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Rheumatoid arthritis and ankylosing spondylitis occurring together: a case report
Teng Huang, Linfeng Li, Bin Hao, Zhiyong Zhao, Shu ling Zhao
5TMR Clinical Research    2019, 2 (2): 74-81.   https://doi.org/10.12032/TMRClinicalRes201900006
Abstract PDF (952KB)  
Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are two different rheumatoid immune diseases. It is not common that the two diseases occur simultaneously in the same patient in clinical practice. Here, we reported a case of meeting the diagnostic criteria for both AS and RA, who was treated with integrated traditional Chinese and Western medicine and received apparent improvement.
Diagnosis and treatment of psoriatic arthritis with concealed rash: a case report
Teng Huang, Shaopeng Du, Xiaojing Liu, Zhenhua Liu, Bin Hao
5TMR Clinical Research    2019, 2 (2): 57-63.   https://doi.org/10.12032/TMRClinicalRes201900008
Abstract PDF (869KB)  

Psoriatic arthritis is a kind of arthritis associated with psoriasis. The clinical manifestations of psoriatic arthritis with arthritis as the first symptom are often similar to ankylosing spondylitis and rheumatoid arthritis. Thus differential diagnosis should be made in clinical practice so as to improve the therapeutic effect. Psoriatic arthritis skin lesions are usually papules or plaques, with scales on the surface and punctate hemorrhage on the basement. About 10% of patients with psoriatic arthritis have skin rash after the onset of arthritis. In order to provide a reference for clinicians, our study the analyzed the clinical diagnosis of psoriatic arthritis in combination with a case of psoriatic arthritis with concealed skin rash and related literatures.

Research progress of microRNA in prevention and treatment of osteonecrosis of the femoral head
Changsui Yu
5TMR Clinical Research    2018, 1 (2): 68-76.   https://doi.org/10.12032/TMRClinicalRes201800018
Abstract PDF (276KB)  
In the 1980s, Feinbaum et al.first discovered miRNA in the development of worms and termed it as Lin-4. With the development of microbial science and continuous improvement in the gene sequencing technology, miRNA has been gradually gaining attention for intensive research in clinical medicine.Among these, one group of miRNAs has been confirmed to play fundamental roles in gene regulation in various orthopedics diseases, such as bone tumors, osteoarthritis, and rheumatoid arthritis. The study of miRNAs in the osteonecrosis of the femoral head (ONFH) can improve the understanding of the pathogenesis of the disease. ONFH is an orthopedic disease that is the primary cause of disrupted blood supply to the femoral head and the main symptoms of bone and muscle dysfunction. Recent studies showed that miRNA played a major role in the regulation of the microcirculation of ONFH, damage and repair of blood vessels, local microcirculation dysfunction caused by other diseases, and apoptosis of bone cells. In this study, recent related research results of miRNA and ONFH were analyzed and summarized, and the prospective in the prevention and treatment of the disease was also discussed.
The beneficial effects of non-drug therapy on osteoarticular disease
TMR Non-Drug Therapy    2018, 1 (1): 1-.  
Abstract PDF (159KB)  

Osteoarticular disease (OD), including rheumatoid arthritis, knee osteoarthritis, lumbar disc bulge, and so on, is a category chronic and progressive disease with the primary character of pain and joint dysfunction. Serious patients are more prone to suffer from disability. The application of analgesic, NSAIDs, and surgical operation in Western medicine is always accompanied with the occurrence of side effects and high cost. Non-drug therapy of traditional Chinese medicine, including Yoga, acupuncture, massage, etc, is the main stream treatment of OD. The current special issue focuses on the field of non-drug therapy of OD.

The clinical progress and potential mechanism of massage therapy on knee osteoarthritis
Dong Si-Jia, Zhang Chi, Wu Jia-Hang, Yin Hao
TMR Non-Drug Therapy    2018, 1 (1): 2-8.   https://doi.org/10.12032/TMRND201801002
Abstract HTML PDF (718KB)  

Highlights

The effectiveness of massage is superior to that of joint cavity injection while the integrated therapeutic method containing massage is superior to that of single massage.

Editor’s Summary

Massage plays a key role in the non-drug therapy of knee osteoarthritis.

Abstract

Knee osteoarthritis (KOA) is a disease due to the degenerative pathological change of knee joint, which commonly occurs in the elderly. The main clinical characters of KOA are the pain, stiffness, and dysfunction of knee joint. Western medicine regarding to the treatment of KOA aims to relieve the pain and delay the progress of disease such as intra-articular injection and functional exercise. Traditional Chinese medicine (TCM) therapy includes massage, herb, acupuncture, microwave, etc. Among them, the massage technique has the advantages of simpleness, effectiveness and non-invasive manipulation. The present study compared the curative effects of different therapies on KOA including Western medicine therapeutic method, single massage, complementary TCM therapeutic method containing massage and integrated TCM and western medicine therapeutic method containing massage. We found that the effectiveness of single massage method is better than that of joint cavity injection. The effectiveness of massage in combination with herb and acupuncture is better than that of massage alone. The effectiveness of joint cavity injection or functional exercise combined with massage and acupuncture is better than that of the single articular cavity injection or functional exercise. However, more research and clinical trials are still needed to determine the exact mechanism of massage.

Prone-positioned upside-done arch exercise, a kind of lumbodorsal muscles training, curbs the progression of lumbar disc bulge
Gao Zeng-Jie, Chen Jiu-Yi, Liu Yang
TMR Non-Drug Therapy    2018, 1 (1): 9-15.   https://doi.org/10.12032/TMRND201801003
Abstract HTML PDF (964KB)  

Highlights

The comprehensive therapy containing prone- positioned upside-done arch exercise showed beneficial effects in patients with lumbar disc bulge in the terms of visual analogue score, bulge size and straight leg raise test.

Editor’s Summary

As a nonoperative treatment for lumbar disc herniation, lumbodorsal muscle training has the potentials to provide better prevention measures for lumbar disc bulge.

Abstract

Objective: To study the effects of prone-positioned upside-done arch exercise, a kind of lumbodorsal muscles training originated from Yoga, on curbing the progression of lumbar disc bulge. Methods: A total of 120 out-patients, diagnosed with lumbar disc bulge by CT and/or MRI, were randomly divided into the observation group and the control group, with 60 patients in each group. Patients in the observation group received the prone-positioned upside-done arch exercise combined with traction and acupuncture for two months and followed with a two-year treatment with prone-positioned upside-done arch exercise while the patients in the control group only received traction and acupuncture for two months. After two years, patients in both groups were investigated for the visual analogue score, MR image and straight leg raise tests. Results: Compared to the control group, prone-positioned upside-done arch exercise combined with traction and acupuncture showed significant decrease in patients’ visual analogue score, bulge size and the positive ratio of straight leg raise test (P = 0.001, P = 0.001 and P = 0.02 respectively), suggesting the inhibitory effect on the progression of lumber disc bulge. Conclusion: Prone-positioned upside-done arch has the potentials to protect patients with lumbar disc bulge from nerve root compression syndrome.

Comparative study for cardiovascular risk factors of rheumatoid arthritis and osteoarthritis
Yue Cai-Ping, Li Ming-Xi, Liu Yan, Li Fang-Kai, Liu Xiao-Ping, Ma Jun-Fu, Zhu Yue-Lan, Hou Xiu-Juan
TMR Non-Drug Therapy    2018, 1 (1): 16-22.   https://doi.org/10.12032/TMRND201801004
Abstract HTML PDF (714KB)  

Highlights

Patients with rheumatoid arthritis have higher incidence rate of cardiovascular diseases than those with osteoarthritis.

Editor’s Summary

This study focuses on the effects of non-traditional risk factors on the incidence rate of cardiovascular diseases in patient with rheumatoid arthritis, including inflammation indexes, echocardiography and carotid ultrasound related indexes etc.

Abstract

Objective: To compare the difference of cardiovascular risk factors in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods: A retrospective analysis was performed to compare the difference of cardiovascular factors between 44 patients with RA and 36 patients with OA in terms of their gender, age, body mass index, course of disease, carotid ultrasound related indicators, homocysteine, blood lipid levels, inflammation index, echocardiographic index, etc. Results: (1) General situation: there was no significant difference between two groups in terms of gender and age (P > 0.05). However, body mass index of OA group was significantly higher than that of RA group and the course of disease of RA group was significantly longer than that of OA group (P = 0.024). (2) Laboratory index: the level of homocysteine of RA group was significantly higher than that of OA group (P = 0.002). Though there was no significant difference between these two groups in terms of total cholesterol, triglyceride, low density lipoprotein, apolipoprotein B and high density lipoprotein (P > 0.05), the level of apolipoprotein A1 of RA group was significantly lower than that of OA group (P < 0.001) and the level of lipoprotein A of RA group was significantly higher than that of OA group (P < 0.001). The levels of erythrocyte sedimentation rate and C reactive protein of group RA were significantly higher than those of OA group (P < 0.001). (3) Stroke volume and ejection fraction of echocardiography of RA patients were significantly lower than those of OA patients (P = 0.022, P = 0.009). However, there was no significant difference between two groups in terms of aortic diameter, left atrial diameter, left ventricular end diastolic diameter, left ventricular end systolic diameter, left ventricular posterior wall thickness, left ventricular fractional shortening, right ventricular diameter, right atrial diameter, and interventricular septum thickness (P > 0.05). Though significant difference in carotid artery plaque incidence between the two groups was not observed (P > 0.05), the incidence of carotid artery thickening and carotid artery middle thickness were significantly different between the two groups (P < 0.001). Conclusion: The rate for the occurrence of cardiovascular events in patients with RA was higher than those with OA. Additionally, effective control of RA patients’ conditions has the potential to reduce the risk of cardiovascular events.

Systematic evaluation and trial sequential analysis of warming acupuncture combined with joint mobilization in the treatment of scapulohumeral periarthritis
Tian Rong, Li Da, Han Yu-Hui, Fan Yi-Hua
TMR Non-Drug Therapy    2018, 1 (3): 96-108.   https://doi.org/10.12032/TMRND201801014
Abstract HTML PDF (1846KB)  

Highlights

Warming acupuncture combined with joint mobilization had a significant effect on the treatment of scapulohumeral periarthritis.

Editor’s Summary

This review provides a new combination of non-drug therapy in the treatment of scapulohumeral periarthritis.

Abstract

Objective: To evaluate the clinical efficacy of warming acupuncture combined with joint mobilization for the treatment of scapulohumeral periarthritis. Methods: A search for published randomized controlled trials (RCT) investigating warming acupuncture combined with joint mobilization for the treatment of scapulohumeral periarthritis was performed using the Cochrane Library, PubMed, Embase, and Web of Science databases. According to requirements of the Cochrane systematic review, all evaluations of RCT investigating warming acupuncture with joint mobilization in the treatment of scapulohumeral periarthritis were performed via method quality assessment, data extraction, and data analysis. Revman 5.3 and Stata 12.0 statistical software were used for the meta-analysis, and the trial sequential analysis (TSA) software estimated the required information size for each outcome. Results: A total of 14 articles were retrieved for meta-analysis, which included 551 cases in the treatment group and 539 cases in the control group. Meta-analysis showed that: (1) warming acupuncture combined with joint mobilization improved total efficiency [OR = 6.16, 95% CI (3.79, 10.00), Z = 7.34; P < 0.001), TSA results confirmed the results of the meta-analysis; (2) warming acupuncture combined with joint mobilization improved the cure rate [OR = 2.84, 95% CI (2.19, 3.70), P < 0.001], TSA results revealed that no further tests were needed to verify; (3) warming acupuncture combined with joint mobilization reduced the number of treatments required for healing [MD = -7.49, 95% CI (-9.75, -5.23), P < 0.001], TSA results confirmed the results of the meta-analysis; (4) in comparing visual analog scale scores before and after treatment, meta-analysis result showed that: SMD = -2.01, 95%CI (-2.37, -1.65), P < 0.001, the difference was statistically significant, TSA results confirmed the results of the meta-analysis. Conclusion: Warming acupuncture combined with joint mobilization had a significant effect on the treatment of scapulohumeral periarthritis.

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