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Editors-in-Chief: XZ Wu, PhD. Prof.
ISSN 2538-0583
9TMR Non-Drug Therapy TMR Non-Drug Therapy is an international peer-reviewed, Open Access journal. It is dedicated to report the research progress and discusses the idea and method in the natural therapies to regulate the organism's disorders which aim to contribute to human health, including acupuncture, cupping, exercise and behavior therapy, physical and mental therapy, massage, moxibustion and other therapy on non-drug treatments around the world. It set up basic research, clinical research, case reports, review and theoretical discussion. It seeks to promote international communication focusing on the latest developments, trends, experiences and achievements on non-drug therapy in clinical practice and scientific research. It has been included in DOAJ, ScienceOpen, China Science and Technology Journal Database (CSTJ), and Google Scholar. ... More


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Current Issue     06 March 2020, Volume 3 Issue 1 Previous Issue   
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Neurophysiological basis of auricular acupuncture for the the treatment of p-chlorophenylalanine-induced insomnia
Xiong-Zhi Wu
9TMR Non-Drug Therapy. 2020, 3 (1): 1-1.   https://doi.org/10.12032/TMRND20200306005
Abstract ( 18 )   HTML ( 1 )     PDF (265KB) ( 12 )  

Electroacupuncture of auricular concha area (EA-ACR) is a method of acupuncture stimulation of auricular concha area, which has been described in ancient China as well as in Egypt, Greece and Rome [1]. The traditional theory proposed that the auricle was represented by the body and internal organs, such that different body regions and organs appear on the external ear to form a humunculus of inverted fetus. In 1950s, French physician Nogier reawakened the interest in ACR by proposing a theory that there is a somatotopic and viscerotopic representation on the auricle. The distribution of auricular acupoints in the ears has a certain regularity, which like an inverted fetus [2]. Disorders from a particular part of the body could be treated by the corresponding point in the ear [1,2].Since then, EA-ACR has been used to relieve pain [3, 4], ameliorate anxiety disorders and help treat sleep disorders [5, 6]. However there is little empirical evidence showing how this theory working. 

 The present study observed the effects of electroacupuncture of auricular concha area (EA-ACR) on the circadian rhythm of melatonin secretion in p-chlorophenylalanine (PCPA) induced insomnia rats. The study divided 36 male Sprague-Dawley rats randomly into three groups: 12 in blank group, 12 in model group, and 12 in EA-ACR group. PCPA was injected to Sprague-Dawley rats through intraperitoneal injection for 2 days to establish insomnia model. EA-ACR group was treated for 28 days. Results showed that compared with the blank group, 28-30 hours after PCPA intraperitoneal injection, the circadian rhythm of sleep and the total sleep time of model rats decreased. Compared with the model group, electrical stimulation in the ear concha region could effectively reverse the behavioral changes of rats, and increase the trend of weight growth (P = 0.010), the crossing score (P = 0.014), vertical motion score (P = 0.015) and the level of plasma melatonin secretion (P = 0.020); The underlying effects of EA-ACR may be excited on the circadian rhythm of melatonin secretion. As the level of melatonin secretion in the EA-ACR group was higher than that in the model group, and the melatonin secretion rhythm in the treatment group was found to have a certain rhythm. Melatonin is one of the important hormones that the human body participates in many physiological activities [7]. 

 The release of melatonin is independent of the alternation of day and night. Melatonin plays an important role in regulating circadian rhythm and sleep cycle, and its release is most closely related to sleep. The present study discussed the mechanism of EA-ACR adjusted the insomnia rats and observe the effects of EA-ACR on the circadian rhythm of melatonin secretion in p-chlorophenylalanine (PCPA)-induced insomnia rats, so as to provide a scientific and practical evidence for the EA-ACR treatment in insomnia.

Acupuncture and moxibustion therapy
Effects of electroacupuncture at auricular concha area on the circadian rhythm of melatonin secretion in p-chlorophenylalanine-induced insomnia rats
Wen-Ya Huang, Wei-Wei Xu, An-Ning Zhu, Si-Yu Liu, Yang Huang, Peng Li, Zong-Bao Yang, Shu-Qiong Huang, Xian-Jun Meng
9TMR Non-Drug Therapy. 2020, 3 (1): 2-11.   https://doi.org/10.12032/TMRND20200121001
Abstract ( 49 )   HTML ( 0 )     PDF (656KB) ( 27 )  

Highlights

The mechanism of auricular concha area (EA-ACR) between the melatonin and insomnia has rarely been studied before. The present study observed the effects of EA-ACR on the circadian rhythm of melatonin secretion in p-chlorophenylalanine(PCPA) induced insomnia rats, and demonstrate that EA-ACR can improve the quality of life (weight), ameliorate exploring irritable and anxiety behaviors in PCPA-induced insomnia rats. The underlying effects of EA-ACR may be excited on the circadian rhythm of melatonin secretion in PCPA-induced insomnia rats. These findings may provide a scientific and practical evidence for the EA-ACR treatment in insomnia.

Abstract

Backgroud: The electroacupuncture of auricular concha area (EA-ACR) proved to have a good regulatory effect on insomnia and the release of melatonin, which is most closely related to sleep. However, there is little research to demonstrate the relationship between EA-ACR and melatonin. The objective of present study is to observe the effects of EA-ACR on the circadian rhythm of melatonin secretion in p-chlorophenylalanine (PCPA)-induced insomnia rats. Methods: The study divided 36 male Sprague-Dawley rats randomly into three groups: 12 in blank group, 12 in model group, and 12 in EA-ACR group. By using PCPA intraperitoneal injection for 2 days, insomnia model was established. EA-ACR group was treated for 28 days. We observed the effects of EA-ACR on the rats' behavioral changes, open-field test and weight during the experiment. After the experiment, the rat tail and heart blood were collected, and the melatonin was detected by enzyme-linked immunosorbent assay. Results: Compared with the blank group, 28-30 hours after PCPA intraperitoneal injection, the circadian rhythm of sleep and the total sleep time of model rats decreased. Compared with the model group, electrical stimulation in the ear concha region could effectively reverse the behavioral changes of rats, and increase the trend of weight growth (P = 0.010), the crossing score (P = 0.014), vertical motion score (P = 0.015) and the level of plasma melatonin secretion (P = 0.020 ) with the trend showing a rhythmic pattern (0-60 minutes upward , 60-120 minutes downward, 120-150 minutes upward). Conclusion: EA-ACR can improve the quality of life (weight), ameliorate exploring irritable and anxiety behaviors in PCPA-induced insomnia rats. The underlying effects of EA-ACR may be excited on the circadian rhythm of melatonin secretion in PCPA-induced insomnia rats.

Core acupoints of acupuncture for hyperplasia of mammary gland: a network analysis
Bao-Min Dou, Yuan-Yuan Sun, Tian-Yi Zhao, Qian-Nan Jia, Jiang Liu, Bo Chen, Yi Guo
9TMR Non-Drug Therapy. 2020, 3 (1): 12-22.   https://doi.org/10.12032/TMRND20200215002
Abstract ( 17 )   HTML ( 0 )     PDF (760KB) ( 24 )  

Highlights

The study established the acupoints database and complex network of acupoints compatibility for acupuncture treatment of hyperplasia of mammary gland (HMG). The results found that the main acupoint compatibility of acupuncture therapy for HMG was the local and remote acupoints, and the selected core acupoints for acupuncture treatment of HMG were Danzhong (CV 17), Wuyi (ST 15), Zusanli (ST 36) and Jianjing (GB 21).

Abstract

Backgroud: Clinical studies on acupuncture treatment of hyperplasia of mammary gland (HMG) have proved its effectiveness, but most studies have paid little attention to acupoints prescription and acupoint compatibility. The clinical prescription is not identical, the curative effect also has the difference. Therefore, through data mining and network analysis, this study explored the core acupoints and the compatibility law of acupoints in acupuncture treatment of HMG. Methods: To search and select qualified literature according to inclusion and exclusion criteria for relevant clinical research literature on acupuncture treatment of HMG in CNKI, VIP database, WanFang database and PubMed, etc. Then extract relevant information and establish a database. Using the method of statistical and complex network analysis, this paper studies the core acupoints and the law of acupoint compatibility. Results: A total of 104 Chinese literatures and 0 English literatures were included and 106 acupuncture prescriptions were extracted. The core acupoints in the treatment of HMG are Danzhong (CV 17), Wuyi (ST 15), Zusanli (ST 36), Jianjing (GB 21). Danzhong (CV 17) and Zusanli (ST 36), Danzhong (CV 17 ) and Wuyi (ST 15), Jianjing (GB 21) and Tianzong (SI 11), Jianjing (GB 21) and Wuyi (ST 15) have the highest correlation degree. The method of acupoint matching mainly consists of local-remote acupoints, upper-lower acupoints and front-rear acupoints. Conclusion: The results of a network analysis substantially accord with the general rules of acupuncture theories in traditional Chinese medicine, able to reflect the points-selection principles and features in acupuncture treatment of HMG and provide evidence for the acupoints selection in the treatment of HMG in acupuncture clinic.

Physiotherapy therapy
Effectiveness of complex decongestive therapy in management of breast cancer associated lymphedema
Ting-Ting Li, Zhen-Dong Zheng, Yue-Hai Ma, Qiu-Hua Li, Zhao-Zhe Liu
9TMR Non-Drug Therapy. 2020, 3 (1): 23-29.   https://doi.org/10.12032/TMRND201902025
Abstract ( 62 )   HTML ( 1 )     PDF (403KB) ( 54 )  

Highlights

The study assesses the edema relief effects of complex decongestive therapy in patients with breast cancer associated lymphedema after axillary lymph node dissection. The results found that there were differences in progress of circumference difference among the patients with different degrees of lymphedema and the effects of patients with severe initial edema (> 5 cm increased) last longer.

Abstract

Background: To assess the edema relief effects of complex decongestive therapy (CDT) in patients with breast cancer associated lymphedema after axillary lymph node dissection (ALND). Methods: 58 breast cancer patients with unilateral arm lymphedema after breast cancer ALND were enrolled. The patients were divided into three groups based on the difference of circumference between the affected and unaffected extremity: group 1, mild lymphedema in circumference difference; group 2, moderate lymphedema, and group 3, severe lymphedema. These patients received four weeks of CDT and self-administered home therapy. Arm circumference was measured before, right after CDT, 3 months and 12 months of follow-up. Results: In the first group, the circumference difference was 1.53 ± 0.73 cm prior to CDT, and 0.32 ± 0.59 cm right after CDT, and the difference was statistically significant (P < 0.001). At the 1-year-follow-up, we got an even higher value than the pre-CDT one, however, there was no significant difference (P = 0.175). At the end of CDT, the circumference difference of the third group was 4.52 ± 2.58 cm, significantly lower than the baseline level (8.76 ± 3.07 cm) (P < 0.001). In the third group, the reduction of circumference difference was persisted for 12 months. Conclusion: The effects of CDT were maintained for 12 months, while there were differences in progress of circumference difference among the three groups. The effects of patients with severe initial edema (> 5 cm increased) last longer.

Review
Research progress on the effect of the combination of Jing acupoints bloodletting therapy and Sangzhi (Mori Ramulus) on shoulder-hand syndrome after stroke
Li Zhu, Jun-Li Wang, Tong-Sheng Su
9TMR Non-Drug Therapy. 2020, 3 (1): 30-35.   https://doi.org/10.12032/TMRND20200220003
Abstract ( 19 )   HTML ( 1 )     PDF (327KB) ( 13 )  

Highlights

The purpose of this paper is to explore more effective treatment of shoulder-hand syndrome after stroke. The combination of acupuncture and medicine broadens the clinical treatment ideas, but it is more limited to the theoretical level, less clinical practice support, and lack of basic experimental evidence. Based on the basic theory of traditional Chinese medicine and the research results of modern medicine, this paper is expected to help patients to solve the pain to the greatest extent.

Abstract

Shoulder-hand syndrome (SHS) is one of the common complications of ischemic stroke. The pathogenesis is not completely clear and the therapeutic effects are not very satisfactory. As one of the Five-Shu acupoints (the general terms of acupoints that the twelve meridians are located below the elbow and knee of the body), Jing acupoints is distributed at the end of fingers and toes where the twelve meridians of the human body pass by, and has the functions of stimulating the meridians and dredging the channels and collaterals. For the effects of discharging neurons, promoting cerebral blood flow and improving the brain micro-circulation, Jing acupoints bloodletting therapy can effectively relieve the clinical symptoms of the patients with SHS after stroke. Sangzhi (Mori Ramulus), with the ability of dredging the meridian and relieving the pain, is also has certain treatment functions to the SHS. In clinical practice, the combination of Jing acupoints bloodletting and Sangzhi (Mori Ramulus) have been widely used in the treatment of various diseases, and in terms of their mechanism of action, the combined treatment has a positive effect on post-stroke SHS, but there are few reports on this. Therefore, it is worth affirming the efficacy of combined treatment of SHS after stroke. This article elaborates the theoretical basis of Jing acupoints bloodletting on SHS after stroke, and the research progress of Sangzhi (Mori Ramulus) in treating SHS after stroke, which provide the theoretical guidance for the combination.

The effects of Chinese herbal fumigation on the prevention of peripheral neurotoxicity caused by chemotherapy: a meta-analysis
Jing Yang, Zhu Yang, Feng-Xi Long, Xu Liu, Xian-Man Wei, Dong-Xin Tang
9TMR Non-Drug Therapy. 2020, 3 (1): 36-43.   https://doi.org/10.12032/TMRND20200301004
Abstract ( 11 )   HTML ( 0 )     PDF (423KB) ( 3 )  

Highlights

The study evaluated the clinical efficacy of Chinese herbal fumigation in the past five years to prevent peripheral neurotoxicity caused by chemotherapy. Five Chinese literatures, with a total of 331 patients, were eventually included. Meta-analysis results demonstrate that herbal fumigation can effectively prevent the occurrence of peripheral neurotoxicity caused by chemotherapy without obvious adverse reactions.

Abstract

Backgroud: To evaluate the clinical efficacy of Chinese herbal fumigation to prevent peripheral neurotoxicity caused by chemotherapy. Methods: CNKI, VIP Database, Wanfang Database, PubMed and Cochrane Databases were searched from January 2014 to July 2019 for randomized controlled trials (RCTs) of herbal fumigation to prevent peripheral neurotoxicity caused by chemotherapy. The RCTs were selected according to the inclusion and exclusion criteria, and the data extraction and bias risk assessment were performed. RevMan 5.3 software was used for statistical analysis. Results: Five Chinese RCTs were eventually included, with a total of 331 patients. Meta-analysis showed that compared with the control group, herbal fumigation could significantly reduce the incidence of peripheral neurotoxicity induced by chemotherapy (OR = 0.34, 95% CI (0.21, 0.55), P < 0.01). Moreover, herbal fumigation could also reduce the incidence of peripheral neurotoxicity above grade 2 (OR = 0.17, 95% CI (0.04, 0.77) P = 0.02). Conclusion: Herbal fumigation can effectively prevent the occurrence of peripheral neurotoxicity caused by chemotherapy without obvious adverse reactions.

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