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92Medical Data Mining  2018, Vol. 1 Issue (1): 2-9    DOI: 10.12032/mdm2018001
    
Association rules analysis of Fufang Kushen injection in combination with traditional Chinese medicine or modern medications in treating Cervical cancer: real-world retrospective study
Fu-Mei Liu1,  Yan-Ming Xie1,  Yin Zhang1,*,  Cen Chen2,  Chang Zhang2,   Yan Zhuang3 
1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. 2School of Statistics, Renmin University of China, Beijing 100872, China. 3Center of Computer Management, Navy General Hospital of PLA, Beijing 100048, China.

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Abstract  

Objective: The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine ( TCM) or modern medications in treating cervical cancer (CC) based on the electrical medical records extracted from real-world hospital information system. Methods: The clinicians’ prescriptions regarding to the combination of  with TCM or modern medications were from hospital information system electronic medical data integration warehouse established by the Institute of Basic Medical Research of Chinese Medicine, China Academy of Chinese Medical Sciences, which integrated the hospital information system data of 22 hospitals. The association rules of the drug characteristics were analyzed through Apriori algorithm. Results: A total of 839 patients with CC were included.  We found that  is often combined with prescriptions which could clear heat, remove toxicity, supplement Qi.  also combined with chemotherapeutic drugs, immunomodulatory drugs, 5-HT receptor blockers, and glucocorticoids. The combination presents a specific law. Conclusion: Fufang Kushen injection combined with hepatoprotective drugs, immunomodulators and glucocorticoids is often used to treat cervical cancer. 



Key wordsFufang Kushen injection      Combinations      Cervical cancer      Real world      Association     
Published: 30 September 2018
Fund:  This study was supported in part by grants from the Research on Risk Signal Assessment Based on Monitoring Data (No.2015ZX09501004-001-002); Beijing Science and Technology Development Project of Traditional Chinese Medicine "Research on Evaluation and Mechanism of Combination of Traditional Chinese Medicine and Western Medicine" (No. JJ2014-53); Chinese Academy of Traditional Chinese Medicine Independent Project "Innovation Team of Key Technologies for Post-marketing Clinical Reevaluation of Traditional Chinese Medicine" (No. PY1303); Central Research Institute of Public Welfare Funds (Z0439).
Corresponding Authors: Yin Zhang, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. E-mail: coolzhangyin@sina.com.   
Cite this article:

Fu-Mei Liu, Yan-Ming Xie, Yin Zhang, Cen Chen, Chang Zhang, Yan Zhuang. Association rules analysis of Fufang Kushen injection in combination with traditional Chinese medicine or modern medications in treating Cervical cancer: real-world retrospective study. 92Medical Data Mining, 2018, 1(1): 2-9.

URL:

https://www.tmrjournals.com/mdm/EN/10.12032/mdm2018001     OR     https://www.tmrjournals.com/mdm/EN/Y2018/V1/I1/2

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