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Editors-in-Chief: HC Shang, PhD. Prof.
ISSN 2537-9798
6TMR Modern Herbal Medicine is a peer-reviewed quarterly journal sponsored by TMR publishing group. The journal publishes peer-reviewed original articles including reviews, commentaries, clinical and basic research, case report, conference announcement and letters to the editor about the modern herbal medicine. TMR Modern Herbal Medicine focus on the areas of herbal resources and planting, processing of herbal medicine and herbal slices, herbal preparation and production technology, pharmacology and toxicology, clinical assessment. ... More

Current Issue     01 May 2020, Volume 3 Issue 2 Previous Issue   
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Article
Dendrobium huoshanense improves doxorubicin-induced heart failure in C57BL/6 mice
Rong Huang, Yuanyu Wang, Yingquan Liang, Maoyun Yu, Yuanli Chen, Jihong Han, Xiaoxiao Yang, Yajun Duan
6TMR Modern Herbal Medicine. 2020, 3 (2): 55-65.   https://doi.org/10.12032/TMRmhm202003064
Abstract ( 125 )     PDF (975KB) ( 91 )  
Objective: To investigate the therapeutic effect of Shihu (Dendrobium huoshanense, DH) on doxorubicin (DOX)-induced heart failure in mice and the involved mechanisms. Methods: Male C57BL/6 mice were randomly divided into 3 groups: Control (Ctrl) group, DOX group and DH group. Chronic heart failure was induced by intraperitoneal injection of doxorubicin solution. Mice in DH group were fed normal chow containing DH powder for 4 weeks. After 4-week treatment, electrocardiograms were measured. At the end of experiment, serum and heart sample were collected for determination of indicators for heart failure indicators. The heart tissues were conducted HE, Masson , Sirius red staining and TUNEL staining to determine cardiac tissue morphology, fibrosis, collagen content and apoptosis, respectively. mRNA and protein expression were determined by qRT-PCR and Western blot, respectively. Results: DH reduced the DOX-induced serum biomarkers (creatine kinase, aspartate aminotransferase and lactate dehydrogenase) of heart damage and reduced heart fibrosis. Mechanically, DH inhibited myocardial apoptosis, decreased interleukin 6 and tumor necrosis factor α levels, but increased superoxide dismutase 2 expression. Conclusion: DH alleviates DOX-induced chronic heart failure by inhibiting inflammatory pathway and enhancing anti-oxidative enzymes. Our study provides the potential of DH for heart failure treatment.
Effects of theophylline/chitosan/β-cyclodextrin microspheres for oral drug delivery on an asthmatic rat model
Saisai Wang, Haijing Zhang, Xiaoming Cui, Liping Zhao, Mingxia Jiang, Zhilu Xu, Dongzhen Mu, Weifen Zhang
6TMR Modern Herbal Medicine. 2020, 3 (2): 66-76.   https://doi.org/10.12032/TMRmhm202003071
Abstract ( 95 )     PDF (1067KB) ( 44 )  
Objective: This study aimed to investigate the effects of TH/CTS/β-CD microspheres by oral administration on ovalbumin allergic asthma of a rat model. Methods: Spray drying method was applied for preparing the TH/CTS/β-CD microspheres, which were used in treatment of asthmatic rats. At a predetermined time, the levels of eosinophil (Eos), protein, lactate dehydrogenase (LDH), aspartate transaminase (AST), glutamic pyruvic transaminase (GPT), and creatinine (Cr) were ascertained by automatic hematology and biochemical analyzers. Lung tissue histology was performed by hematoxylin-eosin staining. Results: No significant differences were found about the contents of Eos in the blood, and the contents of Eos, protein and LDH in the bronchoalveolar lavage fluid between the microsphere-treated and dexamethasone-treated groups, but the levels were lower in both treated groups than in the model group. In the microsphere-treated group, the levels of Cr, AST, and GPT in the serum of rats showed no significant differences compared with the normal group. Based on lung histopathological findings, the microspheres attenuated inflammatory cell infiltration and mucus hypersecretion compared with the model group. Conclusion: This study demonstrated that TH/CTS/β-CD microspheres exerted an anti-inflammatory effect and could serve as a novel promising drug delivery system for asthma treatment.
The functional components and mechanism of Linderae Radix in treating diabetic nephropathy based on the network pharmacology
Su Wu, Yujian Yao, Man Xiao, MeiLin Yan, Yiqiang Xie, Yali Ni
6TMR Modern Herbal Medicine. 2020, 3 (2): 77-85.   https://doi.org/10.12032/TMRmhm202003063
Abstract ( 85 )     PDF (1370KB) ( 83 )  
Objective: To analyze the components and mechanisms of Wuyao (Linderae Radix) in treating diabetic nephropathy (DN) based on network pharmacology. Methods: Multiple online databases were used to search and screen out the active ingredients from Linderae Radix, the related targets of active components of Linderae Radix and the genes related to DN. Search the corresponding genes name of target through UniProt database. Cytoscape 3.2.1 was used to construct the corresponding target gene network of Linderae Radix compounds.Venn diagram was used to screen the intersection genes of the active components corresponding to the target and disease-related genes, and the intersection genes were constructed into the protein interaction relationship network. Finally, DAVID database was used to do GO function enrichment analysis and KEGG signaling pathway enrichment analysis for the intersection genes, and the results of GO and KEGG were visualized. Results: 1. A total of 7 potential active ingredients and 100 target proteins were screened. 2. There are a total of 34 intersection genes between the potential active ingredient target in Linderae Radix in DN. 3. The top 10 of the interaction correlation between intersection proteins include:AR and NCOA2, NCOA2 and NR3C1, NCOA2 and PPARG, etc. 4. There were 16 entries of molecular function, 9 entries of cell component, 47 entries of biological process and 18 entries of signaling pathway (P <0.05). Conclusion: DN was treated by Linderae Radix from multi-component, multi-target and multi-link synergies.
Review
Research progress on chemical composition, pharmacological effects of Forsythia suspensa (Thunb.) Vahl and predictive analysis on Q-marker
Hui Peng, Peng Lu, Yiting Liu, Chuanxin Liu, Yanquan Gao, EbukaOlisaemeka Nwafor, Yuelin Zhang, Zhidong Liu
6TMR Modern Herbal Medicine. 2020, 3 (2): 86-112.   https://doi.org/10.12032/TMRmhm202003069
Abstract ( 128 )     PDF (1963KB) ( 103 )  

Lianqiao (Forsythia suspensa (Thunb.) Vahl, Abbreviated as “F. suspensa below) is traditional Chinese medicine in China, widely distributed all over the country and also highly rich in resources. The Northwest Territories is a genuine producing area. There are many chemical components in F. suspensa, including lignans, phenylethanolic glycosides, flavonoids, C6-C2 natural alcohols and their glycosides, phenolic acids, terpenes and volatile oils. Among them, lignans and phenylethanolic glycosides are the main active components. Based on the review of chemical components or constituents and main pharmacological activities, according to the definition of quality marker, the components of quality marker of F. suspensa were predicted and analyzed from the aspects of plant genetics and chemical composition, traditional efficacy, traditional medicine, new efficacy, blood entering composition, measurable composition, effective composition in different compatibility, and the influence of storage conditions of extract. Further research on its medicinal active ingredients will provide scientific basis for the evaluation of F. suspensa quality.

The research idea of Xuebijing injection in influencing severe pneumonia-pulmonary fibrosis with blood stasis syndrome evolution by inhibiting inflammation, endotoxin and dispersing blood stasis
Rui Zheng, Chengyu Li, Ping Wang, Min Li, Pengqian Wang, Changming Zhong, Jianxun Wang, Hongcai Shang
6TMR Modern Herbal Medicine. 2020, 3 (2): 113-119.   https://doi.org/10.12032/TMRmhm202003070
Abstract ( 58 )     PDF (385KB) ( 51 )  

Severe pneumonia is one of the most serious infectious diseases. Delayed intervention may lead to pulmonary fibrosis, which greatly threatens people’s life and health. Blood stasis syndrome is an important underlying syndrome throughout the evolution of severe pneumonia-pulmonary fibrosis. Xuebijing injection (XBJ) was developed under the theoretical system of “Three syndromes and three methods”, demonstrating a good efficacy in treating severe pneumonia and pulmonary fibrosis due to its effect of removing blood stasis and dispersing toxins. Previous studies have shown that XBJ can protect vascular endothelial function, improve coagulation function and regulate immunity by inhibiting inflammatory. Hence, the research hypothesis is put forward that XBJ treats blood stasis syndrome by removing blood stasis and dredging blood vessels, to inhibit the disease progress of severe pneumonia to pulmonary fibrosis. Further researches are need to confirm the function and explore the mechanism of XBJ.

The roles of traditional Chinese herbal medications in regulating mitochondrial activity to reverse cancer
Lichao Sun, Guihua Tian, Hongcai Shang
6TMR Modern Herbal Medicine. 2020, 3 (2): 120-127.   https://doi.org/10.12032/TMRmhm202003076
Abstract ( 66 )     PDF (296KB) ( 54 )  

Cancer was gradually regarded as a metabolic disease, which might be linked to impairment of mitochondrial function. There are really some essential differences between the mitochondria of normal and cancer cells, which might become promising target for cancer chemotherapy. According to western pharmacology, a known target was needed for drug development. Unfortunately, the number of therapeutic agents relating to the mitochondrion are severely limited because of lacking of knowledge about mitochondrial biology. Unlike the “Western Medicine”, some traditional Chinese herbal medicine (TCHM) might be prone to targeting mitochondria despite the lack of precise molecular mechanisms. If it is the case, we might be able to screen and identify active anti-cancer drugs from traditional Chinese therapeutics by using mitochondrial functional assay. In this review, we would give an overview of the effect of TCHM on the mitochondrion, and the challenges and breakthroughs remaining in cancer treatment.

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