Please wait a minute...
TMR Modern Herbal Medicine  2018, Vol. 1 Issue (4): 241-248    DOI: 10.12032/TMRmhm2017B30
Review     
Toxic effects of BuGuZhi and feasibility analysis of ways to synergistic and attenuated
Cui Qian1, Ma Yu-Hui1, Jin Xiao-Ming1, Liu Jing-Jing1, Zhang Yan-Hong1, Zhang Guo-wei1,*()
1 College of Chinese Medicine, Hebei University, Baoding, Hebei province, China.
Download: HTML     PDF(347KB)
Export: BibTeX | EndNote (RIS)      

BuGuZhi (Psoraleae Fructus) is the dry mature peel of the leguminous plant. After ripening in autumn, the fruit is collected and dried to get its fruit, which has the effect of warming kidney and helping Yang, the effect of absorbing asthma, warming the kidney and relieving diarrhea, and treating vitiligo and alopecia. Because the clinical curative effect is exact, so it has been widely used in the treatment of clinical diseases. However, the recent reports and clinical cases reported that BuGuZhi has some toxic effects. According to domestic and foreign references, toxic effects are mainly divided into hepatotoxicity, nephrotoxicity, phototoxicity, reproductive toxicity, and rare cases of retinal vagueness reported by clinical reports. the toxicity of BuGuZhi is summarized. The article analyzed the way of synergism and reduction of BuGuZhi, which was based on data mainly coming from the compatibility of drugs, pattern identification, constitution identification and drug processing. All o-f analyses and summaries are in order to make the clinical medication safer and more scientific.

Highlights

BuGuZhi (Psoraleae Fructus),belonging to angiosperm, dicotyledoneae, rosidae , leguminosae, Psorslea L. Psoraleae Fructus, which was first recorded in “Kai Bao Ben Cao”, has been used widely in clinics for the functions of warming the kidney and helping the yang, calming the breath, warming the kidney, stopping the diarrhea. As the incidence of adverse reaction events accumulated in recent years, it has attracted the attention of domestic and overseas scholars. Thus, in order to provide a basis for doctors to use BuGuZhi safely, this article summarizes the literature on the toxicity of BuGuZhi, and analyzes the ways of enhancing efficacy and reducing toxicity.



Key wordsBuGuZhi      toxicity      synergistic and attenuated     
Published: 25 October 2018
Fund:  The study was funded by the National Natural Science Foundation of Hebei (No.H2018201179).
Corresponding Authors: Zhang Guo-wei     E-mail: xxzgw@126.com
About author: # Both authors contributed equally to this work.
Cite this article:

Cui Qian, Ma Yu-Hui, Jin Xiao-Ming, Liu Jing-Jing, Zhang Yan-Hong, Zhang Guo-wei. Toxic effects of BuGuZhi and feasibility analysis of ways to synergistic and attenuated. TMR Modern Herbal Medicine, 2018, 1(4): 241-248. doi: 10.12032/TMRmhm2017B30

URL:

https://www.tmrjournals.com/mhm/EN/10.12032/TMRmhm2017B30     OR     https://www.tmrjournals.com/mhm/EN/Y2018/V1/I4/241

1.   Chinese Pharmacopoeia.2015 ed. China Medical Science Press, 2015, 187-188.
2.   Cai Y, Chen B, Zhang RH,et a1. Apoptosis of HL60 Cell Line Induced by Psoralean and Its Effect on Intracellular Ca2+ Concentration. Chin oncol clin 2006, 8: 64-66.
3.   Yang SJ, Zhong SD, Yang JP,et a1. Optimization of Extraction and Purification Process of Bakuchiol and Analysis of Its Effect on Osteoporosis. Chin J Exp Trad Med Formulae 2017, 23: 43-47.
4.   Nam SW, Baek JT, Lee DS,et a1. A case of acute cholestatic hepatitis associated with the seeds of Psoralea corylifolia. Clin Toxicol (Phila) 2005, 43: 589-591.
doi: 10.1081/CLT-200068863
5.   Li YJ, Huang YY.Drug-induced liver injury caused by Psoralea corylifolia:a case report.Shanghai Med 2016, 37: 41-42.
6.   Ma R, Chen Y, Zhao YJ,et a1. Case Report of Liver Damage by Traditional Chinese Medicine Drug Granules. Clin Misdiagn Mistreatment 2018, 31: 84-86.
7.   Li ZJ, Abulizi A, Zhao GL,et a1. Bakuchiol Contributes to the Hepatotoxicity of Psoralea corylifolia in Rats. Phytother Res 2017, 31: 1265-1272.
doi: 10.1002/ptr.5851 pmid: 28639266
8.   Bi YN, Li Z, Zhou K,et a1. Influence of Bakuchiol on liver function and bile acid transporters BSEP and NTCP in mouse. J Tianjin Univ Trad Chin Med 2015, 34: 222-225.
9.   Wang AH, Zhou K, Chai LJ.Study on the influence of Psoralen on HepG2 cell proliferation in vitro and the expression of BSEP, NTCP Proteins. Lishizhen Med Mater Med Res 2015, 26: 1563-1565.
10.   Song L, Bi YN, Yuan XM.Study on the influence of isopsoralen onC57 mice liver injury after intraperitoneal injection for 9. J Toxicol 2018, 32: 21-24.
11.   Bai RY, Zhang Y, Bi YN,et a1. Acute toxicity and drug interaction of psoralen and isopsoralen. Drug Eval Res 2018, 41: 1068
12.   Wang J, Jiang Z, Ji J,et a1. Evaluation of hepatotoxicity and cholestasis in ratstreated with EtOH extract of Fructus Psoraleae. J Ethnopharmacol 2012, 144: 73-81.
doi: 10.1016/j.jep.2012.08.028
13.   Abudumijiti·ABULIZI, Abudujilili·ABUDUAINI, Aiximujiang·REFUKATI, et al. Study on the acute toxicity and sub-acute toxicity of ethanol extract of Psoraleae Fructus in mice by intragastric administration. ChinA Med Herald 2016, 13: 20-24.
14.   MAIMAITI Youliduzi, REFUKATI Aiximujiang, ABUDUAINI Abudujilili.Acute toxicity and subacute toxicity of aqueous extract of Psoralea corylifolia in mice. Chin Pharmacol Bull 2017, 33: 147-148.
15.   Chen Y, Wang M, Song J,et a1. Effect of extract ethanol and wate-r decoction of Psoralea corylifolia L.on bone development and their toxicities in zebrafish . Chin J Pharmacol Toxicol 2017, 31: 661-669.
16.   Zhang YS, Liu YQ, Wu ZL,et a1. Study on bakuchiol on renal toxicity in mice. Bull Trad Chin Med 1981, 3: 30-32.
17.   Jiang F, Zhou XH, Zhang BX,et a1. The toxicity and the mechanism of the combination of bakuchiol and psoralen in HK-2 cells. Chin J Pharmacol Toxicol 2010, 24: 50-58.
18.   Li Af, Shen Gl, Jiao Sy.Metabolic detoxification of bakuchiol is mediated by cytochrome P450 enzymes in hu-man liver microsomes. J Peking Univ 2012, 44: 431-436.
19.   Jiao Sy, Ai Ch, Li AF, et al. In vitro inter-species comparison of metabolism and metabolic detoxification of bakuchiol in liver microsomes. Chin pharmacol Bull 2011,27: 216-220.
20.   Ji YB Wang M, Wang Y, et al. Study on mechanism of HepaRG cell injury induced by bavachinin. Chin pharmacol Bull 2018, 34: 544-555
21.   Wang S, Wang M, Wang M, et al. Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways. Toxins Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways. Toxins (Basel) 2018, 10: pii: E154.
22.   Nagley P, Higgins GC, Atkin JD,et al. Multifaceted deaths orchestrated by mitochondria in neurons, Biochim Biophys Acta 2010, 1802:167-85.
doi: 10.1016/j.bbadis.2009.09.004 pmid: 19751830
23.   Zhang XJ, Cao HQ,Xing ZH,et a1. Effects of Psoraleae Fructus on morphology, liver function and mitochondrial membrane potential of mice liver cells. Chin Pat Med 2014, 36: 160-162.
24.   Yang Y, Tang X, Hao F, Bavachin Induces Apoptosis through Mitochondrial Regulated ER Stress Pathway in HepG2 Cells. Biol Pharm Bull 2018, 41: 198-207
doi: 10.1248/bpb.b17-00672 pmid: 29187671
25.   Zhou K.Psoralidin induces mitochondrial dependent HepG2 cell apoptosis. Chin Soc Toxicol (CSOT) 2014: 1.
26.   Ma YM.Attention should be paid to light induced drug eruption after taking medicine. Cap Med 2000, 2: 55.
27.   Zhang LX, Song LH, Shi QJ,et a1. Study on the method of phototoxicity test. J Environ Health 2002, 19: 60-61.
28.   Xiong HY.Photosensitive reaction of psoralen. Chin J Disinfection 2002, 19: 31-35.
29.   Yao FL, Chen H, Lu Yan,et a1. Report of 12 cases of acute light toxicity contact dermatitis caused by Psoralen Fructus (with spot sticking test). Chin J Dermatovenereol 2000, 14: 410-411.
30.   Diawara MM, Chavez KJ, Hoyer PB, et al. A novel group of ovarian toxicants: the psoralens[J]. Biochem Mol Toxicol 1999, 13: 195-203.
doi: 10.1002/(ISSN)1099-0461
31.   Zhao H.Analysis of 2 cases of adverse reactions of Psoraleae Fructus injection. China pharmacist 2010, 13: 417-418.
32.   Shen GQ, Gong CY.1 cases of blurred vision caused by long termuse of Chinese medicine Psoraleae Fructus. Pharm Clin Res 2009, 17: 260.
33.   Xia YN.The research on the material basis of Paoralea stir fried with salt-to easedryness and toxicity. Chengdu University of Chinese Medicine, 2016.
34.   Wang ZH, Fu J, Wu LB,et a1. Changes of Chemical Constituents in Psoraleae Fructus Before and After Salted Based on UPLC /Q-TOF-MS Technology. Chin J Exp Trad Med Formulae 2014, 20: 51-55.
35.   Tao Y, Jiang YH, Li WD,et a1. Effect of Processing on Contents of Twelve Constituents in Psoraleae Fructus. Chin J Exp Trad Med Formulae 2016, 22: 6-9.
36.   Mao SJ.How to "reduce the toxicity and increase the efficiency" of the poisonous Chinese herbal pieces. China Newsp Tradit Chin Med 2002, 10-16.
37.   Hu X, Wang P, Zhang YJ,et a1. Study on processing technology and quality standard of Psoraleae fructus. Chin Tradit Pat Med 2007, 30: 1026-1031.
38.   Li N, Zhang XM, Yao YY,et a1. Optimization of processing technology for Psoraleae Fructus by Doptimal response surface methodology with UHPLC. Chin Herb Med 2016, 47: 233-239.
39.   Cai TT, Huang NN, Wang L,et a1. Experimental Comparison Study on Acute Toxicity of Different Processing Methods of Psoraleae Fructus on Normal Mice. Chin J Pharmacovigil 2017, 14: 730-736.
40.   Li HF, Xu X, Xu YY.Comparative Study on the Processing Technology of Psoralea corylifolia by Salt Frying and Salt Steaming. China Pharmacy 2017, 28: 1845-1847.
41.   Xu N, Jia TZ.A new thinking for improving Chinese materia medica quality: TCM processing and conversion. China J Tradit Chin Med Pharm 2016, 31: 3173-3177.
42.   Pan X.The mechanism research no processed ESW ehhance the ESW of warming the kidneyand spleen, relieving diarrhea with astringents. Chengdu University of Chinese Medicine, 2015.
43.   Guo WH, Li XY, Huang NN,et a1. Research Progress of Psoraleae Fructus Compatibility Rule Based on Properties and Flavors Theory. Chin J Pharmacovigil 2017, 14: 737-741.
44.   Zhao ZJ, Gong Z, Shi SZ,et a1. Toxicokinetics of bakuchiol, hepatic and renal toxicity in rats after single oral administration of Psoraleae Fructus and combination with Glycyrrhizae Radix et Rhizoma. China J Chin Mater Med 2015, 40: 2221-2226.
45.   Deng PX, Xu M.Comparison of liver toxicity of psoraleae fructus sing-le application and compound application in rats. Guangxi Univ Chin Med 2005, 28: 49-50.
46.   Cheng XF, Liu S, Yang SF,et al. Dose-effect Relationship of Chinese Medicines Cnidium Fruit-Psoralea Fruit in Pairs on the Body Weight and Bone Metabolism of Mammary Cancer bone Metastasis in Nude Mice. J Tradit Chin Med 2011, 52: 2128-2131+2134.
47.   Ma X.Preparation of the effective parts of Scurfpea fruit and white Korra benecolence and the research of anti-tumor synergistic mechanism. Nanjing University of Chinese Medicine, 2013.
48.   Wang C.Correctly understand the toxicity and rational use of Chinese herbal medicine. Chin Med Mod Distance Educ China 2003, 1: 31-33.
49.   Huang LS.Discussion on the safe use of poisonous Chinese Medicine. Prim J Chin Mater Med 2001, 04: 61.
50.   Zhou JG, Ma SJ, Huang YL, et al.Identification of Psoraleae Fructus and its adulterants using ITS2 sequence. World Chin Med 2016, 11: 786-790.
51.   Dai YH. Toxicity reduction and synergistic measures for toxicity of Chinese Materia Medica. Chin J Animal Husb Vet Med 2006-10-01 (012).>
[1] Liu Xiao-Mei, Lv Hong, Wang Xiao-Ming, Guo Ya-Qing, Li Ting-Ting, Pan Gui-Xiang. Application of LC-MS based glutathione-trapped reactive metabolites in the discovery of toxicity of traditional Chinese medicine[J]. TMR Modern Herbal Medicine, 2018, 1(4): 209-219.