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20 December 2019, Volume 1 Issue 3 Previous Issue   
The Future of Rodent Models in the Research of Depression
Peng Chen, Jiexin Lei
92Psychosomatic Medicine Research. 2019, 1 (3): 52-56.   https://doi.org/10.12032/psmr2019-1220-011
Abstract ( 34 )     PDF (665KB) ( 26 )  
Currently, over 300 million people worldwide live with depression, and the financial burden of this mental disease on the public systems is expected to increase significantly in the coming decades in the context of economic globalization. Despite the urgency of the crisis, we are still looking forward to develop improved therapeutics for this disorder, which has resulted in increasing criticism of the value and role of depression models in drug screening and preclinical studies. Recently, a variety of new approaches for studying depression-like behaviors in experimental animals has been developed. In this commentary, we discussed how various strategies such as genetic manipulation and circuit dissection to study the biological mechanisms underlying and/or mediating depression in humans. Finally, we also describe a brief framework for future research that can enhance our understanding about the neurobiological underpinnings of the disease and to address the urgent need to develop alternative therapeutic approaches to treat patients suffering from depression.
A Review of Management Research on Medical Risk in China
Jing Han, Hong-Xia Li , Tao Wang, Ming-Yu Zhang, Yu-Hua Ma, Xin-Yi Li, Yi-Bo Wu
92Psychosomatic Medicine Research. 2019, 1 (3): 57-61.   https://doi.org/10.12032/psmr2019-1220-012
Abstract ( 25 )     PDF (260KB) ( 9 )  
With the development of medical industry and the improvement of people's legal consciousness, the issue of medical risk has been one of the social focusing problems in our country. We explore the current situation of medical risk in China, understand the research findings of medical risk management, and analyze the problems existing in the practice of medical risk management in China through electronic database, internet related websites and related works. Finally, we find that the situation of medical risk in China is severe, the research of medical risk management starts late, and the response system is not perfect. Medical managers should constantly learn and practice, strive to improve the risk management ability, and then improve the hospital's medical risk response ability, so as to promote the sustainable development of the hospital.
Potential Mechanism of Suanzaoren Decoction for Insomnia Based on Network Pharmacology
Bo Liang, Yu-Xiu Zhao, Hui-Ling Liao, Ning Gu
92Psychosomatic Medicine Research. 2019, 1 (3): 62-72.   https://doi.org/10.12032/psmr2019-1220-013
Abstract ( 27 )     PDF (1889KB) ( 30 )  
Objective: To study the mechanism of Suanzaoren Decoction in the treatment of insomnia by using network pharmacology.
Methods: Chemical components and targets related to the Suanzaoren Decoction were searched through the traditional Chinese medicine systems pharmacology database and analysis platform, Traditional Chinese Medicines Database @ Taiwan and Traditional Chinese Medicines Integrated Database to construct the interaction network diagram of the target point of the compounds. The insomnia related targets were screened through GeneCards, MalaCards, NCBI-Gene, OMIM and CTD databases. The interactive target of Suanzaoren Decoction and insomnia was constructed in PPI database; GO analysis of screened core targets between drug target and disease target was carried out using DAVID database, and the related pathways of core targets were enriched using KEGG database.
Results: Using the oral bioavailability ≥ 30%, drug likeness ≥ 0.18, Caco-2 ≥ 0 and 4 ≤ half-life ≤ 8 as screening condition for the compounds, 35 effective components and 121 corresponding protein targets of Suanzaoren Decoction were screened out. A total of 336 enrichment results were obtained, including 301 biological processes, 25 molecular functions, and 10 cell compositions, on the condition of false discovery rate ≤ 0.0001. The selected targets were enriched by KEGG database and 17 pathways playing an important role in insomnia were screen out.
Conclusion: The synergetic effect of Suanzaoren Decoction with multi-components and multi-pathway was confirmed by network pharmacology, and the main possible mechanism of Suanzaoren Decoction in treating insomnia was predicted, which lay a foundation for the identification of effective components, the mechanism of action, and clinical application.
The Effect of Humanized Nursing on Blood Glucose Level of Diabetic Patients: A Meta-Analysis
Meng-Meng Wang, Xiu-Qing Wang
92Psychosomatic Medicine Research. 2019, 1 (3): 73-81.   https://doi.org/10.12032/psmr2019-1220-014
Abstract ( 25 )     PDF (1266KB) ( 20 )  
Objective: Systematic evaluation of the effect of humanized nursing on the control of blood glucose level in Chinese diabetic patients.
Methods: The computer searches the full-text databases of CNKI, Wanfang, PubMed and EMBASE, and looks for the published randomized controlled trials on the effect of human-oriented nursing on the control of blood glucose level in diabetic patients. The retrieval time is from the establishment of the database to May 2019. Based on the inclusion and exclusion criteria, two researchers independently selected literature, extracted data and evaluated the risk of bias in the study, then used Revman 5.3 software for meta analysis, and Stata software for publication bias and sensitivity analysis.
Results: A total of 11 non randomized and non synchronous control studies were included, including 933 patients, 470 in the intervention group and 463 in the control group. The results of meta-analysis showed that the control level of humanized nursing on fasting blood glucose (MD = – 1.53, 95% CI – 2.12 ~ – 0.94) and the control level of humanized nursing on blood glucose 2 hours after meal (MD = -2.53, 95% CI-3.24 ~ -1.82) and the control level of humanized nursing on glycosylated hemoglobin (MD = -1.55, 95%CI -2.21 ~ -0.89) were relatively low, the difference was statistically significant.
Conclusions: The existing evidence shows that humanistic nursing can reduce the fasting blood glucose value, 2 hours postprandial blood glucose value and glycosylated hemoglobin value of diabetic patients, improve the prognosis of diabetic patients, and reduce the occurrence of complications. However, limited by the quantity and quality of the included studies, the effect of humanized nursing on blood glucose level control of diabetic patients still needs to be verified by high-quality and large sample studies.
Efficacy of TCM Therapy of Claustrophobia: A Case Report
Bing-Sheng Yuan
92Psychosomatic Medicine Research. 2019, 1 (3): 82-86.   https://doi.org/10.12032/psmr2019-1220-015
Abstract ( 35 )     PDF (461KB) ( 23 )  
Mrs. S, 55 years old, suffered from claustrophobia for more than 30 years, aggravated for 3 years, with anxiety, headache and tremor. Many kinds of treatments were ineffective. July 2, 2019, first visiting my clinic, according to traditional Chinese medicine (TCM), she was diagnosed as claustrophobia phobia/ psychosis (panic), which was caused by panic injury of kidney and brain. Treatment principle is to tonify Spleen and Kidney, to supplement Qi and blood, to adjust Du meridian, Chong meridian, and Ren meridian; to assist in resolving phlegm and tranquilizing heart. After five acupuncture sessions and TCM herbs, Mrs. S take the elevator (closed and windowless) three times this week, without any discomfort. No panic palpitations have occurred in recent weeks.