9TMR Non-Drug Therapy
TMR Non-Drug Therapy is an international peer-reviewed, Open Access journal. It is dedicated to report the research progress and discusses the idea and method in the natural therapies to regulate the organism's disorders which aim to contribute to human health, including acupuncture, cupping, exercise and behavior therapy, physical and mental therapy, massage, moxibustion and other therapy on non-drug treatments around the world. It set up basic research, clinical research, case reports, review and theoretical discussion. It seeks to promote international communication focusing on the latest developments, trends, experiences and achievements on non-drug therapy in clinical practice and scientific research. It has been included in DOAJ, ScienceOpen, China Science and Technology Journal Database (CSTJ), and Google Scholar.
Backgroud: The electroacupuncture of auricular concha area (EA-ACR) proved to have a good regulatory effect
on insomnia and the release of melatonin, which is most closely related to sleep. However, there is little research to
demonstrate the relationship between EA-ACR and melatonin. The objective of present study is to observe the
effects of EA-ACR on the circadian rhythm of melatonin secretion in p-chlorophenylalanine (PCPA)-induced
insomnia rats. Methods: The study divided 36 male Sprague-Dawley rats randomly into three groups: 12 in blank
group, 12 in model group, and 12 in EA-ACR group. By using PCPA intraperitoneal injection for 2 days, insomnia
model was established. EA-ACR group was treated for 28 days. We observed the effects of EA-ACR on the rats'
behavioral changes, open-field test and weight during the experiment. After the experiment, the rat tail and heart
blood were collected, and the melatonin was detected by enzyme-linked immunosorbent assay. Results: Compared
with the blank group, 28–30 hours after PCPA intraperitoneal injection, the circadian rhythm of sleep and the total sleep
time of model rats decreased. Compared with the model group, electrical stimulation in the ear concha region could
effectively reverse the behavioral changes of rats, and increase the trend of weight growth (P = 0.010), the crossing score
(P = 0.014), vertical motion score (P = 0.015) and the level of plasma melatonin secretion (P = 0.020 ) with the trend
showing a rhythmic pattern (0–60 minutes upward , 60–120 minutes downward, 120–150 minutes upward). Conclusion:
EA-ACR can improve the quality of life (weight), ameliorate exploring irritable and anxiety behaviors in
PCPA-induced insomnia rats. The underlying effects of EA-ACR may be excited on the circadian rhythm of
melatonin secretion in PCPA-induced insomnia rats.
Backgroud: To assess the edema relief effects of complex decongestive therapy (CDT) in
patients with breast cancer associated lymphedema after axillary lymph node dissection
(ALND). Methods: 58 breast cancer patients with unilateral arm lymphedema after breast
cancer ALND were enrolled. The patients were divided into three groups based on the
difference of circumference between the affected and unaffected extremity: group 1, mild
lymphedema in circumference difference; group 2, moderate lymphedema, and group 3, severe
lymphedema. These patients received four weeks of CDT and self-administered home therapy.
Arm circumference was measured before, right after CDT, 3 months and 12 months of
follow-up. Results: In the first group, the circumference difference was 1.53 ± 0.73 cm prior to
CDT, and 0.32 ± 0.59 cm right after CDT, and the difference was statistically significant (P <
0.001). At the 1-year-follow-up, we got an even higher value than the pre-CDT one, however,
there was no significant difference (P = 0.175). At the end of CDT, the circumference difference
of the third group was 4.52 ± 2.58 cm, significantly lower than the baseline level (8.76 ± 3.07
cm) (P < 0.001). In the third group, the reduction of circumference difference was persisted for
12 months. Conclusion: The effects of CDT were maintained for 12 months, while there were
differences in progress of circumference difference among the three groups. The effects of
patients with severe initial edema (> 5 cm increased) last longer.
Ting-Ting Li, Zhen-Dong Zheng, Yue-Hai Ma, Qiu-Hua Li, Zhao-Zhe Liu