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TMR Modern Herbal Medicine  2018, Vol. 1 Issue (4): 241-248    DOI: 10.12032/TMRmhm2017B30
Toxic effects of BuGuZhi and feasibility analysis of ways to synergistic and attenuated
Cui Qian1, Ma Yu-Hui1, Jin Xiao-Ming1, Liu Jing-Jing1, Zhang Yan-Hong1, Zhang Guo-wei1,*()
1 College of Chinese Medicine, Hebei University, Baoding, Hebei province, China.
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BuGuZhi (Psoraleae Fructus) is the dry mature peel of the leguminous plant. After ripening in autumn, the fruit is collected and dried to get its fruit, which has the effect of warming kidney and helping Yang, the effect of absorbing asthma, warming the kidney and relieving diarrhea, and treating vitiligo and alopecia. Because the clinical curative effect is exact, so it has been widely used in the treatment of clinical diseases. However, the recent reports and clinical cases reported that BuGuZhi has some toxic effects. According to domestic and foreign references, toxic effects are mainly divided into hepatotoxicity, nephrotoxicity, phototoxicity, reproductive toxicity, and rare cases of retinal vagueness reported by clinical reports. the toxicity of BuGuZhi is summarized. The article analyzed the way of synergism and reduction of BuGuZhi, which was based on data mainly coming from the compatibility of drugs, pattern identification, constitution identification and drug processing. All o-f analyses and summaries are in order to make the clinical medication safer and more scientific.


BuGuZhi (Psoraleae Fructus),belonging to angiosperm, dicotyledoneae, rosidae , leguminosae, Psorslea L. Psoraleae Fructus, which was first recorded in “Kai Bao Ben Cao”, has been used widely in clinics for the functions of warming the kidney and helping the yang, calming the breath, warming the kidney, stopping the diarrhea. As the incidence of adverse reaction events accumulated in recent years, it has attracted the attention of domestic and overseas scholars. Thus, in order to provide a basis for doctors to use BuGuZhi safely, this article summarizes the literature on the toxicity of BuGuZhi, and analyzes the ways of enhancing efficacy and reducing toxicity.

Key wordsBuGuZhi      toxicity      synergistic and attenuated     
Published: 25 October 2018
Fund:  The study was funded by the National Natural Science Foundation of Hebei (No.H2018201179).
Corresponding Authors: Zhang Guo-wei     E-mail:
About author: # Both authors contributed equally to this work.
Cite this article:

Cui Qian, Ma Yu-Hui, Jin Xiao-Ming, Liu Jing-Jing, Zhang Yan-Hong, Zhang Guo-wei. Toxic effects of BuGuZhi and feasibility analysis of ways to synergistic and attenuated. TMR Modern Herbal Medicine, 2018, 1(4): 241-248. doi: 10.12032/TMRmhm2017B30

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