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TMR Modern Herbal Medicine  2018, Vol. 1 Issue (4): 233-240    DOI: 10.12032/TMRmhm2017B29
Analysis of pharmacological action and clinical application of DaXueTeng based on its anti-inflammatory action
Zhang Li-hui1, Lin Miao-miao1, Chen Ying1, Wu Xue-song2, Cai Li-jing1, Li Mei-shan1, Zhang Guo-wei1,*()
1 College of Chinese Medicine, Hebei University, Baoding, Hebei province, China.
2 Laiyuan hospital of Chinese Medicine, Laiyuan, Hebei province, China.
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As one of the representative drugs for clearing heat-toxicity, Chinese medicine DaXueTeng (Caulis Sargentodoxae) contains various chemical substances such as tannins, glycosides, cyclic polyphenols, triterpenoids, lignins, flavonoids, terpenoids and organic acids. It has a wide range of pharmacological effects. Meanwhile, it is valued by the doctor. Modern research suggests that DaXueTeng has antibacterial, antiviral, anti-inflammatory, anti-tumor, and immunosuppressive effects. It has been experimentally and clinically proven that the active constituents of DaXueTeng have a good therapeutic effect on inflammatory diseases. It is widely used in the treatment of pelvic inflammatory disease, annexitis, prostatitis, appendicitis, periappendiceal abscess, inflammatory intestinal obstruction, UC, endometriosis, inflammatory secondary infertility, gouty arthritis, pharyngitis, and stomatitis. Here we review the anti-inflammatory pharmacological effects and clinical applications of.


DaXueTeng (Caulis Sargentodoxae) belongs to Angiospermae, Dicotyledons, Lardizabalaceae, Sargentodoxa, deciduous woody liana. Caulis Sargentodoxae was first recorded in the “BenCaoTuJing”, saying that it can attack blood and cure blood clots. This dissertation first overview relevant literatures of DaXueTeng recent years. We review the anti-inflammatory effects and clinical application of the current active components of DaXueTeng, which provides a good application prospect in clinic.

Key wordsDaXueTeng      Anti-inflammatory effect      review     
Published: 25 October 2018
Fund:  This work was funded by the National Natural Science Foundation of Hebei (No.H2018201179). Hebei University of Science and Technology (No. QN2016077). Health and Family Planning Commission of Hebei (No. 20160388).
Corresponding Authors: Zhang Guo-wei     E-mail:
About author:

# These authors contributed equally to this study.

Cite this article:

Zhang Li-hui, Lin Miao-miao, Chen Ying, Wu Xue-song, Cai Li-jing, Li Mei-shan, Zhang Guo-wei. Analysis of pharmacological action and clinical application of DaXueTeng based on its anti-inflammatory action. TMR Modern Herbal Medicine, 2018, 1(4): 233-240. doi: 10.12032/TMRmhm2017B29

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1.   Wang HF, Kirchoff BK, Qin HN,et a1. Reproductive morphology of Sargentodoxa cuneata, (Lardizabalaceae) and its systematic implications. Plant Syst Evol 2009, 280: 207-217.
doi: 10.1007/s00606-009-0179-3
2.   Ma Ruili, Yu Xiaofeng, Xu Xiuquan,et a1. Progress in Chemical and Pharmacological Investigation of Snrgentodoxa cuneata. Chin Wild Plant Resour 2012, 31: 1-5.
3.   Ni S, Fu C, Wu P.Progress in Medical Studies of Sargentodoxa cuneata Wils. Chin Wild Plant Resour 2004, 23: 8-10.
4.   Tian Y, Zhang HJ, Tu AP,et a1. Phenolics from traditional Chinese medicine Sargentodoxa cuneata. Yao xue xue bao 2005, 40: 628.
pmid: 16196269
5.   Chang J, Case R.Phenolic glycosides and ionone glycoside from the stem of Sargentodoxa cuneata. Phytochem 2005, 66:2752-2758.
doi: 10.1016/j.phytochem.2005.09.018 pmid: 16271734
6.   Agrawal PK.NMR spectroscopy in the structural elucidation of oligosaccharides and glycosides. Phytochem 1992, 31: 3307-3330.
doi: 10.1016/0031-9422(92)83678-R pmid: 1368855
7.   Cali? I, Kirmizibekmez H.Glycosides from Phlomis lunariifolia. Phytochem 2004, 65: 2619-2625.
doi: 10.1016/j.phytochem.2004.04.038 pmid: 15451327
8.   Chang J, Xuan L, Xu Y.Three new phenolic glycosides from the fertile sprouts of Equisetum arvense. Acta Botanica Sinica 2001, 43: 193-197.
doi: 10.1016/S0168-9452(00)00427-1
9.   Chang J, Xuan LJ, Xu YM,et a1. Cytotoxic terpenoid and immunosuppressive phenolic glycosides from the root bark of Dictamnus dasycarpus. Planta Medica 2002, 68: 425-429.
doi: 10.1055/s-2002-32077
10.   Damu AG, Kuo PC, Shi LS,et a1. Chemical constituents of the stem of Sargentodoxa cuneata. Heterocycles 2003, 60: 1645-1652.
doi: 10.3987/COM-03-9777
11.   Demetzos C, Stahl B, Anastassaki T,et a1. Chemical analysis and antimicrobial activity of the resin Ladano, of its essential oil and of the isolated compounds. Planta Medica 1999, 65: 76.
doi: 10.1055/s-2006-960444
12.   DEYAMA T.The constituents of Eucommia ulmoides olive. I. Isolation of (+)-medioredinol di-O-β-D-glucopyranoside. Chem Parm Bull 1983, 31: 2993-2997.
doi: 10.1248/cpb.31.2993
13.   T. Ers?z, D. Ta?demir, I. ?ali?,et a1. Phenylethanoid glycosides from Scutellaria galericulata. Turk J Chem 2002, 26: 465-471.
14.   Greca MD, Ferrara M, Fiorentino A,et a1. Antialgal compounds from zantedeschia aethiopica. Phytochem 1998, 49: 1299-1304.
doi: 10.1016/S0031-9422(98)00092-2
15.   Chang J, Case R.Phenolic glycosides and ionone glycoside from the stem of Sargentodoxa cuneata. Phytochem 2005, 66: 2752-2758.
doi: 10.1016/j.phytochem.2005.09.018 pmid: 16271734
16.   Zeng X, Wang H, Gong Z,et a1. Antimicrobial and cytotoxic phenolics and phenolic glycosides from Sargentodoxa cuneata. Fitoterapia 2015, 101: 153.
doi: 10.1016/j.fitote.2015.01.008 pmid: 25598187
17.   Huang Shufeng, Meng Jianguo, Sun Xin, Deng Chong.Effects of Caulis Sargentodoxae on serum PGI_2 and TXA_2 in phenolic pelvic inflammatory model rats. J ShanXI Coll Tradi Chin Med 2012, 35: 69-70.
18.   Liu Qing, Deng Wei, Huang Shufeng,et a1. Influence of DaXueTeng on Pathological Morphology.IL-6 and TNF-α of the Rats with Chronic Pelvic Inflammatory Disease. N Western J Chin Med 2016, 29: 11-14.
19.   Xu Hao, Ding Yuan.Experimental Study of Hongteng Decoction on Endometrial Integrinαvβ3 Expression of Rats with Pelvic inflammation. Chin J Tradi Med Sci Technol2017, 24: 159-160+ 184.
20.   Xu XQ.Clinical study on the treatment of chronic pelvic inflammatory disease by adding and reducing Hongteng soup retention enema. J Clin Exp Med 2013, 12: 1325-1326.
21.   Liu DQ, Wang KX, Gao GW.Treatment of inflammatory secondary infertility with Hongteng Sauce and Enema. Chin J of Exp Tradi Med Formulae 2010, 16: 189-190.
22.   Cao Y, Zhao L, Chen H,et a1. Professor Dai Deying’s experience in treating endometriosis with “Hongteng Prescription”. Shanghai J Tradi Chin Med 2013, 47: 4-6.
23.   Ma BY.Caulis Sargentodoxae is the main treatment for attachment inflammatory mass. J Tradi Chin Med 2007, 9: 827.
24.   Wang KL, Li SF, Liang B.Research on the Effect of Compound Daxueteng on Chronic Nonbacterial Prostatitis in Rats. J Guiyang Med Coll 2009, 34: 304-307.
25.   Lu Taikun, Ouyang Honggen, Jin Guanyu,et a1. Treatment of 300 cases of chronic prostatitis with Baijiang Hongteng Decoctio. J New Chin Med 2005, 11: 68-69.
26.   Lou Y.Effect of Sargentgloryvine Stem Antidotal Decoction in the treatment of appendiceal abscess in children. Zhejiang University, 2012.
27.   Wang XJ, Li L, Liu QG,et a1. Therapeutic effect of Hongteng decoction on 102 cases of appendix abscess. Western J Chin Med 2017, 30: 107-108.
28.   Shen FG, Gao LX. Application effect of compound Hongteng decoction in the adjuvant treatment of appendiceal abscess and its effect on prognosis. Chin Mod Doc2017, 55: 132-134+138.
29.   Mou EG, Jiang BQ, Sun GZ, Treatment of 46 cases of chronic appendicitis with Caulis Sargentodoxae and Herba Patriniae. J Sichuan Tradi Chin Med 2003, 02: 41.
30.   Yang HW, Jiang L. Treatment of 485 cases of acute appendicitis with Hongteng Decoction. Chin J Tradi Med Sci Technol 1999, 0): 344-345.
31.   Xie SR.Treatment of 40 cases of acute appendicitis with Hongteng decoction. Guangming J Chin Med 2016, 31: 3447-3449.
32.   Xiao P.Observation on the effect of oral Hongteng Decoction in the treatment of inflammatory intestinal obstruction. J Clin Nurs 2007, 3: 79.
33.   Ma WM, Ni GB, Huang XF, et al. Study on the Mechanism of Hongteng Yuwei Yangwei Decoction in Treating Chronic Atrophic Gastritis. Chin J Tradi Med Sci Technol 2005, 02: 68-70+63.
34.   Hu DZ.Treatment of 50 cases of chronic non-specific ulcerative colitis with traditional Chinese medicine enema. Shaanxi J Tradi Chin Med 2003, 01: 21-22.
35.   Zhou Y, Sun J, Wu YY, et al.Observation of Curative Effect of Hongteng Chang'an Decoction in Treating Ulcerative Colitis. Chin J Inf Tradi Chin Med 2015, 22: 22-25.
36.   Dong SH, Qian XM, Xu XB.Effect of retention enema by caulis sargentodoxae enema combined with oral drugs on the immune inflammatory response and intestinal flora in patients with UC. J Hainan Med Univ 2017, 23: 2353-2356.
37.   Ling JY, Xue S, Shen L.64 cases of acute gouty arthritis treated with external application of Caulis Sargentodoxae and Chinese medicine. J Emerg Tradi Chin Med 2013, 22: 1036-1037.
38.   Liang G, Huang X, Trimble R, et al. Computational Comparison of the Anti-Inflammatory Targets of the Traditional Chinese Medicine Sargentodoxa Cuneata (Hong Teng) and Western Therapeutics for the Treatment of Osteoarthritis. Toxicol 2015: S-330-S-331.
39.   Wang H, Ma S.Immunosuppressive Effect of Caulis Sargentodoxae on Mice. Henan Tradi Chin Med 2009, 37: 756-758.
40.   Ma R, Sun H, Tang J, et al.Anti-inflammatory and immunoregulatory properties of fractions from Sargentodoxa cuneata ethanol extract. J Med Plant Res 2015, 9: 104-110.
doi: 10.5897/JMPR
41.   Fu Y, Wang GY.Effects of Chinese medicine Caulis Sargentodoxae on MMP-2 and MMP-9 in synovial cells of adjuvant arthritis rats. Guizhou Med J 2009, 33: 1097-1099.
42.   FU Y.Influence of caulis on serum level of TNF-α、IL-6 in adjuvant arthritis rat. Mod Hos 2007, 7: 37-39.
43.   Xiang H.Caulis Sargentodoxae treatment of glossitis and oral ulcers. Chin J Ethnomed and Ethnopharm 2011, 20: 139.
44.   Lv FQ.Caulis Sargentodoxae treatment of acute pharyngitis. J Tradi Chin Med, 2007 14: 827.
45.   Li H, Huang SF, Deng W, et al.Study on analgesic and anti-inflammatory effects of Caulis Sargentodoxae. Shaanxi J Tradi Chin Med 2013, 34: 1427-1428.
46.   Zhou Z H, Weng Q, Zhou J, et al.Anti-inflammatory and anti-nociceptive activities of the extracts of Sargentodoxa cuneata and its effects on the model rats with pelvic inflammation. J Animal Plant Sci 2012, 22: 44-50.
47.   Cheng XP.Sargentgloryvine Stem Extracts Regulate Inflammatory reaction through NRF2/ARE Signaling Pathway. Fujian University of Traditional Chinese Medicine, 2017.
48.   Li L, Yang M, Yan M, et al.Inhibition of Caulis Sargentodoxae on immune function and allogeneic skin graft rejection in mice. Chin J Immunol 2009, 25: 223-224.
49.   Sakakibara I., Hayashi K., Shimoda Y., 1995. Extraction of vasodilating polycyclic phenolic compound from Sargentodoxa cuneata stems. Jpn Kokai Tokkyo Koho JP 07149630.
50.   Sakakibara I., Yoshida M., Hayashi K., Maruno M., 1994. Antiin?ammatory activities of glycosides from Sargentodoxa cuneata stems. Jpn Kokai Tokkyo Koho JP 06199885.
51.   Mao SC, Cui CB, Gu QQ.Research Progress in Chemical Constituents and Pharmacological Activities of Traditional Chinese Medicine Caulis Sargentodoxae. Nat Prod Res Dev 2003, 15: 559-562.
52.   Zhao XM, Ke HQ, Yu HB.Studies on Pharmacological Effect and Clinical Application of Sargentodoxa Cuneata. Guid J Tradit Chin Med Pharm 2014, 20: 41-43.
53.   Guo J P, Pang J, Wang X W, et al.In vitro screening of traditionally used medicinal plants in China against enteroviruses. World J Gastroenterol 2006 12: 4078-4081.
doi: 10.3748/wjg.v12.i25.4078
54.   Xiao Y, Ding Q, Zhao D.Study Progress of Sargentgloryvine Stem. Guiding J Tradi Chin Med Pharmacol 2009, 15: 105-107.
55.   Chen H, Wan X M, Zhou X L.Anti-thrombotic and anti-tumor effect of water extract of caulis of Sargentodoxa cuneata (Oliv) Rehd et Wils (Lardizabalaceae) in animal models. Trop J Pharm Res 2016, 15: 2391.
doi: 10.4314/tjpr.v15i11.13
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