Top Read Articles
Published in last 1 year |  In last 2 years |  In last 3 years |  All
Please wait a minute...
Bloodletting Cupping Therapy for postherpetic neuralgia: a systematic review and meta-analysis
Qian Cui, Yu-Hui Ma, Xiao-Ming Jin, Lin-Feng Li, Guo-Wei Zhang
92Medical Data Mining    2018, 1 (2): 57-67.   https://doi.org/10.12032/mdm2018007
Abstract ( 356 PDF (1808KB) ( 100 )  
Objective: To evaluate the clinical effects of bloodletting cupping therapy (BCT) for patients with postherpetic neuralgia. Methods: We comprehensively searched four Chinese databases (Wanfang, China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals,China Biology Medicine disc) and foreign databases (Pubmed, Cochrane Library). The retrieval time was from the build-up time to May 2018. RevMan 5.3 software was used for statistical analysis. Results: We finally obtained 18 eligible studies. Compared with routine western medicine, BCT can significantly improve PHN (OR= 7.45, 95% CI, 3.36-16.51, Z=4.95, P < 0.01). BCT plus other methods of acupuncture with fire needle and filiform needle has significant therapeutic effect (OR=5.54, 95% CI, 3.01-10.19, P < 0.01), BCT plus routine western medicine has significant therapeutic effect (OR=4.99, 95% CI, 2.73-9.11, P<0.00001). Conclusion: It showed that the therapeutic effects of BCT, BCT plus other acupuncture methods with fire needle and filiform needle, and BCT combined with western medicine are better than those treated with single western medicine. It is effective to treat postherpetic neuralgia with Bloodletting Cupping Therapy.
Traditional Chinese Medicine for Bladder Cancer: a Systematic Review and Meta-Analysis
Li-Hui Zhang, Yao Yang, Ying Chen, Guo-Wei Zhang
92Medical Data Mining    2018, 1 (2): 68-82.   https://doi.org/10.12032/mdm2018008
Abstract ( 324 PDF (689KB) ( 45 )  
Objective: To evaluate the efficacy and safety of traditional Chinese medicine in the treatment of bladder cancer. Methods: The databases of CNKI (1989-2018.10), Wan fang Data (1989-2018.10), VIP (1989-2018.10), PubMed (1966-2018.10), EMbase (1986- 2018.10) and Cochrane Library (3rd issue, 2018) were searched.. Evidence quality and rating recommendations were scored using the GRADE system. Results: Thirty-six eligible studies were included with 3,109 patients. The meta-analysis showed that the total effective rate OR combination =2.85[OR=2.85,95% CI(1.98,4.09),P<0.00001].Recurrence OR merge = 0.33 [OR=0.33, 95% CI (0.26,0.42), P<0.00001];Adverse reaction rate OR combination =0.37[OR=0.37, 95%CI(0.32,0.43), P<0.00001];Incidence of adverse reactions OR combination =0.41[OR=0.41, 95%CI(0.30,0.55), P<0.00001];Survival rate OR combination =1.78[OR=1.78, 95%CI(0.55, 5.77), P=0.34];Quality of life improvement rate OR consolidation =12.42[OR=12.42 95%CI(3.21,48.11), P=0.0003].The GRADE system evaluation results show that the evidence level is B and the recommendation level is weak. The traditional Chinese medicine group was superior to the control group in the efficiency rate, postoperative recurrence rate, incidence rate of adverse reactions, survival rate, quality of life improvement rate and incidence rate of toxic and side effects in the treatment of bladder cancer. Conclusion: Traditional Chinese Medicine has a good effect on treating bladder cancer and controlling recurrence of bladder cancer. Due to the impact of the original study on the results of meta-analysis, larger sample and high-quality clinical trials are still needed to verify.
Reanalysis of Lymph node metastasis as predictor of the survival of patients with follicular variant papillary thyroid carcinoma:From SEER database 2004-2014
Jin Yang, Qing-Qing Liu, Hai-Rong He, Hai-Sheng You, Zhen-Yu Pan, Jun Lyu,
92Medical Data Mining    2019, 2 (1): 1-9.   https://doi.org/10.12032/mdm2018011
Abstract ( 270 PDF (524KB) ( 60 )  
Background: Follicular variant papillary thyroid carcinoma (FVPTC) is the most common subset of papillary carcinoma. Lymph-node metastasis (LNM) is one of the main predictors of survival in PTC patients, but we found few data related to the correlation between LNM and FVPTC. We therefore aimed to elucidate the relationship between LNM and survival in patients with FVPTC. Method: Logistic regression models were used to determine the factors associated with LNM. The Cox proportional-hazards model was applied to assess the association between LNM and disease-specific mortality. Kaplan-Meier survival analysis and the log-rank test were used to estimate the disease-specific survival rates in patients with and without LNM. Results: In total, 1418 FVPTC patients were identified. The multivariate logistic regression model showed that age, female sex, being married, tumor size > 4cm and extrathyroidal extension and radiation were predictors of LNM. The multivariate Cox regression model showed that age, multifocality and radiation were risk factors of disease-specific mortality. Especially, LNM (p=0.271) did not independently predict disease-specific mortality. Kaplan-Meier survival analysis and the log-rank method also showed that LNM did not impact survival in FVPTC (p=0.235). Conclusion: Using data in the SEER database from 2004 to 2014, and after multivariate model correction, we found that age, multifocality and radiation were strongly related to disease-specific mortality. It is worth noting that LNM does not impact the survival of FVPTC patients.
Clinical Medicine Characteristics Study of Traditional Chinese Medicine in the treatment of cancer pain based on Data Mining
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang,
92Medical Data Mining    2019, 2 (1): 39-49.   https://doi.org/10.12032/mdm2018014
Abstract ( 170 PDF (762KB) ( 51 )  
Objective: To explore the clinical characteristics of traditional Chinese medicine in the treatment of cancer pain based on traditional Chinese medicine inheritance support system (TCMISS). Methods: China Chinese CNKI database, VIP database, Wanfang database (1979 - 2017) were searched to get the prescriptions for cancer pain treatment. At last, 290 prescriptions were got and used to, set up the cancer pain prescriptions database, The route of administration, medicinal properties and drug use frequency were analyzed, and the rules of drug use were analyzed by mining rules such as association rules and complex system entropy clustering. Results: A total of 286 drugs were involved, and the association rules of drug properties, taste, meridian tropism, drug frequency and drugs were defined, and 20 core combinations and 10 new prescriptions were developed. Conclusion: The clinical medication rule of Chinese medicine for treating cancer pain has been excavated, and its reflected drug philosophy of "Tong" is the main, the emphasis is on pain relief, "tonic" is the main, the emphasis is on harmony, qi and blood are treated together, the emphasis is on dredging, antitumor analgesic, treatment of symptoms and root causes is equally important.
Bibliometrics and social network analysis of clinical researches on acupuncture and moxibustion
Jin-Hua Si , Chen Zhao, Yan Li, Ge Li, Jin-Hui Tian, Hong-Cai Shang
92Medical Data Mining    2018, 1 (2): 46-56.   https://doi.org/10.12032/mdm2018006
Abstract ( 169 PDF (771KB) ( 45 )  
Objective: In order to explore the development trend and research hotspots of clinical researches of acupuncture and moxibustion and provide some insight into the key research direction for researchers. Methods: The clinical studies of acupuncture and moxibustion were searched in PubMed. Using the method of bibliometry, the year, country, journals, authors were analyzed. The cluster analysis was used to analyze subject terms by the social network analysis. Results: A total of 4237 literature were retrieved, published in 617 journals. The number of clinical studies on acupuncture and moxibustion has been increased substantially since 2006. The clinical researches on acupuncture and moxibustion have been conducted worldwide, specifically in China, the United States, Britain, Sweden, etc. Three major author cooperation networks (China, South Korea and European and North American countries) has been formed. The cluster analysis based on 53 high-frequency theme words indicates that
the clinical researches on acupuncture and moxibustion are mainly concerned about acupoint selection associated with pain, stroke, knee osteoarthritis and other diseases in different age groups, blind, treatment outcomes, time factor of acupuncture, etc. Conclusion: Clinical researches on acupuncture and moxibustion have been widely concerned by international medicine. The research direction is clear, Thematic is concentrate, and research paradigm has been formed. However, international influence is still limited academically. The cooperation between different authors or teams is insufficient. The core research hotspots include the selection of acupoint, acupuncture and moxibustion tools, research design, treatment outcome, blind, time factor, follow-up, placebo, clinical protocol, quality of life, patient satisfaction and so on. 
Efficacy and safety of atomized inhalation for Shuanghuanglian on chronic pharyngitis:a Meta-analysis of the randomized controlled trials  
Jian Cheng, Ying Yu -, Chang Yu-, Lei Zhang
92Medical Data Mining    2019, 2 (1): 10-21.   https://doi.org/10.12032/mdm2018010
Abstract ( 168 PDF (2023KB) ( 25 )  
Objective: As a Chinese drugs preparation to clear heat and remove toxicity, Shuanghuanglian(SHL)has been widely used, but the clinical efficacy and safety of SHL on chronic pharyngitis remain unclear, especially the application of atomized inhalation of SHL need to be verified. The aim of this study was to evaluate its clinical efficacy and safety for chronic pharyngitis. Methods: From the Cochrane Library, Pubmed, EMbase, Wanfang Datebase, CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientifc Journals Database), CBM (Chinese Biomedicine Database), We got the qualified randomized controlled trials(RCTs) and adopted RevMan5.3 software and the risk of bias tool according to the Cochrane to perform a meta-analysis. Results: Ten RCTs, a total of 950 cases (involving 472 cases in SHL group and 478 in control group) were included. The results showed that the clinical efficacy in SHL group was superior to control group [Chi2=5.61, 95%CI (4.29, 11.43), P<0.05], and four literatures reported no obvious adverse reactions in SHL group. Conclusion: Application of atomized inhalation of SHL may have a potential advantage in treating chronic pharyngitis. However, due to the limitation of the quality and sample size of those studies, the accuracy of the result should be treated with caution, higher standardized researches are required to justify the conclusion.
Bibliometric Analysis of Nurses’ Empathy Ability in China
Yan-Qiu Huang, Hui-Ping Wang, Si-Qi Xiong, Ming Sang, Chang-De Jin,
92Medical Data Mining    2018, 1 (2): 38-45.   https://doi.org/10.12032/mdm20180005
Abstract ( 164 PDF (537KB) ( 32 )  
Objective: To analyze the current situation and shortcomings of the research on nurses' empathy ability in China by using the method of bibliometrics, in order to provide some reference for the related scholars in this field. Methods: All articles on nurses' empathy ability in China was retrieved from CNKI, Wanfang database ,VIP database and CBM until June 30, 2018. Results: A total of 108 articles were included and distributed in 23 provinces, municipali ties and autonomous regions.Among them, Hunan and Hebei province had the largest number of documents;The proportion of literature had fund supports was 16.67%; the literature was included in 48 periodicals, and 18 articles (16.67%) were published in Chinese Nursing Research; the research institutions were mainly hospitals, 79 (73.15%). A total of 69 articles (63.89%) were non-experimental study, but the qualitative research papers was 0. Conclusion: The research on empathy of nurses in China is still in its infancy, and there are still some problems such as uneven regional distribution, lack of fund support, single type of research and the depth of research content need to be further improved. Therefore, in the future research, we should pay attention to strengthen cooperation and exchanges between regions and encourage relevant scholars to be brave in innovation, so as to promote the further development of research on the empathy ability of nurses in China.
Pharmaceutical Rules of Traditional Chinese Medicine For Stroke Based on Dictionary of Prescriptions and Complex Network Analysis
Xiu-Lei Jiang, Yi-Di Wang, Zun-Hao Tang, Jing-Chao Sun, Meng-Yuan Cai, Yu-Chen Liu, Yu-Qiu Li
92Medical Data Mining    2018, 1 (2): 83-92.   https://doi.org/10.12032/mdm2018009
Abstract ( 161 PDF (964KB) ( 30 )  
Objective: Taking the Dictionary of Prescriptions as a clue, we collected effective prescriptions for treating Stroke, and systematically summarized the medication and compatibility rules of the core Chinese medicines for treating Stroke. Methods: A database of prescriptions for stroke based on complex relationship analysis system of traditional Chinese medicine was established. From the point of view of complex network, the hierarchy of drug compatibility rules of compound prescriptions (such as courtiers and envoys) was analyzed, the statistical characteristics of complex networks were analyzed, and an attempt was made to explain the characteristics of complex networks of drugs for stroke. Results: A total of 974 prescriptions were collected, including 1040 Chinese herbs. The core Chinese herbal medicines with nodal degree (> 500) for Stroke were divaricate saposhnikovia root, liquorice root, Chinese angelica, tall gastrodia tuber, incised notopterygium rhizome and root. The compatibility relationship of the core Chinese medicines in the treatment of stroke is divaricate saposhnikovia root-liquorice root, ephedra-divaricate saposhnikovia root, divaricate saposhnikovia root-sichuan lovage rhizome, divaricate saposhnikovia root-Chinese angelica in order of frequency. Conclusion: Through the analysis of the common network structure of effective prescriptions for Stroke, the core prescription compatibility structure reflecting the prescription thinking and clinical
characteristics was found.
Literature Research on Drug Use Regulation of Miao Medicine in Suppression of Gastric Cancer
Hui-Li Shui, Zhu Yang, Feng-Xi Long, Wen-Qi Huang, Bing Yang, Zhen Zhang, Dong-Xin Tang,
92Medical Data Mining    2019, 2 (1): 31-38.   https://doi.org/10.12032/mdm2018013
Abstract ( 147 PDF (472KB) ( 31 )  
Objective: To investigate the rule of medication used by Miao medicine to inhibit gastric cancer. Methods: Taking the coil named Miao Medicine of Chinese Materia Medica as data source, formulating "drug name" + "gastric cancer" or "drug name" + "stomach tumor" as the key words to search papers in China Knowledge Network, Weipu Chinese database, Wanfang database to gather drugs that have the effect of inhibiting gastric cancer, this paper made statistical analysis from the views of Wu Xing, Zou Guan, Ru Jia, Efficacy and Toxicity. Results: There are 81 kinds of drugs that suppress stomach cancer eligible for inclusion. And the Soil Xing medicines are the mainstay in the Wu Xing classification, accounted for 70.4%; the distribution of Zou Guan drugs are dominated by Middle and Interior Guan drugs which accounted for 87.7%; Every kinds of Jia group was involved in the distribution of Jiu Jia groups, but the Body Jia, abdomen Jia, Lung Jia and Cave Jia have the most frequent occurrences accounted for 66.9%; the efficacy distribution mainly includes antidote and tonification accounted for 71.6%; the toxicity distribution mostly is non-toxic drugs which is up to 70 kinds. Conclusion: Treating poison and tonifying body are mainly used in the treatment of gastric cancer in Miao medicine, with Middle and Interior Guan medicine, most of which are non-toxic drugs effective in disease location.
Heating infusion for gastrointestinal complications in patients with enteral nutrition: A meta-analysis
Ming Sang, Yan-Qiu Huang, Chang-De Jin
92Medical Data Mining    2019, 2 (1): 22-30.   https://doi.org/10.12032/mdm2018012
Abstract ( 146 PDF (2028KB) ( 24 )  
Objective: To systematically evaluate the effects of heating infusion on gastrointestinal complications of patients with enteral nutrition. Methods: The domestic and foreign databases including Cochrane Library, PubMed, EMBASE, Web of Science, Chinese biomedical literature database (CBM), Wan Fang database (Wan Fang), China National Knowledge Infrastructure (CNKI) and VIP Database for Chinese Technical Periodicals(VIP) were retrieved. The retrieval contents were randomized controlled trials on improving gastrointestinal complications of patients with enteral nutrition by heating infusion of nutrient solution. Data were collected by two reviewers according to the data extraction tables. Results: A total of 17 randomized controlled trials with 1683 subjects were chosen. The results of meta analysis showed that the rate of abdominal pain, abdominal distension and nausea in patients with enteral nutrition could be reduced by warm infusion of nutrient solution, but the effect of the infusion on vomiting, constipation, stomach retention and diarrhea was not superior. Conclusion: Heating infusion of nutrient solution can reduce the incidence of abdominal pain, abdominal distension and nausea in patients with enteral nutrition.
The application effect of swaddling bath in neonates: A meta-analysis
Hui-Ping Wang, Chang-De Jin
92Medical Data Mining    2019, 2 (2): 84-89.   https://doi.org/10.12032/mdm2018017
Abstract ( 144 PDF (493KB) ( 51 )  
Objective: The meta-analysis is to objectively evaluate the efficacy of swaddling in neonates. Methods: Randomized controlled trials (RCTs) and Randomized cross-over design (RCD) about the effects of swaddling in neonates from multiple electronic databases (PubMed, Web of Science, the Cochrane Library, EMBASE, CINAHL,CNKI, Wanfang and VIP) until January 2019. Two investigators independently screened eligible studies, extracted data, and assessed the methodological quality by using the quality evaluation criteria for RCTs recommended by Cochrane Handbook. Then data were analyzed by Rev Man 5.3. Results: A total of 6 papers (4 randomized controlled trials and 2 Randomized cross-over design) with 318 participants were included. The meta-analysis indicated that there was a significant difference on Body Temperature, Heart Rate, crying time, incidence of open eyes and incidence of closed eyes (P<0.05); There was no significant difference in Spo2 level between the two groups (p>0.05). Conclusion: Swaddling bath has little influence on the Body Temperature, Heart Rate, and behavioral response of newborn. And it has no significant effect on maintaining Spo2 level. However it can reduce the stress behavior of the newborn. Due to the limitations of the quality of studies included, multi-centered randomized controlled trial large sample size are needed in the future to evaluate the effects of prone position ventilation on neonatal respiratory distress syndrome.
Effect of Transitional Care Model on Low Birth Weight Premature Infants: a meta-analysis
Ya-Nan Leng, Ming Sang, Ting-Ting Liu, Yu-Qi Li, Xiao-Li Pang
Medical Data Mining    2019, 2 (3): 90-99.   https://doi.org/10.12032/mdm2018021
Abstract ( 125 PDF (520KB) ( 27 )  
Objective: To systematically review the effect of Transitional Care model (TCM) on the growth and development of premature infants. Methods: Randomized controlled trials (RCTs) or quasi-RTCs regarding the effect of TCM in low birth weight premature infants were retrieved in electronic databases such as the Cochrane Library, PubMed, EMbase, Web of Science, CBM (Chinese Biomedicine Database), CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database) and Wanfang Database. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 11 articles were included, including 1282 preterm infants. The result showed that compared with the routine care model, TCM can effectively increase the weight when premature infants discharged one week [MD=225.57, 95%CI (171.78, 279.37), P<0.001], increase the weight after discharged one month [MD=0.89, 95%CI (0.72, 1.06), P<0.001], increase the weight after discharged three months [MD=670.44, 95%CI (527.65, 813.23), P<0.001], promote the height of newborns [MD=4.54, 95%CI (2.42, 6.65), P<0.001], reduce readmission rate [RR=0.38, 95%CI (0.25, 0.58), P<0.001], alleviate adverse skin reactions [RR=0.33, 95%CI (0.22, 0.50), P<0.001], increase nursing satisfaction of the families [RR=1.21, 95%CI (1.13, 1.31), P<0.001]. Conclusion: TCM can effectively promote the growth and development of the low birth weight premature infants, reduce the hospital readmission rate, alleviate adverse skin reactions of premature infants and improve the nursing satisfaction of the families. However, due to the limitation of the region and quality of the included studies, which the accuracy of the result still be treated with more caution. Further high-quality studies are needed to verify the conclusion.
Postulation of a period of an unexplored manuscript —— Kashyapa Samhita
Divya Jyothi, Deepa K K
92Medical Data Mining    2019, 2 (2): 50-55.   https://doi.org/10.12032/mdm2018018
Abstract ( 108 PDF (414KB) ( 29 )  
Fixing the date of an unexplored manuscript is always a challenging task for a research scholar. The chronology of an unpublished manuscript can be postulated based on internal and external evidence. Here is the study of a manuscript named Kashyapasamhita which is quite different from deemed Kashyapasamhita that is known off. The study was carried out by deciphering and critically editing six manuscripts collected from IPGT & RA (with accession no 6512 and 10779), Tanjore Sarasvati Mahal Library (with accession no.11045), Sampurnananda Library Varanasi (with accession no 1088604) and Oriental Research Institute Mysore (with accession no A129), MS University Baroda Library (with accession no 13474B). The study resulted in the exploration of the concepts regarding Desha (place), Nadi (pulse), Dosha (the three humours of the body), Daivavyapashravya Chikitsa (rituals related to god) and Rasayoga (mercurial formulations). The full paper details the postulation of a period of an unexplored manuscript -Kashyapa Samhita based on the chronology of available Ayurvedic classics.
Effects of Pilates exercise on balance, walking and lower limbs motor function in stroke patients: A meta-analysis
Ya-Nan Leng, Min Zhang, Yu-Qi Li, Ting-Ting Liu, Xiao-Li Pang
Medical Data Mining    2019, 2 (3): 110-117.   https://doi.org/10.12032/mdm2018022
Abstract ( 103 PDF (477KB) ( 51 )  
Objective: To systematically evaluate the effects of Pilates exercise on balance, walking and lower limbs motor function in stroke patients. Methods: The literature databases such as the Cochrane Library, EMbase, PubMed, Web of Science, Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP) and Wan Fang database (Wan Fang) were retrieved. Randomized controlled trials (RCTs) regarding the effects of Pilates exercise on balance, walking and lower limbs motor function of stroke patients were retrieved. Data were collected and evaluated independently by two researchers. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 5 RCTs were included, including 182 subjects were chosen. The result showed that compared with the routine care group, Pilates exercise can effectively improve the balance of stroke patients when they have trained eight weeks [MD=4.71, 95%CI (2.14, 7.28), P=0.0003], shorten the time of the Timed Up and Go test (TUG) [MD=-1.63, 95%CI (-2.69, -0.56), P=0.003], increase the stride velocity [MD=3.83, 95%CI (1.43, 6.23), P=0.002]. However, the evidence did not support the effectiveness of Pilates exercise on increasing the score of Fugl-Meyer Assessment-Lower Extremity (FMA-LE) of stroke patients [MD=6.70, 95%CI (-3.46, 16.86), P=0.20]. Conclusion: The findings suggest that Pilates could improve the balance and walking speed of stroke patients. However, there still is the lack of the evidence in improving lower limb function. Due to the limitation of the quality of the included studies. high-quality studies still should be conducted to investigate the effect of Pilates exercise in stroke patients.
Bibliometric Analysis of the Elderly’s Frailty in China
Xiao-Hui An, Fu-Liang Sun, Shu-Qing Cao
92Medical Data Mining    2019, 2 (2): 76-83.   https://doi.org/10.12032/mdm2018020
Abstract ( 100 PDF (593KB) ( 20 )  
Objective: To analysis the research status of the elderly's frailty in China by bibliometric, in order to provide  reference for clinical practices and nursing researches. Methods: Search  China National Knowledge Infrastructure (CNKI), WanFang Data, CQVIP, China Biology Medicine (CBM) disc to find the studies concerning frailty of older adults in China, and analysis the information of Published year, Provinces, Institutions, Journals, Types, Contents and Funds. Results: A Total of 248 articles were included in this study. From 2011, the numbe of studies about the elderly's  frailty was growing  rapidly;  the province with  the largest number of publications was Beijing, with a total of 82 articles; the institution with the largest number of publications was Beijing Hospital, with 20 articles; the journal with the largest number of publications was Chinese Journal of Geriatrics, with 27 articles; the research type with the largest number of articles was cross-sectional study, with 92 articles, whose content was mainly about the factors of frailty. Conclusion: The study on the elderly's frailty was just starting in China. Hoping to carry out interventional studies widely in the future, so as to delay the progress of frailty and improve the quality of life of the elderly.
Efficacy of empowerment education in self-management with Type 2 Diabetes Mellitus: A systematic review and meta-analysis
Yu-Di Cao, Ke-Jia Liu, Yue Hu , Li-Jiao Wei
92Medical Data Mining    2019, 2 (2): 56-65.   https://doi.org/10.12032/mdm2018016
Abstract ( 97 PDF (1818KB) ( 25 )  
Objective: To evaluate the impact of empowerment education in self-management with Type 2 Diabetes Mellitus. Methods: A literature search was performed in PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), WanFang Data, CQVIP and China Biology Medicine disc (CBMdisc) and for randomized controlled trials published before November 2018. RevMan5.3 software was used for metaanalysis. Results: A total of 11 articles were included, involving 1139 patients. The group of empowerment education included 574 participants, and the regular education groups 565 participants. Meta-analysis showed that the group of empowerment education has an advantage over the control group in the levels of self-efficacy [MD= 17.55, 95%CI(14.14, 20.96), P<0.00001], self-management [SMD=0.85, 95%CI(0.60,1.11),P<0.00001] , as well as the effectiveness of short-term empowerment education(within 6 months ) on reducing HbA1c ( P<0.05); however failed to long-term empowerment education (beyond 12 months) (P= 0.05). Conclusion: This meta-analysis indicates that empowerment education can be an acceptable and appropriated nursing intervention for type 2 diabetes mellitus patients.
Curcumin in The Treatment of in Animals Myocardial ischemia reperfusion: A Systematic review and Meta-analysis
Qian He, Bin Meng, Hong-Yun Hu, Gao-Jian Zhuang, Qun Tang, Xu Zhu
92Medical Data Mining    2019, 2 (2): 66-75.   https://doi.org/10.12032/mdm2018019
Abstract ( 94 PDF (2923KB) ( 41 )  
Objective: The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion. Methods: The computer was searched for Wanfang, VIP, China National Knowledge Infrastructure(CNKI), SinoMed, and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018. Two researchers independently screened the literature based on inclusion and exclusion criteria, extracted the data, and assessed the risk of bias in the included studies. Meta analysis was performed using RevMan 5.3 software. Results: Finally, 9 studies were included for analysis. Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiar-reperfusion group  (LDH: SMD=-4.75, 95% CI [-6.56, -2.94], P < 0.01, MDA: SMD=-2.27, 95% CI [-3.07, -1.47], P < 0.01), the difference was statistically significant (P<0.01). In the subgroup analysis of different doses of curcumin, different doses of curcumin (0.8, 10, 12.5, 20, 25, 30, 50 mg) were able to reduce LDH content compared with the ischemia-reperfusion group, and the differences were statistically significant. Different doses of curcumin (5,10,20,30,40mg) can reduce MDA content, and the difference is statistically significant; curcumin (0.8mg) group has no statistically significant effect on MDA content (SMD = -0.54, 95% CI [-1.35, 0.28], P = 0.20). The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin (20 mg) group, the curcumin (40 mg) group could better reduce the MDA content, and the difference was statistically significant (P=0.03). Conclusion: Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,  and has a protective effect on myocardium. Moreover,  the ability to reduce the damage is related to the dose of curcumin. However, the sample of the included studies is limited, and this conclusion requires more high-quality experiments to verify.
Application status and development of big data in medical education in China
Ke-Jia Liu, Yu-Di Cao, Yue Hu, Li-Jiao Wei
Medical Data Mining    2019, 2 (3): 118-125.   https://doi.org/10.12032/mdm2018023
Abstract ( 74 PDF (301KB) ( 19 )  
With the development of information technology, big data has been widely used in medical education in China. Through the analysis of the definition, characteristics and development process of big data, summarized the transformation of domestic big data medical education mode compared with the traditional medical education mode in the teaching mode reform, research method innovation, teaching courses optimization, teaching key extension and the teaching quality monitoring. Based on this, this paper expounds the impact and challenge of big data on medical education, and makes an outlook on its development prospect, indicating that the future development of big data will be open, popular and trending. At the same time, some suggestions on further optimization direction of China's big data medical education are put forward.
Effects of Written Emotional Disclosure on Burden, Trauma Symptoms and Health Status in Primary Caregivers of The Patient: A meta-analysis
Ya-Nan Leng, Min Zhang, Ting-Ting Liu, Yu-Qi Li, Xiao-Li Pang
Medical Data Mining    2019, 2 (3): 126-133.   https://doi.org/10.12032/mdm2018025
Abstract ( 61 PDF (508KB) ( 16 )  

Abstract 

Objective: The meta-analysis aims to evaluate the efficacy of written emotional disclosure on burden, trauma symptoms and health status in primary caregivers of the patient. Methods: Randomized controlled trials (RCTs) of written emotional disclosure in primary caregivers of the patient were retrieved from multiple electronic databases such as the Cochrane Library, PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Chinese Biomedicine Database (CBM) and Wan Fang database (Wan Fang) until August 2019. The eligible studies were screened and evaluated independently by two researchers. Then, we analyzed the extracted data by RevMan 5.3 software. Results: A total of 7 randomized controlled trials (RCT) with 352 primary caregivers were included. The quality evaluation grade of the 3 articles included in the literature was “A”, and the rests was “B”. Meta-analysis showed that compared with the control group, written emotional disclosure could alleviate the burden of patients' primary caregivers [SMD = 0.26, 95% CI (0.02, 0.49), P = 0.03]. The results showed that there was no significant difference between the two groups in alleviating trauma-like symptoms [MD = 3.30, 95% CI (-4.52, 11.11), P = 0.41]. There was no significant difference in the mean score of the General Health Questionnaire (GHQ) between the two groups [MD = -1.94, 95% CI (-11.11, 7.23), P = 0.68]. Besides, there was no significant difference between the two groups in improving their physical and mental health [SMD = 0.28, 95% CI (-0.17, 0.73), P = 0.22; SMD = -0.43, 95% CI (-0.88, 0.02), P = 0.06]. Conclusion: Written emotional disclosure can effectively alleviate the burden in patients' primary caregivers. However, the effects on trauma-like symptoms, the GHQ score and health status need to be verified by further studies.

Meta-analysis of Integrated Traditional Chinese and Western Medicine in Treating H Type Hypertension
Jia He, Wen Liu, Wei Zhang, Li-Jin Zhang
Medical Data Mining    2019, 2 (3): 100-109.   https://doi.org/10.12032/mdm2018024
Abstract ( 48 PDF (344KB) ( 10 )  

Abstract 

Objective: The aim of this study was to compare the clinical emcacy of integration of traditional Chinese medicine (TCM) and we stern medicine, and the western medicine therapy for H type hypertension. Methods: The randomized contmlled trials were collected via searching the internet. The literatures were screened according to inclusion and exclusion criteria. All the assignments were performed by two researchers. If there was disagreement between the two researchers, we would ask evidence based medicine expert for advice, to get an optimal result. The database included the ChianInfo (1978—2015), the Superstar database (1955—2017), the CBM(1985—2017), CNKI(1984—2017), PubMed(1966—2017). Accordingto Meta analysis, the RevMan 5.2 software was used to recover and analyze the literatures, and make the assessment of the integration of TCM and westem medicine in treating H Type Hypertension. Results: In the study, 12 trials were included. The total number of cases is 1139. The Meta analysis results showed that: Compared with western medicine the integration of TCM and western medicine would improve the antihypertensive efficacy [OR=0.39, 95%CI (0.25, 0.59), Z=4.38(P< 0.0001)],lower Hcy levels [WMD=-1.93, 95%CI (-2.27, 0.21), Z=4.38 (P< 0.0001)]. Conclusion: The combination therapy can effectively reduce Hcy levels, control blood pressure, better than Western medicine.