several serious illnesses: type 2 diabetes, 3 degrees of obesity, arterial hypertension, peripheral vascular atherosclerosis of the lower extremities with swelling of the shins and feet, fatty hepatosis and metabolic syndrome since June 2019. The patient was restricted in movement due to excessive body weight, shortness of breath and joint pain. Conventional medical methods did not work well for him, so the prognosis is very poor. In this case, we used a new frequency-code therapy which could transmit the signal into the patient's brain by the method of frequency code influence to cure diabetes and associated diseases, restore the patient's body and improve his living quality. According to our forecasts in September 2018 the treatment of acquired diseases and the restoration of the patient's body to a viable level, with the help of our technology, may take more a year. Carrying out step-by-step noninvasive treatment by the method of frequency-code influence on the patient's brain we received positive results at each stage of treatment which together gave a complex positive result in ridding the patient of acquired diseases and restoring his body to the level of active life-activity without restrictions. Now the patient does not follow a diet and enjoys physical activity. No side effects were observed. The human body is unique, even in adulthood, the protective functions of the body are able to defeat the most complex diseases without damage to the body. To do this need to activate the "sleeping protective mechanism" of the body or translate the "healthy memory of the brain" in the period of active resistance to premature age-related diseases.

The impact of genetic and cultural factors on anorexia and bulimia
Shiruli Dash
90Life Research    2019, 2 (2): 71-79.   https://doi.org/10.12032/life2019-0425-004
Abstract ( 275 HTML PDF (923KB) ( 88 )  

This article highlights the fact that anorexia and bulimia nervosa aren't simply psychiatric disturbances, but recent identification of genetic linkages show that they are also physical disease, with higher incidences seen in children who have a parent with an eating disorder. Even having a relative with an eating disorder has become a predisposing factor. However, more research still needs to be carried out on this to establish clear patterns of inheritance. This paper also touches on the greater impact that eating disorders have on society as a whole. Past studies undertaken primarily in female patients have reflected a gradual increase in mortality rates which have been significant enough to be of epidemiological and statistical importance. We then focused on some new treatment approaches and observe an universal pattern of improvement among patients who were also treated with music therapy as compared to standard traditional treatment measures. Finally, we summarized the importance of awareness and education among young adults in preventing mental health disorders and eliminating the stigma around seeking therapy.

The application of improvisational music therapy in autism
Ferdinando M. Suvini
90Life Research    2019, 2 (2): 52-58.   https://doi.org/10.12032/life2019-0425-001
Abstract ( 268 HTML PDF (376KB) ( 90 )  

This article presents the model of improvisational music therapy and its use with people with autism. Firstly, the author provides a brief definition of some theoretical ideas and the clinical characteristics of improvisational music therapy, a relatively new treatment which is becoming more wide-spread on a global level. Particular reference is made to the possibilities which music offers in the creation of relational experiences, and the role of time, rhythm and repetition as regulatory elements both in music and in intersubjective relationships. Following this, the efficacy of improvisational music therapy with people with autism is discussed, with regard to research in the field of neuroscience (specifically, the Mirror Neuron System) and the impact of a multimodal stimulus such as music making. The final section outlines the results of the international research project RCT TIME-A, in which improvisational music therapy was used with children with autism. The literature analysis shows that music therapy has significant effects and contributes to improvements in several aspects of the autistic disorder, such as autistic mannerisms, social awareness and social affect. We can consider these results as the beginning of a pathway towards validating improvisation music therapy as a treatment for children with autism.

Anti-aging theory of quantum nature and brain reprogramming
Yurii Pozniak
90Life Research    2019, 2 (3): 113-118.   https://doi.org/10.12032/life2019-0725-401
Abstract ( 241 HTML PDF (2093KB) ( 81 )  

As many scientists believe, human aging is a very important part of the program of life-human activity rather than a disease. The human brain may be the controller, performer and participant of the natural program of life-human activity, from birth to death. The program of life-activities of the brain and the human body is very similar to a conventional computer program and it may also be malfunctioning. The work of the natural program of life-activity resembles the work of AI. Each program of life-activity of an individual is repeatedly subjected to natural correction of program tasks in the life of a biophysical being. However, in recent years, scientists from different countries began to seek to reprogram the brain and find the real cause of death. Some biologists and evolutionists believe that this process is nonrandom and that it is controlled by a kind of “death program.” So they call a special set of genes, forcing the body to become decrepit and die, giving way to a new generation of their own kind. The aim of our work is to design new technologies and methods to adjust the life-activity programs from biophysical views, increasing the useful life of bodies by delaying destructive processes and the aging process. Our life-activity program is carried out through the device and IT programs in a mobile application, using contact/contactless frequency code effects on the brain, which is decoded and accepted by the human brain for execution (reprogramming), as a natural addition and an integral part of the brain work. Code programs are compiled according to the working algorithms of the Cosmo-terrestrial structure of life-activity of biophysical objects on the planet Earth. Our technology is one of the varieties of brain-computer technology.

A summary of the pharmacologically tested aphrodisiac plants for sexual dysfunction
Marko Mornar Jelavic, Hrvoje Pintaric
90Life Research    2019, 2 (3): 93-98.   https://doi.org/10.12032/life2019-0725-301
Abstract ( 236 HTML PDF (1003KB) ( 139 )  

Sexual dysfunction is a disruption of normal sexual intercourse and may be a consequence of various organic and psychological disorders. It is the most frequent at patients with cardiovascular and neurological diseases sedentary lifestyle arterial hypertension diabetes obesity and metabolic syndrome and may disrupt their emotional life. But sexual dysfunction may occur simply because of the physical aging of the body. Physiologic changes that occur with aging will affect sexual function and could be exacerbated by the above-mentioned diseases. Except for the sexual counseling and standard medications (phosphodiesterase type 5 (PDE5) - inhibitors local estrogen therapy) some of the herbal medicines (aphrodisiacs) may be helpful in the treatment of these patients making them emotionally younger and happier. In this review we bring a list of the pharmacologically tested aphrodisiac plants. But we have a lack of information about their mechanisms of action drug interaction and safety profile. Until the relevant information is collected uses of these products may be risky to the human being and should be prescribed only in consultation with a specialist. Sexual dysfunction is a disruption of normal sexual intercourse and may be a consequence of various organic and psychological disorders. It is the most frequent at patients with cardiovascular and neurological diseases sedentary lifestyle arterial hypertension diabetes obesity and metabolic syndrome and may disrupt their emotional life. But sexual dysfunction may occur simply because of the physical aging of the body. Physiologic changes that occur with aging will affect sexual function and could be exacerbated by the above-mentioned diseases. Except for the sexual counseling and standard medications (phosphodiesterase type 5 (PDE5) - inhibitors local estrogen therapy) some of the herbal medicines (aphrodisiacs) may be helpful in the treatment of these patients making them emotionally younger and happier. In this review we bring a list of the pharmacologically tested aphrodisiac plants. But we have a lack of information about their mechanisms of action drug interaction and safety profile. Until the relevant information is collected uses of these products may be risky to the human being and should be prescribed only in consultation with a specialist.

Intervention and treatment of upper limb lymphedema with traditional Chinese medicine
Qiuhua Li, Yuehai Ma, Ning Wang, Ying Hu, Zhaozhe Liu
90Life Research    2019, 2 (4): 160-164.   https://doi.org/10.12032/life2019-0720-408
Abstract ( 229 HTML PDF (1290KB) ( 94 )  

Breast cancer is a common malignant tumor in women. Because of the clearing of axillary lymph nodes and the radiotherapy of lymph node region, lymphatic dysfunction occurs and lymphatic fluid retards in the interstitial space. These will lead to a series of pathological changes, such as tissue edema, chronic inflammation, tissue fibrosis and fatty fibrosis. Lymphedema is a chronic disease with the feature of slow progression and is currently incurable. The timely treatment and proper care can alleviate the symptoms and improve the quality of life. The internal and external treatment of Chinese medicine intervention is beneficial for upper limb lymphedema, and the purpose of this research is to share our clinical experiences.

Exercise and nutrition research on longevity and quality life
Pierluigi Vagali
90Life Research    2019, 2 (3): 119-123.   https://doi.org/10.12032/life2019-0725-601
Abstract ( 224 HTML PDF (676KB) ( 134 )  

Exercise and Nutrition are complementary parts of a preventive and curative process to improve the quality of life, longevity and compress the life phase subject to disability. Physical activity and nutrition play an essential role both for the prevention of chronic non-communicable diseases and for their treatment. Nutraceuticals and exercise constitute the new frontier for healthy aging. We therefore motivate people by teaching them a new "life style", a delicate balance of adequate physical exercise and correct food hygiene, ensuring an unusual and surprising well-being and well-being, to which it will not be easier to give up.

Empirical six-dimensional framework for slowing and reversing ageing using modern science and ancient wisdom
Asoka Nimal Jinadasa
90Life Research    2019, 2 (3): 106-112.   https://doi.org/10.12032/life2019-0725-303
Abstract ( 209 HTML PDF (1398KB) ( 79 )  

There are numerous published theories that cover the different biological processes relating to ageing. No one seems to have integrated such complex and seemingly unrelated information into a holistic framework that explains in simple terms the key aspects of ageing and provides a set of daily practices for staying young and healthy. An attempt is made here to select a 6-dimensional framework symbolized by heart, mind, passion, focus, body and health, and correlate it to the mental, emotional, physical and health aspects of ageing. Based on grounded theory, this paper empirically correlates 30 practical methods that can be used to develop all six dimensions, with 18 key factors that were found to influence ageing: Neurogenesis; Epigenetic reprogramming; Removing dying cells; Mitochondria resuscitation; Calorie restriction; Plant-based diet; Regular physical activity; Chi Kung (Qigong); Overcoming anxiety, depression and stress; Positive mind-set; Some worrying; Vitamins and minerals; L-Theanine; Omega-3 and healthy fats; Coenzyme Q-10; Pyrroloquinoline quinone; Nitric oxide; Choline. In this study, 26 references were used to establish that all 18 of these seemingly unrelated key anti-ageing factors can be developed using 30 daily practices derived from the 6-dimensional framework. These simple daily practices can help people of all ages to stay young and healthy, and help older people who are living alone to self-improve their quality of life without needing anyone to look after them. Since many anti-ageing drugs seem to be ineffective, this study provides a holistic new research direction for using modern science and ancient human energy practices combined with wholesome nutrition to slow ageing and age-related illnesses.

Tau pathology in Alzheimer’s disease and associated hypotheses
Shiruli Dash
90Life Research    2019, 2 (3): 99-105.   https://doi.org/10.12032/life2019-0725-302
Abstract ( 170 HTML PDF (1156KB) ( 99 )  

This review aims to summarize how Tau pathology, in particular, brings about Alzheimer’s disease (AD). Various studies from the past decade have been analyzed with the purpose of providing a compact description on how Tau protein influences AD. The pathologies associated with the accumulation of Amyloid and Tau have always been at the forefront of all research on Alzheimer’s disease, which have usually centered around a deeper understanding of the pathophysiological mechanisms, or on developing therapeutics targeting these proteins. Recent data has also continuously been challenging the ubiquitous acceptance of amyloid being the driving force for Alzheimer’s disease as anti-amyloid therapies continue to fail. Tau protein shows an independent ability to accumulate within nerve cells, and its propagation shows a continuous seeding and spreading pattern. The purpose of this review is thus to enforce the importance of Tau pathology and tailor future developments in AD treatment accordingly. By the end of this review, we thus infer how regional accumulations of Tau affect AD, how and why the amyloid cascade hypothesis needs to change, and we end by looking at findings from the recent “Beyond Amyloid” symposium where factors like a loss in DNA integrity, cell cycle disorders and microtubular dysregulation have been proposed as potential mediators of AD.

Helping adolescents develop self-realization using art therapy
Xiaoyang Fang
90Life Research    2019, 2 (2): 59-63.   https://doi.org/10.12032/life2019-0425-002
Abstract ( 165 HTML PDF (337KB) ( 52 )  

This report explored psychodynamic developments that adolescents undergo in their process of self-realization and self-identification, including separation-individuation and ego development. The paper maked a case for art therapy as a resource and non-confrontational outlet to guide adolescents through their development and search for their self-identity. The role of the art therapist is presented as an alternative source of support and containment which may be lacking through the adolescents’ peers and parents. The paper ultimately argued that art therapy had many therapeutic qualities that could help the adolescent in their search and consolidation of the self.

Age-related changes of senescence-accelerated mouse prone 10 (SAMP10) mice as an animal model for AD
Lei Yu, Linna Gao, Xue Bai, Ruomei Che, Xiaoli He
90Life Research    2019, 2 (4): 124-136.   https://doi.org/10.12032/life2019-1025-102
Abstract ( 137 HTML PDF (1998KB) ( 59 )  

Background: To explore the influence of age-related changes in learning and memory capacity of SAMP10, an Alzheimer's disease (AD) model mice, and provide theoretical foundation for the selection of month age in related experiment. Methods: SAMP10 female mice with the age of 3, 6 and 9 months were used as the objects of experiment, while the age-matched female SAMR1 were used as the controls, with 12 in each group. The learning memory capacity of mice at different age was detected through Morris water maze and step-down passive avoidance test; meanwhile, the acetylcholine, acetylcholinesterase, choline acetyltransferase, and M-cholinergic receptor binding capacity levels were determined to detect the cholinergic system damage degree in mice with different month age. In addition, the contents of monoamine neurotransmitters such as dopamine, 3,4-dihydroxyphenyl acetic acid, homovanillic acid, norepinephrine and 5-HT, as well as those of amino acid transmitters such as glutamic acid, glutamine, aspartic acid, γ-aminobutyric acid, taurine and glycine in the brain cortex were detected by high performance liquid chromatography-electrochemical deposition. Besides, changes in hippocampal neurons were observed through Nissl staining, and the changes of Aβ in hippocampal CA1 and CA2 regions of SAMP10 were also detected by immunohistochemistry so as to explore the effects of age on the memory capacity of SAMP10. Results: It was discovered in the behavior test and AD-related index tests that: there was no significant difference between the age-matched SAMR1 and the SAMP10 at the age of 3 and 6 months. But the 9-months-old mice suffered remarkable senescence characteristics, including obviously declined learning memory capacity; down-regulated neurotransmitter levels, enzyme activities and amino acid expression; reduced hippocampal neuron number; and increased deposition of hippocampal Aβ protein. Conclusion: It is discovered in this study through behavior tests and AD-related indexs detection that, the learning memory capacity of SAMP10 shows age-dependence, which is gradually decreased with the increase of age, and the 9-months-old mice have developed marked memory impairment and senescence characteristics. SAMP10 is the recognized AD model, the appropriate month age for preventive medication is about 7 months, while that for therapeutic medication is 8-9 months.

Art is therapy
Life Research Editorial Office
90Life Research    2019, 2 (2): 84-86.   https://doi.org/10.12032/life2019-0425-006
Abstract ( 131 HTML PDF (645KB) ( 29 )  

Arts therapy has become more and more popular in a number of medical fields by integrating the physical, emotional, and spiritual treatment. As the importance of psychosocial aspects in the diagnosis and treatment of many diseases has been better recognized and understood, the interest in arts therapies for clinical routine treatment has also increased. Arts therapy is an umbrella term for therapies such as music therapy, sound therapy, drama therapy, dance therapy, and art therapy with visual arts materials. Through artistic media, it offers patients communicate experiences, feelings, and thoughts, which are hard to express verbally. This possibility for an alternative way of communication can even affect the rehabilitation process of many physiological diseases.

New advances in immunotherapy for prostate cancer
Hassan Lois Bala
90Life Research    2019, 2 (4): 152-159.   https://doi.org/10.12032/life2019-1025-302
Abstract ( 123 HTML PDF (235KB) ( 88 )  

In recent years, prostate cancer has been known to have an increasing incidence worldwide. In 2012, prostate cancer was recognized as the second most frequent cancer to occur in men and fifth leading cause of cancer mortality in men. It is known to affect one of every eight men in the world, and even more common in men above the age of 65. However, the long-term survival rate for an average cancer patient continues to decline, creating a need for therapies that could enhance survival rate with favorable advantages. With the minimal side effects and toxicity of the new treatments, it is obvious that these new treatments are the way forward in fighting cancer. This review elaborates the new therapy for prostate cancer treatment that has been developed in very recent times. The goal is not only to create awareness of these new treatments but also gives patients as well as doctors more treatment options. This review builds a foundation on the knowledge of cancer, importantly cancer immunology, and also forms groundwork majorly on prostate cancer, focusing on the mechanism of how immunotherapy could be a better choice over the previously common prostate cancer treatments, proposing a perspective on future directions in the treatment of prostate cancer.

New therapeutic effects of cardiac glycoside: anti-cancer and anti-aging
Haoran Zhang
90Life Research    2019, 2 (4): 165-167.   https://doi.org/10.12032/life2019-1025-601
Abstract ( 100 HTML PDF (161KB) ( 73 )  
Aging is an unavoidable topic in everyone's life, and the aging problem has been puzzling scientists for many years. For thousands of years, we've used many tools to extend life span, and today, new technologies and medical treatments have extended the average human lifespan by about two years in a decade. The incidence of heart disease, tumors and degenerative diseases increases with age. Traditional Chinese Medicine believes that the use of herbs or guidance techniques can improve blood circulation, increase heart function, delay aging and prevent the development of tumors.
Research progress of the relationship between microvesicles derived from stem cells and nervous system diseases
Jiaping Yan, Fuhao Qiao
90Life Research    2019, 2 (4): 145-151.   https://doi.org/10.12032/life2019-1025-301
Abstract ( 69 HTML PDF (227KB) ( 31 )  

Microvesicles, also called microparticles, are membranous vesicles released from the cell membrane surface or by exocytose. Almost any type of cells can secrete vesicles, especially stem cells. Recent years, stem cells are becoming a research hotspot of cytotherapy for their capacity of self-renewing, expansion and proliferation in vitro and the microvesicles derived from the conditioned medium of stem cells have been widely used to regenerative medicine because they are safer, easily obtained, measurable and cause no obvious immune rejection. Stem cells derived microvesicles have been confirmed to be closely related to the progress and treatment of atherosclerosis, diabetes, inflammation and tumor. This review focuses on the new progress of stem cells derived microvesicles treating various nervous system diseases and its application in biological therapy and the behind molecule mechanisms.