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92Medical Data Mining  2019, Vol. 2 Issue (2): 66-75    DOI: 10.12032/mdm2018019
    
Curcumin in The Treatment of in Animals Myocardial ischemia reperfusion: A Systematic review and Meta-analysis
Qian He, Bin Meng, Hong-Yun Hu, Gao-Jian Zhuang, Qun Tang, Xu Zhu*
Hunan University of Chinese Medicine, Changsha, 410208, China.
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Abstract  Objective: The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion. Methods: The computer was searched for Wanfang, VIP, China National Knowledge Infrastructure(CNKI), SinoMed, and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018. Two researchers independently screened the literature based on inclusion and exclusion criteria, extracted the data, and assessed the risk of bias in the included studies. Meta analysis was performed using RevMan 5.3 software. Results: Finally, 9 studies were included for analysis. Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiar-reperfusion group  (LDH: SMD=-4.75, 95% CI [-6.56, -2.94], P < 0.01, MDA: SMD=-2.27, 95% CI [-3.07, -1.47], P < 0.01), the difference was statistically significant (P<0.01). In the subgroup analysis of different doses of curcumin, different doses of curcumin (0.8, 10, 12.5, 20, 25, 30, 50 mg) were able to reduce LDH content compared with the ischemia-reperfusion group, and the differences were statistically significant. Different doses of curcumin (5,10,20,30,40mg) can reduce MDA content, and the difference is statistically significant; curcumin (0.8mg) group has no statistically significant effect on MDA content (SMD = -0.54, 95% CI [-1.35, 0.28], P = 0.20). The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin (20 mg) group, the curcumin (40 mg) group could better reduce the MDA content, and the difference was statistically significant (P=0.03). Conclusion: Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,  and has a protective effect on myocardium. Moreover,  the ability to reduce the damage is related to the dose of curcumin. However, the sample of the included studies is limited, and this conclusion requires more high-quality experiments to verify.

Key wordscurcumin      myocardial ischemia-reperfusion      meta-analysis      animal experiment      systematic review     
Published: 29 June 2019
ZTFLH:  R54  
Corresponding Authors: Xu Zhu, Hunan University of Chinese Medicine, Changsha, 410208, China. E-mail: 409884083@qq.com.   
E-mail: 409884083@qq.com
Cite this article:

Qian He, Bin Meng, Hong-Yun Hu, Gao-Jian Zhuang, Qun Tang, Xu Zhu. Curcumin in The Treatment of in Animals Myocardial ischemia reperfusion: A Systematic review and Meta-analysis. 92Medical Data Mining, 2019, 2(2): 66-75.

URL:

https://www.tmrjournals.com/mdm/EN/10.12032/mdm2018019     OR     https://www.tmrjournals.com/mdm/EN/Y2019/V2/I2/66

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