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The application effect of swaddling bath in neonates: A meta-analysis
Hui-Ping Wang, Chang-De Jin
92Medical Data Mining    2019, 2 (2): 84-89.   https://doi.org/10.12032/mdm2018017
Abstract ( 248 PDF (493KB) ( 112 )  
Objective: The meta-analysis is to objectively evaluate the efficacy of swaddling in neonates. Methods: Randomized controlled trials (RCTs) and Randomized cross-over design (RCD) about the effects of swaddling in neonates from multiple electronic databases (PubMed, Web of Science, the Cochrane Library, EMBASE, CINAHL,CNKI, Wanfang and VIP) until January 2019. Two investigators independently screened eligible studies, extracted data, and assessed the methodological quality by using the quality evaluation criteria for RCTs recommended by Cochrane Handbook. Then data were analyzed by Rev Man 5.3. Results: A total of 6 papers (4 randomized controlled trials and 2 Randomized cross-over design) with 318 participants were included. The meta-analysis indicated that there was a significant difference on Body Temperature, Heart Rate, crying time, incidence of open eyes and incidence of closed eyes (P<0.05); There was no significant difference in Spo2 level between the two groups (p>0.05). Conclusion: Swaddling bath has little influence on the Body Temperature, Heart Rate, and behavioral response of newborn. And it has no significant effect on maintaining Spo2 level. However it can reduce the stress behavior of the newborn. Due to the limitations of the quality of studies included, multi-centered randomized controlled trial large sample size are needed in the future to evaluate the effects of prone position ventilation on neonatal respiratory distress syndrome.
Effects of Pilates exercise on balance, walking and lower limbs motor function in stroke patients: A meta-analysis
Ya-Nan Leng, Min Zhang, Yu-Qi Li, Ting-Ting Liu, Xiao-Li Pang
Medical Data Mining    2019, 2 (3): 110-117.   https://doi.org/10.12032/mdm2018022
Abstract ( 237 PDF (477KB) ( 144 )  
Objective: To systematically evaluate the effects of Pilates exercise on balance, walking and lower limbs motor function in stroke patients. Methods: The literature databases such as the Cochrane Library, EMbase, PubMed, Web of Science, Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP) and Wan Fang database (Wan Fang) were retrieved. Randomized controlled trials (RCTs) regarding the effects of Pilates exercise on balance, walking and lower limbs motor function of stroke patients were retrieved. Data were collected and evaluated independently by two researchers. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 5 RCTs were included, including 182 subjects were chosen. The result showed that compared with the routine care group, Pilates exercise can effectively improve the balance of stroke patients when they have trained eight weeks [MD=4.71, 95%CI (2.14, 7.28), P=0.0003], shorten the time of the Timed Up and Go test (TUG) [MD=-1.63, 95%CI (-2.69, -0.56), P=0.003], increase the stride velocity [MD=3.83, 95%CI (1.43, 6.23), P=0.002]. However, the evidence did not support the effectiveness of Pilates exercise on increasing the score of Fugl-Meyer Assessment-Lower Extremity (FMA-LE) of stroke patients [MD=6.70, 95%CI (-3.46, 16.86), P=0.20]. Conclusion: The findings suggest that Pilates could improve the balance and walking speed of stroke patients. However, there still is the lack of the evidence in improving lower limb function. Due to the limitation of the quality of the included studies. high-quality studies still should be conducted to investigate the effect of Pilates exercise in stroke patients.
Effect of Transitional Care Model on Low Birth Weight Premature Infants: a meta-analysis
Ya-Nan Leng, Ming Sang, Ting-Ting Liu, Yu-Qi Li, Xiao-Li Pang
Medical Data Mining    2019, 2 (3): 90-99.   https://doi.org/10.12032/mdm2018021
Abstract ( 194 PDF (520KB) ( 72 )  
Objective: To systematically review the effect of Transitional Care model (TCM) on the growth and development of premature infants. Methods: Randomized controlled trials (RCTs) or quasi-RTCs regarding the effect of TCM in low birth weight premature infants were retrieved in electronic databases such as the Cochrane Library, PubMed, EMbase, Web of Science, CBM (Chinese Biomedicine Database), CNKI (China National Knowledge Infrastructure), VIP (Chinese Scientific Journals Database) and Wanfang Database. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 11 articles were included, including 1282 preterm infants. The result showed that compared with the routine care model, TCM can effectively increase the weight when premature infants discharged one week [MD=225.57, 95%CI (171.78, 279.37), P<0.001], increase the weight after discharged one month [MD=0.89, 95%CI (0.72, 1.06), P<0.001], increase the weight after discharged three months [MD=670.44, 95%CI (527.65, 813.23), P<0.001], promote the height of newborns [MD=4.54, 95%CI (2.42, 6.65), P<0.001], reduce readmission rate [RR=0.38, 95%CI (0.25, 0.58), P<0.001], alleviate adverse skin reactions [RR=0.33, 95%CI (0.22, 0.50), P<0.001], increase nursing satisfaction of the families [RR=1.21, 95%CI (1.13, 1.31), P<0.001]. Conclusion: TCM can effectively promote the growth and development of the low birth weight premature infants, reduce the hospital readmission rate, alleviate adverse skin reactions of premature infants and improve the nursing satisfaction of the families. However, due to the limitation of the region and quality of the included studies, which the accuracy of the result still be treated with more caution. Further high-quality studies are needed to verify the conclusion.
Postulation of a period of an unexplored manuscript —— Kashyapa Samhita
Divya Jyothi, Deepa K K
92Medical Data Mining    2019, 2 (2): 50-55.   https://doi.org/10.12032/mdm2018018
Abstract ( 165 PDF (414KB) ( 92 )  
Fixing the date of an unexplored manuscript is always a challenging task for a research scholar. The chronology of an unpublished manuscript can be postulated based on internal and external evidence. Here is the study of a manuscript named Kashyapasamhita which is quite different from deemed Kashyapasamhita that is known off. The study was carried out by deciphering and critically editing six manuscripts collected from IPGT & RA (with accession no 6512 and 10779), Tanjore Sarasvati Mahal Library (with accession no.11045), Sampurnananda Library Varanasi (with accession no 1088604) and Oriental Research Institute Mysore (with accession no A129), MS University Baroda Library (with accession no 13474B). The study resulted in the exploration of the concepts regarding Desha (place), Nadi (pulse), Dosha (the three humours of the body), Daivavyapashravya Chikitsa (rituals related to god) and Rasayoga (mercurial formulations). The full paper details the postulation of a period of an unexplored manuscript -Kashyapa Samhita based on the chronology of available Ayurvedic classics.
Identification of core compositions of traditional Chinese medicine for Seborrheic Dermatitis using data mining techniques
Meng-Xi Gao, Ai-Ying Zhang, Zhi-Dan Cao, Wei Fan, Tian-Tian Gai, Yan Wang
Medical Data Mining    2019, 2 (4): 134-141.   https://doi.org/10.12032/mdm2019121001
Abstract ( 159 PDF (604KB) ( 121 )  

Abstract

Objective: To explore the clinical medication rule of seborrheic dermatitis in modern Chinese medicine by data mining, in order to benefit the clinical treatment of seborrheic dermatitis in traditional Chinese medicine. Methods: From January 1, 2010 to September 4, 2019, articles on Chinese medicine for seborrheic dermatitis were searched systematically in CNKI, VIP and Wan Fang databases. Prescription databases were established through the Chinese Medicine Inheritance assistant system to mine and analyze the rules of data. Results: 69 researches were screened out, 72 prescriptions for seborrheic dermatitis. 13 drugs were used more than or equal to 15 times, and 9 pairs of commonly used drugs with correlation coefficient above 0.045 were selected. Six core combinations and two new prescriptions were obtained. Conclusion: Data mining method was used to analyze the high-frequency drugs and drug pairs, which reflected the treatment principle of clearing heat and removing dampness, nourishing blood and moistening dryness, promoting qi and strengthening spleen in the clinical treatment of seborrheic dermatitis, and provided more intuitive research evidence for the follow-up clinical treatment.

Curcumin in The Treatment of in Animals Myocardial ischemia reperfusion: A Systematic review and Meta-analysis
Qian He, Bin Meng, Hong-Yun Hu, Gao-Jian Zhuang, Qun Tang, Xu Zhu
92Medical Data Mining    2019, 2 (2): 66-75.   https://doi.org/10.12032/mdm2018019
Abstract ( 156 PDF (2923KB) ( 73 )  
Objective: The protective effects of curcumin on myocardial ischemia-reperfusion were systematically evaluated by analyzing the related literatures of curcumin and myocardial ischemia-reperfusion. Methods: The computer was searched for Wanfang, VIP, China National Knowledge Infrastructure(CNKI), SinoMed, and Pubmed database to find animal experiments on curcumin treatment of myocardial ischemia-reperfusion.The retrieval time is from the establishment of the database to November 2018. Two researchers independently screened the literature based on inclusion and exclusion criteria, extracted the data, and assessed the risk of bias in the included studies. Meta analysis was performed using RevMan 5.3 software. Results: Finally, 9 studies were included for analysis. Meta-analysis showed that the curcumin group can reduce LDH and MDA levels compared with the ischemiar-reperfusion group  (LDH: SMD=-4.75, 95% CI [-6.56, -2.94], P < 0.01, MDA: SMD=-2.27, 95% CI [-3.07, -1.47], P < 0.01), the difference was statistically significant (P<0.01). In the subgroup analysis of different doses of curcumin, different doses of curcumin (0.8, 10, 12.5, 20, 25, 30, 50 mg) were able to reduce LDH content compared with the ischemia-reperfusion group, and the differences were statistically significant. Different doses of curcumin (5,10,20,30,40mg) can reduce MDA content, and the difference is statistically significant; curcumin (0.8mg) group has no statistically significant effect on MDA content (SMD = -0.54, 95% CI [-1.35, 0.28], P = 0.20). The relationship between the content of MDA and the dose of curcumin showed that compared with the curcumin (20 mg) group, the curcumin (40 mg) group could better reduce the MDA content, and the difference was statistically significant (P=0.03). Conclusion: Curcumin can reduce the content of LDH and MDA in myocardial ischemia-reperfusion,  and has a protective effect on myocardium. Moreover,  the ability to reduce the damage is related to the dose of curcumin. However, the sample of the included studies is limited, and this conclusion requires more high-quality experiments to verify.
Efficacy of empowerment education in self-management with Type 2 Diabetes Mellitus: A systematic review and meta-analysis
Yu-Di Cao, Ke-Jia Liu, Yue Hu , Li-Jiao Wei
92Medical Data Mining    2019, 2 (2): 56-65.   https://doi.org/10.12032/mdm2018016
Abstract ( 153 PDF (1818KB) ( 59 )  
Objective: To evaluate the impact of empowerment education in self-management with Type 2 Diabetes Mellitus. Methods: A literature search was performed in PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), WanFang Data, CQVIP and China Biology Medicine disc (CBMdisc) and for randomized controlled trials published before November 2018. RevMan5.3 software was used for metaanalysis. Results: A total of 11 articles were included, involving 1139 patients. The group of empowerment education included 574 participants, and the regular education groups 565 participants. Meta-analysis showed that the group of empowerment education has an advantage over the control group in the levels of self-efficacy [MD= 17.55, 95%CI(14.14, 20.96), P<0.00001], self-management [SMD=0.85, 95%CI(0.60,1.11),P<0.00001] , as well as the effectiveness of short-term empowerment education(within 6 months ) on reducing HbA1c ( P<0.05); however failed to long-term empowerment education (beyond 12 months) (P= 0.05). Conclusion: This meta-analysis indicates that empowerment education can be an acceptable and appropriated nursing intervention for type 2 diabetes mellitus patients.
Bibliometric Analysis of the Elderly’s Frailty in China
Xiao-Hui An, Fu-Liang Sun, Shu-Qing Cao
92Medical Data Mining    2019, 2 (2): 76-83.   https://doi.org/10.12032/mdm2018020
Abstract ( 147 PDF (593KB) ( 51 )  
Objective: To analysis the research status of the elderly's frailty in China by bibliometric, in order to provide  reference for clinical practices and nursing researches. Methods: Search  China National Knowledge Infrastructure (CNKI), WanFang Data, CQVIP, China Biology Medicine (CBM) disc to find the studies concerning frailty of older adults in China, and analysis the information of Published year, Provinces, Institutions, Journals, Types, Contents and Funds. Results: A Total of 248 articles were included in this study. From 2011, the numbe of studies about the elderly's  frailty was growing  rapidly;  the province with  the largest number of publications was Beijing, with a total of 82 articles; the institution with the largest number of publications was Beijing Hospital, with 20 articles; the journal with the largest number of publications was Chinese Journal of Geriatrics, with 27 articles; the research type with the largest number of articles was cross-sectional study, with 92 articles, whose content was mainly about the factors of frailty. Conclusion: The study on the elderly's frailty was just starting in China. Hoping to carry out interventional studies widely in the future, so as to delay the progress of frailty and improve the quality of life of the elderly.
Application status and development of big data in medical education in China
Ke-Jia Liu, Yu-Di Cao, Yue Hu, Li-Jiao Wei
Medical Data Mining    2019, 2 (3): 118-125.   https://doi.org/10.12032/mdm2018023
Abstract ( 127 PDF (301KB) ( 61 )  
With the development of information technology, big data has been widely used in medical education in China. Through the analysis of the definition, characteristics and development process of big data, summarized the transformation of domestic big data medical education mode compared with the traditional medical education mode in the teaching mode reform, research method innovation, teaching courses optimization, teaching key extension and the teaching quality monitoring. Based on this, this paper expounds the impact and challenge of big data on medical education, and makes an outlook on its development prospect, indicating that the future development of big data will be open, popular and trending. At the same time, some suggestions on further optimization direction of China's big data medical education are put forward.
Effects of Written Emotional Disclosure on Burden, Trauma Symptoms and Health Status in Primary Caregivers of The Patient: A meta-analysis
Ya-Nan Leng, Min Zhang, Ting-Ting Liu, Yu-Qi Li, Xiao-Li Pang
Medical Data Mining    2019, 2 (3): 126-133.   https://doi.org/10.12032/mdm2018025
Abstract ( 118 PDF (508KB) ( 62 )  

Abstract 

Objective: The meta-analysis aims to evaluate the efficacy of written emotional disclosure on burden, trauma symptoms and health status in primary caregivers of the patient. Methods: Randomized controlled trials (RCTs) of written emotional disclosure in primary caregivers of the patient were retrieved from multiple electronic databases such as the Cochrane Library, PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP), Chinese Biomedicine Database (CBM) and Wan Fang database (Wan Fang) until August 2019. The eligible studies were screened and evaluated independently by two researchers. Then, we analyzed the extracted data by RevMan 5.3 software. Results: A total of 7 randomized controlled trials (RCT) with 352 primary caregivers were included. The quality evaluation grade of the 3 articles included in the literature was “A”, and the rests was “B”. Meta-analysis showed that compared with the control group, written emotional disclosure could alleviate the burden of patients' primary caregivers [SMD = 0.26, 95% CI (0.02, 0.49), P = 0.03]. The results showed that there was no significant difference between the two groups in alleviating trauma-like symptoms [MD = 3.30, 95% CI (-4.52, 11.11), P = 0.41]. There was no significant difference in the mean score of the General Health Questionnaire (GHQ) between the two groups [MD = -1.94, 95% CI (-11.11, 7.23), P = 0.68]. Besides, there was no significant difference between the two groups in improving their physical and mental health [SMD = 0.28, 95% CI (-0.17, 0.73), P = 0.22; SMD = -0.43, 95% CI (-0.88, 0.02), P = 0.06]. Conclusion: Written emotional disclosure can effectively alleviate the burden in patients' primary caregivers. However, the effects on trauma-like symptoms, the GHQ score and health status need to be verified by further studies.

Meta-analysis of Integrated Traditional Chinese and Western Medicine in Treating H Type Hypertension
Jia He, Wen Liu, Wei Zhang, Li-Jin Zhang
Medical Data Mining    2019, 2 (3): 100-109.   https://doi.org/10.12032/mdm2018024
Abstract ( 100 PDF (344KB) ( 46 )  

Abstract 

Objective: The aim of this study was to compare the clinical emcacy of integration of traditional Chinese medicine (TCM) and we stern medicine, and the western medicine therapy for H type hypertension. Methods: The randomized contmlled trials were collected via searching the internet. The literatures were screened according to inclusion and exclusion criteria. All the assignments were performed by two researchers. If there was disagreement between the two researchers, we would ask evidence based medicine expert for advice, to get an optimal result. The database included the ChianInfo (1978—2015), the Superstar database (1955—2017), the CBM(1985—2017), CNKI(1984—2017), PubMed(1966—2017). Accordingto Meta analysis, the RevMan 5.2 software was used to recover and analyze the literatures, and make the assessment of the integration of TCM and westem medicine in treating H Type Hypertension. Results: In the study, 12 trials were included. The total number of cases is 1139. The Meta analysis results showed that: Compared with western medicine the integration of TCM and western medicine would improve the antihypertensive efficacy [OR=0.39, 95%CI (0.25, 0.59), Z=4.38(P< 0.0001)],lower Hcy levels [WMD=-1.93, 95%CI (-2.27, 0.21), Z=4.38 (P< 0.0001)]. Conclusion: The combination therapy can effectively reduce Hcy levels, control blood pressure, better than Western medicine.

Efficacy of high-flow nasal cannula on acute exacerbation of chronic obstructive pulmonary disease: A meta-analysis
Ying-Ming Sun, Min Zhang, Na Sun, Zhi Guan, Ying Wang
Medical Data Mining    2019, 2 (4): 142-149.   https://doi.org/10.12032/mdm2019121302
Abstract ( 55 PDF (464KB) ( 34 )  

Abstract 

Objective: To systematically evaluate the efficacy and feasibility of high-flow nasal cannula (HFNC) on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: Systematic searches on PubMed, Web of Science, the Cochrane Library, Embase, CBM (Chinese Biomedicine Database), CNKI (China National Knowledge Infrastructure), Wanfang Database and VIP were performed for randomized controlled trials (RCTs) which explored the effects of HFNC on patients with AECOPD. The retrieval time was from the establishment of each database to July 2019. RevMan5.3 software was used for statistical analysis. Results: A total of 12 articles were included, involving 812 patients. The results showed that: (1) Compared with conventional oxygen therapy, HFNC could improve patients' arterial partial oxygen pressure (PaO2) (MD = 12.70, 95% CI (7.00,18.40), Z = 4.37, P < 0.0001), reduce partial arterial blood carbon dioxide (PaCO2) (MD = -10.99, 95% CI (-14.42, -7.55), Z = 6.26, P < 0.00001) and reduce endotracheal intubation rate (OR = 0.19, 95% CI (0.04, 0.93), Z = 2.05, P = 0.04), shorten the hospitalization time (SMD = -0.74, 95% CI (-1.11,-0.37), Z = 3.95, P < 0.0001). (2) Compared with non-invasive positive pressure ventilation, it has fewer adverse reactions (OR = 0.18, 95% CI (0.09, 0.35), Z = 5.08, P < 0.00001) and shorter hospital stay (SMD = -0.57,95% CI (-0.90,-0.23), Z = 3.33, P = 0.0009). Conclusion: HFNC can improve the patients’ hypoxia symptoms and CO2 retention, reduce the rate of tracheal intubation, and alleviate adverse reactions. However, Limited by the quality and region of the included studies, more high-quality are needed to test it.

Feedforward loop profile among transcription factor, miRNA and mRNA in influenza A virus-infected mouse lungsh
Yanyan Bao, Yujing Shi, Yingjie Gao, Lirun Zhou, Xiaolan Cui
Medical Data Mining    2019, 2 (4): 150-159.   https://doi.org/10.12032/mdm2019122603
Abstract ( 38 PDF (3785KB) ( 17 )  

Abstract 

Purpose: In the present study, we focused on the 46 microRNAs and 719 genes in the microRNA-gene network, reported by us, and aimed to build a research blueprint of feedforward loops and reveal the key TFs in H1N1-infected mouse lung. Method: Based on microRNAs and genes in the microRNA-gene network previously reported by us, we used Jemboss software to find relationships between TFs and microRNAs (or genes), and then built a TF-microRNA-gene network exploiting the interactions between TFs and microRNAs (or genes). Next, we searched the sequences of above genes or microRNAs near the transcription start site (TSS) area, and then used the MatchTM algorithm to predict relevant TFs, and built the TF-Gene-Network. Result: We built a TF-microRNA-gene network and exploreed eight key TFs, namely NF-AT1, GKLF, SRY, SOX10, AML1, MZF1, CRX and myogenin, in the network, and then constructed subgraphs of these eight TFs. Simultaneously, we predicted the possible target genes of microRNAs and identified the feedforward regulation relationship of possible TFs, microRNAs and mRNAs. The results showed that all eight factors with a score greater than 100 were TFs, namely NF-AT1, GKLF, SRY, SOX10, AML1, CRX, myogenin and MZF1. We then constructed subtables of the above eight TFs.Conclusion: In this study, TFs including NF-AT1, GKLF, SRY, SOX10, AML1, MZF1, CRX and myogenin showed the highest score ( > 100) not only in the TF-microRNA-gene network but also in feedforward loops, indicating that these eight TFs play the most important roles in mouse H1N1 influenza virus infection biology.

Regularity of syndrome differentiation and treatment of traditional Chinese medicine for Henoch-Schonlein purpura based on data mining techniques
Shuai Zhang, Yinglin Qin, Jiaqi Yang, Jie Guo, Xueshuai Dai, Xiaoming Jin
Medical Data Mining    2019, 2 (4): 169-175.   https://doi.org/10.12032/mdm2019123005
Abstract ( 36 PDF (374KB) ( 28 )  

Abstract 

Objective: This study aims to explore the regularity of syndrome differentiation and treatment of traditional Chinese medicine (TCM) for allergic purpura. Methods: CNKI, Weipu Chinese science and technology database, wanfang medical network database, and Chinese biomedical literature database were searched for eligible studies. Medical records including complete patient personal information, patient symptoms, TCM syndromes, treatment, and medication were included. The data was analyzed using the Chinese medicine heritage support platform provided by the Chinese Academy of Chinese medicine (V2.5). Results: Differentiation of health gas camp blood was the most commonly used method of differentiation of symptoms and signs in famous veteran TCM. The treatment included cooling blood, activating blood circulation, clearing heat and detoxifying toxins, removing blood stasis and stopping bleeding. Honeysuckle, Forsythia suspensa, cicada slough and other drugs were interrelated. Potential drug pair combinations and drug networks showed the basic drug composition of Qingying Decoction. According to the entropy cluster analysis, 28 core drug combination and 12 new formulations were obtained. Conclusion: The regularity of syndrome differentiation and treatment of traditional Chinese medicine for Henoch-Schonlein purpura based on the famous and old TCM doctors was complex. Further researches are still needed.

The law of oral traditional Chinese medicine for insomnia based on Chinese medical code
Yuyan Li, Yihua Fan, Jinxiang Mao, Naijin Zhang, Aikedai·Abulimiti, Kai Zhong
Medical Data Mining    2019, 2 (4): 160-168.   https://doi.org/10.12032/mdm2019123004
Abstract ( 33 PDF (466KB) ( 26 )  

Abstract 

Objective: This study aimed to collect, sort out and excavate the literature on the diagnosis and treatment of insomnia in Chinese Medical Code, and to explore the law of internal administration of traditional Chinese medicine in the treatment of insomnia. Methods: We used "Chinese Medical Code" as the source of data retrieval, "insomnia", "not sleepy", "no sleeping" and "eye not sleeping" as the key words, and excluded temporary insomnia, physiological insomnia, insomnia caused by other diseases, and excluded other methods such as acupuncture and massage, the medical cases. Prescriptions of insomnia treated with traditional Chinese medicine were screened out. The database was established by using Microsoft excel 2010. Descriptive statistics were used to analyze the frequency, menstruation of nature, taste and efficacy of traditional Chinese medicine. We analyzed the association rules between drugs and mined the rules of prescriptions by the Apriori algorithm in SPSS Modeler 14.1. Results: A total of 147 prescriptions, 138 traditional Chinese medicines, 20 pairs of core drugs, 57 common drug combinations and 3 core pharmaceuticals were included. The basic prescription is:Suan Zao Ren, Bai Zi Ren, Fu Shen, Fu Ling, Yuan Zhi, Dang Gui, Gan Cao (Zhi). Conclusion: In summary, according to the drug analysis above, the main disease of insomnia is in the heart, involving the liver, spleen and kidney. Because it involves different viscera and syndrome, the methods of treatment are also different. However, there is a basic pathogenesis, that’s the loss of mental nourishment. By excavating the law of the use of traditional Chinese medicine in the treatment of insomnia on the Chinese Medical Code, we expect that it can guide the treatment of insomnia.

The law of Chinese herbal medicine decoction for AIDS based on data mining
Ming-Kai Wang, Xue-Qin Qin, Yang-Kai Cai, Hui-Yun Ren, Li-Fen Wang
Medical Data Mining    2020, 3 (1): 37-48.   https://doi.org/10.12032/mdm2020033003
Abstract ( 29 PDF (613KB) ( 10 )  
Objective: To explore the regularity and characteristics of traditional Chinese medicine decoction for the treatment of Acquired Immunodeficiency Syndrome (AIDS) Methods: CNKI, VIP, CBM, Wanfang database and Pubmed were searched to identify potentially eligible studies on clinical observation of Chinese medicine for AIDS. Association rules and hierarchical cluster analysis were conducted. Results:It found that the high-frequency drugs were licorice, ginseng, astragalus and Scutellaria baicalensis, which accounted for more than 56.17% of the total frequency, and the most common combination of drugs was found based on association rules between high-frequency drugs. According to the meridian, the drugs associated with the spleen meridian were used most, followed by the drugs associated with lung, heart, stomach, liver and kidney meridian, which accounted for 61.12% of the total frequency of drugs associated with meridian. Conclusion: The etiology and pathogenesis of AIDS mainly include deficiency of lung and spleen qi, deficiency of liver and kidney, and yin deficiency. It has an important value for the treatment of AIDS with traditional Chinese medicine.
The law of the prescription for non-alcoholic steatohepatitis: a data mining analysis
Xiao-Ting Ma, Feng-Yuan Zhang, Teng-Fei Bai, Bin Hao
Medical Data Mining    2020, 3 (1): 28-36.   https://doi.org/10.12032/mdm2020012101
Abstract ( 25 PDF (683KB) ( 13 )  
Objective: This study aimed to explore the law of the prescription for non-alcoholic steatohepatitis and provide ideas for the clinical application. Methods: This study searched CNKI, Wanfang, CBM, VIP, Web Of Science, PubMed, Elsevier to identify the studies published in nearly three years. The Chinese Medicine Heritage Supporting Platform (V2.5) was used to analyze traditional Chinese medicines used in the treatment of non-alcoholic steatohepatitis prescriptions and their combination rules, extract core combinations to form a new formula. Results: A total of 58 commonly used prescriptions for the treatment of non-alcoholic steatohepatitis were retrieved, including 96 flavors of traditional Chinese medicine. Data mining showed that Chinese medicine with frequency ≥ 6 had a total of 21 flavors, and common pairs of drugs and 26 pairs were used to treat nonalcoholic steatohepatitis. The core drug combination was 6 pairs and evolved into a new party with 3 pairs. Conclusion: The traditional Chinese medicine inheritance platform system has important value for the clinical trial of traditional Chinese medicine for the treatment of nonalcoholic steatohepatitis. The new evolution of the Chinese medicine provides a new idea for the clinical treatment of non-alcoholic steatohepatitis.
Branched-chain/aromatic amino acids as integrated biomarker of type 2 diabetes mellitus: a systematic review and meta-analysis
Jiang-Lan Long, Zhi-Rui Yang, Long Wang, Yu-Mei Han, Can Yan, Dan Yan
Medical Data Mining    2020, 3 (1): 10-21.   https://doi.org/10.12032/mdm2020033002
Abstract ( 24 PDF (2896KB) ( 10 )  
Background: As type 2 diabetes mellitus (T2DM) biomarkers, branched-chain amino acids (BCAAs: valine, leucine and isoleucine) and aromatic amino acids (AAAs: phenylalanine, tryptophan and tyrosine) may be correlated with the occurrence and development of T2DM. However, there is still no consensus on the disperse and isolated biomarkers of T2DM. Purpose: To explore the correlation between amino acids and T2DM based on integrated biomarker approach revealed. Methods: PubMed, Web of Science and CNKI were selected to search the literature published until August 31, 2019. The included studies described the association between BCAAs, AAAs and T2DM. Random effect model and fixed effect model were adopted in pooled analysis to determine mean difference and 95 percent confidence interval of metabolites. Integrated biomarker was constructed in form of concentration change ratios or risk ratio (RR), relative risk (HR) and odds ratio (OR) of BCAAs and AAAs to reflect the integrated change information of amino acids. Results: The selected 20 studies contained 14942 healthy individuals and 3615 T2DM patients. The levels of BCAAs, phenylalanine and tyrosine both in plasma and serum samples were increased among all T2DM patients compared with those of the healthy control subjects (P < 0.00001). However, the mean difference of tryptophan concentration was not statistically significant (P = 0.60). The concentration change ratios or HR/RR/OR of BCAAs and AAAs were connected to form integrated biomarker. Conclusion: The integrated biomarker including BCAAs and AAAs could reflect the basic characteristics of T2DM, which has the potential clinical value on comprehensive diagnosis of T2DM.
The development of Electronic Health Literacy worldwide: a bibliometric analysis
Qi Wu, Zhi-Jian Liu, Ling Cheng, Hui-Li Sun, Guang-Hong Han, Xiao-Li Pang
Medical Data Mining    2020, 3 (1): 1-9.   https://doi.org/10.12032/mdm2020033005
Abstract ( 13 PDF (846KB) ( 13 )  
Objective: This study aimed to review researches on electronic health literacy, provided some suggestions and identified directions for further research. Methods: The literatures were collected by searching the China National Knowledge Infrastructure (CNKI) and the core collection database of Web of Science from inception to November 17, 2019. SPSS software was used for regression analysis, and citespace 5.5.R2 was used for visual analysis. Results: A total of 249 valid documents were retrieved, of which 205 were in English and 44 were in Chinese. Among them, USA had the largest number of publications, followed by Australia, Germany, Netherlands, and China. In China, Beijing has the most published literatures, followed by Anhui, Shanghai, Guangdong, and Shandong. The English-language journal with the most publications was journal of Medical Internet Research, and Chinese-language journal was Chinese health education. However, the Chinese and English core journals were relatively scattered, and no core journal group had yet formed. There were 111 funding institutions in both Chinese and English literature. Research content mainly included current situation investigation, influencing factors, clinical practice interventions, scale preparation and translation, qualitative interviews, etc. Conclusion: At present, there are many researches in the field of e-health literacy worldwide. However, the quality and depth of research still need to be further improved. The field of research also needs to be further expanded to meet the opportunities and challenges that the Internet brings to the medical industry.
The relationship between circulating tumor DNA and epithelial ovarian cancer: a cross-sectional study
Wen-Ming Cao, Xu Wei
Medical Data Mining    2020, 3 (1): 22-27.   https://doi.org/10.12032/mdm2020033004
Abstract ( 9 PDF (289KB) ( 1 )  
Objective: This study aimed to investigate the relationship between circulating tumor DNA and epithelial ovarian cancer. Methods: Twenty-seven cases with epithelial ovarian cancer in changle people's hospital in shandong province were collected. Blood samples before operation were collected to detect circulating tumor DNA. Results: There are 22 ctDNA positive cases, with a proportion of 81.5% (22/27). Proportion of ctDNA positive patients before operation in the early and advanced stage was 60% and 94.1% respectively, with a statistically significant difference (P < 0.05). The difference of proportion of ctDNA positive patients before operation in the subgroup analysis based on clinical stage, histological grading, pathological types, and tumor size was statistically significant (P < 0.05). Conclusion: CtDNA is a promising tumor marker associated with epithelial ovarian cancer.