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92Medical Data Mining  2018, Vol. 1 Issue (1): 10-18    DOI: 10.12032/mdm2018004
    
Efficacy and safety of Buyanghuanwu decoction combined with regular western medicine treatment for ischemic stroke convalescence: a systematic review and meta-analysis
Zhong-Hui Zhao1,2, Li -Juan He2, Jia-Lin Wang2, Qian-Yi Li1, 2, Yang Li1, 2, Yao Yu 1, 2, Jian-Wei Wang3, Wei-Jing Fan1, 2, Wu Sun1, 2, Lina Miao1, 2, Rong-Juan Guo2*
1Beijing University of Chinese Medicine, Beijing, 100029, China. 2Dong-fang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China. 3Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China. 
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Abstract  
Objective: To evaluate the efficacy and safety of Buyanghuanwu (BYHW) decoction for the treatment of ischemic stroke convalescence. Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), Pubmed, the Cochrane Library, Science Citation Index (SCI) and Elsevier SD databases were searched from the origin time to May 2018. Cochrane recommended bias risk assessment method was used to evaluate the bias risk. Review Manager 5.3 was used to perform meta-analysis. Results: A total of 12 studies with a 1246 cases were included in the study. The results of the analysis showed that the efficacy of BYHW decoction combined with western medicine treatment was better than that of control group (OR = 2.88, 95% CI (2.10,3.95), P < 0.001) ]. The neurological deficit score in the treatment group was lower than that in the control group, and the difference was statistically significant [MD = -2.84, 95% CI (-3.22, -2.45), P < 0.001]. The scores of daily living ability in the treatment group were higher than those in the control group, and the difference was statistically significant [MD = 8.89, 95% CI (7.61, 10.16), P < 0.00001]. In the safety aspect, the results of the study are different, and there was a lack of quantitative indicators to evaluate the objectivity of adverse reactions. Conclusion: BYHW decoction combined with the Western medicine is an effective treatment for the recovery period of cerebral infarction, which can significantly improve the clinical efficacy, improve patients' neurological symptoms and their quality of life. 


Key wordsIschemic Stroke      Buyanghuanwu decoction      Curative effect      Safety      Systematic review     
Published: 30 September 2018
Fund:  This study was supported in part by grants from National Key Basic Research Development Program: ("973" Program, NO.2015CB554401); Beijing University of Traditional Chinese Medicine (2018 basic research business fee item, NO.2018-JYB-XS229).
Corresponding Authors: Rong-Juan Guo, Dong-fang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China. E-mail: dfguorongjuan@163.com.   
Cite this article:

Zhong-Hui Zhao, Li -Juan He, Jia-Lin Wang, Qian-Yi Li, Yang Li, Yao Yu, Jian-Wei Wang, Wei-Jing Fan, Wu Sun, Lina Miao, Rong-Juan Guo. Efficacy and safety of Buyanghuanwu decoction combined with regular western medicine treatment for ischemic stroke convalescence: a systematic review and meta-analysis. 92Medical Data Mining, 2018, 1(1): 10-18.

URL:

https://www.tmrjournals.com/mdm/EN/10.12032/mdm2018004     OR     https://www.tmrjournals.com/mdm/EN/Y2018/V1/I1/10

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