Please wait a minute...
9TMR Non-Drug Therapy  2019, Vol. 2 Issue (1): 2-8    DOI: 10.12032/TMRND201902002
Acupuncture and moxibustion therapy     
Research on the influence of traditional Chinese medicine therapy on the intestinal flora in obese patients
Pei-Yao Li1, Wen-Wen Zhao1, Chun-Hua Zhang1, Hui-Xin Ding1, Ling Wang1, Heng Yang1, Chun-Guang Yu1,*()
1 College of Nursing, Beijing University of Traditional Chinese Medicine, Beijing, China.
Download: HTML     PDF(564KB)
Export: BibTeX | EndNote (RIS)      

Highlights

Characteristic TCM therapies including acupuncture, moxibustion, and cupping, etc. have therapeutic effects on obese patients by interfering with the intestinal flora.

Editor’s Summary

Traditional Chinese medicine therapy aiming at regulating intestinal flora is expected to become one of the main treatment methods for obese patients.

Abstract

In recent years, the prevalence of obesity has been increasing year by year, leading to a rise in serious complications. The pathogenesis of obesity is complicated in which the intestinal flora plays an important role. Intestinal micro ecology is composed of large and complex intestinal flora that participate in important physiological functions such as metabolism, energy conversion, maintaining intestinal mucosal defense function, and promoting immune system development and maturation and other important physiological functions; furthermore, they are influenced by the host’s genetic background, diet, and other factors. Therefore, intestinal microflora has potential as a new field of drug therapy. At present, it is found that traditional Chinese medicine therapy may prevent and treat obesity by interfering with the intestinal flora, which is expected to become one of the main treatment methods for obese patients. However, its mechanism of action remains unclear. The balance of intestinal flora can be adjusted by acupuncture, massage, and acupoint application. By analyzing the mechanism of obesity caused by intestinal micro ecology and the impact of obesity on the host’s intestinal micro ecological environment, this paper discusses the influence of oral Chinese medicine, acupuncture, massage, acupoint sticking, and other traditional Chinese medicine therapies on the intestinal microflora in obese patients and provides a scientific basis for its clinical application.



Key wordsIntestinal microflora      Obesity      Traditional Chinese medicine      Dysbacteriosis     
Received: 12 November 2018      Published: 05 March 2019
Corresponding Authors: Yu Chun-Guang     E-mail: bjchunguang@163.com
Cite this article:

Pei-Yao Li, Wen-Wen Zhao, Chun-Hua Zhang, Hui-Xin Ding, Ling Wang, Heng Yang, Chun-Guang Yu. Research on the influence of traditional Chinese medicine therapy on the intestinal flora in obese patients. 9TMR Non-Drug Therapy, 2019, 2(1): 2-8. doi: 10.12032/TMRND201902002

URL:

https://www.tmrjournals.com/ndt/EN/10.12032/TMRND201902002     OR     https://www.tmrjournals.com/ndt/EN/Y2019/V2/I1/2

1.   Elseia PL.Should we officially recognize obesity as a disease? Lancet Diabetes Endocrinol 2017, 5: 483.
doi: 10.1016/S2213-8587(17)30191-2 pmid: 28601583
2.   Sanja S, Jeffrey A. Gusen O.The obesity epidemic and bariatric trends. Clinics Plastic Surgery 2019, 10: 1-7.
3.   Swinburn BA, Sacks G, Hall KD, et al. The global obesity pandemic shaped by global drivers and local environments. Lancet 2011, 378: 804-814.
doi: 10.1016/S0140-6736(11)60813-1 pmid: 21872749
4.   Kang SS, Jeraldo PR, Kurti A, et al. Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition. Mol Neurodegener 2014, 9: 36.
doi: 10.1186/1750-1326-9-36
5.   Bindels LB, Delzenne NM, Cani PD,et al. Towards a more comprehensive concept for prebiotics. Nat Rev Gastroenterol Hepatol 2015, 12: 303-310.
doi: 10.1038/nrgastro.2015.47 pmid: 25824997
6.   Zhang X, Zhao Y, Xu J, et al. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Sci Rep 2015, 5: 14405.
doi: 10.1038/srep14405 pmid: 4585776
7.   Liou AP, Paziuk M, Jr LJ, et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med 2013, 5: 178-190.
doi: 10.1126/scitranslmed.3005687 pmid: 23536013
8.   Che YW, Yu N, Zhai SQ.Theoretical analysis on the correlation between spleen and intestinal flora. World Chin Med 2015, 10: 703-709.
9.   Wang HL, Chen JX, Guo XF, et al. The effect of stratified treatment of obesity with traditional Chinese and western medicine. China Med Herald 2018, 15: 119-122, 130.
10.   Fang S, Wang M, Zheng Y, et al. Acupuncture and lifestyle modification treatment for obesity: a Meta-analysis. Am J Chin Med 2017, 45: 239-254.
doi: 10.1142/S0192415X1750015X pmid: 28231746
11.   Su L, Gao P.Chemerin's mechanism of action in obesity and type 2 diabetes mellitus. J Med Postgraduates 2013, 26: 646-649.
12.   Cani PD, Delzenne NM.Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Curren Opinion Pharmacology 2009, 9: 737-743.
doi: 10.1016/j.coph.2009.06.016 pmid: 19628432
13.   Muccioli GG, Naslain D, B?ckhed F, et al. The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol 2010, 6: 392.
doi: 10.1038/msb.2010.46 pmid: 2925525
14.   Geurts L, Lazarevic V, Derrien M, et al. Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue. Front Microbiol 2011, 2: 149.
doi: 10.3389/fmicb.2011.00149 pmid: 3139240
15.   Perry RJ, Peng L, Barry NA, et al. Acetate mediates a microbiome-brain-beta-cell axis to promote metabolic syndrome. Nature 2016, 534: 213-217.
doi: 10.1038/nature18309
16.   Camp JG, Jazwa AL, Trent CM, et al. Intronic, cis-regulatory modules mediate tissue-specific and microbial control of angptl4 / fiaf transcription. PLoS Genet 2012, 8: e1002585.
doi: 10.1371/journal.pgen.1002585 pmid: 3315460
17.   Yano JM, Yu K, Donaldson GP, et al. Indigenous bacteria from the microbiota regulate host serotonin biosynthesis. Cell 2015, 161: 264-276.
doi: 10.1016/j.cell.2015.02.047
18.   Hylemon PB, Zhou H, Pandak WM, et al. Bile acids as regulatory molecules. J Lipid Res 2009, 50: 1509-1520.
doi: 10.1194/jlr.R900007-JLR200 pmid: 19346331
19.   Mozes S.Intestinal microflora and obesity in rats. Folia Microbiol 2008, 53: 225-228.
doi: 10.1007/s12223-008-0031-0 pmid: 18661297
20.   Chao PT, Liang Y, Susan Aja, et al. Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metabolism 2011, 11: 225-238.
doi: 10.1016/j.cmet.2011.02.019 pmid: 21531339
21.   Paul A B, Amanda S, Susan A, et al. Hypothalamic control of bone formation: distinct actions of leptin and Y2 receptor pathways. J Bone Miner Res 2009, 10: 110.
doi: 10.1359/JBMR.050523 pmid: 16160743
22.   Liu WW, Yan M, Zhou LP, et al. Correlation between obesity and intestinal flora. Chemistry Life 2009, 29: 928-932.
23.   Zhang Y, Sui XL, Liu CC, et al. Correlation between intestinal flora and offspring obesity in obese pregnant women. Chin J Microecology 2016, 28: 1107-1109.
24.   Liu YF, Hu YX, Wang ZP, et al. Advances in the study of biotransformation of intestinal flora on active components of traditional Chinese medicine. Liaoning Univer J 2017, 4: 325-332.
25.   Si FG, Chen R, Si FC, et al. Analysis of TCM syndrome type and formula law of obesity. Henan Tradit Chin med 2016, 36: 2032-2035.
26.   Li JW, Tang AH, Zhao W.Effect of Wenyangyiqihuoxue recipe on intestinal flora changes and lipid metabolism in obese type 2 diabetes mellitus patients. J Tradit Chin Med 2015, 56: 409-413.
27.   Feng B, Gu YM, Meng DZ, et al. Effect of Jianpitiaogan decoction on core body temperature / autonomic activity and browning of white fat in obese mice. Chin J Tradit Chin Med 2018, 36: 2340-2344.
28.   Zhang CH, Ma GQ, Deng YB, et al. Effect of Gegenqinlian decoction on plasma LPS tnf-alpha il6 and intestinal flora in diabetic mice. Chin Herbs 2017, 48: 1611-1616.
29.   Peng XC, Zhang ZC, Huang LZ, et al. Effect of cinnamon essential oil on clostridium IV cluster and bacteroidetes in rat intestinal tract. Chin Herbs 2013, 44: 437-442.
30.   Jin YT, Chen X, Zhuo Y, et al. Clinical research progress of external therapy of traditional Chinese medicine for simple obesity with spleen deficiency and dampness resistance. J Clinical Acupunc Moxibustion 2018, 34: 79-83.
31.   Kong YQ, Zhao ZY.Effect of cupping and auricular point sticking therapy on intestinal flora of simple obesity patients. Chin J Clinical Res 2016, 29: 257-259.
32.   Li P, Gao C, Liu XH.Clinical observation on the treatment of simple obesity by abdominal massage combined with Ganjing Yuji acupoint massage. Inner Mongolia Tradit Chin Med 2018, 37: 74-75.
33.   Hu JH.To discuss the clinical application of acupuncture and massage in weight loss. Cardiovascular Tradit Chin Med 2018, 6: 131-131, 134.
34.   Fu JM, Mai GM, Li YX.Clinical study of acupoint catgut embedding combined with canning therapy in the treatment of simple obesity with spleen deficiency and dampness resistance. Sichuan J Tradit Chin Med 2016, 11: 194-196.
35.   Mao DD, Zhou JP, Wu XY, et al. Effect of meridian scrapping and exercise on intervention of simple obesity with phlegm-dampness constitution. J Nursing Sci 2018, 33: 36-38, 92.
36.   Peng Y, Jin J, Yang JY, et al. The effect of three kinds of spleen-invigorating and qi-invigorating prescriptions on intestinal flora of rats with spleen deficiency syndrome. China J Chin Mater Med 2008, 33: 2530-2534.
[1] Chang Liu. Review of the non-drug treatment in obesity[J]. 9TMR Non-Drug Therapy, 2019, 2(1): 13-19.