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30 September 2018, Volume 1 Issue 1    Next Issue
Medical Data Mining: the pilot of medical data analysis in the era of big data
Xiong-Zhi Wu
92Medical Data Mining. 2018, 1 (1): 1-1.  
Abstract ( 179 )     PDF (169KB) ( 104 )  

Medical Data Mining is a quarterly, peer-reviewed open access journal sponsored by TMR publishing group. Its purpose is to discover the scientific laws of life and medicine through data mining of big data and artificial intelligence, and provide a platform for publication and communication in this field.

Association rules analysis of Fufang Kushen injection in combination with traditional Chinese medicine or modern medications in treating Cervical cancer: real-world retrospective study
Fu-Mei Liu, Yan-Ming Xie, Yin Zhang, Cen Chen, Chang Zhang, Yan Zhuang
92Medical Data Mining. 2018, 1 (1): 2-9.   https://doi.org/10.12032/mdm2018001
Abstract ( 223 )     PDF (789KB) ( 108 )  

Objective: The present study aimed to analyze the association rules of Fufang Kushen injection in combination with other traditional Chinese medicine ( TCM) or modern medications in treating cervical cancer (CC) based on the electrical medical records extracted from real-world hospital information system. Methods: The clinicians’ prescriptions regarding to the combination of  with TCM or modern medications were from hospital information system electronic medical data integration warehouse established by the Institute of Basic Medical Research of Chinese Medicine, China Academy of Chinese Medical Sciences, which integrated the hospital information system data of 22 hospitals. The association rules of the drug characteristics were analyzed through Apriori algorithm. Results: A total of 839 patients with CC were included.  We found that  is often combined with prescriptions which could clear heat, remove toxicity, supplement Qi.  also combined with chemotherapeutic drugs, immunomodulatory drugs, 5-HT receptor blockers, and glucocorticoids. The combination presents a specific law. Conclusion: Fufang Kushen injection combined with hepatoprotective drugs, immunomodulators and glucocorticoids is often used to treat cervical cancer. 

Efficacy and safety of Buyanghuanwu decoction combined with regular western medicine treatment for ischemic stroke convalescence: a systematic review and meta-analysis
Zhong-Hui Zhao, Li -Juan He, Jia-Lin Wang, Qian-Yi Li, Yang Li, Yao Yu, Jian-Wei Wang, Wei-Jing Fan, Wu Sun, Lina Miao, Rong-Juan Guo
92Medical Data Mining. 2018, 1 (1): 10-18.   https://doi.org/10.12032/mdm2018004
Abstract ( 214 )     PDF (1378KB) ( 110 )  
Objective: To evaluate the efficacy and safety of Buyanghuanwu (BYHW) decoction for the treatment of ischemic stroke convalescence. Methods: CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), Pubmed, the Cochrane Library, Science Citation Index (SCI) and Elsevier SD databases were searched from the origin time to May 2018. Cochrane recommended bias risk assessment method was used to evaluate the bias risk. Review Manager 5.3 was used to perform meta-analysis. Results: A total of 12 studies with a 1246 cases were included in the study. The results of the analysis showed that the efficacy of BYHW decoction combined with western medicine treatment was better than that of control group (OR = 2.88, 95% CI (2.10,3.95), P < 0.001) ]. The neurological deficit score in the treatment group was lower than that in the control group, and the difference was statistically significant [MD = -2.84, 95% CI (-3.22, -2.45), P < 0.001]. The scores of daily living ability in the treatment group were higher than those in the control group, and the difference was statistically significant [MD = 8.89, 95% CI (7.61, 10.16), P < 0.00001]. In the safety aspect, the results of the study are different, and there was a lack of quantitative indicators to evaluate the objectivity of adverse reactions. Conclusion: BYHW decoction combined with the Western medicine is an effective treatment for the recovery period of cerebral infarction, which can significantly improve the clinical efficacy, improve patients' neurological symptoms and their quality of life. 
Network meta-analysis of acupuncture treatment for mammary gland hyperplasia
Yi-Hua Fan, Hui -Le Li, Yun-Rui Jin, Qiang Zhang
92Medical Data Mining. 2018, 1 (1): 19-29.   https://doi.org/10.12032/mdm2018002
Abstract ( 390 )     PDF (935KB) ( 174 )  

Objective: To evaluate the efficacy of acupuncture for the treatment of mammary gland hyperplasia. Methods: Randomized controlled trials before December 2017 in CNKI, China Biology Medicine disc, Chinese sci-tech periodical full-text database, Wanfang database, Cochrane Library, Pubmed, Embase and Web of Science were searched. The risks were evaluated by two investigators according to the Cochrane Handbook 5.1.0 criteria. Evaluation GeMTC was used for network-meta analysis. Results: A total of 43 articles were included, involving 5531 patients. Network meta-analysis results showed that there were differences in the comparison before and after treatment: acupuncture + Chinese herbal medicine vs acupuncture, acupuncture + Chinese herbal medicine vs Chinese herbal medicine, acupuncture + Chinese herbal medicine v s acupoint embedding, acupuncture + western medicine vs acupuncture, acupuncture + western medicine vs western medicine, acupuncture + western medicine vs Chinese herbal medicine, fire needle vs acupuncture, fire needle vs Chinese herbal medicine, moxibustion vs acupuncture, moxibustion vs Chinese herbal medicine, acupoint embedding line + Chinese herbal medicine vs Chinese herbal medicine, acupoint embedding line + Chinese herbal medicine vs western medicine, acupoint embedding line + Chinese herbal medicine vs acupuncture, acupoint embedding line + Chinese herbal medicine vs acupuncture + Chinese herbal medicine, acupoint embedding line + Chinese herbal medicine vs acupuncture + western medicine, acupoint embedding line + Chinese herbal medicine vs fire needle, acupoint embedding line + Chinese herbal medicine vs fire needle + Chinese herbal medicine, acupoint embedding line Chinese herbal medicine vs electroacupuncture, acupoint embedding line + Chinese herbal medicine vs acupoint embedding line, Acupoint embedding line + Chinese herbal medicine vs ear acupuncture, acupoint embedding line + Chinese herbal medicine vs moxibustion, acupoint embedding line + Chinese herbal medicine vs moxibustion + Chinese herbal medicine. Conclusion:Acupoint embedding + traditional Chinese medicine, acupuncture + western medicine is the best treatment for mammary gland hyperplasia, but the exact conclusion still needs high-quality clinical research to further verify.

Analysis on the introduction of foreign language scales in Chinese nursing masters dissertation
Si-Qi Xiong, Hui-Ping Wang, Chang-De Jin
92Medical Data Mining. 2018, 1 (1): 30-37.   https://doi.org/10.12032/mdm2018003
Abstract ( 234 )     PDF (618KB) ( 121 )  

Objective: The nursing master’s dissertation were analyzed to understand the situation of theintroduction of foreign language scales. Method: Bibliometric method and content analysis method were used to analyze the introduction of foreign languagescales in the current Chinese nursing master’s dissertation which have been collected from CNKI database and WanFang database before February 1, 2018. Results: The introduction of foreign language scales started late, which was from 2012. In 2013, the foreign scales were most introduced (16.2%). The main source of thesis is from Tianjin Medical University (11.6%). English was the most popular language of the foreign scales (93.8%). 80.2% of researchers did not use translation guides. 31.3% of translators comfort the requirements of the translation guidelines. The introduced scales have good reliability and validity. Conclusion: The number of nursing masters dissertation introducing foreign scales has increased year by year with more sources and high quality. It shows that the academic level of nursing postgraduate student in China has been improved. Postgraduate students have a higher ability to learn foreign nursing knowledge and skills and use foreign nursing research tools. However, the lack of translation guide and the ambiguity of the selection criteria of the translators are widespread.