Erythrocyte aggregation is the tendency of erythrocytes to form aggregates whose shapes change according to normal variations or pathological conditions. Consequently, regardless of cause, these anomalies effect changes to flow dynamics and predispose the inability to carry out transportation activities and decrease functional capillary density or decrease erythrocyte surface area, also decreasing functional efficiency. Functional capillary density is the determination of the number of capillaries in an area that have erythrocyte flow and relates to the subsequent ability of the blood to deliver nutrients, fluid and solute exchange, and waste product excretion. Red blood cell aggregation has a significant impact on functional capillary density. Moringa oleifera, one of the most phytonutrient dense plants as identified by the NIH, has garnered interest by those involved with anti-aging medicine. The US National Institutes of Health, the nation’s medical research agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability, has affirmed Moringa oleifera can “arrest, reverse, and cure, over 300 different diseases and disorders.” Regular use of Moringa oleifera has been shown to have a multitude of health benefits. In addition to this, Moringa oleifera provides all of the essential amino acids, vital vitamins, contains several important minerals, is an incredibly powerful antioxidant, is high in fiber, stimulates the immune system to fight cancerous cells, tumours, ulcers, epileptic seizures and cleanses and detoxifies the entire body. Moringa oleifera has been shown to protect platelets against aggregation. In this investigation, live blood microscopic evaluation indicates positive changes in the shape and spatial orientation of the erythrocytes and decreased incidence of aggregation and rouleaux indicating improved functional capillary density. In conclusion, a proprietary formula of raw organic Moringa oleifera has empirically demonstrated subjective beneficial changes in patients who have supplemented with this formula.
Mental disorders are considerate "the evil of the century" by renowned researchers, because a large part of the population in many countries is a diagnosticated, and currently affect youth and children. Among the numerous therapeutic interventions, the music therapy is a non-invasive approach. However, there are very few people who are professionally engaged in research and studies on the subject. Therefore, this article is a literature to talk about the benefits of music therapy sessions for people with stress, depression and anxiety disorders.
This review dives into the wide prevalence of depression among the adolescents of the current generation. The goal is to bring to light the interrelationship of factors that bring about depression and which, thus, must be the focus if more effective approaches to treating depression are to be established. The review forms the groundwork of depression, touching upon early history and progressing to prominent research studies that have been carried out across the globe. The role of drugs and peer pressure has been tied to the neurobiology of different regions of the brain and hormonal influences have simultaneously been studied. Questions have been raised and a critical analysis of the roots of depression has been made. Through an original interview conducted by the author with ten teenagers battling depression, the review highlights the universality of depression and the importance of acknowledging it and treating it in one of the most influential age groups today: the teenagers.
According to the study, 5-HT mediated AC-cAMP-PKA-CREB is associated with the onset of depression. In recent years, many researchers have expounded the pathogenesis of depression from the perspective of genetic polymorphism. Depression incidence has obvious gender differences, but its mechanism is not clear. Is depression genetically determined? Or does it result from one or more pathological determinants pathological? Which one is more important? On the basis of previous studies, the 5-HT mediated AC-cAMP-PKA-CREB pathway on four protein (5-HT1AR, 5-HT2AR, BDNF, TrkB) whose gene polymorphism and expression may be the keys. Further, 5-HT mediated AC-cAMP-PKA-CREB signaling pathway may be related to Gender differences in depression, so their gene polymorphism variation may provide new ideas for the research on gender differences in depression.
Cardiovascular disease (CVD) remains the leading global cause of the death. Genetic polymorphisms in NKX 2-5 are found to be associated with CVD. However, the results were inconsistent and inconclusive. The present study performed a meta-analysis to get a more precise and comprehensive estimation of the association between the genetic polymorphisms in NKX 2-5 and the risk of CVD. The databases Pubmed, Chinese National Knowledge Infrastructure (CNKI), Wanfang Data and CQVIP were searched for related studies. A total of 9 studies including 1516 cases and 1438 controls were identified for the meta-analysis. The results indicate that the genetic polymorphisms in NKX 2-5 were associated with the significantly risks of CVD in the allelic model, dominant model, codominant model and superdominant model of rs3729753 (OR = 1.94, 2.00, 2.00 and 0.50 respectively) and rs118026695 (OR = 1.83, 1.98, 2.02 and 0.49 respectively). No significant associations were found between rs2277923 and g.1467G > A and CVD susceptibility in any of the studies. Therefore, rs3729753 and rs118026695 might be recommended as a predictor for the risk of CVD, while rs2277923 and g.1467G > A are not.
As early as 2000 years ago, ancient Chinese medical records had described the relationship between diseases and appearance in detail. Moreover, modern medicine has also constantly studied the relationship between facial features and health in evolutionary terms. It is well known that many hereditary diseases involve certain abnormal facial features and gene mutations. The tumor is also considered as genetic disorder to some extent, so what is the relationship between cancer genetics and congenital development of facial features? Here, we reviewed some clues to the appearance-gene-tumor relation, which might become the targets in the early prevention or gene therapy of cancer in the future. This summary provided us a new strategy for the cancer genetic screening and a new research direction for genetic diagnosis of the potential disease.
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