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TMR Modern Herbal Medicine  2018, Vol. 1 Issue (4): 249-258    DOI: 10.12032/TMRmhm2017B33
Review     
Survey of dose-effect relationship in Chinese materia medica
Kao Hsiu-Ying1#, Jiang Yong1,#*()
1 Basic Medical Colleague, Chendu University of TCM, Chendu, Sichuan, China.
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The research on the dose-effect relationship in Chinese materia medica is delayed due to the complexity of its composition, multi-efficacy, multi-targeting and other factors. Many experts put forward relevant research ideas and methods and worked out more and more research results in literature, experimental and clinical categories because of the progress of statistical methods and scientific and technological means in recent years. In this paper, these results were preliminarily combed to show the basic situation of dose-effect relationship research in Chinese materia medica.

Highlights

The research on the dose-effect relationship in Chinese materia medica was delayed due to the complexity of its composition, multi-efficacy, multi-targeting and other factors. However, there are more and more research results in literature, experimental and clinical categories because of the progress of statistical methods and scientific and technological means in recent years. This paper aimed to present the current basic situation.



Key wordsTraditional Chinese Medicine      Chinese medicinal      Chinese materia medica      Dose-effect relationship      Research progress      Research overview     
Published: 25 October 2018
Corresponding Authors: Jiang Yong     E-mail: jiangyong@pyztcm.com;415561560@qq.com
About author: # Both authors contributed equally to this work.
Cite this article:

Kao Hsiu-Ying, Jiang Yong. Survey of dose-effect relationship in Chinese materia medica. TMR Modern Herbal Medicine, 2018, 1(4): 249-258. doi: 10.12032/TMRmhm2017B33

URL:

https://www.tmrjournals.com/mhm/EN/10.12032/TMRmhm2017B33     OR     https://www.tmrjournals.com/mhm/EN/Y2018/V1/I4/249

Group Dose /g·kg-1 Time of first black grain /min Number of black grain within 6H Black grain weight at 6 H /g
Blank Group - 156.60 ± 87.74 5.60 ± 4.41 0.99 ± 0.64
Model Group - 252.40 ± 118.83# 5.57 ± 3.82 0.93 ± 0.39
Lactulose Group 1 128.41 ± 62.04** 5.39 ± 2.31 0.93 ± 0.35
Cistanche Low Dose 1 205.30 ± 84.43 5.70 ± 4.27 1.13 ± 0.72
Cistanche Middle Dose 2 163.90 ± 90.91**Δ 5.50 ± 3.44 1.23 ± 0.62*Δ
Cistanche High Dose 4 119.20 ± 68.11**Δ 4.90 ± 2.69 1.04 ± 0.58
Table 1 Effect of Different Doses of Cistanche on Defecation of SD Rats with Yang Deficiency Constipation (n=10, mean ± S.D) [19]
Group Dose FPG FIns IR
Blank Group - 3.60±0.30 2.10±0.11 0.34±0.03
Model Group - 23.58±1.30 1) 7.73±0.16 1) 8.11±0.48 1)
Metformin Hydrochloride Group 0.2 21.73±1.45 2) 6.92±0.52 2) 6.97±0.34 2)
Pueraria,Scutellaria,and Coptis Decoction 1.65 22.45±0.90 6.90±0.24 2) 7.01±0.36
Pueraria,Scutellaria,and Coptis Decoction 4.95 21.13±2.53 2) 6.97±0.61 2) 6.53±0.86 2)
Pueraria,Scutellaria,and Coptis Decoction 8.25 20.15±3.55 2) 7.17±0.26 2) 6.68±1.10 2)
Pueraria,Scutellaria,and Coptis Decoction 11.55 18.00±2.77 2) 7.27±0.30 6.06±1.01 2)
Pueraria,Scutellaria,and Coptis Decoction 14.85 17.78±4.16 2) 7.33±0.56 5.86±1.22 2)
Pueraria,Scutellaria,and Coptis Decoction 18.15 16.43±4.58 2) 6.66±0.75 2) 4.98±1.28 2)
Pueraria,Scutellaria,and Coptis Decoction 21.45 21.38±2.52 2) 7.18±0.35 2) 6.84±1.00 2)
Pueraria,Scutellaria,and Coptis Decoction 24.75 23.50±3.24 7.15±0.34 7.52±0.96
Pueraria,Scutellaria,and Coptis Decoction 28.05 22.05±3.19 7.23±0.33 7.07±0.95
Table 2 The Influences of FPG, FIns, IR for Pueraria, Scutellaria, and Coptis Decoction Treatment on the Rats with Type 2 Diabetes Damp-Heat Syndrome (n=6, mean ± S.D). [21]
Figure 1 Serum ALT, ALP, AST, TBIL, DBIL and γ-GT levels in 9 group of rats treated with or without CDTHD.
N: Normal, M: Model, A: 5.4 g/kg CDTHD, B: 10.8 g/kg CDTHD, C: 21.6 g/kg CDTHD, D: 43.2 g/kg, E: 86.4 g/kg CDTHD, F:35.1 g/kg CDTHD, G: 62.1 g/kg CDTHD.
P < 0.05, △△P < 0.01 compared with normal group. ▲P < 0.05, ▲▲ P <0.01 compared with model group.
Groups n First Time Defecation/d
Low Dose 20 38.40 ± 16.12*
Middle Dose 20 28.54 ± 12.18*
High Dose 20 21.00 ± 10.02
Table 3 First Time Defecation for the 3 Groups of STC Patients after Treatment of Fructus Aurantii and Atractylodes Macrocephala (mean ± S.D)
Figure 2 Schematic diagram of the “Focus” mode of integrated biomarker identification
Group Red Blood Cell (10 12/L) Hb (g/L)
Blank Group 7.5071±0.215* 148.14±6.842*
Model Group 5.5544±0.290 109.86±4.375
Chinese Angelica Blood-Supplementing Decoction Group 6.5114±0.278* 125.14±1.215*
Saponin and Polysaccharide 10:0 5.8174±0.409 123.57±5.563*
Saponin and Polysaccharide 8:2 5.6514±0.333 119.86±4.100
Saponin and Polysaccharide 6:4 6.2571±0.183* 131.57±3.409*
Saponin and Polysaccharide 4:6 5.8050±0.561 122.57±10.309*
Saponin and Polysaccharide 2:8 6.0557±0.516 127.43±9.090*
Saponin and Polysaccharide 0:10 6.0243±0.321 124.57±6.604*
Table 4 Red Blood Cell Numbers and Hb Weights after the Treatment on the Rats by Chinese Angelica Blood-Supplementing Decoction and its Components Combination (mean ± S.D) [32]
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